The impact of a change in hypertension management guidelines on diuretic use in Japan: trends in antihypertensive drug prescriptions from ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-06

AUTHORS

Takahide Kohro, Tsutomu Yamazaki, Hiroki Sato, Kazuhiko Ohe, Ryozo Nagai

ABSTRACT

The Japanese Society of Hypertension (JSH) updated its hypertension management guidelines in 2009. One of the most significant changes with respect to the 2004 version was the stance towards the use of diuretics: in 2004, their use was cautioned against, but in 2009, it was actively promoted. The purpose of this study was to measure the impact of this change in guidelines on prescription patterns for antihypertensive medications, and to investigate the overall trend in the use of antihypertensives. We used monthly claims data obtained from a database company. Data of patients who were 20 or more years old and prescribed antihypertensives were extracted and analyzed. There were 66 223 patients who were prescribed antihypertensives (mean age 53.6±11.0). Of these, 38 130 were men and 28 093 were women. The two most prescribed classes of antihypertensives were angiotensin receptor blockers, whose usage steadily increased over a 7-year period, and calcium channel blockers. Prescriptions for antihypertensives in these two classes were also more likely to be continued than those for other antihypertensive classes. The prescription rate for diuretics increased from December 2006 (P<0.0001), but the rate of increase was the same before and after 2009 (P=0.09). The clinical guidelines published in 2009 had no apparent impact on the trend of diuretic prescriptions, despite the radical change in stance concerning the use of antihypertensives. Further effort to disseminate the content of these guidelines, so that it is reflected in actual clinical practice, may be warranted. More... »

PAGES

559

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/hr.2012.216

DOI

http://dx.doi.org/10.1038/hr.2012.216

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004984700

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23388884


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiotensin II Type 1 Receptor Blockers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antihypertensive Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium Channel Blockers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Databases, Factual", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diuretics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Prescriptions", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Utilization", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guideline Adherence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Guidelines as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Japan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Practice Patterns, Physicians'", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Thiazides", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Translational Research for Healthcare and Clinical Science, School of Medicine, The University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kohro", 
        "givenName": "Takahide", 
        "id": "sg:person.0600041350.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600041350.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412708.8", 
          "name": [
            "Clinical Research Support Center, The University of Tokyo Hospital, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamazaki", 
        "givenName": "Tsutomu", 
        "id": "sg:person.01270006264.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270006264.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Preventive Medicine and Public Health, National Defense Medical College, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Hiroki", 
        "id": "sg:person.011371334541.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011371334541.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Medical Informatics and Economics, Division of Social Medicine, School of Medicine, The University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohe", 
        "givenName": "Kazuhiko", 
        "id": "sg:person.015411176101.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015411176101.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Jichi Medical University, Tochigi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagai", 
        "givenName": "Ryozo", 
        "id": "sg:person.0772176333.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772176333.38"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/sj.jhh.1001977", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007948453", 
          "https://doi.org/10.1038/sj.jhh.1001977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jhh.1001977", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007948453", 
          "https://doi.org/10.1038/sj.jhh.1001977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/hr.2008.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009767304", 
          "https://doi.org/10.1038/hr.2008.31"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0828-282x(07)70799-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023024184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2188/jea.je20090066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028691966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2188/jea.je20090066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028691966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jhh.1001899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029766698", 
          "https://doi.org/10.1038/sj.jhh.1001899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jhh.1001899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029766698", 
          "https://doi.org/10.1038/sj.jhh.1001899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jhh.1001899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029766698", 
          "https://doi.org/10.1038/sj.jhh.1001899"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02849881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036666995", 
          "https://doi.org/10.1007/bf02849881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02849881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036666995", 
          "https://doi.org/10.1007/bf02849881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.282.9.867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046458725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/pgmj.2010.116012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050585484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/pgmj.2010.116012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050585484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005650-199609000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060223286"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1291/hypres.29.s1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064749255"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-06", 
    "datePublishedReg": "2013-06-01", 
    "description": "The Japanese Society of Hypertension (JSH) updated its hypertension management guidelines in 2009. One of the most significant changes with respect to the 2004 version was the stance towards the use of diuretics: in 2004, their use was cautioned against, but in 2009, it was actively promoted. The purpose of this study was to measure the impact of this change in guidelines on prescription patterns for antihypertensive medications, and to investigate the overall trend in the use of antihypertensives. We used monthly claims data obtained from a database company. Data of patients who were 20 or more years old and prescribed antihypertensives were extracted and analyzed. There were 66\u2009223 patients who were prescribed antihypertensives (mean age 53.6\u00b111.0). Of these, 38\u2009130 were men and 28\u2009093 were women. The two most prescribed classes of antihypertensives were angiotensin receptor blockers, whose usage steadily increased over a 7-year period, and calcium channel blockers. Prescriptions for antihypertensives in these two classes were also more likely to be continued than those for other antihypertensive classes. The prescription rate for diuretics increased from December 2006 (P<0.0001), but the rate of increase was the same before and after 2009 (P=0.09). The clinical guidelines published in 2009 had no apparent impact on the trend of diuretic prescriptions, despite the radical change in stance concerning the use of antihypertensives. Further effort to disseminate the content of these guidelines, so that it is reflected in actual clinical practice, may be warranted.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/hr.2012.216", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1313717", 
        "issn": [
          "0916-9636", 
          "1348-4214"
        ], 
        "name": "Hypertension Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "36"
      }
    ], 
    "name": "The impact of a change in hypertension management guidelines on diuretic use in Japan: trends in antihypertensive drug prescriptions from 2005 to 2011", 
    "pagination": "559", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "17c0b4abc742634f5743f564b9bf319f21090d0f7d22e0835d550c1e2eb7def7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23388884"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9307690"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/hr.2012.216"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004984700"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/hr.2012.216", 
      "https://app.dimensions.ai/details/publication/pub.1004984700"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/hr2012216"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/hr.2012.216'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/hr.2012.216'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/hr.2012.216'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/hr.2012.216'


 

This table displays all metadata directly associated to this object as RDF triples.

217 TRIPLES      21 PREDICATES      58 URIs      40 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/hr.2012.216 schema:about N0502ab09f9f9479187a52879c9a75851
2 N138f162ff340480ba4ac6900aa8e597e
3 N1e40b73f925345b3a6459490977e1d8a
4 N3aa0d2851328445eb800efc6f82a6825
5 N3c6563fd219b494797fb39645513f4fa
6 N48aa15e31887433bbdf76bcaf7a52699
7 N4a7a6400bae9438198ba693c4c10018d
8 N52f282b7b8434c8a98c7b01c43a38dd8
9 N639c1d4fc7db4968af4094cae41d57d6
10 N6475cc48ccc94d069d702276b28a2c13
11 N649d471ad3a14f88ae551429748e9104
12 N716030733b8f4f76b9c672db5118f794
13 N9e676b15ee6b4182848d9a462e4acd3f
14 Nb051c624d34047bbab87cd12df643d4a
15 Nb5bd68e0013d43e6838d47405e1261fd
16 Nb987ce47b20046f78882747cb7e3b657
17 Nd1c74268a7464d8fbc7a35f312682f38
18 Ndc97d37f3dce414294354df63212b3c4
19 Nfa6a5201f3254173946df0609b6ddeff
20 anzsrc-for:11
21 anzsrc-for:1103
22 schema:author Nff78cdfa46a14bc18e636d78d2bfc0ae
23 schema:citation sg:pub.10.1007/bf02849881
24 sg:pub.10.1038/hr.2008.31
25 sg:pub.10.1038/sj.jhh.1001899
26 sg:pub.10.1038/sj.jhh.1001977
27 https://doi.org/10.1001/jama.282.9.867
28 https://doi.org/10.1016/s0828-282x(07)70799-7
29 https://doi.org/10.1097/00005650-199609000-00002
30 https://doi.org/10.1136/pgmj.2010.116012
31 https://doi.org/10.1291/hypres.29.s1
32 https://doi.org/10.2188/jea.je20090066
33 schema:datePublished 2013-06
34 schema:datePublishedReg 2013-06-01
35 schema:description The Japanese Society of Hypertension (JSH) updated its hypertension management guidelines in 2009. One of the most significant changes with respect to the 2004 version was the stance towards the use of diuretics: in 2004, their use was cautioned against, but in 2009, it was actively promoted. The purpose of this study was to measure the impact of this change in guidelines on prescription patterns for antihypertensive medications, and to investigate the overall trend in the use of antihypertensives. We used monthly claims data obtained from a database company. Data of patients who were 20 or more years old and prescribed antihypertensives were extracted and analyzed. There were 66 223 patients who were prescribed antihypertensives (mean age 53.6±11.0). Of these, 38 130 were men and 28 093 were women. The two most prescribed classes of antihypertensives were angiotensin receptor blockers, whose usage steadily increased over a 7-year period, and calcium channel blockers. Prescriptions for antihypertensives in these two classes were also more likely to be continued than those for other antihypertensive classes. The prescription rate for diuretics increased from December 2006 (P<0.0001), but the rate of increase was the same before and after 2009 (P=0.09). The clinical guidelines published in 2009 had no apparent impact on the trend of diuretic prescriptions, despite the radical change in stance concerning the use of antihypertensives. Further effort to disseminate the content of these guidelines, so that it is reflected in actual clinical practice, may be warranted.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree true
39 schema:isPartOf N27ec5c65625a494dbe7c6416085c1664
40 N9faacf94ce90440599ca6554bc4d192f
41 sg:journal.1313717
42 schema:name The impact of a change in hypertension management guidelines on diuretic use in Japan: trends in antihypertensive drug prescriptions from 2005 to 2011
43 schema:pagination 559
44 schema:productId N173cc3e8422044e494262302923cb075
45 N6a6a5c216c464fddbded65680f6b91cc
46 N70f5e2d2bf524c84b5c643369cd69c7a
47 Nb79742a677ad4b54b883e98c02a78ff1
48 Nee14f820b81d4687b5a730cead042435
49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004984700
50 https://doi.org/10.1038/hr.2012.216
51 schema:sdDatePublished 2019-04-10T23:13
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher N42d6a6b058694fc39b4e28250d6455f7
54 schema:url https://www.nature.com/articles/hr2012216
55 sgo:license sg:explorer/license/
56 sgo:sdDataset articles
57 rdf:type schema:ScholarlyArticle
58 N0502ab09f9f9479187a52879c9a75851 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name Drug Prescriptions
60 rdf:type schema:DefinedTerm
61 N138f162ff340480ba4ac6900aa8e597e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Middle Aged
63 rdf:type schema:DefinedTerm
64 N173cc3e8422044e494262302923cb075 schema:name doi
65 schema:value 10.1038/hr.2012.216
66 rdf:type schema:PropertyValue
67 N1e40b73f925345b3a6459490977e1d8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Thiazides
69 rdf:type schema:DefinedTerm
70 N27ec5c65625a494dbe7c6416085c1664 schema:volumeNumber 36
71 rdf:type schema:PublicationVolume
72 N3aa0d2851328445eb800efc6f82a6825 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Guideline Adherence
74 rdf:type schema:DefinedTerm
75 N3c6563fd219b494797fb39645513f4fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Diuretics
77 rdf:type schema:DefinedTerm
78 N42d6a6b058694fc39b4e28250d6455f7 schema:name Springer Nature - SN SciGraph project
79 rdf:type schema:Organization
80 N48aa15e31887433bbdf76bcaf7a52699 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Male
82 rdf:type schema:DefinedTerm
83 N4a7a6400bae9438198ba693c4c10018d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Female
85 rdf:type schema:DefinedTerm
86 N52f282b7b8434c8a98c7b01c43a38dd8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Databases, Factual
88 rdf:type schema:DefinedTerm
89 N639c1d4fc7db4968af4094cae41d57d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Survival Analysis
91 rdf:type schema:DefinedTerm
92 N6475cc48ccc94d069d702276b28a2c13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Japan
94 rdf:type schema:DefinedTerm
95 N649d471ad3a14f88ae551429748e9104 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Antihypertensive Agents
97 rdf:type schema:DefinedTerm
98 N6a6a5c216c464fddbded65680f6b91cc schema:name dimensions_id
99 schema:value pub.1004984700
100 rdf:type schema:PropertyValue
101 N70f5e2d2bf524c84b5c643369cd69c7a schema:name pubmed_id
102 schema:value 23388884
103 rdf:type schema:PropertyValue
104 N716030733b8f4f76b9c672db5118f794 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Drug Utilization
106 rdf:type schema:DefinedTerm
107 N725ad404c4184521af86869623c21c7b rdf:first sg:person.01270006264.53
108 rdf:rest Ncd84d290e3ec452799493bc5453678ce
109 N99d20146681c4283bbc5edfcdbcf3a66 rdf:first sg:person.015411176101.15
110 rdf:rest Ne0008a48149645dc826a80c9f9de53c4
111 N9e676b15ee6b4182848d9a462e4acd3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Aged
113 rdf:type schema:DefinedTerm
114 N9faacf94ce90440599ca6554bc4d192f schema:issueNumber 6
115 rdf:type schema:PublicationIssue
116 Nb051c624d34047bbab87cd12df643d4a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Practice Patterns, Physicians'
118 rdf:type schema:DefinedTerm
119 Nb5bd68e0013d43e6838d47405e1261fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Calcium Channel Blockers
121 rdf:type schema:DefinedTerm
122 Nb79742a677ad4b54b883e98c02a78ff1 schema:name readcube_id
123 schema:value 17c0b4abc742634f5743f564b9bf319f21090d0f7d22e0835d550c1e2eb7def7
124 rdf:type schema:PropertyValue
125 Nb987ce47b20046f78882747cb7e3b657 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Angiotensin II Type 1 Receptor Blockers
127 rdf:type schema:DefinedTerm
128 Ncd84d290e3ec452799493bc5453678ce rdf:first sg:person.011371334541.42
129 rdf:rest N99d20146681c4283bbc5edfcdbcf3a66
130 Nd1c74268a7464d8fbc7a35f312682f38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Humans
132 rdf:type schema:DefinedTerm
133 Ndc97d37f3dce414294354df63212b3c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Guidelines as Topic
135 rdf:type schema:DefinedTerm
136 Ne0008a48149645dc826a80c9f9de53c4 rdf:first sg:person.0772176333.38
137 rdf:rest rdf:nil
138 Nee14f820b81d4687b5a730cead042435 schema:name nlm_unique_id
139 schema:value 9307690
140 rdf:type schema:PropertyValue
141 Nfa6a5201f3254173946df0609b6ddeff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Hypertension
143 rdf:type schema:DefinedTerm
144 Nff78cdfa46a14bc18e636d78d2bfc0ae rdf:first sg:person.0600041350.35
145 rdf:rest N725ad404c4184521af86869623c21c7b
146 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
147 schema:name Medical and Health Sciences
148 rdf:type schema:DefinedTerm
149 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
150 schema:name Clinical Sciences
151 rdf:type schema:DefinedTerm
152 sg:journal.1313717 schema:issn 0916-9636
153 1348-4214
154 schema:name Hypertension Research
155 rdf:type schema:Periodical
156 sg:person.011371334541.42 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
157 schema:familyName Sato
158 schema:givenName Hiroki
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011371334541.42
160 rdf:type schema:Person
161 sg:person.01270006264.53 schema:affiliation https://www.grid.ac/institutes/grid.412708.8
162 schema:familyName Yamazaki
163 schema:givenName Tsutomu
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270006264.53
165 rdf:type schema:Person
166 sg:person.015411176101.15 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
167 schema:familyName Ohe
168 schema:givenName Kazuhiko
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015411176101.15
170 rdf:type schema:Person
171 sg:person.0600041350.35 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
172 schema:familyName Kohro
173 schema:givenName Takahide
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600041350.35
175 rdf:type schema:Person
176 sg:person.0772176333.38 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
177 schema:familyName Nagai
178 schema:givenName Ryozo
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772176333.38
180 rdf:type schema:Person
181 sg:pub.10.1007/bf02849881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036666995
182 https://doi.org/10.1007/bf02849881
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/hr.2008.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009767304
185 https://doi.org/10.1038/hr.2008.31
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/sj.jhh.1001899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029766698
188 https://doi.org/10.1038/sj.jhh.1001899
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/sj.jhh.1001977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007948453
191 https://doi.org/10.1038/sj.jhh.1001977
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1001/jama.282.9.867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046458725
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/s0828-282x(07)70799-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023024184
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1097/00005650-199609000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060223286
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1136/pgmj.2010.116012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050585484
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1291/hypres.29.s1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064749255
202 rdf:type schema:CreativeWork
203 https://doi.org/10.2188/jea.je20090066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028691966
204 rdf:type schema:CreativeWork
205 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
206 schema:name Department of Medical Informatics and Economics, Division of Social Medicine, School of Medicine, The University of Tokyo, Tokyo, Japan
207 Department of Translational Research for Healthcare and Clinical Science, School of Medicine, The University of Tokyo, Tokyo, Japan
208 rdf:type schema:Organization
209 https://www.grid.ac/institutes/grid.410804.9 schema:alternateName Jichi Medical University
210 schema:name Jichi Medical University, Tochigi, Japan
211 rdf:type schema:Organization
212 https://www.grid.ac/institutes/grid.412708.8 schema:alternateName University of Tokyo Hospital
213 schema:name Clinical Research Support Center, The University of Tokyo Hospital, Tokyo, Japan
214 rdf:type schema:Organization
215 https://www.grid.ac/institutes/grid.416614.0 schema:alternateName National Defense Medical College
216 schema:name Department of Preventive Medicine and Public Health, National Defense Medical College, Saitama, Japan
217 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...