Impact of RGS2 deficiency on the therapeutic effect of telmisartan in angiotensin II-induced aortic aneurysm View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-09-30

AUTHORS

Sachiko Matsumoto, Kei Kamide, Fumiaki Banno, Nobutaka Inoue, Naoki Mochizuki, Yuhei Kawano, Toshiyuki Miyata

ABSTRACT

Regulator of G-protein signaling 2 (RGS2) negatively regulates the signaling of G-protein-coupled receptors, such as the angiotensin II (AngII) type 1 receptor by accelerating the inactivation of Gαq. Rgs2-deficient mice show increased sensitivity and prolonged responsiveness to vasoconstrictors, and genetic variations in the RGS2 gene are associated with hypertension in humans. This study aimed to clarify whether Rgs2 deficiency contributes to the development of vascular remodeling and therapeutic efficacy of the angiotensin receptor blocker telmisartan on atherosclerotic vascular damage. We treated Rgs2+/+, Rgs2+/− and Rgs2−/− mice with saline (control group), AngII (1000 ng per kg per min, AngII group) or low-dose telmisartan (0.3 mg per kg per day) with AngII infusion (AngII+Telmi group) for 4 weeks. For all genotypes, the AngII groups exhibited significantly higher blood pressure, a higher mortality rate and a higher incidence of aortic aneurysm than the respective control group. Interestingly, aneurysm incidence was decreased in the AngII+Telmi group compared with the AngII group in Rgs2−/− mice (6.7 vs. 42.9%, P<0.05), but not in Rgs2+/+ mice (38.9 vs. 40.0%). Moreover, in Rgs2−/− mice, the AngII+Telmi group exhibited significant improvement in survival, reduction of enlarged aortic diameter, inhibition of superoxide production and suppression of NAD(P)H oxidase activity compared with the AngII group. Thus, Rgs2 deficiency potentiates the vascular protection effect of low-dose telmisartan. Our results suggest that angiotensin receptor blocker may be useful for protection from cardiovascular events in hypertensive subjects with risk alleles in the RGS2 gene. More... »

PAGES

1244-1249

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/hr.2010.184

DOI

http://dx.doi.org/10.1038/hr.2010.184

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010507394

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20882024


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Analysis of Variance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiotensin II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiotensin II Type 1 Receptor Blockers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aorta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aortic Aneurysm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzimidazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Benzoates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neovascularization, Physiologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RGS Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Superoxides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Telmisartan", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsumoto", 
        "givenName": "Sachiko", 
        "id": "sg:person.0641772445.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641772445.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan", 
            "Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamide", 
        "givenName": "Kei", 
        "id": "sg:person.01172555442.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172555442.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Banno", 
        "givenName": "Fumiaki", 
        "id": "sg:person.0626442606.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626442606.36"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, Kobe Rosai Hospital, Kobe, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.415418.d", 
          "name": [
            "Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan", 
            "Department of Cardiovascular Medicine, Kobe Rosai Hospital, Kobe, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inoue", 
        "givenName": "Nobutaka", 
        "id": "sg:person.01240712105.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240712105.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mochizuki", 
        "givenName": "Naoki", 
        "id": "sg:person.0715762471.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715762471.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Division of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawano", 
        "givenName": "Yuhei", 
        "id": "sg:person.01004731377.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004731377.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miyata", 
        "givenName": "Toshiyuki", 
        "id": "sg:person.010666543652.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010666543652.74"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/hr.2009.190", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052170090", 
          "https://doi.org/10.1038/hr.2009.190"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005094251", 
          "https://doi.org/10.1038/nm958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/hr.2009.193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047762349", 
          "https://doi.org/10.1038/hr.2009.193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/hr.2010.13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000012017", 
          "https://doi.org/10.1038/hr.2010.13"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/31701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040460300", 
          "https://doi.org/10.1038/31701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1291/hypres.31.203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034718833", 
          "https://doi.org/10.1291/hypres.31.203"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/hr.2009.95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033979448", 
          "https://doi.org/10.1038/hr.2009.95"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-09-30", 
    "datePublishedReg": "2010-09-30", 
    "description": "Regulator of G-protein signaling 2 (RGS2) negatively regulates the signaling of G-protein-coupled receptors, such as the angiotensin II (AngII) type 1 receptor by accelerating the inactivation of G\u03b1q. Rgs2-deficient mice show increased sensitivity and prolonged responsiveness to vasoconstrictors, and genetic variations in the RGS2 gene are associated with hypertension in humans. This study aimed to clarify whether Rgs2 deficiency contributes to the development of vascular remodeling and therapeutic efficacy of the angiotensin receptor blocker telmisartan on atherosclerotic vascular damage. We treated Rgs2+/+, Rgs2+/\u2212 and Rgs2\u2212/\u2212 mice with saline (control group), AngII (1000\u2009ng per kg per min, AngII group) or low-dose telmisartan (0.3\u2009mg per kg per day) with AngII infusion (AngII+Telmi group) for 4 weeks. For all genotypes, the AngII groups exhibited significantly higher blood pressure, a higher mortality rate and a higher incidence of aortic aneurysm than the respective control group. Interestingly, aneurysm incidence was decreased in the AngII+Telmi group compared with the AngII group in Rgs2\u2212/\u2212 mice (6.7 vs. 42.9%, P<0.05), but not in Rgs2+/+ mice (38.9 vs. 40.0%). Moreover, in Rgs2\u2212/\u2212 mice, the AngII+Telmi group exhibited significant improvement in survival, reduction of enlarged aortic diameter, inhibition of superoxide production and suppression of NAD(P)H oxidase activity compared with the AngII group. Thus, Rgs2 deficiency potentiates the vascular protection effect of low-dose telmisartan. Our results suggest that angiotensin receptor blocker may be useful for protection from cardiovascular events in hypertensive subjects with risk alleles in the RGS2 gene.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/hr.2010.184", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6055458", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1313717", 
        "issn": [
          "0916-9636", 
          "1348-4214"
        ], 
        "name": "Hypertension Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "33"
      }
    ], 
    "keywords": [
      "low-dose telmisartan", 
      "AngII group", 
      "aortic aneurysm", 
      "RGS2 deficiency", 
      "angiotensin receptor blocker telmisartan", 
      "angiotensin II type 1 receptor", 
      "angiotensin receptor blockers", 
      "atherosclerotic vascular damage", 
      "high blood pressure", 
      "type 1 receptor", 
      "high mortality rate", 
      "RGS2 gene", 
      "respective control groups", 
      "protein-coupled receptors", 
      "AngII infusion", 
      "receptor blockers", 
      "cardiovascular events", 
      "blood pressure", 
      "hypertensive subjects", 
      "blocker telmisartan", 
      "aortic diameter", 
      "aneurysm incidence", 
      "vascular damage", 
      "angiotensin II", 
      "therapeutic effect", 
      "vascular remodeling", 
      "high incidence", 
      "mortality rate", 
      "control group", 
      "therapeutic efficacy", 
      "risk alleles", 
      "telmisartan", 
      "mice", 
      "superoxide production", 
      "aneurysms", 
      "incidence", 
      "Increased sensitivity", 
      "oxidase activity", 
      "receptors", 
      "deficiency", 
      "group", 
      "significant improvement", 
      "hypertension", 
      "vasoconstrictor", 
      "AngII", 
      "protection effect", 
      "infusion", 
      "blockers", 
      "saline", 
      "weeks", 
      "efficacy", 
      "survival", 
      "remodeling", 
      "responsiveness", 
      "G\u03b1q", 
      "inhibition", 
      "subjects", 
      "genes", 
      "effect", 
      "signaling", 
      "humans", 
      "suppression", 
      "genotypes", 
      "damage", 
      "alleles", 
      "genetic variation", 
      "inactivation", 
      "activity", 
      "study", 
      "sensitivity", 
      "protein", 
      "rate", 
      "reduction", 
      "events", 
      "pressure", 
      "improvement", 
      "protection", 
      "regulator", 
      "development", 
      "impact", 
      "diameter", 
      "production", 
      "results", 
      "variation", 
      "II (AngII) type 1 receptor", 
      "inactivation of G\u03b1q", 
      "receptor blocker telmisartan", 
      "vascular protection effect"
    ], 
    "name": "Impact of RGS2 deficiency on the therapeutic effect of telmisartan in angiotensin II-induced aortic aneurysm", 
    "pagination": "1244-1249", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010507394"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/hr.2010.184"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20882024"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/hr.2010.184", 
      "https://app.dimensions.ai/details/publication/pub.1010507394"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_505.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/hr.2010.184"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/hr.2010.184'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/hr.2010.184'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/hr.2010.184'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/hr.2010.184'


 

This table displays all metadata directly associated to this object as RDF triples.

308 TRIPLES      22 PREDICATES      140 URIs      124 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/hr.2010.184 schema:about N00e68ccced3f448a90a6f13d5887cb53
2 N01a1f23b38aa48598c12e14172873ac4
3 N01e52456c0cb4e1ab0f5e8fe35409154
4 N0756d18a56b54996b162ef38f4aeb46e
5 N364c90b202c548e1be3d11d40798182c
6 N422b9fef14af4a61a1402d49536ae38f
7 N43a8cfa8389943b9b582e35035f1c980
8 N58658ed64f6a4bf2bfcaedb0a4d792d0
9 N6a4335f3bd8e48228bfdbac337b06ecd
10 N7896bd812d3b4828846cf27ffd6869ae
11 N7fd104fbfed3431fba957f90def72fb0
12 N849a9a770fc342488795e1ae3fd4d707
13 N84e31dbb8b384d23a2c7c70c1d38cfe6
14 N865156b229d84d51b8ec3468507ece9f
15 N8f0a5b5249624cabad7f43a88ba39ca6
16 Nc42fd6b8d39f47abbb0991a3015ac895
17 Nc6e1f03bcc7d45cc82d7ec063b6e8911
18 Nf53eef7cdb3d4fea837ce3aa71713acf
19 anzsrc-for:11
20 anzsrc-for:1102
21 anzsrc-for:1115
22 schema:author Nc9edf7422f5a4077b850fcf2bb93b63b
23 schema:citation sg:pub.10.1038/31701
24 sg:pub.10.1038/hr.2009.190
25 sg:pub.10.1038/hr.2009.193
26 sg:pub.10.1038/hr.2009.95
27 sg:pub.10.1038/hr.2010.13
28 sg:pub.10.1038/nm958
29 sg:pub.10.1291/hypres.31.203
30 schema:datePublished 2010-09-30
31 schema:datePublishedReg 2010-09-30
32 schema:description Regulator of G-protein signaling 2 (RGS2) negatively regulates the signaling of G-protein-coupled receptors, such as the angiotensin II (AngII) type 1 receptor by accelerating the inactivation of Gαq. Rgs2-deficient mice show increased sensitivity and prolonged responsiveness to vasoconstrictors, and genetic variations in the RGS2 gene are associated with hypertension in humans. This study aimed to clarify whether Rgs2 deficiency contributes to the development of vascular remodeling and therapeutic efficacy of the angiotensin receptor blocker telmisartan on atherosclerotic vascular damage. We treated Rgs2+/+, Rgs2+/− and Rgs2−/− mice with saline (control group), AngII (1000 ng per kg per min, AngII group) or low-dose telmisartan (0.3 mg per kg per day) with AngII infusion (AngII+Telmi group) for 4 weeks. For all genotypes, the AngII groups exhibited significantly higher blood pressure, a higher mortality rate and a higher incidence of aortic aneurysm than the respective control group. Interestingly, aneurysm incidence was decreased in the AngII+Telmi group compared with the AngII group in Rgs2−/− mice (6.7 vs. 42.9%, P<0.05), but not in Rgs2+/+ mice (38.9 vs. 40.0%). Moreover, in Rgs2−/− mice, the AngII+Telmi group exhibited significant improvement in survival, reduction of enlarged aortic diameter, inhibition of superoxide production and suppression of NAD(P)H oxidase activity compared with the AngII group. Thus, Rgs2 deficiency potentiates the vascular protection effect of low-dose telmisartan. Our results suggest that angiotensin receptor blocker may be useful for protection from cardiovascular events in hypertensive subjects with risk alleles in the RGS2 gene.
33 schema:genre article
34 schema:inLanguage en
35 schema:isAccessibleForFree true
36 schema:isPartOf N67a036f49cd24f25a2c17338cb0d3c10
37 N85c655ceacf445cdbc84ed951f4ab34e
38 sg:journal.1313717
39 schema:keywords AngII
40 AngII group
41 AngII infusion
42 Gαq
43 II (AngII) type 1 receptor
44 Increased sensitivity
45 RGS2 deficiency
46 RGS2 gene
47 activity
48 alleles
49 aneurysm incidence
50 aneurysms
51 angiotensin II
52 angiotensin II type 1 receptor
53 angiotensin receptor blocker telmisartan
54 angiotensin receptor blockers
55 aortic aneurysm
56 aortic diameter
57 atherosclerotic vascular damage
58 blocker telmisartan
59 blockers
60 blood pressure
61 cardiovascular events
62 control group
63 damage
64 deficiency
65 development
66 diameter
67 effect
68 efficacy
69 events
70 genes
71 genetic variation
72 genotypes
73 group
74 high blood pressure
75 high incidence
76 high mortality rate
77 humans
78 hypertension
79 hypertensive subjects
80 impact
81 improvement
82 inactivation
83 inactivation of Gαq
84 incidence
85 infusion
86 inhibition
87 low-dose telmisartan
88 mice
89 mortality rate
90 oxidase activity
91 pressure
92 production
93 protection
94 protection effect
95 protein
96 protein-coupled receptors
97 rate
98 receptor blocker telmisartan
99 receptor blockers
100 receptors
101 reduction
102 regulator
103 remodeling
104 respective control groups
105 responsiveness
106 results
107 risk alleles
108 saline
109 sensitivity
110 signaling
111 significant improvement
112 study
113 subjects
114 superoxide production
115 suppression
116 survival
117 telmisartan
118 therapeutic effect
119 therapeutic efficacy
120 type 1 receptor
121 variation
122 vascular damage
123 vascular protection effect
124 vascular remodeling
125 vasoconstrictor
126 weeks
127 schema:name Impact of RGS2 deficiency on the therapeutic effect of telmisartan in angiotensin II-induced aortic aneurysm
128 schema:pagination 1244-1249
129 schema:productId N0986112ab1194a3da3fe6fc9cbc6f9c3
130 Nbc49ceda12ca4a61871021956df6c04c
131 Nea208d6da307405da9a1de4d4037a375
132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010507394
133 https://doi.org/10.1038/hr.2010.184
134 schema:sdDatePublished 2021-12-01T19:23
135 schema:sdLicense https://scigraph.springernature.com/explorer/license/
136 schema:sdPublisher Na1b5d6e791c4466296811b96b2c1ca67
137 schema:url https://doi.org/10.1038/hr.2010.184
138 sgo:license sg:explorer/license/
139 sgo:sdDataset articles
140 rdf:type schema:ScholarlyArticle
141 N00e68ccced3f448a90a6f13d5887cb53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Benzimidazoles
143 rdf:type schema:DefinedTerm
144 N01a1f23b38aa48598c12e14172873ac4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Angiotensin II
146 rdf:type schema:DefinedTerm
147 N01e52456c0cb4e1ab0f5e8fe35409154 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Benzoates
149 rdf:type schema:DefinedTerm
150 N0756d18a56b54996b162ef38f4aeb46e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Alleles
152 rdf:type schema:DefinedTerm
153 N0986112ab1194a3da3fe6fc9cbc6f9c3 schema:name pubmed_id
154 schema:value 20882024
155 rdf:type schema:PropertyValue
156 N29a91956012849e9b5e27d443f632e86 rdf:first sg:person.01240712105.05
157 rdf:rest N94409a6cc5df4d95b0bcb6ec4830f0a3
158 N364c90b202c548e1be3d11d40798182c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Genotype
160 rdf:type schema:DefinedTerm
161 N422b9fef14af4a61a1402d49536ae38f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Mice
163 rdf:type schema:DefinedTerm
164 N43a8cfa8389943b9b582e35035f1c980 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Analysis of Variance
166 rdf:type schema:DefinedTerm
167 N58658ed64f6a4bf2bfcaedb0a4d792d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Animals
169 rdf:type schema:DefinedTerm
170 N67a036f49cd24f25a2c17338cb0d3c10 schema:volumeNumber 33
171 rdf:type schema:PublicationVolume
172 N6a4335f3bd8e48228bfdbac337b06ecd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name RGS Proteins
174 rdf:type schema:DefinedTerm
175 N7896bd812d3b4828846cf27ffd6869ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Angiotensin II Type 1 Receptor Blockers
177 rdf:type schema:DefinedTerm
178 N7e66266c247b4e54830ce42561cb30ab rdf:first sg:person.010666543652.74
179 rdf:rest rdf:nil
180 N7fd104fbfed3431fba957f90def72fb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Aortic Aneurysm
182 rdf:type schema:DefinedTerm
183 N849894f98703475ea12fd1af29c8cbe2 rdf:first sg:person.01172555442.88
184 rdf:rest Nb44e30add30547889f702759760037c4
185 N849a9a770fc342488795e1ae3fd4d707 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Mice, Knockout
187 rdf:type schema:DefinedTerm
188 N84e31dbb8b384d23a2c7c70c1d38cfe6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Blood Pressure
190 rdf:type schema:DefinedTerm
191 N85c655ceacf445cdbc84ed951f4ab34e schema:issueNumber 12
192 rdf:type schema:PublicationIssue
193 N865156b229d84d51b8ec3468507ece9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Aorta
195 rdf:type schema:DefinedTerm
196 N8f0a5b5249624cabad7f43a88ba39ca6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Neovascularization, Physiologic
198 rdf:type schema:DefinedTerm
199 N94409a6cc5df4d95b0bcb6ec4830f0a3 rdf:first sg:person.0715762471.09
200 rdf:rest Nc300547efb004cb8a5b53aebaa13ea5e
201 Na1b5d6e791c4466296811b96b2c1ca67 schema:name Springer Nature - SN SciGraph project
202 rdf:type schema:Organization
203 Nb44e30add30547889f702759760037c4 rdf:first sg:person.0626442606.36
204 rdf:rest N29a91956012849e9b5e27d443f632e86
205 Nbc49ceda12ca4a61871021956df6c04c schema:name dimensions_id
206 schema:value pub.1010507394
207 rdf:type schema:PropertyValue
208 Nc300547efb004cb8a5b53aebaa13ea5e rdf:first sg:person.01004731377.08
209 rdf:rest N7e66266c247b4e54830ce42561cb30ab
210 Nc42fd6b8d39f47abbb0991a3015ac895 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Telmisartan
212 rdf:type schema:DefinedTerm
213 Nc6e1f03bcc7d45cc82d7ec063b6e8911 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Superoxides
215 rdf:type schema:DefinedTerm
216 Nc9edf7422f5a4077b850fcf2bb93b63b rdf:first sg:person.0641772445.36
217 rdf:rest N849894f98703475ea12fd1af29c8cbe2
218 Nea208d6da307405da9a1de4d4037a375 schema:name doi
219 schema:value 10.1038/hr.2010.184
220 rdf:type schema:PropertyValue
221 Nf53eef7cdb3d4fea837ce3aa71713acf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Male
223 rdf:type schema:DefinedTerm
224 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
225 schema:name Medical and Health Sciences
226 rdf:type schema:DefinedTerm
227 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
228 schema:name Cardiorespiratory Medicine and Haematology
229 rdf:type schema:DefinedTerm
230 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
231 schema:name Pharmacology and Pharmaceutical Sciences
232 rdf:type schema:DefinedTerm
233 sg:grant.6055458 http://pending.schema.org/fundedItem sg:pub.10.1038/hr.2010.184
234 rdf:type schema:MonetaryGrant
235 sg:journal.1313717 schema:issn 0916-9636
236 1348-4214
237 schema:name Hypertension Research
238 schema:publisher Springer Nature
239 rdf:type schema:Periodical
240 sg:person.01004731377.08 schema:affiliation grid-institutes:grid.410796.d
241 schema:familyName Kawano
242 schema:givenName Yuhei
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004731377.08
244 rdf:type schema:Person
245 sg:person.010666543652.74 schema:affiliation grid-institutes:grid.410796.d
246 schema:familyName Miyata
247 schema:givenName Toshiyuki
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010666543652.74
249 rdf:type schema:Person
250 sg:person.01172555442.88 schema:affiliation grid-institutes:grid.136593.b
251 schema:familyName Kamide
252 schema:givenName Kei
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172555442.88
254 rdf:type schema:Person
255 sg:person.01240712105.05 schema:affiliation grid-institutes:grid.415418.d
256 schema:familyName Inoue
257 schema:givenName Nobutaka
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240712105.05
259 rdf:type schema:Person
260 sg:person.0626442606.36 schema:affiliation grid-institutes:grid.410796.d
261 schema:familyName Banno
262 schema:givenName Fumiaki
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626442606.36
264 rdf:type schema:Person
265 sg:person.0641772445.36 schema:affiliation grid-institutes:grid.410796.d
266 schema:familyName Matsumoto
267 schema:givenName Sachiko
268 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641772445.36
269 rdf:type schema:Person
270 sg:person.0715762471.09 schema:affiliation grid-institutes:grid.410796.d
271 schema:familyName Mochizuki
272 schema:givenName Naoki
273 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715762471.09
274 rdf:type schema:Person
275 sg:pub.10.1038/31701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040460300
276 https://doi.org/10.1038/31701
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/hr.2009.190 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052170090
279 https://doi.org/10.1038/hr.2009.190
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/hr.2009.193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047762349
282 https://doi.org/10.1038/hr.2009.193
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/hr.2009.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033979448
285 https://doi.org/10.1038/hr.2009.95
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/hr.2010.13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000012017
288 https://doi.org/10.1038/hr.2010.13
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/nm958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005094251
291 https://doi.org/10.1038/nm958
292 rdf:type schema:CreativeWork
293 sg:pub.10.1291/hypres.31.203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034718833
294 https://doi.org/10.1291/hypres.31.203
295 rdf:type schema:CreativeWork
296 grid-institutes:grid.136593.b schema:alternateName Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
297 schema:name Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
298 Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
299 rdf:type schema:Organization
300 grid-institutes:grid.410796.d schema:alternateName Division of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
301 Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
302 schema:name Division of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
303 Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
304 rdf:type schema:Organization
305 grid-institutes:grid.415418.d schema:alternateName Department of Cardiovascular Medicine, Kobe Rosai Hospital, Kobe, Hyogo, Japan
306 schema:name Department of Cardiovascular Medicine, Kobe Rosai Hospital, Kobe, Hyogo, Japan
307 Research Institute, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
308 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...