Pathogenesis Of The Graft-Versus-Host Reaction In Chicken Embryos. The Development Of Haemorrhagic Lesions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1973-02

AUTHORS

Karen Z Walker, Gutta I Schoefl, KJ Lafferty, EP Adams

ABSTRACT

Adult, allogeneic lymphoid tissue was introduced into chicken embryos on day 4 or clay 6 by inoculation on the chorio-allantoic membrane, intravenous injection or intracoelomic grafting. Severe haemorrhagic lesions appeared on the body surface and in the chorio-allantoic membrane within 6 days after the inoculation of donor cells. However, there was no spleen enlargement in these embryos. The development of haemorrhages appeared to be the result of a graft-versus-host reaction since they were not observed in embryos inoculated with lymphoid tissue from a syngeneic adult donor. The vascular damage has been examined by light and electron microscopy. Vascular damage was associated with an elevation of lysosomal enzyme activity in the plasma ard the resulting haemorrhages could also be related to a low level of thrombocytes in the circulating blood. More... »

PAGES

93

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/icb.1973.7

DOI

http://dx.doi.org/10.1038/icb.1973.7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035593599

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/4144670


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217 grid-institutes:None schema:alternateName Departments of Experimental Pathology and Immunology, John Curtin School of Medical Research, The Australian National University; Canberra A.C.T.
218 schema:name Departments of Experimental Pathology and Immunology, John Curtin School of Medical Research, The Australian National University; Canberra A.C.T.
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