Effect of hydrochlorothiazide in addition to telmisartan/amlodipine combination for treating hypertensive patients uncontrolled with telmisartan/amlodipine: a randomized, double-blind study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-10-20

AUTHORS

Jitsuo Higaki, Issei Komuro, Kosuke Shiki, Ganghyuck Lee, Atsushi Taniguchi, Hiroshi Ikeda, Daisuke Kuroki, Seiichiro Nishimura, Toshio Ogihara

ABSTRACT

The efficacy and safety of telmisartan 80 mg/amlodipine 5 mg plus hydrochlorothiazide 12.5 mg (T80/A5/H12.5) was examined for its ability to treat hypertension in Japanese patients whose hypertension is uncontrolled with telmisartan 80 mg/amlodipine 5 mg (T80/A5). Patients aged ⩾20 years who had essential hypertension despite taking two or three antihypertensive drugs entered a 6-week run-in period on T80/A5. Patients whose hypertension remained uncontrolled were randomly assigned to either the T80/A5/H12.5 group (n=149) or the T80/A5 group (n=160), once daily for 8 weeks. After 8 weeks, patients in the T80/A5/H12.5 group showed a significantly greater adjusted mean reduction in both seated diastolic blood pressure and seated systolic blood pressure than those in the T80/A5 group. Furthermore, more patients achieved a diastolic/systolic blood pressure of <90/140 mm Hg in the T80/A5/H12.5 group compared with the T80/A5 group. The most common adverse events were nasopharyngitis, elevated blood uric acid levels and hyperuricemia, and the latter two events were more frequent in the T80/A5/H12.5 group than in the T80/A5 group. Overall, T80/A5/H12.5 administered for 8 weeks significantly reduced systolic and diastolic blood pressure and was well tolerated by patients with hypertension uncontrolled with T80/A5. More... »

PAGES

251-258

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/hr.2016.124

DOI

http://dx.doi.org/10.1038/hr.2016.124

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011635776

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27761000


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amlodipine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antihypertensive Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzimidazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzoates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Combinations", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Therapy, Combination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydrochlorothiazide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Telmisartan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine, Ehime Japan", 
          "id": "http://www.grid.ac/institutes/grid.255464.4", 
          "name": [
            "Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine, Ehime Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Higaki", 
        "givenName": "Jitsuo", 
        "id": "sg:person.01144702071.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144702071.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Komuro", 
        "givenName": "Issei", 
        "id": "sg:person.01012024207.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012024207.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Division, Nippon Boehringer Ingelheim, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.459839.a", 
          "name": [
            "Medical Division, Nippon Boehringer Ingelheim, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shiki", 
        "givenName": "Kosuke", 
        "id": "sg:person.012510377655.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012510377655.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Division, Nippon Boehringer Ingelheim, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.459839.a", 
          "name": [
            "Medical Division, Nippon Boehringer Ingelheim, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Ganghyuck", 
        "id": "sg:person.013305760255.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013305760255.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Division, Nippon Boehringer Ingelheim, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.459839.a", 
          "name": [
            "Medical Division, Nippon Boehringer Ingelheim, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Taniguchi", 
        "givenName": "Atsushi", 
        "id": "sg:person.01025541307.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025541307.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Division, Nippon Boehringer Ingelheim, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.459839.a", 
          "name": [
            "Medical Division, Nippon Boehringer Ingelheim, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ikeda", 
        "givenName": "Hiroshi", 
        "id": "sg:person.014700721255.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014700721255.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Division, Nippon Boehringer Ingelheim, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.459839.a", 
          "name": [
            "Medical Division, Nippon Boehringer Ingelheim, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuroki", 
        "givenName": "Daisuke", 
        "id": "sg:person.015476301655.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015476301655.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Medical Division, Nippon Boehringer Ingelheim, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.459839.a", 
          "name": [
            "Medical Division, Nippon Boehringer Ingelheim, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishimura", 
        "givenName": "Seiichiro", 
        "id": "sg:person.016273662255.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016273662255.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Morinomiya University of Medical Sciences, Osaka Japan", 
          "id": "http://www.grid.ac/institutes/grid.440914.c", 
          "name": [
            "Morinomiya University of Medical Sciences, Osaka Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ogihara", 
        "givenName": "Toshio", 
        "id": "sg:person.01174620432.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174620432.33"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/hr.2013.80", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041803518", 
          "https://doi.org/10.1038/hr.2013.80"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/hr.2015.3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006326583", 
          "https://doi.org/10.1038/hr.2015.3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/hr.2014.20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044401479", 
          "https://doi.org/10.1038/hr.2014.20"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jhh.1001808", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049032128", 
          "https://doi.org/10.1038/sj.jhh.1001808"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-10-20", 
    "datePublishedReg": "2016-10-20", 
    "description": "The efficacy and safety of telmisartan 80\u2009mg/amlodipine 5\u2009mg plus hydrochlorothiazide 12.5\u2009mg (T80/A5/H12.5) was examined for its ability to treat hypertension in Japanese patients whose hypertension is uncontrolled with telmisartan 80\u2009mg/amlodipine 5\u2009mg (T80/A5). Patients aged \u2a7e20 years who had essential hypertension despite taking two or three antihypertensive drugs entered a 6-week run-in period on T80/A5. Patients whose hypertension remained uncontrolled were randomly assigned to either the T80/A5/H12.5 group (n=149) or the T80/A5 group (n=160), once daily for 8 weeks. After 8 weeks, patients in the T80/A5/H12.5 group showed a significantly greater adjusted mean reduction in both seated diastolic blood pressure and seated systolic blood pressure than those in the T80/A5 group. Furthermore, more patients achieved a diastolic/systolic blood pressure of <90/140\u2009mm\u2009Hg in the T80/A5/H12.5 group compared with the T80/A5 group. The most common adverse events were nasopharyngitis, elevated blood uric acid levels and hyperuricemia, and the latter two events were more frequent in the T80/A5/H12.5 group than in the T80/A5 group. Overall, T80/A5/H12.5 administered for 8 weeks significantly reduced systolic and diastolic blood pressure and was well tolerated by patients with hypertension uncontrolled with T80/A5.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/hr.2016.124", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1313717", 
        "issn": [
          "0916-9636", 
          "1348-4214"
        ], 
        "name": "Hypertension Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "40"
      }
    ], 
    "keywords": [
      "T80/A5", 
      "diastolic blood pressure", 
      "systolic blood pressure", 
      "blood pressure", 
      "A5 group", 
      "amlodipine 5", 
      "diastolic/systolic blood pressure", 
      "telmisartan/amlodipine combination", 
      "blood uric acid levels", 
      "telmisartan/amlodipine", 
      "common adverse events", 
      "effect of hydrochlorothiazide", 
      "double-blind study", 
      "uric acid levels", 
      "hydrochlorothiazide 12.5", 
      "amlodipine combination", 
      "hypertensive patients", 
      "adverse events", 
      "essential hypertension", 
      "more patients", 
      "antihypertensive drugs", 
      "Japanese patients", 
      "hypertension", 
      "mean reduction", 
      "patients", 
      "acid levels", 
      "weeks", 
      "group", 
      "nasopharyngitis", 
      "hyperuricemia", 
      "amlodipine", 
      "hydrochlorothiazide", 
      "A5", 
      "drugs", 
      "efficacy", 
      "pressure", 
      "Hg", 
      "events", 
      "safety", 
      "years", 
      "period", 
      "levels", 
      "study", 
      "reduction", 
      "effect", 
      "combination", 
      "ability", 
      "addition", 
      "run", 
      "T80/A5/H12.5 group", 
      "A5/H12.5 group", 
      "H12.5 group", 
      "T80/A5 group", 
      "elevated blood uric acid levels", 
      "T80/A5/H12.5", 
      "A5/H12.5", 
      "H12.5"
    ], 
    "name": "Effect of hydrochlorothiazide in addition to telmisartan/amlodipine combination for treating hypertensive patients uncontrolled with telmisartan/amlodipine: a randomized, double-blind study", 
    "pagination": "251-258", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1011635776"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/hr.2016.124"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27761000"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/hr.2016.124", 
      "https://app.dimensions.ai/details/publication/pub.1011635776"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:35", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_686.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/hr.2016.124"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/hr.2016.124'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/hr.2016.124'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/hr.2016.124'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/hr.2016.124'


 

This table displays all metadata directly associated to this object as RDF triples.

272 TRIPLES      22 PREDICATES      105 URIs      93 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/hr.2016.124 schema:about N0db21141ac494059ad709bbf19be04d6
2 N1ef7ca0023524653b9504625ce50ca50
3 N310f9ca3d86a473995ac5f353401db73
4 N48650389a814479db8be450063747f67
5 N4bf5fcfe27ad4af59d5389a9d753d967
6 N50498012a0c44b1cb87d8ac7fa759008
7 N55cb2371fbf949dbade64c90a989a719
8 N562029b89aa74082bcba661ac505983c
9 N5cdea23807b14603b06cf0fa7097c948
10 N6b396d46276e4d91b20ab1c4281afb8a
11 N773132f4b96841c299f099ab85851818
12 N8594009b92144e099d692c579b9985a2
13 N8e04b2a0b6814ba2a3a1e5b7a9f75c5d
14 N9d89c907ffea4fbe87407d7d801e20e4
15 Nc503cba752404beaad4048a4be7fdf41
16 Ncae605ec1e1d4cb6b63fbca3a9a876bc
17 Nd7b4dc703c504e24a86878c398958859
18 Ne306bfbff2794781a937bda4f77f4bef
19 anzsrc-for:11
20 anzsrc-for:1102
21 schema:author N0c7796bac29b45dbaca0be4936e89b1f
22 schema:citation sg:pub.10.1038/hr.2013.80
23 sg:pub.10.1038/hr.2014.20
24 sg:pub.10.1038/hr.2015.3
25 sg:pub.10.1038/sj.jhh.1001808
26 schema:datePublished 2016-10-20
27 schema:datePublishedReg 2016-10-20
28 schema:description The efficacy and safety of telmisartan 80 mg/amlodipine 5 mg plus hydrochlorothiazide 12.5 mg (T80/A5/H12.5) was examined for its ability to treat hypertension in Japanese patients whose hypertension is uncontrolled with telmisartan 80 mg/amlodipine 5 mg (T80/A5). Patients aged ⩾20 years who had essential hypertension despite taking two or three antihypertensive drugs entered a 6-week run-in period on T80/A5. Patients whose hypertension remained uncontrolled were randomly assigned to either the T80/A5/H12.5 group (n=149) or the T80/A5 group (n=160), once daily for 8 weeks. After 8 weeks, patients in the T80/A5/H12.5 group showed a significantly greater adjusted mean reduction in both seated diastolic blood pressure and seated systolic blood pressure than those in the T80/A5 group. Furthermore, more patients achieved a diastolic/systolic blood pressure of <90/140 mm Hg in the T80/A5/H12.5 group compared with the T80/A5 group. The most common adverse events were nasopharyngitis, elevated blood uric acid levels and hyperuricemia, and the latter two events were more frequent in the T80/A5/H12.5 group than in the T80/A5 group. Overall, T80/A5/H12.5 administered for 8 weeks significantly reduced systolic and diastolic blood pressure and was well tolerated by patients with hypertension uncontrolled with T80/A5.
29 schema:genre article
30 schema:inLanguage en
31 schema:isAccessibleForFree true
32 schema:isPartOf N4fe52b674a4943efb36e4c7a93c4b412
33 Nc5bc84879550438cb3258f38a102234e
34 sg:journal.1313717
35 schema:keywords A5
36 A5 group
37 A5/H12.5
38 A5/H12.5 group
39 H12.5
40 H12.5 group
41 Hg
42 Japanese patients
43 T80/A5
44 T80/A5 group
45 T80/A5/H12.5
46 T80/A5/H12.5 group
47 ability
48 acid levels
49 addition
50 adverse events
51 amlodipine
52 amlodipine 5
53 amlodipine combination
54 antihypertensive drugs
55 blood pressure
56 blood uric acid levels
57 combination
58 common adverse events
59 diastolic blood pressure
60 diastolic/systolic blood pressure
61 double-blind study
62 drugs
63 effect
64 effect of hydrochlorothiazide
65 efficacy
66 elevated blood uric acid levels
67 essential hypertension
68 events
69 group
70 hydrochlorothiazide
71 hydrochlorothiazide 12.5
72 hypertension
73 hypertensive patients
74 hyperuricemia
75 levels
76 mean reduction
77 more patients
78 nasopharyngitis
79 patients
80 period
81 pressure
82 reduction
83 run
84 safety
85 study
86 systolic blood pressure
87 telmisartan/amlodipine
88 telmisartan/amlodipine combination
89 uric acid levels
90 weeks
91 years
92 schema:name Effect of hydrochlorothiazide in addition to telmisartan/amlodipine combination for treating hypertensive patients uncontrolled with telmisartan/amlodipine: a randomized, double-blind study
93 schema:pagination 251-258
94 schema:productId N04e65dbcb136427c97289cb25c9b8a4f
95 N135f5666e14f430398cd66b23aab923b
96 N3f0c936791154dcda67c50aed9814267
97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011635776
98 https://doi.org/10.1038/hr.2016.124
99 schema:sdDatePublished 2021-12-01T19:35
100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
101 schema:sdPublisher N8b633ee73f6e401f824c5f32af53f7de
102 schema:url https://doi.org/10.1038/hr.2016.124
103 sgo:license sg:explorer/license/
104 sgo:sdDataset articles
105 rdf:type schema:ScholarlyArticle
106 N04e65dbcb136427c97289cb25c9b8a4f schema:name doi
107 schema:value 10.1038/hr.2016.124
108 rdf:type schema:PropertyValue
109 N0c7796bac29b45dbaca0be4936e89b1f rdf:first sg:person.01144702071.12
110 rdf:rest N31b259ea65a94caa9ca91bec29a273c5
111 N0db21141ac494059ad709bbf19be04d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Amlodipine
113 rdf:type schema:DefinedTerm
114 N135f5666e14f430398cd66b23aab923b schema:name dimensions_id
115 schema:value pub.1011635776
116 rdf:type schema:PropertyValue
117 N1ef7ca0023524653b9504625ce50ca50 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Treatment Outcome
119 rdf:type schema:DefinedTerm
120 N310f9ca3d86a473995ac5f353401db73 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Benzoates
122 rdf:type schema:DefinedTerm
123 N31b259ea65a94caa9ca91bec29a273c5 rdf:first sg:person.01012024207.33
124 rdf:rest Ne576b197623d49d5a5a31c21107c8219
125 N3f0c936791154dcda67c50aed9814267 schema:name pubmed_id
126 schema:value 27761000
127 rdf:type schema:PropertyValue
128 N469bffe917c841348f38c838d9730b9a rdf:first sg:person.015476301655.72
129 rdf:rest Na721260d4fc84f0baf59c3e4c21502f4
130 N48650389a814479db8be450063747f67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Male
132 rdf:type schema:DefinedTerm
133 N4bf5fcfe27ad4af59d5389a9d753d967 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Benzimidazoles
135 rdf:type schema:DefinedTerm
136 N4fe52b674a4943efb36e4c7a93c4b412 schema:issueNumber 3
137 rdf:type schema:PublicationIssue
138 N50498012a0c44b1cb87d8ac7fa759008 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Antihypertensive Agents
140 rdf:type schema:DefinedTerm
141 N538295d8ddd04f4b8b70a67ff2bc1507 rdf:first sg:person.013305760255.20
142 rdf:rest Ndb7ef59e51c14593b4acdb056b04a7ed
143 N55cb2371fbf949dbade64c90a989a719 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Drug Combinations
145 rdf:type schema:DefinedTerm
146 N562029b89aa74082bcba661ac505983c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Female
148 rdf:type schema:DefinedTerm
149 N5cdea23807b14603b06cf0fa7097c948 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Hypertension
151 rdf:type schema:DefinedTerm
152 N6b396d46276e4d91b20ab1c4281afb8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Aged
154 rdf:type schema:DefinedTerm
155 N6b5d3070d63a4b248f58988db03e7303 rdf:first sg:person.014700721255.60
156 rdf:rest N469bffe917c841348f38c838d9730b9a
157 N773132f4b96841c299f099ab85851818 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Double-Blind Method
159 rdf:type schema:DefinedTerm
160 N8594009b92144e099d692c579b9985a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Humans
162 rdf:type schema:DefinedTerm
163 N8b633ee73f6e401f824c5f32af53f7de schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 N8e04b2a0b6814ba2a3a1e5b7a9f75c5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Aged, 80 and over
167 rdf:type schema:DefinedTerm
168 N9d89c907ffea4fbe87407d7d801e20e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Telmisartan
170 rdf:type schema:DefinedTerm
171 Na721260d4fc84f0baf59c3e4c21502f4 rdf:first sg:person.016273662255.16
172 rdf:rest Nbfb38252012842a1b9c01959024729e5
173 Nbfb38252012842a1b9c01959024729e5 rdf:first sg:person.01174620432.33
174 rdf:rest rdf:nil
175 Nc503cba752404beaad4048a4be7fdf41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Middle Aged
177 rdf:type schema:DefinedTerm
178 Nc5bc84879550438cb3258f38a102234e schema:volumeNumber 40
179 rdf:type schema:PublicationVolume
180 Ncae605ec1e1d4cb6b63fbca3a9a876bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Drug Therapy, Combination
182 rdf:type schema:DefinedTerm
183 Nd7b4dc703c504e24a86878c398958859 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Hydrochlorothiazide
185 rdf:type schema:DefinedTerm
186 Ndb7ef59e51c14593b4acdb056b04a7ed rdf:first sg:person.01025541307.58
187 rdf:rest N6b5d3070d63a4b248f58988db03e7303
188 Ne306bfbff2794781a937bda4f77f4bef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Adult
190 rdf:type schema:DefinedTerm
191 Ne576b197623d49d5a5a31c21107c8219 rdf:first sg:person.012510377655.63
192 rdf:rest N538295d8ddd04f4b8b70a67ff2bc1507
193 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
194 schema:name Medical and Health Sciences
195 rdf:type schema:DefinedTerm
196 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
197 schema:name Cardiorespiratory Medicine and Haematology
198 rdf:type schema:DefinedTerm
199 sg:journal.1313717 schema:issn 0916-9636
200 1348-4214
201 schema:name Hypertension Research
202 schema:publisher Springer Nature
203 rdf:type schema:Periodical
204 sg:person.01012024207.33 schema:affiliation grid-institutes:grid.26999.3d
205 schema:familyName Komuro
206 schema:givenName Issei
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012024207.33
208 rdf:type schema:Person
209 sg:person.01025541307.58 schema:affiliation grid-institutes:grid.459839.a
210 schema:familyName Taniguchi
211 schema:givenName Atsushi
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025541307.58
213 rdf:type schema:Person
214 sg:person.01144702071.12 schema:affiliation grid-institutes:grid.255464.4
215 schema:familyName Higaki
216 schema:givenName Jitsuo
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144702071.12
218 rdf:type schema:Person
219 sg:person.01174620432.33 schema:affiliation grid-institutes:grid.440914.c
220 schema:familyName Ogihara
221 schema:givenName Toshio
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01174620432.33
223 rdf:type schema:Person
224 sg:person.012510377655.63 schema:affiliation grid-institutes:grid.459839.a
225 schema:familyName Shiki
226 schema:givenName Kosuke
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012510377655.63
228 rdf:type schema:Person
229 sg:person.013305760255.20 schema:affiliation grid-institutes:grid.459839.a
230 schema:familyName Lee
231 schema:givenName Ganghyuck
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013305760255.20
233 rdf:type schema:Person
234 sg:person.014700721255.60 schema:affiliation grid-institutes:grid.459839.a
235 schema:familyName Ikeda
236 schema:givenName Hiroshi
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014700721255.60
238 rdf:type schema:Person
239 sg:person.015476301655.72 schema:affiliation grid-institutes:grid.459839.a
240 schema:familyName Kuroki
241 schema:givenName Daisuke
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015476301655.72
243 rdf:type schema:Person
244 sg:person.016273662255.16 schema:affiliation grid-institutes:grid.459839.a
245 schema:familyName Nishimura
246 schema:givenName Seiichiro
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016273662255.16
248 rdf:type schema:Person
249 sg:pub.10.1038/hr.2013.80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041803518
250 https://doi.org/10.1038/hr.2013.80
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/hr.2014.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044401479
253 https://doi.org/10.1038/hr.2014.20
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/hr.2015.3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006326583
256 https://doi.org/10.1038/hr.2015.3
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/sj.jhh.1001808 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049032128
259 https://doi.org/10.1038/sj.jhh.1001808
260 rdf:type schema:CreativeWork
261 grid-institutes:grid.255464.4 schema:alternateName Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine, Ehime Japan
262 schema:name Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine, Ehime Japan
263 rdf:type schema:Organization
264 grid-institutes:grid.26999.3d schema:alternateName Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo Japan
265 schema:name Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo Japan
266 rdf:type schema:Organization
267 grid-institutes:grid.440914.c schema:alternateName Morinomiya University of Medical Sciences, Osaka Japan
268 schema:name Morinomiya University of Medical Sciences, Osaka Japan
269 rdf:type schema:Organization
270 grid-institutes:grid.459839.a schema:alternateName Medical Division, Nippon Boehringer Ingelheim, Tokyo, Japan
271 schema:name Medical Division, Nippon Boehringer Ingelheim, Tokyo, Japan
272 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...