Ontology type: schema:ScholarlyArticle Open Access: True
2014-09
AUTHORSJ Peplies, D Jiménez-Pavón, S C Savva, C Buck, K Günther, A Fraterman, P Russo, L Iacoviello, T Veidebaum, M Tornaritis, S De Henauw, S Mårild, D Molnár, L A Moreno, W Ahrens
ABSTRACTOBJECTIVES: The aim of this study is to present age- and sex-specific reference values of insulin, glucose, glycosylated haemoglobin (HbA1c) and the homeostasis model assessment to quantify insulin resistance (HOMA-IR) for pre-pubertal children. METHODS: The reference population consists of 7074 normal weight 3- to 10.9-year-old pre-pubertal children from eight European countries who participated in at least one wave of the IDEFICS ('identification and prevention of dietary- and lifestyle-induced health effects in children and infants') surveys (2007-2010) and for whom standardised laboratory measurements were obtained. Percentile curves of insulin (measured by an electrochemiluminescence immunoassay), glucose, HbA1c and HOMA-IR were calculated as a function of age stratified by sex using the general additive model for location scale and shape (GAMLSS) method. RESULTS: Levels of insulin, fasting glucose and HOMA-IR continuously show an increasing trend with age, whereas HbA1c shows an upward trend only beyond the age of 8 years. Insulin and HOMA-IR values are higher in girls of all age groups, whereas glucose values are slightly higher in boys. Median serum levels of insulin range from 17.4 and 13.2 pmol l(-1) in 3-<3.5-year-old girls and boys, respectively, to 53.5 and 43.0 pmol l(-1) in 10.5-<11-year-old girls and boys. Median values of glucose are 4.3 and 4.5 mmol l(-1) in the youngest age group and 49.3 and 50.6 mmol l(-1) in the oldest girls and boys. For HOMA-IR, median values range from 0.5 and 0.4 in 3-<3.5-year-old girls and boys to 1.7 and 1.4 in 10.5-<11-year-old girls and boys, respectively. CONCLUSIONS: Our study provides the first standardised reference values for an international European children's population and provides the, up to now, largest data set of healthy pre-pubertal children to model reference percentiles for markers of insulin resistance. Our cohort shows higher values of Hb1Ac as compared with a single Swedish study while our percentiles for the other glucose metabolic markers are in good accordance with previous studies. More... »
PAGESs39
http://scigraph.springernature.com/pub.10.1038/ijo.2014.134
DOIhttp://dx.doi.org/10.1038/ijo.2014.134
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1015644353
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25376219
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Age Distribution",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Blood Glucose",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Body Mass Index",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Child",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Child, Preschool",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cohort Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Diet",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Europe",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "European Continental Ancestry Group",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fasting",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glycated Hemoglobin A",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Health Surveys",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Homeostasis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Insulin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Insulin Resistance",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Life Style",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Reference Values",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sex Distribution",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sexual Maturation",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Leibniz Institute for Prevention Research and Epidemiology - BIPS",
"id": "https://www.grid.ac/institutes/grid.418465.a",
"name": [
"Leibniz Institute for Prevention Research and Epidemiology\u2014BIPS, Bremen, Germany"
],
"type": "Organization"
},
"familyName": "Peplies",
"givenName": "J",
"id": "sg:person.0735365547.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735365547.74"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Zaragoza",
"id": "https://www.grid.ac/institutes/grid.11205.37",
"name": [
"GENUD (Growth, Exercise, Nutrition and Development) Research Group, School of Health Sciences, University of Zaragoza, Zaragoza, Spain"
],
"type": "Organization"
},
"familyName": "Jim\u00e9nez-Pav\u00f3n",
"givenName": "D",
"id": "sg:person.01271663624.01",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271663624.01"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Research & Education Institute of Child Health, Strovolos, Cyprus"
],
"type": "Organization"
},
"familyName": "Savva",
"givenName": "S C",
"id": "sg:person.0650307213.99",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650307213.99"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Leibniz Institute for Prevention Research and Epidemiology - BIPS",
"id": "https://www.grid.ac/institutes/grid.418465.a",
"name": [
"Leibniz Institute for Prevention Research and Epidemiology\u2014BIPS, Bremen, Germany"
],
"type": "Organization"
},
"familyName": "Buck",
"givenName": "C",
"id": "sg:person.01042320410.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042320410.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Leibniz Institute for Prevention Research and Epidemiology - BIPS",
"id": "https://www.grid.ac/institutes/grid.418465.a",
"name": [
"Leibniz Institute for Prevention Research and Epidemiology\u2014BIPS, Bremen, Germany"
],
"type": "Organization"
},
"familyName": "G\u00fcnther",
"givenName": "K",
"id": "sg:person.01006024400.19",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006024400.19"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Center for HIV and Hepatogastroenterology",
"id": "https://www.grid.ac/institutes/grid.417595.b",
"name": [
"Medizinisches Versorgungszentrum (MVZ), Dr Eberhard und Partner Dortmund, Dortmund, Germany"
],
"type": "Organization"
},
"familyName": "Fraterman",
"givenName": "A",
"id": "sg:person.01112427621.55",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112427621.55"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Food Science",
"id": "https://www.grid.ac/institutes/grid.429574.9",
"name": [
"Epidemiology and Population Genetics, Institute of Food Science, CNR, Avellino, Italy"
],
"type": "Organization"
},
"familyName": "Russo",
"givenName": "P",
"id": "sg:person.01171557712.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01171557712.88"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Catholic University of the Sacred Heart",
"id": "https://www.grid.ac/institutes/grid.8142.f",
"name": [
"Centre for High Technology Research and Education in Biomedical Sciences, Universita Cattolica del Sacro Cuore, Campobasso, Italy"
],
"type": "Organization"
},
"familyName": "Iacoviello",
"givenName": "L",
"id": "sg:person.01054443021.99",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01054443021.99"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Institute for Health Development",
"id": "https://www.grid.ac/institutes/grid.416712.7",
"name": [
"National Institute for Health Development (NIHD), Tallinn, Estonia"
],
"type": "Organization"
},
"familyName": "Veidebaum",
"givenName": "T",
"id": "sg:person.01030636537.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030636537.08"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Research & Education Institute of Child Health, Strovolos, Cyprus"
],
"type": "Organization"
},
"familyName": "Tornaritis",
"givenName": "M",
"id": "sg:person.01100002067.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100002067.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ghent University",
"id": "https://www.grid.ac/institutes/grid.5342.0",
"name": [
"Department of Public Health, Ghent University, Ghent, Belgium"
],
"type": "Organization"
},
"familyName": "De Henauw",
"givenName": "S",
"id": "sg:person.01167234665.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167234665.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Drottning Silvias barn- och ungdomssjukhus",
"id": "https://www.grid.ac/institutes/grid.415579.b",
"name": [
"Department of Paedriatrics, The Queen Silvia Children's Hospital, Gothenburg, Sweden"
],
"type": "Organization"
},
"familyName": "M\u00e5rild",
"givenName": "S",
"id": "sg:person.01035523667.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035523667.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Pecs",
"id": "https://www.grid.ac/institutes/grid.9679.1",
"name": [
"Chronic Diseases Department, National Institute of Health Promotion, University of P\u00e9cs, P\u00e9cs, Hungary"
],
"type": "Organization"
},
"familyName": "Moln\u00e1r",
"givenName": "D",
"id": "sg:person.01337520027.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337520027.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Zaragoza",
"id": "https://www.grid.ac/institutes/grid.11205.37",
"name": [
"GENUD (Growth, Exercise, Nutrition and Development) Research Group, School of Health Sciences, University of Zaragoza, Zaragoza, Spain"
],
"type": "Organization"
},
"familyName": "Moreno",
"givenName": "L A",
"id": "sg:person.011602340402.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011602340402.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Bremen",
"id": "https://www.grid.ac/institutes/grid.7704.4",
"name": [
"Leibniz Institute for Prevention Research and Epidemiology\u2014BIPS, Bremen, Germany",
"Institute of Statistics, Faculty of Mathematics and Computer Science, University Bremen, Bremen, Germany"
],
"type": "Organization"
},
"familyName": "Ahrens",
"givenName": "W",
"id": "sg:person.0633614701.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633614701.43"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/ijo.2011.30",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000196894",
"https://doi.org/10.1038/ijo.2011.30"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ijo.2011.30",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000196894",
"https://doi.org/10.1038/ijo.2011.30"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/adc.42.224.375",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005339537"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/00365513.2013.783931",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005359520"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1373/clinchem.2006.077784",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006108561"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/00365510802691771",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007243879"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/17477161003615583",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009563199"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/14651858.cd002968.pub2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010848196"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1542/peds.2011-0449",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012049351"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4067/s0034-98872011001100007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012206383"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/0004563213482890",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013337866"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/0004563213482890",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013337866"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/dc08-s273",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014346064"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4274/jcrpe.v2i3.100",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014622048"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1530/eje-11-0844",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015814017"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/14651858.cd001871.pub3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015989385"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ijo.2011.41",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016239584",
"https://doi.org/10.1038/ijo.2011.41"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ijo.2011.41",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016239584",
"https://doi.org/10.1038/ijo.2011.41"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00431-013-2017-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016271001",
"https://doi.org/10.1007/s00431-013-2017-4"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/sim.4780111005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018381687"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/aje/kwt088",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024698836"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00280883",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027902786",
"https://doi.org/10.1007/bf00280883"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00280883",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027902786",
"https://doi.org/10.1007/bf00280883"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00280883",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027902786",
"https://doi.org/10.1007/bf00280883"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1515/jpem.2007.20.2.187",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031060911"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0140-6736(92)92814-v",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035358640"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0140-6736(92)92814-v",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035358640"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/14651858.cd001871.pub2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036501414"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/14651858.cd001871.pub2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036501414"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10654-010-9481-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036727204",
"https://doi.org/10.1007/s10654-010-9481-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10654-010-9481-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036727204",
"https://doi.org/10.1007/s10654-010-9481-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1373/49.4.644",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036915521"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/sim.3504",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039944616"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.ijo.0803187",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040191498",
"https://doi.org/10.1038/sj.ijo.0803187"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.ijo.0803187",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040191498",
"https://doi.org/10.1038/sj.ijo.0803187"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm199806043382302",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041842101"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/00365510410003110",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041977640"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/sim.746",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043672837"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.2047-6310.2012.00064.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047193200"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ejcn.2010.8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050385681",
"https://doi.org/10.1038/ejcn.2010.8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ejcn.2010.8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050385681",
"https://doi.org/10.1038/ejcn.2010.8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.clinbiochem.2006.02.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050867037"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1515/jpem.2009.22.8.695",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051125580"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1542/peds.2010-1290",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1067828605"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.18637/jss.v023.i07",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1068672343"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2471/blt.07.043497",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1070836960"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4239/wjd.v1.i2.36",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072397340"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075063820",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077056940",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077948897",
"type": "CreativeWork"
},
{
"id": "https://doi.org//s0034-98872011001100007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1078537529"
],
"type": "CreativeWork"
}
],
"datePublished": "2014-09",
"datePublishedReg": "2014-09-01",
"description": "OBJECTIVES: The aim of this study is to present age- and sex-specific reference values of insulin, glucose, glycosylated haemoglobin (HbA1c) and the homeostasis model assessment to quantify insulin resistance (HOMA-IR) for pre-pubertal children.\nMETHODS: The reference population consists of 7074 normal weight 3- to 10.9-year-old pre-pubertal children from eight European countries who participated in at least one wave of the IDEFICS ('identification and prevention of dietary- and lifestyle-induced health effects in children and infants') surveys (2007-2010) and for whom standardised laboratory measurements were obtained. Percentile curves of insulin (measured by an electrochemiluminescence immunoassay), glucose, HbA1c and HOMA-IR were calculated as a function of age stratified by sex using the general additive model for location scale and shape (GAMLSS) method.\nRESULTS: Levels of insulin, fasting glucose and HOMA-IR continuously show an increasing trend with age, whereas HbA1c shows an upward trend only beyond the age of 8 years. Insulin and HOMA-IR values are higher in girls of all age groups, whereas glucose values are slightly higher in boys. Median serum levels of insulin range from 17.4 and 13.2\u2009pmol\u2009l(-1) in 3-<3.5-year-old girls and boys, respectively, to 53.5 and 43.0\u2009pmol\u2009l(-1) in 10.5-<11-year-old girls and boys. Median values of glucose are 4.3 and 4.5\u2009mmol\u2009l(-1) in the youngest age group and 49.3 and 50.6\u2009mmol\u2009l(-1) in the oldest girls and boys. For HOMA-IR, median values range from 0.5 and 0.4 in 3-<3.5-year-old girls and boys to 1.7 and 1.4 in 10.5-<11-year-old girls and boys, respectively.\nCONCLUSIONS: Our study provides the first standardised reference values for an international European children's population and provides the, up to now, largest data set of healthy pre-pubertal children to model reference percentiles for markers of insulin resistance. Our cohort shows higher values of Hb1Ac as compared with a single Swedish study while our percentiles for the other glucose metabolic markers are in good accordance with previous studies.",
"genre": "research_article",
"id": "sg:pub.10.1038/ijo.2014.134",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.3767420",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1035838",
"issn": [
"0307-0565",
"1476-5497"
],
"name": "International Journal of Obesity",
"type": "Periodical"
},
{
"issueNumber": "S2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "38"
}
],
"name": "Percentiles of fasting serum insulin, glucose, HbA1c and HOMA-IR in pre-pubertal normal weight European children from the IDEFICS cohort",
"pagination": "s39",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"4a898aadb37ad522996571662a5c523fceed989286892f0811dbf27d1b12727e"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"25376219"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101256108"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/ijo.2014.134"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1015644353"
]
}
],
"sameAs": [
"https://doi.org/10.1038/ijo.2014.134",
"https://app.dimensions.ai/details/publication/pub.1015644353"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T22:20",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000434.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/ijo2014134"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ijo.2014.134'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ijo.2014.134'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ijo.2014.134'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ijo.2014.134'
This table displays all metadata directly associated to this object as RDF triples.
420 TRIPLES
21 PREDICATES
93 URIs
44 LITERALS
32 BLANK NODES