Angiotensin II receptor blocker irbesartan attenuates cardiac dysfunction induced by myocardial infarction in the presence of renal failure View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-04

AUTHORS

Ryo Watanabe, Jun-ichi Suzuki, Kouji Wakayama, Hidetoshi Kumagai, Yuichi Ikeda, Hiroshi Akazawa, Issei Komuro, Mitsuaki Isobe

ABSTRACT

The activity of the renin-angiotensin system is known to be a key factor in the pathophysiology of heart failure and renal failure. Irbesartan, an angiotensin II receptor blocker, has non-hemodynamic cardiovascular and renal protective effects. However, the effect of irbesartan on heart failure complicated by renal failure has not yet been elucidated. Thus the purpose of this study was to evaluate the effect of irbesartan on the pathophysiology of cardiorenal syndrome in a rat model. Subtotal nephrectomy (NTX) was performed in rats was using a two-step surgical procedure. Twenty-eight days after NTX, myocardial infarction (MI) was induced by ligation of the left anterior descending coronary artery. The animals were orally administered vehicle or irbesartan (10 mg kg(-1) day(-1)) after NTX. The hearts were harvested 28 days after MI. MI with NTX model rats showed an impaired post-MI survival rate and enhanced cardiac inflammation in comparison to MI without NTX rats. Although irbesartan treatment did not improve the survival rate, it suppressed cardiac inflammation, left ventricular function decline, cardiac fibrosis, hypertrophy of cardiomyocytes and renal fibrosis in MI with NTX rats. Moreover, increases in protein expression levels related to oxidative stress and inflammation (NADPH oxidase 4, phospho-nuclear factor-κB and phospho-c-Jun) observed in the hearts of non-treated MI with NTX rats were attenuated by irbesartan treatment. These effects of irbesartan treatment were independent of blood pressure. We conclude that irbesartan has a cardioprotective effect after MI when renal dysfunction is present. More... »

PAGES

237

References to SciGraph publications

  • 2012-12. Impaired post-infarction cardiac remodeling in chronic kidney disease is due to excessive renin release in LABORATORY INVESTIGATION
  • 2011-06. Telmisartan, a unique ARB, improves left ventricular remodeling of infarcted heart by activating PPAR gamma in LABORATORY INVESTIGATION
  • 2014-12. Myocardial infarction worsens glomerular injury and microalbuminuria in rats with pre-existing renal impairment accompanied by the activation of ER stress and inflammation in MOLECULAR BIOLOGY REPORTS
  • 2014-01. Telmisartan delays myocardial fibrosis in rats with hypertensive left ventricular hypertrophy by TGF-β1/Smad signal pathway in HYPERTENSION RESEARCH
  • 2004-05. Irbesartan in DRUGS
  • 2010-10. A small difference in the molecular structure of angiotensin II receptor blockers induces AT1 receptor-dependent and -independent beneficial effects in HYPERTENSION RESEARCH
  • 2012-03. Increased cardiovascular risk in rats with primary renal dysfunction; mediating role for vascular endothelial function in BASIC RESEARCH IN CARDIOLOGY
  • 2013-06. Role of STAT3 in angiotensin II-induced hypertension and cardiac remodeling revealed by mice lacking STAT3 serine 727 phosphorylation in HYPERTENSION RESEARCH
  • 2015-01. Comparative effects of valsartan in combination with cilnidipine or amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats in HYPERTENSION RESEARCH
  • 2012-03. The kinase Pyk2 is involved in renal fibrosis by means of mechanical stretch–induced growth factor expression in renal tubules in KIDNEY INTERNATIONAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/hr.2015.141

    DOI

    http://dx.doi.org/10.1038/hr.2015.141

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036733537

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26657004


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Cardiorespiratory Medicine and Haematology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Angiotensin II Type 1 Receptor Blockers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biphenyl Compounds", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myocardial Infarction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myocardium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "NADPH Oxidase 4", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "NADPH Oxidases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "NF-kappa B", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphorylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins c-jun", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats, Sprague-Dawley", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Renal Insufficiency", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Renin-Angiotensin System", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tetrazoles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ventricular Dysfunction, Left", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Tokyo Medical and Dental University", 
              "id": "https://www.grid.ac/institutes/grid.265073.5", 
              "name": [
                "Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Watanabe", 
            "givenName": "Ryo", 
            "id": "sg:person.0664160400.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664160400.92"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suzuki", 
            "givenName": "Jun-ichi", 
            "id": "sg:person.0772072503.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772072503.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wakayama", 
            "givenName": "Kouji", 
            "id": "sg:person.0714750211.11", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714750211.11"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kumagai", 
            "givenName": "Hidetoshi", 
            "id": "sg:person.0736053075.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736053075.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ikeda", 
            "givenName": "Yuichi", 
            "id": "sg:person.012757402652.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012757402652.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Akazawa", 
            "givenName": "Hiroshi", 
            "id": "sg:person.01150350762.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150350762.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Komuro", 
            "givenName": "Issei", 
            "id": "sg:person.01012024207.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012024207.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tokyo Medical and Dental University", 
              "id": "https://www.grid.ac/institutes/grid.265073.5", 
              "name": [
                "Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Isobe", 
            "givenName": "Mitsuaki", 
            "id": "sg:person.01266743300.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266743300.99"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.ejheart.2006.05.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001206535"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.ajkd.2010.04.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003203476"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/hr.2010.135", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003902715", 
              "https://doi.org/10.1038/hr.2010.135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yjmcc.2009.08.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004571216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa041031", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005610447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00395-011-0242-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007035389", 
              "https://doi.org/10.1007/s00395-011-0242-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpregu.00727.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007613377"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa011303", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007722379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ijms141123011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008729933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yjmcc.2006.10.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008773568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.00341.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010252895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.regpep.2009.02.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011300868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.109.886473", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011623267"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0895-7061(97)00391-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015737416"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/jaha.113.000103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016344017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0082201", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018030075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.00549.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019340909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/hr.2012.223", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020049647", 
              "https://doi.org/10.1038/hr.2012.223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cardiores.2005.10.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020541524"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cardiores.2006.10.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021854022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.clinthera.2008.12.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022577186"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1253/circj.cj-13-0013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023881089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.2011.45", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024905795", 
              "https://doi.org/10.1038/labinvest.2011.45"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1517/14656560903103820", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025536016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cvr/cvn333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027112879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.114.011079", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030575610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.114.011079", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030575610"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/labinvest.2012.136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030741051", 
              "https://doi.org/10.1038/labinvest.2012.136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/hr.2014.136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034426067", 
              "https://doi.org/10.1038/hr.2014.136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.2011.403", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037017377", 
              "https://doi.org/10.1038/ki.2011.403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yjmcc.2013.09.015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037796732"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yjmcc.2010.12.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038641913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1254/fpj.133.275", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040447496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ndt/gft376", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040565404"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajprenal.00392.2012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041131620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2011.04.142", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042969696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lfs.2004.11.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043126528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000130526.20854.fa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043572253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000130526.20854.fa", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043572253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.amjcard.2009.10.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043824631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.110.226803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044360776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circresaha.110.226803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044360776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1253/circj.cj-11-1114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047230121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-200464090-00011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047278519", 
              "https://doi.org/10.2165/00003495-200464090-00011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00003495-200464090-00011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047278519", 
              "https://doi.org/10.2165/00003495-200464090-00011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejphar.2004.04.046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049084223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/hjh.0b013e32834786f0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049225701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/hjh.0b013e32834786f0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049225701"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/eurheartj/ehi020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049226729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/107424840300800307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050423468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/107424840300800307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050423468"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000313363", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050744385"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11033-014-3685-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051107119", 
              "https://doi.org/10.1007/s11033-014-3685-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1590/s0102-86502006000400012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051289157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cellsig.2014.06.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051502486"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/hr.2013.119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052959530", 
              "https://doi.org/10.1038/hr.2013.119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/hr.2013.119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052959530", 
              "https://doi.org/10.1038/hr.2013.119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7326/0003-4819-138-11-200306030-00013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073705988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074598978", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-04", 
        "datePublishedReg": "2016-04-01", 
        "description": "The activity of the renin-angiotensin system is known to be a key factor in the pathophysiology of heart failure and renal failure. Irbesartan, an angiotensin II receptor blocker, has non-hemodynamic cardiovascular and renal protective effects. However, the effect of irbesartan on heart failure complicated by renal failure has not yet been elucidated. Thus the purpose of this study was to evaluate the effect of irbesartan on the pathophysiology of cardiorenal syndrome in a rat model. Subtotal nephrectomy (NTX) was performed in rats was using a two-step surgical procedure. Twenty-eight days after NTX, myocardial infarction (MI) was induced by ligation of the left anterior descending coronary artery. The animals were orally administered vehicle or irbesartan (10\u2009mg\u2009kg(-1)\u2009day(-1)) after NTX. The hearts were harvested 28 days after MI. MI with NTX model rats showed an impaired post-MI survival rate and enhanced cardiac inflammation in comparison to MI without NTX rats. Although irbesartan treatment did not improve the survival rate, it suppressed cardiac inflammation, left ventricular function decline, cardiac fibrosis, hypertrophy of cardiomyocytes and renal fibrosis in MI with NTX rats. Moreover, increases in protein expression levels related to oxidative stress and inflammation (NADPH oxidase 4, phospho-nuclear factor-\u03baB and phospho-c-Jun) observed in the hearts of non-treated MI with NTX rats were attenuated by irbesartan treatment. These effects of irbesartan treatment were independent of blood pressure. We conclude that irbesartan has a cardioprotective effect after MI when renal dysfunction is present. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/hr.2015.141", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.5863147", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6121593", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5917705", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6139743", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5862646", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.5924270", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1313717", 
            "issn": [
              "0916-9636", 
              "1348-4214"
            ], 
            "name": "Hypertension Research", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "39"
          }
        ], 
        "name": "Angiotensin II receptor blocker irbesartan attenuates cardiac dysfunction induced by myocardial infarction in the presence of renal failure", 
        "pagination": "237", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "aefc03924b9407769fd180b89e518fc48b6022a3bf4e8ca7beed7d5dbf7141d3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26657004"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9307690"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/hr.2015.141"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1036733537"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/hr.2015.141", 
          "https://app.dimensions.ai/details/publication/pub.1036733537"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T15:40", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000437.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/hr2015141"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/hr.2015.141'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/hr.2015.141'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/hr.2015.141'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/hr.2015.141'


     

    This table displays all metadata directly associated to this object as RDF triples.

    371 TRIPLES      21 PREDICATES      99 URIs      39 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/hr.2015.141 schema:about N021645d61ff9405db2747d98de2a925b
    2 N0446812e34a04093b6ad18488c8e400f
    3 N20324bb145ac4f13bce80456026b3e63
    4 N23533451b94d41dd92595aeb608da6a2
    5 N34443c2ba1d742319377b178415c0b31
    6 N51daa9d1ba374fd1a640ffaaef4c23d1
    7 N65f074ba697b421ca3abfb1574a264e3
    8 N721a48cae05541b581b39f832402fbe6
    9 N80373f8dabb84e038ce3d973f161756c
    10 N8e4e9c735e2540a08a8e54d06e158abb
    11 Naf60b3d635ed4bf6a5a9271d7a365ff1
    12 Nb2d783b5311c4bb281872519f5340564
    13 Nb423d0cf948f4fe3a4f10265e8537e11
    14 Nbc1f1d52399946f1929dc6e96b2668fd
    15 Nc1c1edd325a74603b38f0361ceb8c425
    16 Nc68e8d79bc024e0cae6d13bbd7fb8fd5
    17 Ndd33ef71fd0a4de1ba8dd7ec985ad532
    18 Nfda44f9f7bcb4e19aa87809a76f85d92
    19 anzsrc-for:11
    20 anzsrc-for:1102
    21 schema:author N89bb5993e4fc46e7bf4fd56a110a9886
    22 schema:citation sg:pub.10.1007/s00395-011-0242-4
    23 sg:pub.10.1007/s11033-014-3685-5
    24 sg:pub.10.1038/hr.2010.135
    25 sg:pub.10.1038/hr.2012.223
    26 sg:pub.10.1038/hr.2013.119
    27 sg:pub.10.1038/hr.2014.136
    28 sg:pub.10.1038/ki.2011.403
    29 sg:pub.10.1038/labinvest.2011.45
    30 sg:pub.10.1038/labinvest.2012.136
    31 sg:pub.10.2165/00003495-200464090-00011
    32 https://app.dimensions.ai/details/publication/pub.1074598978
    33 https://doi.org/10.1016/j.amjcard.2009.10.009
    34 https://doi.org/10.1016/j.bbrc.2011.04.142
    35 https://doi.org/10.1016/j.cardiores.2005.10.002
    36 https://doi.org/10.1016/j.cardiores.2006.10.002
    37 https://doi.org/10.1016/j.cellsig.2014.06.011
    38 https://doi.org/10.1016/j.clinthera.2008.12.002
    39 https://doi.org/10.1016/j.ejheart.2006.05.007
    40 https://doi.org/10.1016/j.ejphar.2004.04.046
    41 https://doi.org/10.1016/j.lfs.2004.11.028
    42 https://doi.org/10.1016/j.regpep.2009.02.006
    43 https://doi.org/10.1016/j.yjmcc.2006.10.006
    44 https://doi.org/10.1016/j.yjmcc.2009.08.002
    45 https://doi.org/10.1016/j.yjmcc.2010.12.021
    46 https://doi.org/10.1016/j.yjmcc.2013.09.015
    47 https://doi.org/10.1016/s0895-7061(97)00391-9
    48 https://doi.org/10.1053/j.ajkd.2010.04.012
    49 https://doi.org/10.1056/nejmoa011303
    50 https://doi.org/10.1056/nejmoa041031
    51 https://doi.org/10.1093/cvr/cvn333
    52 https://doi.org/10.1093/eurheartj/ehi020
    53 https://doi.org/10.1093/ndt/gft376
    54 https://doi.org/10.1097/hjh.0b013e32834786f0
    55 https://doi.org/10.1152/ajpheart.00341.2006
    56 https://doi.org/10.1152/ajpheart.00549.2006
    57 https://doi.org/10.1152/ajpregu.00727.2009
    58 https://doi.org/10.1152/ajprenal.00392.2012
    59 https://doi.org/10.1159/000313363
    60 https://doi.org/10.1161/01.res.0000130526.20854.fa
    61 https://doi.org/10.1161/circresaha.110.226803
    62 https://doi.org/10.1161/circulationaha.109.886473
    63 https://doi.org/10.1161/circulationaha.114.011079
    64 https://doi.org/10.1161/jaha.113.000103
    65 https://doi.org/10.1177/107424840300800307
    66 https://doi.org/10.1253/circj.cj-11-1114
    67 https://doi.org/10.1253/circj.cj-13-0013
    68 https://doi.org/10.1254/fpj.133.275
    69 https://doi.org/10.1371/journal.pone.0082201
    70 https://doi.org/10.1517/14656560903103820
    71 https://doi.org/10.1590/s0102-86502006000400012
    72 https://doi.org/10.3390/ijms141123011
    73 https://doi.org/10.7326/0003-4819-138-11-200306030-00013
    74 schema:datePublished 2016-04
    75 schema:datePublishedReg 2016-04-01
    76 schema:description The activity of the renin-angiotensin system is known to be a key factor in the pathophysiology of heart failure and renal failure. Irbesartan, an angiotensin II receptor blocker, has non-hemodynamic cardiovascular and renal protective effects. However, the effect of irbesartan on heart failure complicated by renal failure has not yet been elucidated. Thus the purpose of this study was to evaluate the effect of irbesartan on the pathophysiology of cardiorenal syndrome in a rat model. Subtotal nephrectomy (NTX) was performed in rats was using a two-step surgical procedure. Twenty-eight days after NTX, myocardial infarction (MI) was induced by ligation of the left anterior descending coronary artery. The animals were orally administered vehicle or irbesartan (10 mg kg(-1) day(-1)) after NTX. The hearts were harvested 28 days after MI. MI with NTX model rats showed an impaired post-MI survival rate and enhanced cardiac inflammation in comparison to MI without NTX rats. Although irbesartan treatment did not improve the survival rate, it suppressed cardiac inflammation, left ventricular function decline, cardiac fibrosis, hypertrophy of cardiomyocytes and renal fibrosis in MI with NTX rats. Moreover, increases in protein expression levels related to oxidative stress and inflammation (NADPH oxidase 4, phospho-nuclear factor-κB and phospho-c-Jun) observed in the hearts of non-treated MI with NTX rats were attenuated by irbesartan treatment. These effects of irbesartan treatment were independent of blood pressure. We conclude that irbesartan has a cardioprotective effect after MI when renal dysfunction is present.
    77 schema:genre research_article
    78 schema:inLanguage en
    79 schema:isAccessibleForFree false
    80 schema:isPartOf N41d1036a70ef461aad87bbba338cdd27
    81 Na59fa49e2fd84db6bfb87c8b8df15ff9
    82 sg:journal.1313717
    83 schema:name Angiotensin II receptor blocker irbesartan attenuates cardiac dysfunction induced by myocardial infarction in the presence of renal failure
    84 schema:pagination 237
    85 schema:productId N1e80a2bb93bf40d1abb13263fa725c6d
    86 N2dee12a3b6f34228a69e59f8756f1afa
    87 N8e89b2905c0e4d4284b23fd5aaf02385
    88 N8f85d21d8d5a45abbadc753186e8a3e7
    89 Nf2467c201272470eaf1c6048a965ebd6
    90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036733537
    91 https://doi.org/10.1038/hr.2015.141
    92 schema:sdDatePublished 2019-04-10T15:40
    93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    94 schema:sdPublisher N3551e113b82540a289aaff03ea2d9641
    95 schema:url https://www.nature.com/articles/hr2015141
    96 sgo:license sg:explorer/license/
    97 sgo:sdDataset articles
    98 rdf:type schema:ScholarlyArticle
    99 N021645d61ff9405db2747d98de2a925b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Angiotensin II Type 1 Receptor Blockers
    101 rdf:type schema:DefinedTerm
    102 N0446812e34a04093b6ad18488c8e400f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Animals
    104 rdf:type schema:DefinedTerm
    105 N07ad98ec957e4faf961466deead974cf rdf:first sg:person.01012024207.33
    106 rdf:rest Ncd8be0759d934970a322ae1494a80693
    107 N1ba6b8c6441944af9bbfffd8cf490ad3 rdf:first sg:person.0772072503.18
    108 rdf:rest Nc2a9bb7e56e94ab8b07b4673accf29f4
    109 N1e80a2bb93bf40d1abb13263fa725c6d schema:name doi
    110 schema:value 10.1038/hr.2015.141
    111 rdf:type schema:PropertyValue
    112 N20324bb145ac4f13bce80456026b3e63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Myocardial Infarction
    114 rdf:type schema:DefinedTerm
    115 N23533451b94d41dd92595aeb608da6a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Male
    117 rdf:type schema:DefinedTerm
    118 N2dee12a3b6f34228a69e59f8756f1afa schema:name pubmed_id
    119 schema:value 26657004
    120 rdf:type schema:PropertyValue
    121 N34443c2ba1d742319377b178415c0b31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Tetrazoles
    123 rdf:type schema:DefinedTerm
    124 N3551e113b82540a289aaff03ea2d9641 schema:name Springer Nature - SN SciGraph project
    125 rdf:type schema:Organization
    126 N41d1036a70ef461aad87bbba338cdd27 schema:volumeNumber 39
    127 rdf:type schema:PublicationVolume
    128 N51daa9d1ba374fd1a640ffaaef4c23d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Biphenyl Compounds
    130 rdf:type schema:DefinedTerm
    131 N65f074ba697b421ca3abfb1574a264e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Proto-Oncogene Proteins c-jun
    133 rdf:type schema:DefinedTerm
    134 N721a48cae05541b581b39f832402fbe6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Rats
    136 rdf:type schema:DefinedTerm
    137 N80373f8dabb84e038ce3d973f161756c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    138 schema:name Myocardium
    139 rdf:type schema:DefinedTerm
    140 N89bb5993e4fc46e7bf4fd56a110a9886 rdf:first sg:person.0664160400.92
    141 rdf:rest N1ba6b8c6441944af9bbfffd8cf490ad3
    142 N8e4e9c735e2540a08a8e54d06e158abb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Rats, Sprague-Dawley
    144 rdf:type schema:DefinedTerm
    145 N8e89b2905c0e4d4284b23fd5aaf02385 schema:name nlm_unique_id
    146 schema:value 9307690
    147 rdf:type schema:PropertyValue
    148 N8f85d21d8d5a45abbadc753186e8a3e7 schema:name dimensions_id
    149 schema:value pub.1036733537
    150 rdf:type schema:PropertyValue
    151 Na59fa49e2fd84db6bfb87c8b8df15ff9 schema:issueNumber 4
    152 rdf:type schema:PublicationIssue
    153 Naf60b3d635ed4bf6a5a9271d7a365ff1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Heart
    155 rdf:type schema:DefinedTerm
    156 Nb2d783b5311c4bb281872519f5340564 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Renal Insufficiency
    158 rdf:type schema:DefinedTerm
    159 Nb423d0cf948f4fe3a4f10265e8537e11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name NF-kappa B
    161 rdf:type schema:DefinedTerm
    162 Nb96cf28aba264509a91472854837e274 rdf:first sg:person.0736053075.51
    163 rdf:rest Nf0fc5e01733446ba8795c0174f7774ba
    164 Nbc1f1d52399946f1929dc6e96b2668fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name NADPH Oxidase 4
    166 rdf:type schema:DefinedTerm
    167 Nc1c1edd325a74603b38f0361ceb8c425 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Renin-Angiotensin System
    169 rdf:type schema:DefinedTerm
    170 Nc2a9bb7e56e94ab8b07b4673accf29f4 rdf:first sg:person.0714750211.11
    171 rdf:rest Nb96cf28aba264509a91472854837e274
    172 Nc68e8d79bc024e0cae6d13bbd7fb8fd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name NADPH Oxidases
    174 rdf:type schema:DefinedTerm
    175 Ncd8be0759d934970a322ae1494a80693 rdf:first sg:person.01266743300.99
    176 rdf:rest rdf:nil
    177 Ndd33ef71fd0a4de1ba8dd7ec985ad532 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Phosphorylation
    179 rdf:type schema:DefinedTerm
    180 Nf0fc5e01733446ba8795c0174f7774ba rdf:first sg:person.012757402652.04
    181 rdf:rest Nf33f75408b7c4c269865c020744720b8
    182 Nf2467c201272470eaf1c6048a965ebd6 schema:name readcube_id
    183 schema:value aefc03924b9407769fd180b89e518fc48b6022a3bf4e8ca7beed7d5dbf7141d3
    184 rdf:type schema:PropertyValue
    185 Nf33f75408b7c4c269865c020744720b8 rdf:first sg:person.01150350762.93
    186 rdf:rest N07ad98ec957e4faf961466deead974cf
    187 Nfda44f9f7bcb4e19aa87809a76f85d92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Ventricular Dysfunction, Left
    189 rdf:type schema:DefinedTerm
    190 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    191 schema:name Medical and Health Sciences
    192 rdf:type schema:DefinedTerm
    193 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
    194 schema:name Cardiorespiratory Medicine and Haematology
    195 rdf:type schema:DefinedTerm
    196 sg:grant.5862646 http://pending.schema.org/fundedItem sg:pub.10.1038/hr.2015.141
    197 rdf:type schema:MonetaryGrant
    198 sg:grant.5863147 http://pending.schema.org/fundedItem sg:pub.10.1038/hr.2015.141
    199 rdf:type schema:MonetaryGrant
    200 sg:grant.5917705 http://pending.schema.org/fundedItem sg:pub.10.1038/hr.2015.141
    201 rdf:type schema:MonetaryGrant
    202 sg:grant.5924270 http://pending.schema.org/fundedItem sg:pub.10.1038/hr.2015.141
    203 rdf:type schema:MonetaryGrant
    204 sg:grant.6121593 http://pending.schema.org/fundedItem sg:pub.10.1038/hr.2015.141
    205 rdf:type schema:MonetaryGrant
    206 sg:grant.6139743 http://pending.schema.org/fundedItem sg:pub.10.1038/hr.2015.141
    207 rdf:type schema:MonetaryGrant
    208 sg:journal.1313717 schema:issn 0916-9636
    209 1348-4214
    210 schema:name Hypertension Research
    211 rdf:type schema:Periodical
    212 sg:person.01012024207.33 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    213 schema:familyName Komuro
    214 schema:givenName Issei
    215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012024207.33
    216 rdf:type schema:Person
    217 sg:person.01150350762.93 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    218 schema:familyName Akazawa
    219 schema:givenName Hiroshi
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150350762.93
    221 rdf:type schema:Person
    222 sg:person.01266743300.99 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
    223 schema:familyName Isobe
    224 schema:givenName Mitsuaki
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266743300.99
    226 rdf:type schema:Person
    227 sg:person.012757402652.04 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    228 schema:familyName Ikeda
    229 schema:givenName Yuichi
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012757402652.04
    231 rdf:type schema:Person
    232 sg:person.0664160400.92 schema:affiliation https://www.grid.ac/institutes/grid.265073.5
    233 schema:familyName Watanabe
    234 schema:givenName Ryo
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0664160400.92
    236 rdf:type schema:Person
    237 sg:person.0714750211.11 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    238 schema:familyName Wakayama
    239 schema:givenName Kouji
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714750211.11
    241 rdf:type schema:Person
    242 sg:person.0736053075.51 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    243 schema:familyName Kumagai
    244 schema:givenName Hidetoshi
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0736053075.51
    246 rdf:type schema:Person
    247 sg:person.0772072503.18 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    248 schema:familyName Suzuki
    249 schema:givenName Jun-ichi
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772072503.18
    251 rdf:type schema:Person
    252 sg:pub.10.1007/s00395-011-0242-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007035389
    253 https://doi.org/10.1007/s00395-011-0242-4
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1007/s11033-014-3685-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051107119
    256 https://doi.org/10.1007/s11033-014-3685-5
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/hr.2010.135 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003902715
    259 https://doi.org/10.1038/hr.2010.135
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/hr.2012.223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020049647
    262 https://doi.org/10.1038/hr.2012.223
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/hr.2013.119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052959530
    265 https://doi.org/10.1038/hr.2013.119
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/hr.2014.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034426067
    268 https://doi.org/10.1038/hr.2014.136
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/ki.2011.403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037017377
    271 https://doi.org/10.1038/ki.2011.403
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.1038/labinvest.2011.45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024905795
    274 https://doi.org/10.1038/labinvest.2011.45
    275 rdf:type schema:CreativeWork
    276 sg:pub.10.1038/labinvest.2012.136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030741051
    277 https://doi.org/10.1038/labinvest.2012.136
    278 rdf:type schema:CreativeWork
    279 sg:pub.10.2165/00003495-200464090-00011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047278519
    280 https://doi.org/10.2165/00003495-200464090-00011
    281 rdf:type schema:CreativeWork
    282 https://app.dimensions.ai/details/publication/pub.1074598978 schema:CreativeWork
    283 https://doi.org/10.1016/j.amjcard.2009.10.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043824631
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1016/j.bbrc.2011.04.142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042969696
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1016/j.cardiores.2005.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020541524
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1016/j.cardiores.2006.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021854022
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1016/j.cellsig.2014.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051502486
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1016/j.clinthera.2008.12.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022577186
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1016/j.ejheart.2006.05.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001206535
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1016/j.ejphar.2004.04.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049084223
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1016/j.lfs.2004.11.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043126528
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1016/j.regpep.2009.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011300868
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1016/j.yjmcc.2006.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008773568
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1016/j.yjmcc.2009.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004571216
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1016/j.yjmcc.2010.12.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038641913
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1016/j.yjmcc.2013.09.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037796732
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/s0895-7061(97)00391-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015737416
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1053/j.ajkd.2010.04.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003203476
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1056/nejmoa011303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007722379
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1056/nejmoa041031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005610447
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1093/cvr/cvn333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027112879
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1093/eurheartj/ehi020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049226729
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1093/ndt/gft376 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040565404
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1097/hjh.0b013e32834786f0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049225701
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1152/ajpheart.00341.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010252895
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1152/ajpheart.00549.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019340909
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1152/ajpregu.00727.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007613377
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1152/ajprenal.00392.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041131620
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1159/000313363 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050744385
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1161/01.res.0000130526.20854.fa schema:sameAs https://app.dimensions.ai/details/publication/pub.1043572253
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1161/circresaha.110.226803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044360776
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1161/circulationaha.109.886473 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011623267
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1161/circulationaha.114.011079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030575610
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1161/jaha.113.000103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016344017
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1177/107424840300800307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050423468
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1253/circj.cj-11-1114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047230121
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1253/circj.cj-13-0013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023881089
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1254/fpj.133.275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040447496
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1371/journal.pone.0082201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018030075
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1517/14656560903103820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025536016
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1590/s0102-86502006000400012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051289157
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.3390/ijms141123011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008729933
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.7326/0003-4819-138-11-200306030-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073705988
    364 rdf:type schema:CreativeWork
    365 https://www.grid.ac/institutes/grid.265073.5 schema:alternateName Tokyo Medical and Dental University
    366 schema:name Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    367 rdf:type schema:Organization
    368 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
    369 schema:name Department of Advanced Clinical Science and Therapeutics, The University of Tokyo, Tokyo, Japan
    370 Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan
    371 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...