Gut hormones, early dumping and resting energy expenditure in patients with good and poor weight loss response after Roux-en-Y gastric ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-11

AUTHORS

C Dirksen, N B Jørgensen, K N Bojsen-Møller, U Kielgast, S H Jacobsen, T R Clausen, D Worm, B Hartmann, J F Rehfeld, M Damgaard, J L Madsen, S Madsbad, J J Holst, D L Hansen

ABSTRACT

OBJECTIVE: To identify factors contributing to the variation in weight loss after Roux-en-Y gastric bypass (RYGB). DESIGN: Cross-sectional study of patients with good (excess body mass index lost (EBL) >60%) and poor weight loss response (EBL <50%) >12 months after RYGB and a lean control group matched for age and gender. MATERIALS AND METHODS: Sixteen patients with good weight loss response, 17 patients with poor weight loss response, and eight control subjects were included in the study. Participants underwent dual energy X-ray absorptiometry scan, indirect calorimetry and a 9 h multiple-meal test with measurements of glucose, insulin, total bile acids (TBA), glucagon-like peptide (GLP)-1, peptide YY3-36 (PYY), cholecystokinin (CCK), ghrelin, neurotensin and pancreatic polypeptide (PP) as well as assessment of early dumping and appetite. RESULTS: Suppression of hunger was more pronounced in the good than the poor responders in response to the multiple-meal test (P=0.006). In addition, the good responders had a larger release of GLP-1 (P=0.009) and a greater suppression of ghrelin (P=0.037) during the test, whereas the postprandial secretion of CCK was highest in the poor responders (P=0.005). PYY, neurotensin, PP and TBA release did not differ between the RYGB-operated groups. Compared with control subjects, patients had exaggerated release of GLP-1 (P<0.001), PYY (P=0.008), CCK (P=0.010) and neurotensin (P<0.001). Early dumping was comparable in the good and poor responders, but more pronounced than in controlled subjects. Differences in resting energy expenditure between the three groups were entirely explained by differences in body composition. CONCLUSION: Favorable meal-induced changes in hunger and gut hormone release in patients with good compared with poor weight loss response support the role of gut hormones in the weight loss after RYGB. More... »

PAGES

1452

References to SciGraph publications

  • 2008-06. Long-term Weight Regain after Gastric Bypass: A 5-year Prospective Study in OBESITY SURGERY
  • 2003-08. Abstracts of the IDF Congress in Paris 2003 in DIABETOLOGIA
  • 2007-03. Early Changes in Ghrelin following Roux-en-Y Gastric Bypass: Influence of Vagal Nerve Functionality? in OBESITY SURGERY
  • 2012-05. Association of Ghrelin Receptor Promoter Polymorphisms with Weight Loss Following Roux-en-Y Gastric Bypass Surgery in OBESITY SURGERY
  • 2002-08. Gut hormone PYY3-36 physiologically inhibits food intake in NATURE
  • 2009-03. Persistent Correlation of Ghrelin Plasma Levels with Body Mass Index Both in Stable Weight Conditions and during Gastric-bypass-induced Weight Loss in OBESITY SURGERY
  • 2011-02. Changes in neurohormonal gut peptides following bariatric surgery in INTERNATIONAL JOURNAL OF OBESITY
  • 2007-03. Meal suppression of circulating ghrelin is normalized in obese individuals following gastric bypass surgery in INTERNATIONAL JOURNAL OF OBESITY
  • 2012-05. Metabolic and Hormonal Changes After Laparoscopic Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: a Randomized, Prospective Trial in OBESITY SURGERY
  • 2011-06. Bile Acid Metabolism and the Pathogenesis of Type 2 Diabetes in CURRENT DIABETES REPORTS
  • 2008-11. Postprandial changes in gut regulatory peptides in gastric bypass patients in INTERNATIONAL JOURNAL OF OBESITY
  • 2010-05. Effects of Two Variants of Roux-en-Y Gastric Bypass on Metabolism Behaviour: Focus on Plasma Ghrelin Concentrations Over a 2-Year Follow-up in OBESITY SURGERY
  • 2012-03. Changes in eating behaviour and meal pattern following Roux-en-Y gastric bypass in INTERNATIONAL JOURNAL OF OBESITY
  • 2012-07. Changes in Gastrointestinal Hormone Responses, Insulin Sensitivity, and Beta-Cell Function Within 2 Weeks After Gastric Bypass in Non-diabetic Subjects in OBESITY SURGERY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ijo.2013.15

    DOI

    http://dx.doi.org/10.1038/ijo.2013.15

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049334002

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23419600


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