Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01

AUTHORS

Yasutomi Higashikuni, Minoru Takaoka, Hiroshi Iwata, Kimie Tanaka, Yasunobu Hirata, Ryozo Nagai, Masataka Sata

ABSTRACT

The efficacy of aliskiren, a direct renin inhibitor, in ventricular remodeling after myocardial infarction (MI) compared with conventional renin-angiotensin system (RAS) inhibitors remains to be defined. This study was performed to examine the protective effects of aliskiren and its addition to valsartan, an angiotensin-II receptor blocker, against ventricular remodeling after MI. MI was induced in 8- to 12-week-old C57BL/6 mice by ligating the left anterior descending artery. At 3 days after MI, mice were divided into five groups and were treated with the following: (1) phosphate-buffered saline (PBS); (2) hydralazine (10 mg kg(-1) day(-1)); (3) valsartan (8 mg kg(-1) day(-1)); (4) aliskiren (25 mg kg(-1) day(-1)); and (5) combined aliskiren (25 mg kg(-1) day(-1)) and valsartan (8 mg kg(-1) day(-1)). With these doses of drugs, blood pressure-lowering effects compared with the PBS group were similar among the treated groups in sham-operated mice. At 28 days after MI, echocardiographic, hemodynamic and histological assessments demonstrated that monotherapy with valsartan or aliskiren alone significantly and similarly ameliorated ventricular remodeling after MI compared with the PBS and the hydralazine groups. Combination therapy of valsartan and aliskiren more greatly improved ventricular remodeling after MI with enhancement of angiogenesis and greater attenuation of tissue oxidative stress and inflammation. Our results indicate that aliskiren can be an alternative to conventional RAS inhibitors in the treatment of post-MI patients. Moreover, the dual therapy of valsartan and aliskiren may be more beneficial than either monotherapy. Further clinical trials will be warranted to sufficiently assess the safety and the efficacy of the use of aliskiren in post-MI patients. More... »

PAGES

hr2011136

References to SciGraph publications

  • 2008-05. Aliskiren: the first renin inhibitor for clinical treatment in NATURE REVIEWS DRUG DISCOVERY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/hr.2011.136

    DOI

    http://dx.doi.org/10.1038/hr.2011.136

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1007926962

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21833001


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Angiotensin II Type 1 Receptor Blockers", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antihypertensive Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blood Pressure", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Drug Synergism", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fumarates", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Heart", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lipid Peroxidation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myocardial Infarction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Myocardium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Renin-Angiotensin System", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tetrazoles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Valine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Valsartan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ventricular Remodeling", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Cardiovascular Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Higashikuni", 
            "givenName": "Yasutomi", 
            "id": "sg:person.01032527663.02", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032527663.02"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Cardiovascular Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takaoka", 
            "givenName": "Minoru", 
            "id": "sg:person.01004145323.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004145323.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Cardiovascular Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Iwata", 
            "givenName": "Hiroshi", 
            "id": "sg:person.01117156143.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117156143.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Cardiovascular Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tanaka", 
            "givenName": "Kimie", 
            "id": "sg:person.01112562276.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112562276.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Cardiovascular Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hirata", 
            "givenName": "Yasunobu", 
            "id": "sg:person.07703025442.98", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07703025442.98"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Cardiovascular Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nagai", 
            "givenName": "Ryozo", 
            "id": "sg:person.0772176333.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772176333.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokushima", 
              "id": "https://www.grid.ac/institutes/grid.267335.6", 
              "name": [
                "Department of Cardiovascular Medicine, University of Tokushima, Tokushima-shi, Tokushima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sata", 
            "givenName": "Masataka", 
            "id": "sg:person.01263307474.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263307474.04"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1056/nejm200104263441707", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000294039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pcad.2004.04.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000358222"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cardfail.2007.11.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001018581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.hyp.33.6.1399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001744820"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.yjmcc.2009.08.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004571216"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/dc09-0168", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005475791"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs20060301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006274514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/cs20060301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006274514"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.105.551143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010580667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2004.10.106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011102089"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.108.182519", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014613667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.108.182519", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014613667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hypertensionaha.109.133884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015200977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hypertensionaha.109.133884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015200977"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(08)61236-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016139020"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0735-1097(00)00996-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016464856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.hyp.32.3.387", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020082230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa032292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020366713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/eurheartj/ehq522", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021135373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archinte.167.18.1930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023774810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199512213332503", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025734830"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cvr/cvn333", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027112879"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmra021498", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028607375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0801317", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032359861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.81.4.1161", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032601562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1440-1681.2003.03930.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033199669"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.110.211755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036528809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/atvbaha.110.211755", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036528809"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hypertensionaha.108.116350", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037322110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/hypertensionaha.108.116350", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037322110"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci18212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040905806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2459/01.jcm.0000199787.45940.68", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042681736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2459/01.jcm.0000199787.45940.68", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042681736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/cvr/cvn335", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043847449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.108.826214", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044451364"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.cir.76.1.44", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045470454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circheartfailure.107.740704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046307443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circheartfailure.107.740704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046307443"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0708379", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046355145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/circulationaha.108.787630", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049040467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm200001203420301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050329362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/1357-2725(96)00012-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052506129"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2550", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053341882", 
              "https://doi.org/10.1038/nrd2550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm199209033271001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053464475"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/ars.2006.8.1597", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059230407"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.00416.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063193939"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci24408", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063416810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074598978", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2012-01", 
        "datePublishedReg": "2012-01-01", 
        "description": "The efficacy of aliskiren, a direct renin inhibitor, in ventricular remodeling after myocardial infarction (MI) compared with conventional renin-angiotensin system (RAS) inhibitors remains to be defined. This study was performed to examine the protective effects of aliskiren and its addition to valsartan, an angiotensin-II receptor blocker, against ventricular remodeling after MI. MI was induced in 8- to 12-week-old C57BL/6 mice by ligating the left anterior descending artery. At 3 days after MI, mice were divided into five groups and were treated with the following: (1) phosphate-buffered saline (PBS); (2) hydralazine (10 mg kg(-1) day(-1)); (3) valsartan (8 mg kg(-1) day(-1)); (4) aliskiren (25 mg kg(-1) day(-1)); and (5) combined aliskiren (25 mg kg(-1) day(-1)) and valsartan (8 mg kg(-1) day(-1)). With these doses of drugs, blood pressure-lowering effects compared with the PBS group were similar among the treated groups in sham-operated mice. At 28 days after MI, echocardiographic, hemodynamic and histological assessments demonstrated that monotherapy with valsartan or aliskiren alone significantly and similarly ameliorated ventricular remodeling after MI compared with the PBS and the hydralazine groups. Combination therapy of valsartan and aliskiren more greatly improved ventricular remodeling after MI with enhancement of angiogenesis and greater attenuation of tissue oxidative stress and inflammation. Our results indicate that aliskiren can be an alternative to conventional RAS inhibitors in the treatment of post-MI patients. Moreover, the dual therapy of valsartan and aliskiren may be more beneficial than either monotherapy. Further clinical trials will be warranted to sufficiently assess the safety and the efficacy of the use of aliskiren in post-MI patients.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/hr.2011.136", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6039106", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6074842", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6045505", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.6106282", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1313717", 
            "issn": [
              "0916-9636", 
              "1348-4214"
            ], 
            "name": "Hypertension Research", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "35"
          }
        ], 
        "name": "Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice", 
        "pagination": "hr2011136", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "25c2fa848412ed415ae45b5e38d1c4e4e411242f9f7350171f1ea17f2902b34e"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21833001"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9307690"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/hr.2011.136"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1007926962"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/hr.2011.136", 
          "https://app.dimensions.ai/details/publication/pub.1007926962"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:03", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000422.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/hr2011136"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/hr.2011.136'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/hr.2011.136'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/hr.2011.136'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/hr.2011.136'


     

    This table displays all metadata directly associated to this object as RDF triples.

    317 TRIPLES      21 PREDICATES      88 URIs      39 LITERALS      27 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/hr.2011.136 schema:about N07039f9b9b284b649e5df55f3f72c942
    2 N12edce988aba4797a04ec8654178df79
    3 N24472acacea64c49890e1027df5ffef9
    4 N29a2c1dd3a894aaaa0ea21f6a675a575
    5 N36f6e6299c9648babc4d60ae66a89526
    6 N56a8a6a053f5468d8a816b83c6df7f29
    7 N5ec6110e3c6942b9b3c801da667a091c
    8 N5f613159402e4c7fa0443026f67efa66
    9 N8aabb15637534691b1f3a38c8eb09fdd
    10 Na0ab752dfc7445c8bd1eb98826224fc6
    11 Na4a05152731742ed87567be31dc44449
    12 Naedd5242e24f42e7895c95c961278b0a
    13 Nb9c8cfa4663644f3a72bc2df8b6bc022
    14 Nc0ec30a6f8e74afc8491be3aa2e15732
    15 Nd5869d32c7f34e009d578cb6bd3ed9b0
    16 Nd9b189069abe444e8f124c18a87a54ce
    17 Ndb41badc65d54ac998977041a7b0b30f
    18 Ne6fb5d6169fb4389afdb56a9d7c7f56e
    19 anzsrc-for:11
    20 anzsrc-for:1103
    21 schema:author Na91afd3292c94974af4c42c63f79f464
    22 schema:citation sg:pub.10.1038/nrd2550
    23 https://app.dimensions.ai/details/publication/pub.1074598978
    24 https://doi.org/10.1001/archinte.167.18.1930
    25 https://doi.org/10.1016/1357-2725(96)00012-x
    26 https://doi.org/10.1016/j.bbrc.2004.10.106
    27 https://doi.org/10.1016/j.cardfail.2007.11.008
    28 https://doi.org/10.1016/j.pcad.2004.04.003
    29 https://doi.org/10.1016/j.yjmcc.2009.08.002
    30 https://doi.org/10.1016/s0140-6736(08)61236-2
    31 https://doi.org/10.1016/s0735-1097(00)00996-7
    32 https://doi.org/10.1042/cs20060301
    33 https://doi.org/10.1046/j.1440-1681.2003.03930.x
    34 https://doi.org/10.1056/nejm199209033271001
    35 https://doi.org/10.1056/nejm199512213332503
    36 https://doi.org/10.1056/nejm200001203420301
    37 https://doi.org/10.1056/nejm200104263441707
    38 https://doi.org/10.1056/nejmoa032292
    39 https://doi.org/10.1056/nejmoa0708379
    40 https://doi.org/10.1056/nejmoa0801317
    41 https://doi.org/10.1056/nejmra021498
    42 https://doi.org/10.1089/ars.2006.8.1597
    43 https://doi.org/10.1093/cvr/cvn333
    44 https://doi.org/10.1093/cvr/cvn335
    45 https://doi.org/10.1093/eurheartj/ehq522
    46 https://doi.org/10.1152/ajpheart.00416.2002
    47 https://doi.org/10.1161/01.cir.76.1.44
    48 https://doi.org/10.1161/01.cir.81.4.1161
    49 https://doi.org/10.1161/01.hyp.32.3.387
    50 https://doi.org/10.1161/01.hyp.33.6.1399
    51 https://doi.org/10.1161/atvbaha.108.182519
    52 https://doi.org/10.1161/atvbaha.110.211755
    53 https://doi.org/10.1161/circheartfailure.107.740704
    54 https://doi.org/10.1161/circulationaha.105.551143
    55 https://doi.org/10.1161/circulationaha.108.787630
    56 https://doi.org/10.1161/circulationaha.108.826214
    57 https://doi.org/10.1161/hypertensionaha.108.116350
    58 https://doi.org/10.1161/hypertensionaha.109.133884
    59 https://doi.org/10.1172/jci18212
    60 https://doi.org/10.1172/jci24408
    61 https://doi.org/10.2337/dc09-0168
    62 https://doi.org/10.2459/01.jcm.0000199787.45940.68
    63 schema:datePublished 2012-01
    64 schema:datePublishedReg 2012-01-01
    65 schema:description The efficacy of aliskiren, a direct renin inhibitor, in ventricular remodeling after myocardial infarction (MI) compared with conventional renin-angiotensin system (RAS) inhibitors remains to be defined. This study was performed to examine the protective effects of aliskiren and its addition to valsartan, an angiotensin-II receptor blocker, against ventricular remodeling after MI. MI was induced in 8- to 12-week-old C57BL/6 mice by ligating the left anterior descending artery. At 3 days after MI, mice were divided into five groups and were treated with the following: (1) phosphate-buffered saline (PBS); (2) hydralazine (10 mg kg(-1) day(-1)); (3) valsartan (8 mg kg(-1) day(-1)); (4) aliskiren (25 mg kg(-1) day(-1)); and (5) combined aliskiren (25 mg kg(-1) day(-1)) and valsartan (8 mg kg(-1) day(-1)). With these doses of drugs, blood pressure-lowering effects compared with the PBS group were similar among the treated groups in sham-operated mice. At 28 days after MI, echocardiographic, hemodynamic and histological assessments demonstrated that monotherapy with valsartan or aliskiren alone significantly and similarly ameliorated ventricular remodeling after MI compared with the PBS and the hydralazine groups. Combination therapy of valsartan and aliskiren more greatly improved ventricular remodeling after MI with enhancement of angiogenesis and greater attenuation of tissue oxidative stress and inflammation. Our results indicate that aliskiren can be an alternative to conventional RAS inhibitors in the treatment of post-MI patients. Moreover, the dual therapy of valsartan and aliskiren may be more beneficial than either monotherapy. Further clinical trials will be warranted to sufficiently assess the safety and the efficacy of the use of aliskiren in post-MI patients.
    66 schema:genre research_article
    67 schema:inLanguage en
    68 schema:isAccessibleForFree true
    69 schema:isPartOf N3eb4cacdaff843c2882a1abf4c395015
    70 N703473f7af0d4131a29398870a9549dc
    71 sg:journal.1313717
    72 schema:name Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice
    73 schema:pagination hr2011136
    74 schema:productId Na629f5677f424b51ad450d420f5b8cfb
    75 Nb37ef2d8fde346e0b036aa6fb0ab7d2b
    76 Nc404403949ae4be786db9731bccc89d3
    77 Nd8e1a696d64f4ac5aa8fd3cc364d5b84
    78 Nf7977899eeb2466b95b03a4d1f2d1d25
    79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007926962
    80 https://doi.org/10.1038/hr.2011.136
    81 schema:sdDatePublished 2019-04-11T00:03
    82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    83 schema:sdPublisher N78a4b11aea4243ec9943ebb734032b78
    84 schema:url http://www.nature.com/articles/hr2011136
    85 sgo:license sg:explorer/license/
    86 sgo:sdDataset articles
    87 rdf:type schema:ScholarlyArticle
    88 N07039f9b9b284b649e5df55f3f72c942 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    89 schema:name Myocardial Infarction
    90 rdf:type schema:DefinedTerm
    91 N12edce988aba4797a04ec8654178df79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Ventricular Remodeling
    93 rdf:type schema:DefinedTerm
    94 N22e5eb1388c840598e694410d52f2eb0 rdf:first sg:person.01263307474.04
    95 rdf:rest rdf:nil
    96 N24472acacea64c49890e1027df5ffef9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Tetrazoles
    98 rdf:type schema:DefinedTerm
    99 N29a2c1dd3a894aaaa0ea21f6a675a575 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Heart
    101 rdf:type schema:DefinedTerm
    102 N2d7f6100acf7451abe0081bccfbde8f5 rdf:first sg:person.0772176333.38
    103 rdf:rest N22e5eb1388c840598e694410d52f2eb0
    104 N36f6e6299c9648babc4d60ae66a89526 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Myocardium
    106 rdf:type schema:DefinedTerm
    107 N375a28211583434c8497195f7e40aca8 rdf:first sg:person.01004145323.65
    108 rdf:rest Nab3477b64b824054872e017d6cc21089
    109 N3eb4cacdaff843c2882a1abf4c395015 schema:volumeNumber 35
    110 rdf:type schema:PublicationVolume
    111 N56a8a6a053f5468d8a816b83c6df7f29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Fumarates
    113 rdf:type schema:DefinedTerm
    114 N5ec6110e3c6942b9b3c801da667a091c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Drug Synergism
    116 rdf:type schema:DefinedTerm
    117 N5f613159402e4c7fa0443026f67efa66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Animals
    119 rdf:type schema:DefinedTerm
    120 N703473f7af0d4131a29398870a9549dc schema:issueNumber 1
    121 rdf:type schema:PublicationIssue
    122 N78a4b11aea4243ec9943ebb734032b78 schema:name Springer Nature - SN SciGraph project
    123 rdf:type schema:Organization
    124 N8aabb15637534691b1f3a38c8eb09fdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Renin-Angiotensin System
    126 rdf:type schema:DefinedTerm
    127 Na0ab752dfc7445c8bd1eb98826224fc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Antihypertensive Agents
    129 rdf:type schema:DefinedTerm
    130 Na4a05152731742ed87567be31dc44449 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Valsartan
    132 rdf:type schema:DefinedTerm
    133 Na629f5677f424b51ad450d420f5b8cfb schema:name dimensions_id
    134 schema:value pub.1007926962
    135 rdf:type schema:PropertyValue
    136 Na91afd3292c94974af4c42c63f79f464 rdf:first sg:person.01032527663.02
    137 rdf:rest N375a28211583434c8497195f7e40aca8
    138 Naa00e36035b2410ebe279b023434e24f rdf:first sg:person.01112562276.34
    139 rdf:rest Ne34d39bb30a549ff93d416a0d2d75cbf
    140 Nab3477b64b824054872e017d6cc21089 rdf:first sg:person.01117156143.59
    141 rdf:rest Naa00e36035b2410ebe279b023434e24f
    142 Naedd5242e24f42e7895c95c961278b0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Amides
    144 rdf:type schema:DefinedTerm
    145 Nb37ef2d8fde346e0b036aa6fb0ab7d2b schema:name readcube_id
    146 schema:value 25c2fa848412ed415ae45b5e38d1c4e4e411242f9f7350171f1ea17f2902b34e
    147 rdf:type schema:PropertyValue
    148 Nb9c8cfa4663644f3a72bc2df8b6bc022 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Male
    150 rdf:type schema:DefinedTerm
    151 Nc0ec30a6f8e74afc8491be3aa2e15732 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Valine
    153 rdf:type schema:DefinedTerm
    154 Nc404403949ae4be786db9731bccc89d3 schema:name doi
    155 schema:value 10.1038/hr.2011.136
    156 rdf:type schema:PropertyValue
    157 Nd5869d32c7f34e009d578cb6bd3ed9b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Mice
    159 rdf:type schema:DefinedTerm
    160 Nd8e1a696d64f4ac5aa8fd3cc364d5b84 schema:name nlm_unique_id
    161 schema:value 9307690
    162 rdf:type schema:PropertyValue
    163 Nd9b189069abe444e8f124c18a87a54ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    164 schema:name Lipid Peroxidation
    165 rdf:type schema:DefinedTerm
    166 Ndb41badc65d54ac998977041a7b0b30f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Angiotensin II Type 1 Receptor Blockers
    168 rdf:type schema:DefinedTerm
    169 Ne34d39bb30a549ff93d416a0d2d75cbf rdf:first sg:person.07703025442.98
    170 rdf:rest N2d7f6100acf7451abe0081bccfbde8f5
    171 Ne6fb5d6169fb4389afdb56a9d7c7f56e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Blood Pressure
    173 rdf:type schema:DefinedTerm
    174 Nf7977899eeb2466b95b03a4d1f2d1d25 schema:name pubmed_id
    175 schema:value 21833001
    176 rdf:type schema:PropertyValue
    177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    178 schema:name Medical and Health Sciences
    179 rdf:type schema:DefinedTerm
    180 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    181 schema:name Clinical Sciences
    182 rdf:type schema:DefinedTerm
    183 sg:grant.6039106 http://pending.schema.org/fundedItem sg:pub.10.1038/hr.2011.136
    184 rdf:type schema:MonetaryGrant
    185 sg:grant.6045505 http://pending.schema.org/fundedItem sg:pub.10.1038/hr.2011.136
    186 rdf:type schema:MonetaryGrant
    187 sg:grant.6074842 http://pending.schema.org/fundedItem sg:pub.10.1038/hr.2011.136
    188 rdf:type schema:MonetaryGrant
    189 sg:grant.6106282 http://pending.schema.org/fundedItem sg:pub.10.1038/hr.2011.136
    190 rdf:type schema:MonetaryGrant
    191 sg:journal.1313717 schema:issn 0916-9636
    192 1348-4214
    193 schema:name Hypertension Research
    194 rdf:type schema:Periodical
    195 sg:person.01004145323.65 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    196 schema:familyName Takaoka
    197 schema:givenName Minoru
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004145323.65
    199 rdf:type schema:Person
    200 sg:person.01032527663.02 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    201 schema:familyName Higashikuni
    202 schema:givenName Yasutomi
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032527663.02
    204 rdf:type schema:Person
    205 sg:person.01112562276.34 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    206 schema:familyName Tanaka
    207 schema:givenName Kimie
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112562276.34
    209 rdf:type schema:Person
    210 sg:person.01117156143.59 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    211 schema:familyName Iwata
    212 schema:givenName Hiroshi
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01117156143.59
    214 rdf:type schema:Person
    215 sg:person.01263307474.04 schema:affiliation https://www.grid.ac/institutes/grid.267335.6
    216 schema:familyName Sata
    217 schema:givenName Masataka
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01263307474.04
    219 rdf:type schema:Person
    220 sg:person.07703025442.98 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    221 schema:familyName Hirata
    222 schema:givenName Yasunobu
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07703025442.98
    224 rdf:type schema:Person
    225 sg:person.0772176333.38 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    226 schema:familyName Nagai
    227 schema:givenName Ryozo
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772176333.38
    229 rdf:type schema:Person
    230 sg:pub.10.1038/nrd2550 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053341882
    231 https://doi.org/10.1038/nrd2550
    232 rdf:type schema:CreativeWork
    233 https://app.dimensions.ai/details/publication/pub.1074598978 schema:CreativeWork
    234 https://doi.org/10.1001/archinte.167.18.1930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023774810
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1016/1357-2725(96)00012-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052506129
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1016/j.bbrc.2004.10.106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011102089
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1016/j.cardfail.2007.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001018581
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1016/j.pcad.2004.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000358222
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1016/j.yjmcc.2009.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004571216
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/s0140-6736(08)61236-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016139020
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/s0735-1097(00)00996-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016464856
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1042/cs20060301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006274514
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1046/j.1440-1681.2003.03930.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033199669
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1056/nejm199209033271001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053464475
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1056/nejm199512213332503 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025734830
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1056/nejm200001203420301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050329362
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1056/nejm200104263441707 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000294039
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1056/nejmoa032292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020366713
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1056/nejmoa0708379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046355145
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1056/nejmoa0801317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032359861
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1056/nejmra021498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028607375
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1089/ars.2006.8.1597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059230407
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1093/cvr/cvn333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027112879
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1093/cvr/cvn335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043847449
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1093/eurheartj/ehq522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021135373
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1152/ajpheart.00416.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063193939
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1161/01.cir.76.1.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045470454
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1161/01.cir.81.4.1161 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032601562
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1161/01.hyp.32.3.387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020082230
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1161/01.hyp.33.6.1399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001744820
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1161/atvbaha.108.182519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014613667
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1161/atvbaha.110.211755 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036528809
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1161/circheartfailure.107.740704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046307443
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1161/circulationaha.105.551143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010580667
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1161/circulationaha.108.787630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049040467
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1161/circulationaha.108.826214 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044451364
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1161/hypertensionaha.108.116350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037322110
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1161/hypertensionaha.109.133884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015200977
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1172/jci18212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040905806
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1172/jci24408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416810
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.2337/dc09-0168 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005475791
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.2459/01.jcm.0000199787.45940.68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042681736
    311 rdf:type schema:CreativeWork
    312 https://www.grid.ac/institutes/grid.267335.6 schema:alternateName University of Tokushima
    313 schema:name Department of Cardiovascular Medicine, University of Tokushima, Tokushima-shi, Tokushima, Japan
    314 rdf:type schema:Organization
    315 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
    316 schema:name Department of Cardiovascular Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan
    317 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...