Improved acylated ghrelin suppression at 2 years in obese patients with type 2 diabetes: effects of bariatric surgery vs standard ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-03

AUTHORS

S K Malin, A Samat, K Wolski, B Abood, C E Pothier, D L Bhatt, S Nissen, S A Brethauer, P R Schauer, J P Kirwan, S R Kashyap

ABSTRACT

OBJECTIVE: Roux-en-Y gastric bypass (RYGB) produces more durable glycemic control than sleeve gastrectomy (SG) or intensive medical therapy (IMT). However, the contribution of acylated ghrelin (AG), a gluco-regulatory/appetite hormone, to improve glucose metabolism and body composition in patients with type 2 diabetes (T2D) following RYGB is unknown. DESIGN: STAMPEDE (Surgical Treatment and Medication Potentially Eradicate Diabetes Efficiently) was a prospective, randomized controlled trial. SUBJECTS: Fifty-three (body mass index: 36±3 kg m(-2), age: 49±9 years) poorly controlled patients with T2D (HbA1c (glycated hemoglobin): 9.7±2%) were randomized to IMT, IMT+RYGB or IMT+SG and underwent a mixed-meal tolerance test at baseline, 12, and 24 months for evaluation of AG suppression (postprandial minus fasting) and beta-cell function (oral disposition index; glucose-stimulated insulin secretion × Matsuda index). Total/android body fat (dual-energy X-ray absorptiometry) was also assessed. RESULTS: RYGB and SG reduced body fat comparably (15-23 kg) at 12 and 24 months, whereas IMT had no effect. Beta-cell function increased 5.8-fold in RYGB and was greater than IMT at 24 months (P<0.001). However, there was no difference in insulin secretion between SG vs IMT at 24 months (P=0.32). Fasting AG was reduced fourfold following SG (P<0.01) and did not change with RYGB or IMT at 24 months. AG suppression improved more following RYGB than SG or IMT at 24 months (P=0.01 vs SG, P=0.07 vs IMT). At 24 months, AG suppression was associated with increased postprandial glucagon-like peptide-1 (r=-0.32, P<0.02) and decreased android fat (r=0.38; P<0.006). CONCLUSIONS: Enhanced AG suppression persists for up to 2 years after RYGB, and this effect is associated with decreased android obesity and improved insulin secretion. Together, these findings suggest that AG suppression is partly responsible for the improved glucose control after RYGB surgery. More... »

PAGES

364

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ijo.2013.196

DOI

http://dx.doi.org/10.1038/ijo.2013.196

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033111548

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24166065


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Absorptiometry, Photon", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Acylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anti-Obesity Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Mass Index", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feeding Behavior", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastric Bypass", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ghrelin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycated Hemoglobin A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Secretion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity, Morbid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Postprandial Period", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Weight Loss", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Cleveland Clinic", 
          "id": "https://www.grid.ac/institutes/grid.239578.2", 
          "name": [
            "Department of Pathobiology, Cleveland Clinic, Cleveland, OH, USA", 
            "Department of Nutrition, Case Western Reserve University, Cleveland Clinic, Cleveland, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Malin", 
        "givenName": "S K", 
        "id": "sg:person.01064545154.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064545154.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cleveland Clinic", 
          "id": "https://www.grid.ac/institutes/grid.239578.2", 
          "name": [
            "Department of Endocrinology, Cleveland Clinic, Cleveland, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Samat", 
        "givenName": "A", 
        "id": "sg:person.01276053301.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276053301.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cleveland Clinic", 
          "id": "https://www.grid.ac/institutes/grid.239578.2", 
          "name": [
            "Department of Heart and Vascular, Cleveland Clinic, Cleveland, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wolski", 
        "givenName": "K", 
        "id": "sg:person.0576565657.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576565657.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cleveland Clinic", 
          "id": "https://www.grid.ac/institutes/grid.239578.2", 
          "name": [
            "Department of Endocrinology, Cleveland Clinic, Cleveland, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abood", 
        "givenName": "B", 
        "id": "sg:person.01263271023.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263271023.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cleveland Clinic", 
          "id": "https://www.grid.ac/institutes/grid.239578.2", 
          "name": [
            "Department of Heart and Vascular, Cleveland Clinic, Cleveland, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pothier", 
        "givenName": "C E", 
        "id": "sg:person.01222152704.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222152704.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Veterans Affairs Boston Healthcare System, Brigham and Women\u2019s Hospital, and Harvard Medical School, Boston, MA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bhatt", 
        "givenName": "D L", 
        "id": "sg:person.01111066700.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111066700.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cleveland Clinic", 
          "id": "https://www.grid.ac/institutes/grid.239578.2", 
          "name": [
            "Department of Heart and Vascular, Cleveland Clinic, Cleveland, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nissen", 
        "givenName": "S", 
        "id": "sg:person.0700554327.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700554327.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cleveland Clinic", 
          "id": "https://www.grid.ac/institutes/grid.239578.2", 
          "name": [
            "Department of Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, OH, USA", 
            "Metabolic Translational Research Center, Endocrine and Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brethauer", 
        "givenName": "S A", 
        "id": "sg:person.0756332431.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756332431.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cleveland Clinic", 
          "id": "https://www.grid.ac/institutes/grid.239578.2", 
          "name": [
            "Department of Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, OH, USA", 
            "Metabolic Translational Research Center, Endocrine and Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schauer", 
        "givenName": "P R", 
        "id": "sg:person.016133735277.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016133735277.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cleveland Clinic", 
          "id": "https://www.grid.ac/institutes/grid.239578.2", 
          "name": [
            "Department of Pathobiology, Cleveland Clinic, Cleveland, OH, USA", 
            "Department of Nutrition, Case Western Reserve University, Cleveland Clinic, Cleveland, OH, USA", 
            "Metabolic Translational Research Center, Endocrine and Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kirwan", 
        "givenName": "J P", 
        "id": "sg:person.0716365423.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716365423.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cleveland Clinic", 
          "id": "https://www.grid.ac/institutes/grid.239578.2", 
          "name": [
            "Department of Endocrinology, Cleveland Clinic, Cleveland, OH, USA", 
            "Metabolic Translational Research Center, Endocrine and Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kashyap", 
        "givenName": "S R", 
        "id": "sg:person.01006507214.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006507214.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1001/archinternmed.2010.380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000230351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.regpep.2007.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000463320"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.soard.2007.08.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001688350"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1200225", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005294597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa012908", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007925895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1200111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008610882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/oby.20441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009213036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e318156f012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010113295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e318156f012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010113295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/sla.0b013e318156f012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010113295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jamainternmed.2013.7783", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011371405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db10-0504", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013754785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/dom.12118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013913603"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11695-009-0014-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016640661", 
          "https://doi.org/10.1007/s11695-009-0014-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db06-0730", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017982943"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jes.0b013e3181c5cd98", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018763890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jes.0b013e3181c5cd98", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018763890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/jes.0b013e3181c5cd98", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018763890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-009-1288-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019761845", 
          "https://doi.org/10.1007/s00125-009-1288-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-009-1288-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019761845", 
          "https://doi.org/10.1007/s00125-009-1288-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-009-1288-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019761845", 
          "https://doi.org/10.1007/s00125-009-1288-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/oby.2007.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019977841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11695-012-0622-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022979092", 
          "https://doi.org/10.1007/s11695-012-0622-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ijo.2009.254", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025292388", 
          "https://doi.org/10.1038/ijo.2009.254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc10-1548", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031233900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034631385", 
          "https://doi.org/10.1038/nature05482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034631385", 
          "https://doi.org/10.1038/nature05482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034631385", 
          "https://doi.org/10.1038/nature05482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc12-1596", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035048348"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.regpep.2005.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035968045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.regpep.2005.04.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035968045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2265.2010.03916.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036143704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/eje-08-0735", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037059055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2004-1076", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037729186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/oby.20272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039218944"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.soard.2011.07.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039310843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/oby.2004.118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040435447"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-012-2556-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041144492", 
          "https://doi.org/10.1007/s00125-012-2556-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-012-2556-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041144492", 
          "https://doi.org/10.1007/s00125-012-2556-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11695-009-0066-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042864203", 
          "https://doi.org/10.1007/s11695-009-0066-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11695-009-0066-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042864203", 
          "https://doi.org/10.1007/s11695-009-0066-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc12-1535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045888777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1467-789x.2009.00699.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046003247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1467-789x.2009.00699.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046003247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2012.67929", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046432855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci25811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046966962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ijo.0803440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047158637", 
          "https://doi.org/10.1038/sj.ijo.0803440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ijo.0803440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047158637", 
          "https://doi.org/10.1038/sj.ijo.0803440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/dc11-0925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049797951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1463-1326.2009.01172.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052197913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1463-1326.2009.01172.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052197913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2012.06.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053034870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2009-0367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064249978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2004-0433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064287777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jc.2010-2876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064292614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.86.10.7885", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064323857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.2008-0432", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064328273"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-03", 
    "datePublishedReg": "2014-03-01", 
    "description": "OBJECTIVE: Roux-en-Y gastric bypass (RYGB) produces more durable glycemic control than sleeve gastrectomy (SG) or intensive medical therapy (IMT). However, the contribution of acylated ghrelin (AG), a gluco-regulatory/appetite hormone, to improve glucose metabolism and body composition in patients with type 2 diabetes (T2D) following RYGB is unknown.\nDESIGN: STAMPEDE (Surgical Treatment and Medication Potentially Eradicate Diabetes Efficiently) was a prospective, randomized controlled trial.\nSUBJECTS: Fifty-three (body mass index: 36\u00b13\u2009kg\u2009m(-2), age: 49\u00b19 years) poorly controlled patients with T2D (HbA1c (glycated hemoglobin): 9.7\u00b12%) were randomized to IMT, IMT+RYGB or IMT+SG and underwent a mixed-meal tolerance test at baseline, 12, and 24 months for evaluation of AG suppression (postprandial minus fasting) and beta-cell function (oral disposition index; glucose-stimulated insulin secretion \u00d7 Matsuda index). Total/android body fat (dual-energy X-ray absorptiometry) was also assessed.\nRESULTS: RYGB and SG reduced body fat comparably (15-23\u2009kg) at 12 and 24 months, whereas IMT had no effect. Beta-cell function increased 5.8-fold in RYGB and was greater than IMT at 24 months (P<0.001). However, there was no difference in insulin secretion between SG vs IMT at 24 months (P=0.32). Fasting AG was reduced fourfold following SG (P<0.01) and did not change with RYGB or IMT at 24 months. AG suppression improved more following RYGB than SG or IMT at 24 months (P=0.01 vs SG, P=0.07 vs IMT). At 24 months, AG suppression was associated with increased postprandial glucagon-like peptide-1 (r=-0.32, P<0.02) and decreased android fat (r=0.38; P<0.006).\nCONCLUSIONS: Enhanced AG suppression persists for up to 2 years after RYGB, and this effect is associated with decreased android obesity and improved insulin secretion. Together, these findings suggest that AG suppression is partly responsible for the improved glucose control after RYGB surgery.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ijo.2013.196", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2683175", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2705236", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2705139", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2500235", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1035838", 
        "issn": [
          "0307-0565", 
          "1476-5497"
        ], 
        "name": "International Journal of Obesity", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "38"
      }
    ], 
    "name": "Improved acylated ghrelin suppression at 2 years in obese patients with type 2 diabetes: effects of bariatric surgery vs standard medical therapy", 
    "pagination": "364", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9dbcc1edf5c08543c0ce9383208f8f7f0f457f7f9818fe292909ff7caa292a25"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24166065"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101256108"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ijo.2013.196"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033111548"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ijo.2013.196", 
      "https://app.dimensions.ai/details/publication/pub.1033111548"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:18", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117100_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ijo2013196"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ijo.2013.196'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ijo.2013.196'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ijo.2013.196'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ijo.2013.196'


 

This table displays all metadata directly associated to this object as RDF triples.

375 TRIPLES      21 PREDICATES      93 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ijo.2013.196 schema:about N09e0d26da5934a98bc93ba310c2b0dc0
2 N0f30f80d40224bc48bd5d0cfdad4d2e0
3 N14853b80b2314d7ab5683b8117129028
4 N301bca663ffe4694ae43b8217487097d
5 N3c103b6abcbb4cbd9ba7bb820f5afbc7
6 N40639ee66f1c439085f4a441f6d5a84e
7 N487fbab569f840c185360eda63e90d47
8 N529b185d8df04bc6a504d1339960e535
9 N642c67231c864abb882033c1a395f648
10 N6d9dcbfffa5545088f10b8c107dbc1c5
11 N7a3782b4fbfa4ce2aac10015f885f4c3
12 N84314fc8fd2f4f30baf5abdac07f6410
13 N8f0460b4ef064faea4a5f50f47467226
14 N969241b31af0492e8146353c59eb8088
15 N978a4c480fae44dfba90da6b8ad5c733
16 N9ca6db99c5fb4d7a8a9d27b9cb9698d6
17 Nb06c2eef00c04001bb77430317abec23
18 Nb1a245fae6dc497ebdcebc81492b9abd
19 Nbe08320414dd4cab8d6b919fe9ba9935
20 Nc263a3430a1342e9b7349c823db90bde
21 Ncbb0ec45ed354253b010fd5123df03aa
22 anzsrc-for:11
23 anzsrc-for:1103
24 schema:author N2e60f403192f41268c7e595420511e21
25 schema:citation sg:pub.10.1007/s00125-009-1288-9
26 sg:pub.10.1007/s00125-012-2556-7
27 sg:pub.10.1007/s11695-009-0014-5
28 sg:pub.10.1007/s11695-009-0066-6
29 sg:pub.10.1007/s11695-012-0622-3
30 sg:pub.10.1038/ijo.2009.254
31 sg:pub.10.1038/nature05482
32 sg:pub.10.1038/sj.ijo.0803440
33 https://doi.org/10.1001/archinternmed.2010.380
34 https://doi.org/10.1001/jama.2012.67929
35 https://doi.org/10.1001/jamainternmed.2013.7783
36 https://doi.org/10.1002/oby.20272
37 https://doi.org/10.1002/oby.20441
38 https://doi.org/10.1016/j.febslet.2012.06.034
39 https://doi.org/10.1016/j.regpep.2005.04.004
40 https://doi.org/10.1016/j.regpep.2007.03.002
41 https://doi.org/10.1016/j.soard.2007.08.004
42 https://doi.org/10.1016/j.soard.2011.07.009
43 https://doi.org/10.1038/oby.2004.118
44 https://doi.org/10.1038/oby.2007.83
45 https://doi.org/10.1056/nejmoa012908
46 https://doi.org/10.1056/nejmoa1200111
47 https://doi.org/10.1056/nejmoa1200225
48 https://doi.org/10.1097/jes.0b013e3181c5cd98
49 https://doi.org/10.1097/sla.0b013e318156f012
50 https://doi.org/10.1111/dom.12118
51 https://doi.org/10.1111/j.1365-2265.2010.03916.x
52 https://doi.org/10.1111/j.1463-1326.2009.01172.x
53 https://doi.org/10.1111/j.1467-789x.2009.00699.x
54 https://doi.org/10.1172/jci25811
55 https://doi.org/10.1210/en.2009-0367
56 https://doi.org/10.1210/jc.2004-0433
57 https://doi.org/10.1210/jc.2004-1076
58 https://doi.org/10.1210/jc.2010-2876
59 https://doi.org/10.1210/jcem.86.10.7885
60 https://doi.org/10.1210/me.2008-0432
61 https://doi.org/10.1530/eje-08-0735
62 https://doi.org/10.2337/db06-0730
63 https://doi.org/10.2337/db10-0504
64 https://doi.org/10.2337/dc10-1548
65 https://doi.org/10.2337/dc11-0925
66 https://doi.org/10.2337/dc12-1535
67 https://doi.org/10.2337/dc12-1596
68 schema:datePublished 2014-03
69 schema:datePublishedReg 2014-03-01
70 schema:description OBJECTIVE: Roux-en-Y gastric bypass (RYGB) produces more durable glycemic control than sleeve gastrectomy (SG) or intensive medical therapy (IMT). However, the contribution of acylated ghrelin (AG), a gluco-regulatory/appetite hormone, to improve glucose metabolism and body composition in patients with type 2 diabetes (T2D) following RYGB is unknown. DESIGN: STAMPEDE (Surgical Treatment and Medication Potentially Eradicate Diabetes Efficiently) was a prospective, randomized controlled trial. SUBJECTS: Fifty-three (body mass index: 36±3 kg m(-2), age: 49±9 years) poorly controlled patients with T2D (HbA1c (glycated hemoglobin): 9.7±2%) were randomized to IMT, IMT+RYGB or IMT+SG and underwent a mixed-meal tolerance test at baseline, 12, and 24 months for evaluation of AG suppression (postprandial minus fasting) and beta-cell function (oral disposition index; glucose-stimulated insulin secretion × Matsuda index). Total/android body fat (dual-energy X-ray absorptiometry) was also assessed. RESULTS: RYGB and SG reduced body fat comparably (15-23 kg) at 12 and 24 months, whereas IMT had no effect. Beta-cell function increased 5.8-fold in RYGB and was greater than IMT at 24 months (P<0.001). However, there was no difference in insulin secretion between SG vs IMT at 24 months (P=0.32). Fasting AG was reduced fourfold following SG (P<0.01) and did not change with RYGB or IMT at 24 months. AG suppression improved more following RYGB than SG or IMT at 24 months (P=0.01 vs SG, P=0.07 vs IMT). At 24 months, AG suppression was associated with increased postprandial glucagon-like peptide-1 (r=-0.32, P<0.02) and decreased android fat (r=0.38; P<0.006). CONCLUSIONS: Enhanced AG suppression persists for up to 2 years after RYGB, and this effect is associated with decreased android obesity and improved insulin secretion. Together, these findings suggest that AG suppression is partly responsible for the improved glucose control after RYGB surgery.
71 schema:genre research_article
72 schema:inLanguage en
73 schema:isAccessibleForFree true
74 schema:isPartOf N67b93f2fa2714b5089b8583cc2a2db3a
75 N6be30068b16240bfbe17b922b247eaff
76 sg:journal.1035838
77 schema:name Improved acylated ghrelin suppression at 2 years in obese patients with type 2 diabetes: effects of bariatric surgery vs standard medical therapy
78 schema:pagination 364
79 schema:productId N08b3907297d641288bfa3f5ff2b88413
80 N2072748a27b14cb6943cd2a03f26ca03
81 N28363b41025a4659a4995a5417c4ac9d
82 Nb5de1c25f9bb490d96dd264038d25ed9
83 Nf8f7dcca7b6e478796f210fc09051add
84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033111548
85 https://doi.org/10.1038/ijo.2013.196
86 schema:sdDatePublished 2019-04-11T14:18
87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
88 schema:sdPublisher Nd4b87c0250d44593aa2ccc228c08df3c
89 schema:url https://www.nature.com/articles/ijo2013196
90 sgo:license sg:explorer/license/
91 sgo:sdDataset articles
92 rdf:type schema:ScholarlyArticle
93 N08b3907297d641288bfa3f5ff2b88413 schema:name dimensions_id
94 schema:value pub.1033111548
95 rdf:type schema:PropertyValue
96 N09e0d26da5934a98bc93ba310c2b0dc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Male
98 rdf:type schema:DefinedTerm
99 N0f30f80d40224bc48bd5d0cfdad4d2e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Postprandial Period
101 rdf:type schema:DefinedTerm
102 N14853b80b2314d7ab5683b8117129028 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Ghrelin
104 rdf:type schema:DefinedTerm
105 N1cf8db0f055d411c9860737a62899465 rdf:first sg:person.01276053301.28
106 rdf:rest Nef887986345143dba5e11a3a2e4f5b32
107 N2072748a27b14cb6943cd2a03f26ca03 schema:name readcube_id
108 schema:value 9dbcc1edf5c08543c0ce9383208f8f7f0f457f7f9818fe292909ff7caa292a25
109 rdf:type schema:PropertyValue
110 N28363b41025a4659a4995a5417c4ac9d schema:name doi
111 schema:value 10.1038/ijo.2013.196
112 rdf:type schema:PropertyValue
113 N2e60f403192f41268c7e595420511e21 rdf:first sg:person.01064545154.58
114 rdf:rest N1cf8db0f055d411c9860737a62899465
115 N301bca663ffe4694ae43b8217487097d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Prospective Studies
117 rdf:type schema:DefinedTerm
118 N3338bb1a37874047a378e7fd7411bfef rdf:first sg:person.01222152704.35
119 rdf:rest Nfda755c10d7344238cb825a26c6a6a4e
120 N3c103b6abcbb4cbd9ba7bb820f5afbc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Middle Aged
122 rdf:type schema:DefinedTerm
123 N3e40c752725d40da90e00838be36fe6c rdf:first sg:person.0716365423.83
124 rdf:rest Ndac502ec931444f0ae5ae7195b7ee4ae
125 N40639ee66f1c439085f4a441f6d5a84e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Acylation
127 rdf:type schema:DefinedTerm
128 N487fbab569f840c185360eda63e90d47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Insulin Secretion
130 rdf:type schema:DefinedTerm
131 N51233ced14234480b348bd74c053b2a7 rdf:first sg:person.016133735277.06
132 rdf:rest N3e40c752725d40da90e00838be36fe6c
133 N529b185d8df04bc6a504d1339960e535 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Absorptiometry, Photon
135 rdf:type schema:DefinedTerm
136 N56aa56dd108347b79e4e7cc5470a3f17 schema:name Veterans Affairs Boston Healthcare System, Brigham and Women’s Hospital, and Harvard Medical School, Boston, MA, USA
137 rdf:type schema:Organization
138 N642c67231c864abb882033c1a395f648 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Female
140 rdf:type schema:DefinedTerm
141 N67b93f2fa2714b5089b8583cc2a2db3a schema:volumeNumber 38
142 rdf:type schema:PublicationVolume
143 N6bccfc92b1f940e697e8911df908aab9 rdf:first sg:person.0700554327.63
144 rdf:rest Ndeedffe0c54d49b183b97ff70f9825d4
145 N6be30068b16240bfbe17b922b247eaff schema:issueNumber 3
146 rdf:type schema:PublicationIssue
147 N6d9dcbfffa5545088f10b8c107dbc1c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Diabetes Mellitus, Type 2
149 rdf:type schema:DefinedTerm
150 N7a3782b4fbfa4ce2aac10015f885f4c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Humans
152 rdf:type schema:DefinedTerm
153 N84314fc8fd2f4f30baf5abdac07f6410 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Anti-Obesity Agents
155 rdf:type schema:DefinedTerm
156 N8f0460b4ef064faea4a5f50f47467226 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Weight Loss
158 rdf:type schema:DefinedTerm
159 N969241b31af0492e8146353c59eb8088 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Glycated Hemoglobin A
161 rdf:type schema:DefinedTerm
162 N978a4c480fae44dfba90da6b8ad5c733 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Blood Glucose
164 rdf:type schema:DefinedTerm
165 N9ca6db99c5fb4d7a8a9d27b9cb9698d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Feeding Behavior
167 rdf:type schema:DefinedTerm
168 Nb06c2eef00c04001bb77430317abec23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Insulin
170 rdf:type schema:DefinedTerm
171 Nb1a245fae6dc497ebdcebc81492b9abd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Treatment Outcome
173 rdf:type schema:DefinedTerm
174 Nb5de1c25f9bb490d96dd264038d25ed9 schema:name pubmed_id
175 schema:value 24166065
176 rdf:type schema:PropertyValue
177 Nbe08320414dd4cab8d6b919fe9ba9935 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Obesity, Morbid
179 rdf:type schema:DefinedTerm
180 Nc263a3430a1342e9b7349c823db90bde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Gastric Bypass
182 rdf:type schema:DefinedTerm
183 Ncbb0ec45ed354253b010fd5123df03aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Body Mass Index
185 rdf:type schema:DefinedTerm
186 Nd4b87c0250d44593aa2ccc228c08df3c schema:name Springer Nature - SN SciGraph project
187 rdf:type schema:Organization
188 Ndac502ec931444f0ae5ae7195b7ee4ae rdf:first sg:person.01006507214.08
189 rdf:rest rdf:nil
190 Ndeedffe0c54d49b183b97ff70f9825d4 rdf:first sg:person.0756332431.14
191 rdf:rest N51233ced14234480b348bd74c053b2a7
192 Nec12e5a693454dcd939e357e8bc9b2c4 rdf:first sg:person.01263271023.73
193 rdf:rest N3338bb1a37874047a378e7fd7411bfef
194 Nef887986345143dba5e11a3a2e4f5b32 rdf:first sg:person.0576565657.13
195 rdf:rest Nec12e5a693454dcd939e357e8bc9b2c4
196 Nf8f7dcca7b6e478796f210fc09051add schema:name nlm_unique_id
197 schema:value 101256108
198 rdf:type schema:PropertyValue
199 Nfda755c10d7344238cb825a26c6a6a4e rdf:first sg:person.01111066700.89
200 rdf:rest N6bccfc92b1f940e697e8911df908aab9
201 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
202 schema:name Medical and Health Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
205 schema:name Clinical Sciences
206 rdf:type schema:DefinedTerm
207 sg:grant.2500235 http://pending.schema.org/fundedItem sg:pub.10.1038/ijo.2013.196
208 rdf:type schema:MonetaryGrant
209 sg:grant.2683175 http://pending.schema.org/fundedItem sg:pub.10.1038/ijo.2013.196
210 rdf:type schema:MonetaryGrant
211 sg:grant.2705139 http://pending.schema.org/fundedItem sg:pub.10.1038/ijo.2013.196
212 rdf:type schema:MonetaryGrant
213 sg:grant.2705236 http://pending.schema.org/fundedItem sg:pub.10.1038/ijo.2013.196
214 rdf:type schema:MonetaryGrant
215 sg:journal.1035838 schema:issn 0307-0565
216 1476-5497
217 schema:name International Journal of Obesity
218 rdf:type schema:Periodical
219 sg:person.01006507214.08 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
220 schema:familyName Kashyap
221 schema:givenName S R
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006507214.08
223 rdf:type schema:Person
224 sg:person.01064545154.58 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
225 schema:familyName Malin
226 schema:givenName S K
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064545154.58
228 rdf:type schema:Person
229 sg:person.01111066700.89 schema:affiliation N56aa56dd108347b79e4e7cc5470a3f17
230 schema:familyName Bhatt
231 schema:givenName D L
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111066700.89
233 rdf:type schema:Person
234 sg:person.01222152704.35 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
235 schema:familyName Pothier
236 schema:givenName C E
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222152704.35
238 rdf:type schema:Person
239 sg:person.01263271023.73 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
240 schema:familyName Abood
241 schema:givenName B
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263271023.73
243 rdf:type schema:Person
244 sg:person.01276053301.28 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
245 schema:familyName Samat
246 schema:givenName A
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276053301.28
248 rdf:type schema:Person
249 sg:person.016133735277.06 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
250 schema:familyName Schauer
251 schema:givenName P R
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016133735277.06
253 rdf:type schema:Person
254 sg:person.0576565657.13 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
255 schema:familyName Wolski
256 schema:givenName K
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576565657.13
258 rdf:type schema:Person
259 sg:person.0700554327.63 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
260 schema:familyName Nissen
261 schema:givenName S
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700554327.63
263 rdf:type schema:Person
264 sg:person.0716365423.83 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
265 schema:familyName Kirwan
266 schema:givenName J P
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716365423.83
268 rdf:type schema:Person
269 sg:person.0756332431.14 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
270 schema:familyName Brethauer
271 schema:givenName S A
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756332431.14
273 rdf:type schema:Person
274 sg:pub.10.1007/s00125-009-1288-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019761845
275 https://doi.org/10.1007/s00125-009-1288-9
276 rdf:type schema:CreativeWork
277 sg:pub.10.1007/s00125-012-2556-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041144492
278 https://doi.org/10.1007/s00125-012-2556-7
279 rdf:type schema:CreativeWork
280 sg:pub.10.1007/s11695-009-0014-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016640661
281 https://doi.org/10.1007/s11695-009-0014-5
282 rdf:type schema:CreativeWork
283 sg:pub.10.1007/s11695-009-0066-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042864203
284 https://doi.org/10.1007/s11695-009-0066-6
285 rdf:type schema:CreativeWork
286 sg:pub.10.1007/s11695-012-0622-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022979092
287 https://doi.org/10.1007/s11695-012-0622-3
288 rdf:type schema:CreativeWork
289 sg:pub.10.1038/ijo.2009.254 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025292388
290 https://doi.org/10.1038/ijo.2009.254
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/nature05482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034631385
293 https://doi.org/10.1038/nature05482
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/sj.ijo.0803440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047158637
296 https://doi.org/10.1038/sj.ijo.0803440
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1001/archinternmed.2010.380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000230351
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1001/jama.2012.67929 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046432855
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1001/jamainternmed.2013.7783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011371405
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1002/oby.20272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039218944
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1002/oby.20441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009213036
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.febslet.2012.06.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053034870
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.regpep.2005.04.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035968045
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.regpep.2007.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000463320
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.soard.2007.08.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001688350
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.soard.2011.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039310843
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1038/oby.2004.118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040435447
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1038/oby.2007.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019977841
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1056/nejmoa012908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007925895
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1056/nejmoa1200111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008610882
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1056/nejmoa1200225 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005294597
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1097/jes.0b013e3181c5cd98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018763890
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1097/sla.0b013e318156f012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010113295
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1111/dom.12118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013913603
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1111/j.1365-2265.2010.03916.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036143704
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1111/j.1463-1326.2009.01172.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052197913
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1111/j.1467-789x.2009.00699.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1046003247
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1172/jci25811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046966962
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1210/en.2009-0367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064249978
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1210/jc.2004-0433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064287777
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1210/jc.2004-1076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037729186
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1210/jc.2010-2876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064292614
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1210/jcem.86.10.7885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064323857
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1210/me.2008-0432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064328273
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1530/eje-08-0735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037059055
355 rdf:type schema:CreativeWork
356 https://doi.org/10.2337/db06-0730 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017982943
357 rdf:type schema:CreativeWork
358 https://doi.org/10.2337/db10-0504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013754785
359 rdf:type schema:CreativeWork
360 https://doi.org/10.2337/dc10-1548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031233900
361 rdf:type schema:CreativeWork
362 https://doi.org/10.2337/dc11-0925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049797951
363 rdf:type schema:CreativeWork
364 https://doi.org/10.2337/dc12-1535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045888777
365 rdf:type schema:CreativeWork
366 https://doi.org/10.2337/dc12-1596 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035048348
367 rdf:type schema:CreativeWork
368 https://www.grid.ac/institutes/grid.239578.2 schema:alternateName Cleveland Clinic
369 schema:name Department of Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, OH, USA
370 Department of Endocrinology, Cleveland Clinic, Cleveland, OH, USA
371 Department of Heart and Vascular, Cleveland Clinic, Cleveland, OH, USA
372 Department of Nutrition, Case Western Reserve University, Cleveland Clinic, Cleveland, OH, USA
373 Department of Pathobiology, Cleveland Clinic, Cleveland, OH, USA
374 Metabolic Translational Research Center, Endocrine and Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA
375 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...