WNT10A variants isolated from Japanese patients with congenital tooth agenesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-11-09

AUTHORS

Junichiro Machida, Hiroaki Goto, Tadashi Tatematsu, Akio Shibata, Hitoshi Miyachi, Katsu Takahashi, Hiroto Izumi, Atsuo Nakayama, Kazuo Shimozato, Yoshihito Tokita

ABSTRACT

It has been reported that dozens of WNT10A variants are associated with human isolated tooth agenesis, however, little is known about the precise phenotypes. In 50 Japanese patients with severe congenital tooth agenesis, we identified 11 patients with WNT10A variants. Comparing phenotypes between the tooth agenesis patients carrying the wild-type and variants of WNT10A, we revealed that the development of lateral incisors is relatively susceptive to insufficiency of WNT/β-catenin signaling. More... »

PAGES

17047

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/hgv.2017.47

DOI

http://dx.doi.org/10.1038/hgv.2017.47

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1092591497

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29367877


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168 grid-institutes:grid.410836.8 schema:alternateName Department of Embryology, Aichi Human Service Center, Kasugai, Japan
169 Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Japan
170 schema:name Department of Embryology, Aichi Human Service Center, Kasugai, Japan
171 Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Japan
172 Department of Perinatology, Institute for Developmental Research, Aichi Human Service Center, Kasugai, Japan
173 rdf:type schema:Organization
174 grid-institutes:grid.411253.0 schema:alternateName Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Japan
175 schema:name Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Japan
176 rdf:type schema:Organization
177 grid-institutes:grid.416762.0 schema:alternateName Department of Oral and Maxillofacial Surgery, Ogaki Municipal Hospital, Ogaki, Japan
178 schema:name Department of Oral and Maxillofacial Surgery, Ogaki Municipal Hospital, Ogaki, Japan
179 rdf:type schema:Organization
180 grid-institutes:grid.417248.c schema:alternateName Department of Oral and Maxillofacial Surgery, Toyota Memorial Hospital, Toyota, Japan
181 schema:name Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Japan
182 Department of Oral and Maxillofacial Surgery, Toyota Memorial Hospital, Toyota, Japan
183 rdf:type schema:Organization
 




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