Distinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-10

AUTHORS

B Rachid, S van de Sande-Lee, S Rodovalho, F Folli, G C Beltramini, J Morari, B J Amorim, T Pedro, A F Ramalho, B Bombassaro, A J Tincani, E Chaim, J C Pareja, B Geloneze, C D Ramos, F Cendes, M J A Saad, L A Velloso

ABSTRACT

BACKGROUND/OBJECTIVES: The identification of brown/beige adipose tissue in adult humans has motivated the search for methods aimed at increasing its thermogenic activity as an approach to treat obesity. In rodents, the brown adipose tissue is under the control of sympathetic signals originating in the hypothalamus. However, the putative connection between the depots of brown/beige adipocytes and the hypothalamus in humans has never been explored. The objective of this study was to evaluate the response of the hypothalamus and brown/beige adipose tissue to cold stimulus in obese subjects undergoing body mass reduction following gastric bypass. SUBJECTS/METHODS: We evaluated twelve obese, non-diabetic subjects undergoing Roux-in-Y gastric bypass and 12 lean controls. Obese subjects were evaluated before and approximately 8 months after gastric bypass. Lean subjects were evaluated only at admission. Subjects were evaluated for hypothalamic activity in response to cold by functional magnetic resonance, whereas brown/beige adipose tissue activity was evaluated using a (F 18) fluorodeoxyglucose positron emisson tomography/computed tomography scan and real-time PCR measurement of signature genes. RESULTS: Body mass reduction resulted in a significant increase in brown/beige adipose tissue activity in response to cold; however, no change in cold-induced hypothalamic activity was observed after body mass reduction. No correlation was found between brown/beige adipose tissue activation and hypothalamus activity in obese subjects or in lean controls. CONCLUSIONS: In humans, the increase in brown/beige adipose tissue activity related to body mass reduction occurs independently of changes in hypothalamic activity as determined by functional magnetic resonance. More... »

PAGES

1515

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ijo.2015.94

DOI

http://dx.doi.org/10.1038/ijo.2015.94

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020084676

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25994805


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptation, Physiological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipose Tissue, Brown", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brazil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cold Temperature", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorodeoxyglucose F18", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastric Bypass", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypothalamus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondrial Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Positron-Emission Tomography", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiopharmaceuticals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Real-Time Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thermogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thinness", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Laboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rachid", 
        "givenName": "B", 
        "id": "sg:person.01051261611.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051261611.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Laboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "van de Sande-Lee", 
        "givenName": "S", 
        "id": "sg:person.01337702231.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337702231.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Laboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rodovalho", 
        "givenName": "S", 
        "id": "sg:person.01221001104.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221001104.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas Health Science Center at San Antonio", 
          "id": "https://www.grid.ac/institutes/grid.267309.9", 
          "name": [
            "Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Folli", 
        "givenName": "F", 
        "id": "sg:person.0622273004.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622273004.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Neurophysics Group, Institute of Physics Gleb Wataghin, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Beltramini", 
        "givenName": "G C", 
        "id": "sg:person.0767264532.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767264532.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Laboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morari", 
        "givenName": "J", 
        "id": "sg:person.01345241115.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345241115.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Division of Nuclear Medicine, Department of Radiology, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Amorim", 
        "givenName": "B J", 
        "id": "sg:person.01322757475.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322757475.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Neuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pedro", 
        "givenName": "T", 
        "id": "sg:person.0733240162.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733240162.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Laboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ramalho", 
        "givenName": "A F", 
        "id": "sg:person.0740674311.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740674311.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Laboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bombassaro", 
        "givenName": "B", 
        "id": "sg:person.01202251040.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202251040.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Department of Surgery, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tincani", 
        "givenName": "A J", 
        "id": "sg:person.0631207033.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631207033.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Department of Surgery, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chaim", 
        "givenName": "E", 
        "id": "sg:person.01250364240.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250364240.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Department of Surgery, University of Campinas, Campinas, Brazil.", 
            "Laboratory of Investigation in Metabolism and Diabetes, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pareja", 
        "givenName": "J C", 
        "id": "sg:person.014432075614.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014432075614.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Laboratory of Investigation in Metabolism and Diabetes, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Geloneze", 
        "givenName": "B", 
        "id": "sg:person.0753022030.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753022030.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Division of Nuclear Medicine, Department of Radiology, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ramos", 
        "givenName": "C D", 
        "id": "sg:person.0724263161.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724263161.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Neuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cendes", 
        "givenName": "F", 
        "id": "sg:person.0711476427.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711476427.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Laboratory of Experimental Endocrinology, Department of Internal Medicine, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saad", 
        "givenName": "M J A", 
        "id": "sg:person.012545605342.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012545605342.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "State University of Campinas", 
          "id": "https://www.grid.ac/institutes/grid.411087.b", 
          "name": [
            "Laboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Velloso", 
        "givenName": "L A", 
        "id": "sg:person.01213266244.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213266244.62"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.2337/db10-1614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000877926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/med.0b013e328337a81f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002087890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/med.0b013e328337a81f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002087890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tem.2012.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002493320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-012-2748-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004788574", 
          "https://doi.org/10.1007/s00125-012-2748-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-012-2748-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004788574", 
          "https://doi.org/10.1007/s00125-012-2748-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci59660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006963732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0610416104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010015248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db11-0390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011342427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ijo.2010.182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012577746", 
          "https://doi.org/10.1038/ijo.2010.182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/adip.26896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014024394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.030874", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015827359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/bjn19750025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015953356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/bjn19750025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015953356"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.05.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018204198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ijo.2010.177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018487300", 
          "https://doi.org/10.1038/ijo.2010.177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2003.050369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018538263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cmet.2013.04.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018700183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tins.2012.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019909815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0808718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020175954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc11-s011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023520038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db12-0288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025185549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2012-1289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026600767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.rlu.0000259570.69163.04", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027472267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.rlu.0000259570.69163.04", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027472267"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2014.50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027596670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/jcbfm.2014.50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027596670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci60433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027882187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db12-1605", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028090208"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11695-008-9678-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028903073", 
          "https://doi.org/10.1007/s11695-008-9678-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.09.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029733192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0808949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031171399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpregu.00427.2006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034802039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35016590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035780752", 
          "https://doi.org/10.1038/35016590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35016590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035780752", 
          "https://doi.org/10.1038/35016590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ijo.2011.56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037023216", 
          "https://doi.org/10.1038/ijo.2011.56"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3223-10.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037382919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.3223-10.2011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037382919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-006-0318-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038954624", 
          "https://doi.org/10.1007/s00259-006-0318-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00259-006-0318-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038954624", 
          "https://doi.org/10.1007/s00259-006-0318-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10863-011-9325-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040615366", 
          "https://doi.org/10.1007/s10863-011-9325-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2010.64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040722950", 
          "https://doi.org/10.1038/nrendo.2010.64"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrendo.2010.64", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040722950", 
          "https://doi.org/10.1038/nrendo.2010.64"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0361-9230(00)00346-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045204750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045364560", 
          "https://doi.org/10.1038/nature05026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045364560", 
          "https://doi.org/10.1038/nature05026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045364560", 
          "https://doi.org/10.1038/nature05026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1523/jneurosci.0130-04.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047083454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0810780", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049326570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nn.3219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050477217", 
          "https://doi.org/10.1038/nn.3219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm.3361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051594830", 
          "https://doi.org/10.1038/nm.3361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1207911109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053448311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo.137.1.8536614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064280434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/55.2.615s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077378984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/jappl.1988.65.6.2395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079533656"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-10", 
    "datePublishedReg": "2015-10-01", 
    "description": "BACKGROUND/OBJECTIVES: The identification of brown/beige adipose tissue in adult humans has motivated the search for methods aimed at increasing its thermogenic activity as an approach to treat obesity. In rodents, the brown adipose tissue is under the control of sympathetic signals originating in the hypothalamus. However, the putative connection between the depots of brown/beige adipocytes and the hypothalamus in humans has never been explored. The objective of this study was to evaluate the response of the hypothalamus and brown/beige adipose tissue to cold stimulus in obese subjects undergoing body mass reduction following gastric bypass.\nSUBJECTS/METHODS: We evaluated twelve obese, non-diabetic subjects undergoing Roux-in-Y gastric bypass and 12 lean controls. Obese subjects were evaluated before and approximately 8 months after gastric bypass. Lean subjects were evaluated only at admission. Subjects were evaluated for hypothalamic activity in response to cold by functional magnetic resonance, whereas brown/beige adipose tissue activity was evaluated using a (F 18) fluorodeoxyglucose positron emisson tomography/computed tomography scan and real-time PCR measurement of signature genes.\nRESULTS: Body mass reduction resulted in a significant increase in brown/beige adipose tissue activity in response to cold; however, no change in cold-induced hypothalamic activity was observed after body mass reduction. No correlation was found between brown/beige adipose tissue activation and hypothalamus activity in obese subjects or in lean controls.\nCONCLUSIONS: In humans, the increase in brown/beige adipose tissue activity related to body mass reduction occurs independently of changes in hypothalamic activity as determined by functional magnetic resonance.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ijo.2015.94", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1035838", 
        "issn": [
          "0307-0565", 
          "1476-5497"
        ], 
        "name": "International Journal of Obesity", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "39"
      }
    ], 
    "name": "Distinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesity", 
    "pagination": "1515", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5fb22329aec7fcd58103fe983bb01b490120f24bd119db2f1b362103a3bb8902"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "25994805"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101256108"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ijo.2015.94"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020084676"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ijo.2015.94", 
      "https://app.dimensions.ai/details/publication/pub.1020084676"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000434.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ijo201594"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ijo.2015.94'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ijo.2015.94'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ijo.2015.94'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ijo.2015.94'


 

This table displays all metadata directly associated to this object as RDF triples.

417 TRIPLES      21 PREDICATES      92 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ijo.2015.94 schema:about N0effea630bb745b6a4c12bff34df48a3
2 N0fcd9b86df3a42c897ab19264a863093
3 N158fae48150d490baab3e7c9b5672d47
4 N17da0fa2eaef4154b139654765c10df8
5 N2e4ddfe6ab9e46f99a9cfa86fddacffb
6 N2fbc64eab4b54b3886cbe74a34dd6e74
7 N46fadf91560b48cc91b46710bf4ab031
8 N4c81799d1b3c4b7ba283f5ae64e3a37f
9 N582d1adfad0c47e78a2767316b94c43c
10 N6e36ce9e33ce4878a1b1ad344b661829
11 N80ca9ec2d06140009e32489f58f68a45
12 N88eae53a24d24fc68be5dea41913d8ca
13 N91dc18099dcb47b1b55ea162d3bf8519
14 Nb10acad9a1e243418bd2dcb8eb61e75b
15 Nb7b88b29694b4156b5c51232f099dd45
16 Ne2dee92b7f994679932009fe860a2e6c
17 Nf00c88e81833483781761e2123dbe62a
18 Nf22a3168c6654547bee05260b4a097c9
19 Nf6c5758005f543c8b5e326248e2f1ecb
20 anzsrc-for:11
21 anzsrc-for:1103
22 schema:author N1840a39730774841bdbe2975d7a34d69
23 schema:citation sg:pub.10.1007/s00125-012-2748-1
24 sg:pub.10.1007/s00259-006-0318-9
25 sg:pub.10.1007/s10863-011-9325-z
26 sg:pub.10.1007/s11695-008-9678-5
27 sg:pub.10.1038/35016590
28 sg:pub.10.1038/ijo.2010.177
29 sg:pub.10.1038/ijo.2010.182
30 sg:pub.10.1038/ijo.2011.56
31 sg:pub.10.1038/nature05026
32 sg:pub.10.1038/nm.3361
33 sg:pub.10.1038/nn.3219
34 sg:pub.10.1038/nrendo.2010.64
35 https://doi.org/10.1016/j.cell.2012.05.016
36 https://doi.org/10.1016/j.cell.2012.09.020
37 https://doi.org/10.1016/j.cmet.2013.04.011
38 https://doi.org/10.1016/j.tem.2012.11.003
39 https://doi.org/10.1016/j.tins.2012.12.005
40 https://doi.org/10.1016/s0361-9230(00)00346-4
41 https://doi.org/10.1038/jcbfm.2014.50
42 https://doi.org/10.1056/nejmoa0808718
43 https://doi.org/10.1056/nejmoa0808949
44 https://doi.org/10.1056/nejmoa0810780
45 https://doi.org/10.1073/pnas.0610416104
46 https://doi.org/10.1073/pnas.1207911109
47 https://doi.org/10.1074/jbc.m109.030874
48 https://doi.org/10.1079/bjn19750025
49 https://doi.org/10.1093/ajcn/55.2.615s
50 https://doi.org/10.1097/01.rlu.0000259570.69163.04
51 https://doi.org/10.1097/med.0b013e328337a81f
52 https://doi.org/10.1113/jphysiol.2003.050369
53 https://doi.org/10.1152/ajpregu.00427.2006
54 https://doi.org/10.1152/jappl.1988.65.6.2395
55 https://doi.org/10.1172/jci59660
56 https://doi.org/10.1172/jci60433
57 https://doi.org/10.1210/endo.137.1.8536614
58 https://doi.org/10.1210/jc.2012-1289
59 https://doi.org/10.1523/jneurosci.0130-04.2004
60 https://doi.org/10.1523/jneurosci.3223-10.2011
61 https://doi.org/10.2337/db10-1614
62 https://doi.org/10.2337/db11-0390
63 https://doi.org/10.2337/db12-0288
64 https://doi.org/10.2337/db12-1605
65 https://doi.org/10.2337/dc11-s011
66 https://doi.org/10.4161/adip.26896
67 schema:datePublished 2015-10
68 schema:datePublishedReg 2015-10-01
69 schema:description BACKGROUND/OBJECTIVES: The identification of brown/beige adipose tissue in adult humans has motivated the search for methods aimed at increasing its thermogenic activity as an approach to treat obesity. In rodents, the brown adipose tissue is under the control of sympathetic signals originating in the hypothalamus. However, the putative connection between the depots of brown/beige adipocytes and the hypothalamus in humans has never been explored. The objective of this study was to evaluate the response of the hypothalamus and brown/beige adipose tissue to cold stimulus in obese subjects undergoing body mass reduction following gastric bypass. SUBJECTS/METHODS: We evaluated twelve obese, non-diabetic subjects undergoing Roux-in-Y gastric bypass and 12 lean controls. Obese subjects were evaluated before and approximately 8 months after gastric bypass. Lean subjects were evaluated only at admission. Subjects were evaluated for hypothalamic activity in response to cold by functional magnetic resonance, whereas brown/beige adipose tissue activity was evaluated using a (F 18) fluorodeoxyglucose positron emisson tomography/computed tomography scan and real-time PCR measurement of signature genes. RESULTS: Body mass reduction resulted in a significant increase in brown/beige adipose tissue activity in response to cold; however, no change in cold-induced hypothalamic activity was observed after body mass reduction. No correlation was found between brown/beige adipose tissue activation and hypothalamus activity in obese subjects or in lean controls. CONCLUSIONS: In humans, the increase in brown/beige adipose tissue activity related to body mass reduction occurs independently of changes in hypothalamic activity as determined by functional magnetic resonance.
70 schema:genre research_article
71 schema:inLanguage en
72 schema:isAccessibleForFree false
73 schema:isPartOf N29dada73190042bca5555fe605da44a1
74 Nd97e81b8042f44b3b7076fa3b73704f8
75 sg:journal.1035838
76 schema:name Distinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesity
77 schema:pagination 1515
78 schema:productId N1ce268c75b7544c58a47221cbfdfb1bb
79 N3bd628ac95b041f98e6d7efe4bf93b37
80 N44f4a69d35934cb8b50d813af2821723
81 N481e59c1f4454cf6aec4cd01af4c00c3
82 Nc7fabc1afcac45fb9b0efa5155081607
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020084676
84 https://doi.org/10.1038/ijo.2015.94
85 schema:sdDatePublished 2019-04-10T13:57
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher Nf4146f66b3b743f69677a923ee67c9ce
88 schema:url https://www.nature.com/articles/ijo201594
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N0effea630bb745b6a4c12bff34df48a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Mitochondrial Proteins
94 rdf:type schema:DefinedTerm
95 N0fcd9b86df3a42c897ab19264a863093 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Brazil
97 rdf:type schema:DefinedTerm
98 N11c8c25183454c7d8dbadc065062f6c6 rdf:first sg:person.012545605342.86
99 rdf:rest N61c5e9a7d5c14347a8710a7b9ecd12b4
100 N14af4b8b082a4245a82621dce9c80f5b rdf:first sg:person.0622273004.10
101 rdf:rest N6dc06d412818412388c8fc0455881c60
102 N158fae48150d490baab3e7c9b5672d47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Signal Transduction
104 rdf:type schema:DefinedTerm
105 N162de8a7f0484d6e88745eef6411e4cf rdf:first sg:person.0724263161.64
106 rdf:rest N3fa5704aa06944099476f9a15ae9f0bd
107 N17da0fa2eaef4154b139654765c10df8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Gastric Bypass
109 rdf:type schema:DefinedTerm
110 N1840a39730774841bdbe2975d7a34d69 rdf:first sg:person.01051261611.63
111 rdf:rest N76a4c973a87e4194b73339fd8de04f14
112 N1ce268c75b7544c58a47221cbfdfb1bb schema:name dimensions_id
113 schema:value pub.1020084676
114 rdf:type schema:PropertyValue
115 N1f012ee462c146538ae5165d741aef24 rdf:first sg:person.0753022030.41
116 rdf:rest N162de8a7f0484d6e88745eef6411e4cf
117 N29dada73190042bca5555fe605da44a1 schema:volumeNumber 39
118 rdf:type schema:PublicationVolume
119 N2e4ddfe6ab9e46f99a9cfa86fddacffb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Gene Expression Regulation
121 rdf:type schema:DefinedTerm
122 N2fbc64eab4b54b3886cbe74a34dd6e74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Thinness
124 rdf:type schema:DefinedTerm
125 N3bd628ac95b041f98e6d7efe4bf93b37 schema:name nlm_unique_id
126 schema:value 101256108
127 rdf:type schema:PropertyValue
128 N3fa5704aa06944099476f9a15ae9f0bd rdf:first sg:person.0711476427.47
129 rdf:rest N11c8c25183454c7d8dbadc065062f6c6
130 N44ca7db2b1b34bdabce7940053a35ee2 rdf:first sg:person.01322757475.80
131 rdf:rest N48ad81c3045742c9b11658d1bcb9f052
132 N44f4a69d35934cb8b50d813af2821723 schema:name readcube_id
133 schema:value 5fb22329aec7fcd58103fe983bb01b490120f24bd119db2f1b362103a3bb8902
134 rdf:type schema:PropertyValue
135 N46fadf91560b48cc91b46710bf4ab031 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Adult
137 rdf:type schema:DefinedTerm
138 N481e59c1f4454cf6aec4cd01af4c00c3 schema:name pubmed_id
139 schema:value 25994805
140 rdf:type schema:PropertyValue
141 N48ad81c3045742c9b11658d1bcb9f052 rdf:first sg:person.0733240162.01
142 rdf:rest Ne03fb8318d9741af91783eb972b8c99d
143 N4c81799d1b3c4b7ba283f5ae64e3a37f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Fluorodeoxyglucose F18
145 rdf:type schema:DefinedTerm
146 N582d1adfad0c47e78a2767316b94c43c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Cold Temperature
148 rdf:type schema:DefinedTerm
149 N61c5e9a7d5c14347a8710a7b9ecd12b4 rdf:first sg:person.01213266244.62
150 rdf:rest rdf:nil
151 N6dc06d412818412388c8fc0455881c60 rdf:first sg:person.0767264532.05
152 rdf:rest N839aefdf1a2b4de39239de85a793e63b
153 N6e36ce9e33ce4878a1b1ad344b661829 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Radiopharmaceuticals
155 rdf:type schema:DefinedTerm
156 N76a4c973a87e4194b73339fd8de04f14 rdf:first sg:person.01337702231.19
157 rdf:rest Nbcb2115953c943eebc49eb5ab9256f0e
158 N80ca9ec2d06140009e32489f58f68a45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Adipose Tissue, Brown
160 rdf:type schema:DefinedTerm
161 N839aefdf1a2b4de39239de85a793e63b rdf:first sg:person.01345241115.63
162 rdf:rest N44ca7db2b1b34bdabce7940053a35ee2
163 N88eae53a24d24fc68be5dea41913d8ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Adaptation, Physiological
165 rdf:type schema:DefinedTerm
166 N91dc18099dcb47b1b55ea162d3bf8519 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Female
168 rdf:type schema:DefinedTerm
169 Nac0dc8518e774801bad7fb0deb28e3d2 rdf:first sg:person.01202251040.18
170 rdf:rest Nba3d30e5b2694971b058c130e503167a
171 Nb10acad9a1e243418bd2dcb8eb61e75b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Positron-Emission Tomography
173 rdf:type schema:DefinedTerm
174 Nb7b88b29694b4156b5c51232f099dd45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Obesity
176 rdf:type schema:DefinedTerm
177 Nba3d30e5b2694971b058c130e503167a rdf:first sg:person.0631207033.65
178 rdf:rest Nf1d1e0bdd997418692ae9bd6d3ece22f
179 Nbcb2115953c943eebc49eb5ab9256f0e rdf:first sg:person.01221001104.34
180 rdf:rest N14af4b8b082a4245a82621dce9c80f5b
181 Nc7fabc1afcac45fb9b0efa5155081607 schema:name doi
182 schema:value 10.1038/ijo.2015.94
183 rdf:type schema:PropertyValue
184 Nd97e81b8042f44b3b7076fa3b73704f8 schema:issueNumber 10
185 rdf:type schema:PublicationIssue
186 Ne03fb8318d9741af91783eb972b8c99d rdf:first sg:person.0740674311.14
187 rdf:rest Nac0dc8518e774801bad7fb0deb28e3d2
188 Ne2dee92b7f994679932009fe860a2e6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Real-Time Polymerase Chain Reaction
190 rdf:type schema:DefinedTerm
191 Nf00c88e81833483781761e2123dbe62a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Thermogenesis
193 rdf:type schema:DefinedTerm
194 Nf1d1e0bdd997418692ae9bd6d3ece22f rdf:first sg:person.01250364240.00
195 rdf:rest Nf7c451cdd5f744848a0239ce14526c35
196 Nf22a3168c6654547bee05260b4a097c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Hypothalamus
198 rdf:type schema:DefinedTerm
199 Nf4146f66b3b743f69677a923ee67c9ce schema:name Springer Nature - SN SciGraph project
200 rdf:type schema:Organization
201 Nf6c5758005f543c8b5e326248e2f1ecb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Humans
203 rdf:type schema:DefinedTerm
204 Nf7c451cdd5f744848a0239ce14526c35 rdf:first sg:person.014432075614.91
205 rdf:rest N1f012ee462c146538ae5165d741aef24
206 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
207 schema:name Medical and Health Sciences
208 rdf:type schema:DefinedTerm
209 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
210 schema:name Clinical Sciences
211 rdf:type schema:DefinedTerm
212 sg:journal.1035838 schema:issn 0307-0565
213 1476-5497
214 schema:name International Journal of Obesity
215 rdf:type schema:Periodical
216 sg:person.01051261611.63 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
217 schema:familyName Rachid
218 schema:givenName B
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051261611.63
220 rdf:type schema:Person
221 sg:person.01202251040.18 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
222 schema:familyName Bombassaro
223 schema:givenName B
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202251040.18
225 rdf:type schema:Person
226 sg:person.01213266244.62 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
227 schema:familyName Velloso
228 schema:givenName L A
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213266244.62
230 rdf:type schema:Person
231 sg:person.01221001104.34 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
232 schema:familyName Rodovalho
233 schema:givenName S
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01221001104.34
235 rdf:type schema:Person
236 sg:person.01250364240.00 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
237 schema:familyName Chaim
238 schema:givenName E
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250364240.00
240 rdf:type schema:Person
241 sg:person.012545605342.86 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
242 schema:familyName Saad
243 schema:givenName M J A
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012545605342.86
245 rdf:type schema:Person
246 sg:person.01322757475.80 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
247 schema:familyName Amorim
248 schema:givenName B J
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322757475.80
250 rdf:type schema:Person
251 sg:person.01337702231.19 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
252 schema:familyName van de Sande-Lee
253 schema:givenName S
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337702231.19
255 rdf:type schema:Person
256 sg:person.01345241115.63 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
257 schema:familyName Morari
258 schema:givenName J
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01345241115.63
260 rdf:type schema:Person
261 sg:person.014432075614.91 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
262 schema:familyName Pareja
263 schema:givenName J C
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014432075614.91
265 rdf:type schema:Person
266 sg:person.0622273004.10 schema:affiliation https://www.grid.ac/institutes/grid.267309.9
267 schema:familyName Folli
268 schema:givenName F
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0622273004.10
270 rdf:type schema:Person
271 sg:person.0631207033.65 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
272 schema:familyName Tincani
273 schema:givenName A J
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631207033.65
275 rdf:type schema:Person
276 sg:person.0711476427.47 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
277 schema:familyName Cendes
278 schema:givenName F
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711476427.47
280 rdf:type schema:Person
281 sg:person.0724263161.64 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
282 schema:familyName Ramos
283 schema:givenName C D
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724263161.64
285 rdf:type schema:Person
286 sg:person.0733240162.01 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
287 schema:familyName Pedro
288 schema:givenName T
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0733240162.01
290 rdf:type schema:Person
291 sg:person.0740674311.14 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
292 schema:familyName Ramalho
293 schema:givenName A F
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740674311.14
295 rdf:type schema:Person
296 sg:person.0753022030.41 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
297 schema:familyName Geloneze
298 schema:givenName B
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753022030.41
300 rdf:type schema:Person
301 sg:person.0767264532.05 schema:affiliation https://www.grid.ac/institutes/grid.411087.b
302 schema:familyName Beltramini
303 schema:givenName G C
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767264532.05
305 rdf:type schema:Person
306 sg:pub.10.1007/s00125-012-2748-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004788574
307 https://doi.org/10.1007/s00125-012-2748-1
308 rdf:type schema:CreativeWork
309 sg:pub.10.1007/s00259-006-0318-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038954624
310 https://doi.org/10.1007/s00259-006-0318-9
311 rdf:type schema:CreativeWork
312 sg:pub.10.1007/s10863-011-9325-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1040615366
313 https://doi.org/10.1007/s10863-011-9325-z
314 rdf:type schema:CreativeWork
315 sg:pub.10.1007/s11695-008-9678-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028903073
316 https://doi.org/10.1007/s11695-008-9678-5
317 rdf:type schema:CreativeWork
318 sg:pub.10.1038/35016590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035780752
319 https://doi.org/10.1038/35016590
320 rdf:type schema:CreativeWork
321 sg:pub.10.1038/ijo.2010.177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018487300
322 https://doi.org/10.1038/ijo.2010.177
323 rdf:type schema:CreativeWork
324 sg:pub.10.1038/ijo.2010.182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012577746
325 https://doi.org/10.1038/ijo.2010.182
326 rdf:type schema:CreativeWork
327 sg:pub.10.1038/ijo.2011.56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037023216
328 https://doi.org/10.1038/ijo.2011.56
329 rdf:type schema:CreativeWork
330 sg:pub.10.1038/nature05026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045364560
331 https://doi.org/10.1038/nature05026
332 rdf:type schema:CreativeWork
333 sg:pub.10.1038/nm.3361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051594830
334 https://doi.org/10.1038/nm.3361
335 rdf:type schema:CreativeWork
336 sg:pub.10.1038/nn.3219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050477217
337 https://doi.org/10.1038/nn.3219
338 rdf:type schema:CreativeWork
339 sg:pub.10.1038/nrendo.2010.64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040722950
340 https://doi.org/10.1038/nrendo.2010.64
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1016/j.cell.2012.05.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018204198
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1016/j.cell.2012.09.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029733192
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1016/j.cmet.2013.04.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018700183
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1016/j.tem.2012.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002493320
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1016/j.tins.2012.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019909815
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1016/s0361-9230(00)00346-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045204750
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1038/jcbfm.2014.50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027596670
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1056/nejmoa0808718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020175954
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1056/nejmoa0808949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031171399
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1056/nejmoa0810780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049326570
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1073/pnas.0610416104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010015248
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1073/pnas.1207911109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053448311
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1074/jbc.m109.030874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015827359
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1079/bjn19750025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015953356
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1093/ajcn/55.2.615s schema:sameAs https://app.dimensions.ai/details/publication/pub.1077378984
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1097/01.rlu.0000259570.69163.04 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027472267
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1097/med.0b013e328337a81f schema:sameAs https://app.dimensions.ai/details/publication/pub.1002087890
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1113/jphysiol.2003.050369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018538263
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1152/ajpregu.00427.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034802039
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1152/jappl.1988.65.6.2395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079533656
381 rdf:type schema:CreativeWork
382 https://doi.org/10.1172/jci59660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006963732
383 rdf:type schema:CreativeWork
384 https://doi.org/10.1172/jci60433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027882187
385 rdf:type schema:CreativeWork
386 https://doi.org/10.1210/endo.137.1.8536614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064280434
387 rdf:type schema:CreativeWork
388 https://doi.org/10.1210/jc.2012-1289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026600767
389 rdf:type schema:CreativeWork
390 https://doi.org/10.1523/jneurosci.0130-04.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047083454
391 rdf:type schema:CreativeWork
392 https://doi.org/10.1523/jneurosci.3223-10.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037382919
393 rdf:type schema:CreativeWork
394 https://doi.org/10.2337/db10-1614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000877926
395 rdf:type schema:CreativeWork
396 https://doi.org/10.2337/db11-0390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011342427
397 rdf:type schema:CreativeWork
398 https://doi.org/10.2337/db12-0288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025185549
399 rdf:type schema:CreativeWork
400 https://doi.org/10.2337/db12-1605 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028090208
401 rdf:type schema:CreativeWork
402 https://doi.org/10.2337/dc11-s011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023520038
403 rdf:type schema:CreativeWork
404 https://doi.org/10.4161/adip.26896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014024394
405 rdf:type schema:CreativeWork
406 https://www.grid.ac/institutes/grid.267309.9 schema:alternateName The University of Texas Health Science Center at San Antonio
407 schema:name Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
408 rdf:type schema:Organization
409 https://www.grid.ac/institutes/grid.411087.b schema:alternateName State University of Campinas
410 schema:name Department of Surgery, University of Campinas, Campinas, Brazil.
411 Division of Nuclear Medicine, Department of Radiology, University of Campinas, Campinas, Brazil.
412 Laboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
413 Laboratory of Experimental Endocrinology, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
414 Laboratory of Investigation in Metabolism and Diabetes, University of Campinas, Campinas, Brazil.
415 Neuroimaging Laboratory, Department of Neurology, University of Campinas, Campinas, Brazil.
416 Neurophysics Group, Institute of Physics Gleb Wataghin, University of Campinas, Campinas, Brazil.
417 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...