Efficacy of clonidine in patients with essential hypertension with neurovascular contact of the rostral ventrolateral medulla View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-04-09

AUTHORS

Takao Sakuma, Satoshi Morimoto, Yasuko Aota, Nobuyuki Takahashi, Nagaoki Toyoda, Atsushi Kosaki, Minoru Maehara, Noboru Tanigawa, Koshi Ikeda, Satoshi Sawada, Toshiji Iwasaka

ABSTRACT

The rostral ventrolateral medulla (RVLM) is an important center for regulation of sympathetic nerve activity. Several clinical studies have suggested an association between neurovascular contact (NVC) of RVLM and essential hypertension. Microvascular decompression (MVD) of RVLM decreases blood pressure (BP) in hypertensive patients with NVC of this region. Therefore, MVD could be a useful therapeutic strategy to reduce BP in these patients. However, as MVD is an invasive procedure, it is worthy to seek useful antihypertensive agents for hypertensive patients with NVC. It is reported that sympathetic nerve activity is elevated in patients with hypertension accompanied by NVC of RVLM. It is anticipated that sympatholytic agents could be effective in lowering BP in these patients. In this study, we investigated the efficacy of clonidine, an α2 adrenergic agonist, in essential hypertensives with NVC of RVLM. Thirty consecutive essential hypertensive patients with NVC and 30 consecutive essential hypertensive patients without contact were treated with clonidine for 4 weeks, and decreases in BP and plasma norepinephrine levels were compared between the two groups. Decreases in BP and plasma norepinephrine levels were significantly greater in patients with NVC than in those without contact. These results suggest that clonidine exhibits significantly greater reductions of BP and sympathetic nerve activity in essential hypertensive patients with NVC compared with those without contact of the rostral ventrolateral medulla. More... »

PAGES

633-637

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/hr.2010.41

DOI

http://dx.doi.org/10.1038/hr.2010.41

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029400625

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20379192


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