Could home arterial stiffness index be a novel marker for arterial stiffness in patients with type 2 diabetes? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-02-14

AUTHORS

Michiaki Fukui, Emi Ushigome, Muhei Tanaka, Masahide Hamaguchi, Toru Tanaka, Haruhiko Atsuta, Masayoshi Ohnishi, Yohei Oda, Goji Hasegawa, Naoto Nakamura

ABSTRACT

Recent studies suggested that home arterial stiffness index (HASI) may be a new measure of arterial stiffness. The aim of this study was to investigate whether HASI is more strongly associated with arterial stiffness than is pulse pressure (PP) and thus a more suitable tool than PP for evaluating arterial stiffness in patients with type 2 diabetes. We evaluated the relationship of HASI or PP with pulse wave velocity (PWV) as well as with major cardiovascular risk factors in 332 patients with type 2 diabetes. Furthermore, we compared the area under the receiver-operator characteristic curve (AUC) of HASI or PP for PWV. Morning PP was positively associated with PWV (r=0.303, P<0.0001), while morning HASI was not (r=−0.006, P=0.9063). Multiple regression analysis demonstrated that morning PP (β=0.179, P=0.0210), but not morning HASI (β=−0.040, P=0.5036), was independently associated with PWV. The AUCs (95% confidence interval (CI)) of morning HASI and morning PP for arterial stiffness were 0.510 (0.448–0.573) (P=0.745) and 0.638 (0.578–0.698) (P<0.0001), respectively. The AUC (95% CI) of morning HASI for arterial stiffness was significantly less than that of morning PP (P=0.0005). In conclusion, morning HASI is less correlated with PWV than is morning PP in patients with type 2 diabetes. More... »

PAGES

645-649

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/hr.2013.4

DOI

http://dx.doi.org/10.1038/hr.2013.4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042410669

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23407244


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