Altered hypothalamic function in diet-induced obesity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

L A Velloso, M W Schwartz

ABSTRACT

Energy homeostasis involves a complex network of hypothalamic and extra-hypothalamic neurons that transduce hormonal, nutrient and neuronal signals into responses that ultimately match caloric intake to energy expenditure and thereby promote stability of body fat stores. Growing evidence suggests that rather than reflecting a failure to regulate caloric intake, common forms of obesity involve fundamental changes to this homeostatic system that favor the defense of an elevated level of body adiposity. This article reviews emerging evidence that during high-fat feeding, obesity pathogenesis involves fundamental alteration of hypothalamic systems that regulate food intake and energy expenditure. More... »

PAGES

1455

References to SciGraph publications

  • 2009-06. The future of obesity reduction: beyond weight loss in NATURE REVIEWS ENDOCRINOLOGY
  • 2009-04. Gut peptides in the control of food intake in INTERNATIONAL JOURNAL OF OBESITY
  • 2004-07. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3 in NATURE MEDICINE
  • 2004-07. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity in NATURE MEDICINE
  • 2008-12. Leptin receptor signaling and the regulation of mammalian physiology in INTERNATIONAL JOURNAL OF OBESITY
  • 2008-09. Global burden of obesity in 2005 and projections to 2030 in INTERNATIONAL JOURNAL OF OBESITY
  • 1981-03. Insulin acting as a modulator of feeding through the hypothalamus in DIABETOLOGIA
  • 1995-12. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action in NATURE MEDICINE
  • 1967-09. Insulin in the Cerebrospinal Fluid in NATURE
  • 2009-04. Complications of obesity in children and adolescents in INTERNATIONAL JOURNAL OF OBESITY
  • 1978-04. Insulin receptors are widely distributed in the central nervous system of the rat in NATURE
  • 2003-06. Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production in NATURE MEDICINE
  • 2006-09. Central nervous system control of food intake and body weight in NATURE
  • 2009-04. Health-related quality of life in obese children and adolescents in INTERNATIONAL JOURNAL OF OBESITY
  • 2000-08. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats in NATURE NEUROSCIENCE
  • 1995-11. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects in NATURE MEDICINE
  • 2008-02. The impact of obesity on the musculoskeletal system in INTERNATIONAL JOURNAL OF OBESITY
  • 1996-05. Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans in NATURE MEDICINE
  • 2009-04. The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake in INTERNATIONAL JOURNAL OF OBESITY
  • 2004-04. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus in NATURE
  • 1973-08. Effects of parabiosis of obese with diabetes and normal mice in DIABETOLOGIA
  • 1994-12. Positional cloning of the mouse obese gene and its human homologue in NATURE
  • 2006-08. Neuronal PTP1B regulates body weight, adiposity and leptin action in NATURE MEDICINE
  • 2008-12. Cost-effectiveness of pharmacological anti-obesity treatments: a systematic review in INTERNATIONAL JOURNAL OF OBESITY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ijo.2011.56

    DOI

    http://dx.doi.org/10.1038/ijo.2011.56

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037023216

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21386802


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