Toward defining the autoimmune microbiome for type 1 diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-07-08

AUTHORS

Adriana Giongo, Kelsey A Gano, David B Crabb, Nabanita Mukherjee, Luis L Novelo, George Casella, Jennifer C Drew, Jorma Ilonen, Mikael Knip, Heikki Hyöty, Riitta Veijola, Tuula Simell, Olli Simell, Josef Neu, Clive H Wasserfall, Desmond Schatz, Mark A Atkinson, Eric W Triplett

ABSTRACT

Several studies have shown that gut bacteria have a role in diabetes in murine models. Specific bacteria have been correlated with the onset of diabetes in a rat model. However, it is unknown whether human intestinal microbes have a role in the development of autoimmunity that often leads to type 1 diabetes (T1D), an autoimmune disorder in which insulin-secreting pancreatic islet cells are destroyed. High-throughput, culture-independent approaches identified bacteria that correlate with the development of T1D-associated autoimmunity in young children who are at high genetic risk for this disorder. The level of bacterial diversity diminishes overtime in these autoimmune subjects relative to that of age-matched, genotype-matched, nonautoimmune individuals. A single species, Bacteroides ovatus, comprised nearly 24% of the total increase in the phylum Bacteroidetes in cases compared with controls. Conversely, another species in controls, represented by the human firmicute strain CO19, represented nearly 20% of the increase in Firmicutes compared with cases overtime. Three lines of evidence are presented that support the notion that, as healthy infants approach the toddler stage, their microbiomes become healthier and more stable, whereas, children who are destined for autoimmunity develop a microbiome that is less diverse and stable. Hence, the autoimmune microbiome for T1D may be distinctly different from that found in healthy children. These data also suggest bacterial markers for the early diagnosis of T1D. In addition, bacteria that negatively correlated with the autoimmune state may prove to be useful in the prevention of autoimmunity development in high-risk children. More... »

PAGES

82-91

References to SciGraph publications

  • 2001-03. Feasibility of genetic and immunological prediction of Type I diabetes in a population-based birth cohort in DIABETOLOGIA
  • 2006-12. An obesity-associated gut microbiome with increased capacity for energy harvest in NATURE
  • 2006-08-07. UniFrac – An online tool for comparing microbial community diversity in a phylogenetic context in BMC BIOINFORMATICS
  • 2006-07-01. Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes? in DIABETOLOGIA
  • 2010-02-25. PANGEA: pipeline for analysis of next generation amplicons in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2008-09-21. Innate immunity and intestinal microbiota in the development of Type 1 diabetes in NATURE
  • 2009-02-19. Culture-independent identification of gut bacteria correlated with the onset of diabetes in a rat model in THE ISME JOURNAL: MULTIDISCIPLINARY JOURNAL OF MICROBIAL ECOLOGY
  • 2006-11-21. Comment on: Brugman S et al. (2006) Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes? Diabetologia 49:2105–2108 in DIABETOLOGIA
  • 2008-11-30. A core gut microbiome in obese and lean twins in NATURE
  • 2005-06-29. Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse in DIABETOLOGIA
  • 2004-08-19. MUSCLE: a multiple sequence alignment method with reduced time and space complexity in BMC BIOINFORMATICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ismej.2010.92

    DOI

    http://dx.doi.org/10.1038/ismej.2010.92

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039284129

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20613793


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