A Periodontal pathogen Porphyromonas gingivalis deteriorates Isoproterenol-Induced myocardial remodeling in mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-09-08

AUTHORS

Hiroki Sato, Jun-ichi Suzuki, Norio Aoyama, Ryo Watanabe, Makoto Kaneko, Yuka Shiheido, Asuka Yoshida, Kouji Wakayama, Hidetoshi Kumagai, Yuichi Ikeda, Hiroshi Akazawa, Issei Komuro, Mitsuaki Isobe, Yuichi Izumi

ABSTRACT

Heart failure is a serious disease induced by several conditions, including hypertrophic cardiomyopathy. Although many reports suggest that there is an association between periodontal disease and cardiovascular disease, the mechanisms have yet to be elucidated. The purpose of this study was to clarify the relationship between periodontal disease and heart disease, especially in cardiac hypertrophy. We used C57BL/6J mice and implanted two types of subcutaneous chambers. First, we subcutaneously implanted a coil-shaped chamber into the back of a mouse. Porphyromonas gingivalis (P.g.), a major periodontal pathogen, was injected into the chamber. Then, an osmotic pump was implanted to infuse isoproterenol. Four weeks after the ISO infusion, we performed echocardiography and harvested the heart and blood. We measured the serum level of anti-P.g.-IgG using ELISA. The mRNA levels of several factors were measured using PCR. We found stronger cardiomyocyte hypertrophy in the ISO(+)/P.g.(+) mice compared with the ISO(+)/P.g.(−) mice. The total square of randomly selected cardiomyocytes was 23% larger in the ISO(+)/P.g.(+) mice than in the ISO(+)/P.g.(−) mice. We detected a higher level of mRNA expression in Toll-like receptor 2 and NADPH oxidase 4 in the ISO(+)/P.g.(−) mice compared with the control group. We revealed that a periodontal pathogen affected ISO-induced cardiac hypertrophy via oxidative stress. More... »

PAGES

35-40

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/hr.2016.114

DOI

http://dx.doi.org/10.1038/hr.2016.114

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042677236

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27604343


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47 chamber
48 coil-shaped chamber
49 conditions
50 control group
51 disease
52 echocardiography
53 expression
54 factors
55 failure
56 gingivalis
57 group
58 heart
59 heart disease
60 heart failure
61 high levels
62 hypertrophic cardiomyopathy
63 hypertrophy
64 infusion
65 isoproterenol
66 levels
67 mRNA expression
68 mRNA levels
69 major periodontal pathogens
70 mechanism
71 mice
72 myocardial remodeling
73 osmotic pump
74 oxidase 4
75 oxidative stress
76 pathogen Porphyromonas gingivalis
77 pathogens
78 periodontal disease
79 periodontal pathogen Porphyromonas gingivalis
80 periodontal pathogens
81 pump
82 purpose
83 receptor 2
84 relationship
85 remodeling
86 report
87 serious disease
88 serum levels
89 squares
90 stress
91 stronger cardiomyocyte hypertrophy
92 study
93 subcutaneous chambers
94 total square
95 types
96 weeks
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