Epigenetic changes in early life and future risk of obesity View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-01

AUTHORS

K A Lillycrop, G C Burdge

ABSTRACT

The rapid increase in incidence of obesity over the past two decades cannot be explained solely by genetic and adult lifestyle factors. There is now considerable evidence that the fetal and early postnatal environments also strongly influence the risk of developing obesity in later life. Initially, human studies showed that low birth weight was associated with an increased risk of obesity but increasingly there is evidence that overnutrition in the early life can also increase susceptibility to future obesity. These findings have now been replicated in animal models, which have shown that both maternal under- and overnutrition can induce persistent changes in gene expression and metabolism. The mechanism by which the maternal nutritional environment induces such changes is beginning to be understood and involves the altered epigenetic regulation of specific genes. In this review, we discuss the recent evidence that shows that early-life environment can induce altered epigenetic regulation leading to the induction of an altered phenotype. The demonstration of a role for altered epigenetic regulation of genes in the developmental induction of obesity opens the possibility that interventions, either through nutrition or specific drugs, may modify long-term obesity risk and combat this rapid rise in obesity. More... »

PAGES

72

References to SciGraph publications

  • 1993-12. Role for DNA methylation in genomic imprinting in NATURE
  • 2001-01. Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation in NATURE GENETICS
  • 2001-03. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins in NATURE
  • 1983-11. Is hypomethylation linked to activation of δ-crystallin genes during lens development? in NATURE
  • 2007-10. The Effect of Maternal Undernutrition in Early Gestation on Gestation Length and Fetal and Postnatal Growth in Sheep in PEDIATRIC RESEARCH
  • 2000-07. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci in NATURE GENETICS
  • 2007-02. Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation in NATURE
  • 2006-02. The Polycomb group protein EZH2 directly controls DNA methylation in NATURE
  • 1999-02. A mammalian protein with specific demethylase activity for mCpG DNA in NATURE
  • 2001-08. The effect of leptin treatment on the development of obesity in overfed suckling Wistar rats in INTERNATIONAL JOURNAL OF OBESITY
  • 2004-08. Epigenetic programming by maternal behavior in NATURE NEUROSCIENCE
  • 2006-05. Exposure to undernutrition in fetal life determines fat distribution, locomotor activity and food intake in ageing rats in INTERNATIONAL JOURNAL OF OBESITY
  • 2000-01. DNA methyltransferase Dnmt1 associates with histone deacetylase activity in NATURE GENETICS
  • 2001-02. Maternal factors that determine neonatal size and body fat in CURRENT DIABETES REPORTS
  • 2008-09. Methyl donor supplementation prevents transgenerational amplification of obesity in INTERNATIONAL JOURNAL OF OBESITY
  • 2004-01. Lifespan: Catch-up growth and obesity in male mice in NATURE
  • 1996-09. Chronic Maternal Undernutrition in the Rat Leads to Delayed Postnatal Growth and Elevated Blood Pressure of Offspring in PEDIATRIC RESEARCH
  • 1998-10. Transcription of IAP endogenous retroviruses is constrained by cytosine methylation in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ijo.2010.122

    DOI

    http://dx.doi.org/10.1038/ijo.2010.122

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018703220

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20548303


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

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