Environmental origins of hypertension: phylogeny, ontogeny and epigenetics View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-05

AUTHORS

Melvin Khee-Shing Leow

ABSTRACT

Hypertension and renal parenchymal disease are intricately linked. Primary renal parenchymal disease can impact on sodium and volume regulation and lead to hypertension, while arterial hypertension can induce renal parenchymal injury and precipitate renal dysfunction. The examination for clues to the environmental origins of renal disease and hypertension necessitates an approach that integrates epidemiology, clinical medicine, developmental biology, environmental science and epigenetics, such that the manner in which genes and the environment interact can be better understood to pave the way for innovative management paradigms with regards to prevention, diagnosis and treatment. This review summarizes the extant literature and provides cogent arguments for the need to evaluate chronic adult onset disease models such as hypertension and renal disease from the modern perspective that takes into account prenatal exposures, the intrauterine environment and development, postnatal growth and transgenerational epigenetic modifications with their attendant future disease risk from the individual to the population level. More... »

PAGES

299

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/hr.2015.7

    DOI

    http://dx.doi.org/10.1038/hr.2015.7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036054741

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25693856


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