Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-01

AUTHORS

Theresia M. Schnurr, Anna Viitasalo, Aino-Maija Eloranta, Camilla T. Damsgaard, Yuvaraj Mahendran, Christian T. Have, Juuso Väistö, Mads F. Hjorth, Line B. Christensen, Soren Brage, Mustafa Atalay, Leo-Pekka Lyytikäinen, Virpi Lindi, Timo Lakka, Kim F. Michaelsen, Tuomas O. Kilpeläinen, Torben Hansen

ABSTRACT

Increased sedentariness has been linked to the growing prevalence of obesity in children, but some longitudinal studies suggest that sedentariness may be a consequence rather than a cause of increased adiposity. We used Mendelian randomization to examine the causal relations between body mass index (BMI) and objectively assessed sedentary time and physical activity in 3-8 year-old children from one Finnish and two Danish cohorts [NTOTAL=679]. A genetic risk score (GRS) comprised of 15 independent genetic variants associated with childhood BMI was used as the instrumental variable to test causal effects of BMI on sedentary time, total physical activity, and moderate-to-vigorous physical activity (MVPA). In fixed effects meta-analyses, the GRS was associated with 0.05 SD/allele increase in sedentary time (P=0.019), but there was no significant association with total physical activity (beta=0.011 SD/allele, P=0.58) or MVPA (beta=0.001 SD/allele, P=0.96), adjusting for age, sex, monitor wear-time and first three genome-wide principal components. In two-stage least squares regression analyses, each genetically instrumented one unit increase in BMI z-score increased sedentary time by 0.47 SD (P=0.072). Childhood BMI may have a causal influence on sedentary time but not on total physical activity or MVPA in young children. Our results provide important insights into the regulation of movement behaviour in childhood. More... »

PAGES

111

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ijo.2017.235

DOI

http://dx.doi.org/10.1038/ijo.2017.235

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091926770

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28947836


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ijo.2017.235'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ijo.2017.235'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ijo.2017.235'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ijo.2017.235'


 

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