Adipose tissue mitochondrial capacity associates with long-term weight loss success View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-04

AUTHORS

R Jokinen, R Rinnankoski-Tuikka, S Kaye, L Saarinen, S Heinonen, M Myöhänen, E Rappou, S Jukarainen, A Rissanen, A Pessia, V Velagapudi, K A Virtanen, E Pirinen, K H Pietiläinen

ABSTRACT

OBJECTIVES: We investigated whether (1) subcutaneous adipose tissue (SAT) mitochondrial capacity predicts weight loss success and (2) weight loss ameliorates obesity-related SAT mitochondrial abnormalities. METHODS: SAT biopsies were obtained from 19 clinically healthy obese subjects (body mass index (BMI) 34.6±2.7 kg m-2) during a weight loss intervention (0, 5 and 12 months) and from 19 lean reference subjects (BMI 22.7±1.1 kg m-2) at baseline. Based on 1-year weight loss outcome, the subjects were divided into two groups: continuous weight losers (WL, n=6) and weight regainers (WR, n=13). Main outcome measures included SAT mitochondrial pathways from transcriptomics, mitochondrial amount (mitochondrial DNA (mtDNA), Porin protein levels), mtDNA-encoded transcripts, oxidative phosphorylation (OXPHOS) proteins, and plasma metabolites of the mitochondrial branched-chain amino-acid catabolism (BCAA) pathway. SAT and visceral adipose tissue (VAT) glucose uptake was measured with positron emission tomography. RESULTS: Despite similar baseline clinical characteristics, SAT in the WL group exhibited higher gene expression level of nuclear-encoded mitochondrial pathways (P=0.0224 OXPHOS, P=0.0086 tricarboxylic acid cycle, P=0.0074 fatty acid beta-oxidation and P=0.0122 BCAA), mtDNA transcript COX1 (P=0.0229) and protein level of Porin (P=0.0462) than the WR group. Many baseline mitochondrial parameters correlated with WL success, and with SAT and VAT glucose uptake. During WL, the nuclear-encoded mitochondrial pathways were downregulated, together with increased plasma metabolite levels of BCAAs in both groups. MtDNA copy number increased in the WR group at 5 months (P=0.012), but decreased to baseline level between 5 and 12 months (P=0.015). The only significant change in the WL group for mtDNA was a reduction between 5 and 12 months (P=0.004). The levels of Porin did not change in either group upon WL. CONCLUSIONS: Higher mitochondrial capacity in SAT predicts good long-term WL success. WL does not ameliorate SAT mitochondrial downregulation and based on pathway expression, may paradoxically further reduce it.Data availability:The transcriptomics data generated in this study have been deposited to the Gene Expression Omnibus public repository, accession number GSE103769. More... »

PAGES

817

References to SciGraph publications

  • 2014-01. Characterising metabolically healthy obesity in weight-discordant monozygotic twins in DIABETOLOGIA
  • 2017-02. Adipose tissue gene expression is differentially regulated with different rates of weight loss in overweight and obese humans in INTERNATIONAL JOURNAL OF OBESITY
  • 2008-09. Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity in GENOME BIOLOGY
  • 2008-05. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2007-02. qBase relative quantification framework and software for management and automated analysis of real-time quantitative PCR data in GENOME BIOLOGY
  • 2014-12. Branched-chain amino acids in metabolic signalling and insulin resistance in NATURE REVIEWS ENDOCRINOLOGY
  • 2012-03. Does dieting make you fat? A twin study in INTERNATIONAL JOURNAL OF OBESITY
  • 2018-03. Subcutaneous adipose tissue gene expression and DNA methylation respond to both short- and long-term weight loss in INTERNATIONAL JOURNAL OF OBESITY
  • 2015-12. Weight loss-induced changes in adipose tissue proteins associated with fatty acid and glucose metabolism correlate with adaptations in energy expenditure in NUTRITION & METABOLISM
  • 2015-12. Roux-en-Y Gastric Bypass Acutely Decreases Protein Carbonylation and Increases Expression of Mitochondrial Biogenesis Genes in Subcutaneous Adipose Tissue in OBESITY SURGERY
  • 2017-05. Diet-induced weight loss decreases adipose tissue oxygen tension with parallel changes in adipose tissue phenotype and insulin sensitivity in overweight humans in INTERNATIONAL JOURNAL OF OBESITY
  • 2015-12. Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue in SCIENTIFIC REPORTS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ijo.2017.299

    DOI

    http://dx.doi.org/10.1038/ijo.2017.299

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1095859576

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29203860


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