A critical role of sympathetic nerve regulation for the treatment of impaired daily rhythm in hypertensive Dahl rats View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-10

AUTHORS

Jun-ichi Suzuki, Masahito Ogawa, Noriko Tamura, Yasuhiro Maejima, Kiyoshi Takayama, Koji Maemura, Kazuki Honda, Yasunobu Hirata, Ryozo Nagai, Mitsuaki Isobe

ABSTRACT

There is a deep relationship between impaired circadian rhythm and hypertension. However, the detailed mechanisms between the daily sleep-wake rhythm and cardiovascular disorders have not yet been elucidated. To clarify the mechanism, we examined salt-sensitive Dahl rats that were fed normal chow (n=10), high-salt chow (n=10) and high-salt chow with bisoprolol (n=10). Simultaneous electroencephalogram, electromyogram and locomotor activity were examined to analyze the sleep-wake state. We also examined heart rate, blood pressure and echocardiographic findings to verify the presence of hypertension. Hypertension with impaired ventricular contraction was observed in the rats with high-salt-chow consumption whereas normal-chow rats did not show these disorders. Although rats with the normal diet showed a standard daily rhythm with normal rapid eye movement (REM) sleep duration and locomotor activity, the high-salt-diet group exhibited an impaired daily rhythm with suppressed REM sleep and significant abnormal locomotor activity. Bisoprolol significantly improved the daily sleep-wake rhythm and locomotor activity. We showed that an impaired daily rhythm was closely related to the development of hypertension. Regulation of sympathetic nerve alterations may have a key role in the treatment of hypertension and circadian rhythm disorder. More... »

PAGES

1060

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/hr.2010.125

DOI

http://dx.doi.org/10.1038/hr.2010.125

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039718960

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20668456


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