T allele of −344C/T polymorphism in aldosterone synthase gene is not associated with resistant hypertension View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-02

AUTHORS

Riccardo Lacchini, Maricene Sabha, Fernanda B Coeli, Fabrício F Favero, Juan Yugar-Toledo, Tatiane C Izidoro-Toledo, Valéria C Sandrim, José E Tanus-Santos, Maricilda P de Mello, Heitor Moreno

ABSTRACT

Resistant hypertension (RH) is the maintenance of elevated blood pressure concurrent with the use of three different anti-hypertensive drugs, one of which is a diuretic. The Renin-Angiotensin-Aldosterone System plays a major role in volume-dependent hypertension. Therefore, its components are interesting targets for genetic association studies. This work focused on the -344 C/T polymorphism in the CYP11b2 gene, which encodes aldosterone synthase. This work evaluates the association between T allele and resistance to anti-hypertensive treatment. Genotyping analysis included 88 subjects with RH, 142 who were responsive to anti-hypertensive treatment and 110 subjects as a control group. Plasmatic concentrations of aldosterone, renin and cortisol, carotid intima-media thickness and carotid-femoral pulse wave velocity were assessed in a smaller subset of hypertensive patients. An association was found between T allele and hypertension (P<0.005), but there was no difference in allele frequencies between both hypertensive groups. There was no difference in plasmatic parameters either, in remodeling indicators between the genotypic groups. More... »

PAGES

hr200836

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/hr.2008.36

DOI

http://dx.doi.org/10.1038/hr.2008.36

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031653411

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19262476


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