Long-term expression of melanopsin and channelrhodopsin causes no gross alterations in the dystrophic dog retina View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-09-07

AUTHORS

B Ameline, K-T Tshilenge, M Weber, M Biget, L Libeau, R Caplette, A Mendes-Madeira, N Provost, C Guihal, S Picaud, P Moullier, V Pichard, T Cronin, C Isiegas

ABSTRACT

Several preclinical studies have investigated the potential of algal channelrhodopsin and human melanopsin as optogenetic tools for vision restoration. In the present study, we assessed the potentially deleterious effects of long-term expression of these optogenes on the diseased retina in a large animal model of retinal degeneration, the RPE65-deficient Briard dog model of Leber congenital amaurosis. Intravitreal injection of adeno-associated virus vectors expressing channelrhodopsin and melanopsin had no effect on retinal thickness over a 16-month period post injection. Our data support the safety of the optogenetic approach for the treatment of blindness. More... »

PAGES

735-741

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/gt.2017.63

DOI

http://dx.doi.org/10.1038/gt.2017.63

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091500561

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28880021


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31 schema:description Several preclinical studies have investigated the potential of algal channelrhodopsin and human melanopsin as optogenetic tools for vision restoration. In the present study, we assessed the potentially deleterious effects of long-term expression of these optogenes on the diseased retina in a large animal model of retinal degeneration, the RPE65-deficient Briard dog model of Leber congenital amaurosis. Intravitreal injection of adeno-associated virus vectors expressing channelrhodopsin and melanopsin had no effect on retinal thickness over a 16-month period post injection. Our data support the safety of the optogenetic approach for the treatment of blindness.
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39 Leber congenital amaurosis
40 RPE65-deficient Briard dog model
41 adeno
42 algal channelrhodopsin
43 alterations
44 amaurosis
45 animal models
46 approach
47 blindness
48 channelrhodopsin
49 congenital amaurosis
50 data
51 degeneration
52 deleterious effects
53 diseased retina
54 dog model
55 dog retina
56 dystrophic dog retina
57 effect
58 expression
59 gross alterations
60 human melanopsin
61 injection
62 intravitreal injection
63 large animal model
64 long-term expression
65 melanopsin
66 model
67 optogenes
68 optogenetic approach
69 optogenetic tools
70 period post injection
71 post injection
72 potential
73 preclinical studies
74 present study
75 restoration
76 retina
77 retinal degeneration
78 retinal thickness
79 safety
80 study
81 thickness
82 tool
83 treatment
84 treatment of blindness
85 vector
86 virus vectors
87 vision restoration
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