APOBEC3A intratumoral DNA electroporation in mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-02

AUTHORS

A Kostrzak, V Caval, M Escande, E Pliquet, J Thalmensi, T Bestetti, M Julithe, L Fiette, T Huet, S Wain-Hobson, P Langlade-Demoyen

ABSTRACT

Human APOBEC3A (A3A) cytidine deaminase shows pro-apoptotic properties resulting from hypermutation of genomic DNA, induction of double-stranded DNA breaks (DSBs) and G1 cell cycle arrest. Given this, we evaluated the antitumor efficacy of A3A by intratumoral electroporation of an A3A expression plasmid. DNA was repeatedly electroporated into B16OVA, B16Luc tumors of C57BL/6J mice as well as the aggressive fibrosarcoma Sarc2 tumor of HLA-A*0201/DRB1*0101 transgenic mice using noninvasive plate electrodes. Intratumoral electroporation of A3A plasmid DNA resulted in regression of ~50% of small B16OVA melanoma tumors that did not rebound in the following 2 months without treatment. Larger or more aggressive tumors escaped regression when so treated. As APOBEC3A was much less efficient in provoking hypermutation and DSBs in B16OVA cells compared with human or quail cells, it is likely that APOBEC3A would be more efficient in a human setting than in a mouse model. More... »

PAGES

74

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/gt.2016.77

DOI

http://dx.doi.org/10.1038/gt.2016.77

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009194191

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27858943


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytidine Deaminase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electroporation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocytes, Tumor-Infiltrating", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma, Experimental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasmids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Invectys, Pepini\u00e8re Paris Biotech Sant\u00e9 Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kostrzak", 
        "givenName": "A", 
        "id": "sg:person.01143143051.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143143051.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Molecular Retrovirology Unit, Institut Pasteur, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Caval", 
        "givenName": "V", 
        "id": "sg:person.01274264236.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274264236.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Invectys, Pepini\u00e8re Paris Biotech Sant\u00e9 Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Escande", 
        "givenName": "M", 
        "id": "sg:person.016626324455.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016626324455.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Invectys, Pepini\u00e8re Paris Biotech Sant\u00e9 Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pliquet", 
        "givenName": "E", 
        "id": "sg:person.01104127415.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104127415.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Invectys, Pepini\u00e8re Paris Biotech Sant\u00e9 Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thalmensi", 
        "givenName": "J", 
        "id": "sg:person.0642534517.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642534517.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Invectys, Pepini\u00e8re Paris Biotech Sant\u00e9 Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bestetti", 
        "givenName": "T", 
        "id": "sg:person.01230512515.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230512515.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Invectys, Pepini\u00e8re Paris Biotech Sant\u00e9 Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Julithe", 
        "givenName": "M", 
        "id": "sg:person.0741551627.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741551627.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Paris Descartes University", 
          "id": "https://www.grid.ac/institutes/grid.10992.33", 
          "name": [
            "Human Histopathology and Animal Models, Infection & Epidemiology Department, Institut Pasteur, Paris, France", 
            "Universit\u00e9 Paris Descartes, Sorbonne Paris-Cit\u00e9, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fiette", 
        "givenName": "L", 
        "id": "sg:person.01313017623.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313017623.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Invectys, Pepini\u00e8re Paris Biotech Sant\u00e9 Cochin, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huet", 
        "givenName": "T", 
        "id": "sg:person.01276625715.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276625715.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Invectys, Pepini\u00e8re Paris Biotech Sant\u00e9 Cochin, Paris, France", 
            "Molecular Retrovirology Unit, Institut Pasteur, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wain-Hobson", 
        "givenName": "S", 
        "id": "sg:person.055642406.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.055642406.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Pasteur", 
          "id": "https://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Invectys, Pepini\u00e8re Paris Biotech Sant\u00e9 Cochin, Paris, France", 
            "Molecular Retrovirology Unit, Institut Pasteur, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Langlade-Demoyen", 
        "givenName": "P", 
        "id": "sg:person.0637624375.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637624375.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/nar/gkq174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000987600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cub.2006.01.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001980938"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002558962", 
          "https://doi.org/10.1038/nsmb.1744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.1744", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002558962", 
          "https://doi.org/10.1038/nsmb.1744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002579839", 
          "https://doi.org/10.1038/ng.2955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003607076", 
          "https://doi.org/10.1038/nrc3380"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01089-09", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004445400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1002221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006068211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0603313103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007050514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-11-3782", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007073195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv935", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008538512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008390-200012000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010262913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008390-200012000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010262913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00008390-200012000-00010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010262913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2010.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010648678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011403111", 
          "https://doi.org/10.1038/sj.gt.3301519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301519", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011403111", 
          "https://doi.org/10.1038/sj.gt.3301519"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/mthe.2002.0601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013965248"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.87.21.8350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014312250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1009687108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014441277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1479-5876-13-s1-o11", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014959746", 
          "https://doi.org/10.1186/1479-5876-13-s1-o11"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015386551", 
          "https://doi.org/10.1038/sj.gt.3301802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301802", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015386551", 
          "https://doi.org/10.1038/sj.gt.3301802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-009-0760-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020234535", 
          "https://doi.org/10.1007/s00262-009-0760-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-009-0760-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020234535", 
          "https://doi.org/10.1007/s00262-009-0760-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-009-0760-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020234535", 
          "https://doi.org/10.1007/s00262-009-0760-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/gt.2014.88", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020751506", 
          "https://doi.org/10.1038/gt.2014.88"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2660(05)54005-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022721745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2660(05)54005-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022721745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023030166", 
          "https://doi.org/10.1038/nature03884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023030166", 
          "https://doi.org/10.1038/nature03884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03884", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023030166", 
          "https://doi.org/10.1038/nature03884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-immunol-032712-100008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024858697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.immuni.2006.03.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026551704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jgm.760", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026793686"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/gt.2011.198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028398808", 
          "https://doi.org/10.1038/gt.2011.198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.24418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029624199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.24418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029624199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.10.762", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030517264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/mthe.2000.0257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035046192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0063461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035667992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/molbev/mst195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036590406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-4165(00)00101-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036810124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.13.9048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037498461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ymthe.2003.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038170829"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00300234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038878459", 
          "https://doi.org/10.1007/bf00300234"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200425463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043064577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700976", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047735548", 
          "https://doi.org/10.1038/sj.cgt.7700976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700976", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047735548", 
          "https://doi.org/10.1038/sj.cgt.7700976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049465305", 
          "https://doi.org/10.1038/nrc3237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature12477", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050004918", 
          "https://doi.org/10.1038/nature12477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/14760584.2013.836903", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050446274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncomms6129", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050779071", 
          "https://doi.org/10.1038/ncomms6129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.97.1.354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051258754"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.914401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051908786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-59745-194-9_27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053027731", 
          "https://doi.org/10.1007/978-1-59745-194-9_27"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-59745-194-9_27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053027731", 
          "https://doi.org/10.1007/978-1-59745-194-9_27"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-925x-9-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053050291", 
          "https://doi.org/10.1186/1475-925x-9-13"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1153201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062457319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.15.6794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064204378"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14712598.8.11.1645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067589988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/onci.28131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072306638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074539432", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074801116", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.180.6.4000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077616269"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-02", 
    "datePublishedReg": "2017-02-01", 
    "description": "Human APOBEC3A (A3A) cytidine deaminase shows pro-apoptotic properties resulting from hypermutation of genomic DNA, induction of double-stranded DNA breaks (DSBs) and G1 cell cycle arrest. Given this, we evaluated the antitumor efficacy of A3A by intratumoral electroporation of an A3A expression plasmid. DNA was repeatedly electroporated into B16OVA, B16Luc tumors of C57BL/6J mice as well as the aggressive fibrosarcoma Sarc2 tumor of HLA-A*0201/DRB1*0101 transgenic mice using noninvasive plate electrodes. Intratumoral electroporation of A3A plasmid DNA resulted in regression of ~50% of small B16OVA melanoma tumors that did not rebound in the following 2 months without treatment. Larger or more aggressive tumors escaped regression when so treated. As APOBEC3A was much less efficient in provoking hypermutation and DSBs in B16OVA cells compared with human or quail cells, it is likely that APOBEC3A would be more efficient in a human setting than in a mouse model.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/gt.2016.77", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1105638", 
        "issn": [
          "0969-7128", 
          "1476-5462"
        ], 
        "name": "Gene Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "name": "APOBEC3A intratumoral DNA electroporation in mice", 
    "pagination": "74", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2bcc973d59e02bbb44bbeb0d6cb8363934414f3c04eba5fdbc717bc31df27610"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27858943"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9421525"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/gt.2016.77"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009194191"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/gt.2016.77", 
      "https://app.dimensions.ai/details/publication/pub.1009194191"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000435.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/gt201677"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/gt.2016.77'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/gt.2016.77'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/gt.2016.77'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/gt.2016.77'


 

This table displays all metadata directly associated to this object as RDF triples.

381 TRIPLES      21 PREDICATES      94 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/gt.2016.77 schema:about N056770ca174e42c68257540d10807c3d
2 N2fb9d8b93b1847949eeea558ed1036ae
3 N318096a1b1524f8f9c5521719af7c67b
4 N4101d130af3641da8e2cd54d9960076a
5 N46c3671444764f4bbc487a37b12824da
6 N535ce262aee04cf391241f2c216431f0
7 N6e843235c56848c9829df8e8ea744004
8 N80e1f8abf3ed4a988fda4821cbc302c9
9 Na847b839b2f84511a667cd7cf34591cc
10 Nc516ba8693884d4dbac7f96f02a26e77
11 Nf46a08fc8eba4f49bc5e271ea85ecb00
12 Nf5a2ecf22e51402b9064635a470ad9da
13 Nfc792885ea824a4b8dd5d1f2244ec6ae
14 anzsrc-for:11
15 anzsrc-for:1112
16 schema:author Nd08ed66715d546a2925c4c72cde53d52
17 schema:citation sg:pub.10.1007/978-1-59745-194-9_27
18 sg:pub.10.1007/bf00300234
19 sg:pub.10.1007/s00262-009-0760-1
20 sg:pub.10.1038/gt.2011.198
21 sg:pub.10.1038/gt.2014.88
22 sg:pub.10.1038/nature03884
23 sg:pub.10.1038/nature12477
24 sg:pub.10.1038/ncomms6129
25 sg:pub.10.1038/ng.2955
26 sg:pub.10.1038/nrc3237
27 sg:pub.10.1038/nrc3380
28 sg:pub.10.1038/nsmb.1744
29 sg:pub.10.1038/sj.cgt.7700976
30 sg:pub.10.1038/sj.gt.3301519
31 sg:pub.10.1038/sj.gt.3301802
32 sg:pub.10.1186/1475-925x-9-13
33 sg:pub.10.1186/1479-5876-13-s1-o11
34 https://app.dimensions.ai/details/publication/pub.1074539432
35 https://app.dimensions.ai/details/publication/pub.1074801116
36 https://doi.org/10.1002/eji.200425463
37 https://doi.org/10.1002/ijc.24418
38 https://doi.org/10.1002/jgm.760
39 https://doi.org/10.1006/mthe.2000.0257
40 https://doi.org/10.1006/mthe.2002.0601
41 https://doi.org/10.1016/j.ctrv.2010.11.001
42 https://doi.org/10.1016/j.cub.2006.01.031
43 https://doi.org/10.1016/j.immuni.2006.03.021
44 https://doi.org/10.1016/j.ymthe.2003.08.002
45 https://doi.org/10.1016/s0065-2660(05)54005-7
46 https://doi.org/10.1016/s0304-4165(00)00101-x
47 https://doi.org/10.1073/pnas.0603313103
48 https://doi.org/10.1073/pnas.1009687108
49 https://doi.org/10.1073/pnas.87.21.8350
50 https://doi.org/10.1073/pnas.97.1.354
51 https://doi.org/10.1093/jnci/94.10.762
52 https://doi.org/10.1093/molbev/mst195
53 https://doi.org/10.1093/nar/gkq174
54 https://doi.org/10.1093/nar/gkv935
55 https://doi.org/10.1097/00008390-200012000-00010
56 https://doi.org/10.1101/gad.914401
57 https://doi.org/10.1126/science.1153201
58 https://doi.org/10.1128/jvi.01089-09
59 https://doi.org/10.1146/annurev-immunol-032712-100008
60 https://doi.org/10.1158/0008-5472.can-11-3782
61 https://doi.org/10.1200/jco.2007.13.9048
62 https://doi.org/10.1200/jco.2007.15.6794
63 https://doi.org/10.1371/journal.pone.0063461
64 https://doi.org/10.1371/journal.ppat.1002221
65 https://doi.org/10.1517/14712598.8.11.1645
66 https://doi.org/10.1586/14760584.2013.836903
67 https://doi.org/10.4049/jimmunol.180.6.4000
68 https://doi.org/10.4161/onci.28131
69 schema:datePublished 2017-02
70 schema:datePublishedReg 2017-02-01
71 schema:description Human APOBEC3A (A3A) cytidine deaminase shows pro-apoptotic properties resulting from hypermutation of genomic DNA, induction of double-stranded DNA breaks (DSBs) and G1 cell cycle arrest. Given this, we evaluated the antitumor efficacy of A3A by intratumoral electroporation of an A3A expression plasmid. DNA was repeatedly electroporated into B16OVA, B16Luc tumors of C57BL/6J mice as well as the aggressive fibrosarcoma Sarc2 tumor of HLA-A*0201/DRB1*0101 transgenic mice using noninvasive plate electrodes. Intratumoral electroporation of A3A plasmid DNA resulted in regression of ~50% of small B16OVA melanoma tumors that did not rebound in the following 2 months without treatment. Larger or more aggressive tumors escaped regression when so treated. As APOBEC3A was much less efficient in provoking hypermutation and DSBs in B16OVA cells compared with human or quail cells, it is likely that APOBEC3A would be more efficient in a human setting than in a mouse model.
72 schema:genre research_article
73 schema:inLanguage en
74 schema:isAccessibleForFree false
75 schema:isPartOf N4abbdc3dc30b49019f70b3564e7be214
76 Nd2ea106ce64e477d9996abe0b7e752d9
77 sg:journal.1105638
78 schema:name APOBEC3A intratumoral DNA electroporation in mice
79 schema:pagination 74
80 schema:productId N1bd069868422464386bc493cb026acd2
81 N5313db3a4645475e89e1a0de046522c8
82 N560a669029cd41ea98d8c277922c5c7b
83 N77ac820777eb4c0cab4b1f0d21c84ce1
84 Ndb292720462d48a5924d79f82bb2785d
85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009194191
86 https://doi.org/10.1038/gt.2016.77
87 schema:sdDatePublished 2019-04-10T19:46
88 schema:sdLicense https://scigraph.springernature.com/explorer/license/
89 schema:sdPublisher N5d8711662e774a288394ee14107efc63
90 schema:url https://www.nature.com/articles/gt201677
91 sgo:license sg:explorer/license/
92 sgo:sdDataset articles
93 rdf:type schema:ScholarlyArticle
94 N056770ca174e42c68257540d10807c3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Female
96 rdf:type schema:DefinedTerm
97 N07b06ad273ff44949139447777df8054 rdf:first sg:person.01230512515.92
98 rdf:rest N2385dfeeb6ba45c5be681fc92db04a32
99 N0892b72089c243f7953992d16dd6f679 rdf:first sg:person.055642406.07
100 rdf:rest N52fb4c65b7c0498ba7b2b397840da1f1
101 N18ab27bce398456bb5e7e72228cae0c8 schema:name Invectys, Pepinière Paris Biotech Santé Cochin, Paris, France
102 rdf:type schema:Organization
103 N1bd069868422464386bc493cb026acd2 schema:name doi
104 schema:value 10.1038/gt.2016.77
105 rdf:type schema:PropertyValue
106 N1fd5cb0d61d04a81bddc13d70da08dbc schema:name Invectys, Pepinière Paris Biotech Santé Cochin, Paris, France
107 rdf:type schema:Organization
108 N2385dfeeb6ba45c5be681fc92db04a32 rdf:first sg:person.0741551627.71
109 rdf:rest Nd5217abe66b743eb83a91db765b68eb9
110 N2700f08770d34c518e4eaf9c13e09c3d rdf:first sg:person.0642534517.39
111 rdf:rest N07b06ad273ff44949139447777df8054
112 N2fb9d8b93b1847949eeea558ed1036ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Animals
114 rdf:type schema:DefinedTerm
115 N30aa5674db1a47a584ac580e81afbab0 rdf:first sg:person.01276625715.15
116 rdf:rest N0892b72089c243f7953992d16dd6f679
117 N318096a1b1524f8f9c5521719af7c67b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Lymphocytes, Tumor-Infiltrating
119 rdf:type schema:DefinedTerm
120 N4101d130af3641da8e2cd54d9960076a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Plasmids
122 rdf:type schema:DefinedTerm
123 N46c3671444764f4bbc487a37b12824da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Proteins
125 rdf:type schema:DefinedTerm
126 N4abbdc3dc30b49019f70b3564e7be214 schema:issueNumber 2
127 rdf:type schema:PublicationIssue
128 N52fb4c65b7c0498ba7b2b397840da1f1 rdf:first sg:person.0637624375.02
129 rdf:rest rdf:nil
130 N5313db3a4645475e89e1a0de046522c8 schema:name pubmed_id
131 schema:value 27858943
132 rdf:type schema:PropertyValue
133 N535ce262aee04cf391241f2c216431f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Genetic Therapy
135 rdf:type schema:DefinedTerm
136 N560a669029cd41ea98d8c277922c5c7b schema:name readcube_id
137 schema:value 2bcc973d59e02bbb44bbeb0d6cb8363934414f3c04eba5fdbc717bc31df27610
138 rdf:type schema:PropertyValue
139 N5d8711662e774a288394ee14107efc63 schema:name Springer Nature - SN SciGraph project
140 rdf:type schema:Organization
141 N6e843235c56848c9829df8e8ea744004 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Tumor Cells, Cultured
143 rdf:type schema:DefinedTerm
144 N77ac820777eb4c0cab4b1f0d21c84ce1 schema:name dimensions_id
145 schema:value pub.1009194191
146 rdf:type schema:PropertyValue
147 N80e1f8abf3ed4a988fda4821cbc302c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cytidine Deaminase
149 rdf:type schema:DefinedTerm
150 N818239ae53f34f7e9b27202512da7101 schema:name Invectys, Pepinière Paris Biotech Santé Cochin, Paris, France
151 rdf:type schema:Organization
152 N98c2d7ecee7140cba46a564d58ee2932 rdf:first sg:person.01104127415.03
153 rdf:rest N2700f08770d34c518e4eaf9c13e09c3d
154 Na1a4e70ef74e43b889a5060c06e2a296 rdf:first sg:person.016626324455.76
155 rdf:rest N98c2d7ecee7140cba46a564d58ee2932
156 Na25fd027f5af4deb9e0e9db1e97a7b3b schema:name Invectys, Pepinière Paris Biotech Santé Cochin, Paris, France
157 rdf:type schema:Organization
158 Na847b839b2f84511a667cd7cf34591cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Mice, Inbred C57BL
160 rdf:type schema:DefinedTerm
161 Nbf7a8de8045848109014d44bbd309b09 schema:name Invectys, Pepinière Paris Biotech Santé Cochin, Paris, France
162 rdf:type schema:Organization
163 Nc34a8752df8043148d3660174c3b43b1 rdf:first sg:person.01274264236.49
164 rdf:rest Na1a4e70ef74e43b889a5060c06e2a296
165 Nc516ba8693884d4dbac7f96f02a26e77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Mice
167 rdf:type schema:DefinedTerm
168 Nd08ed66715d546a2925c4c72cde53d52 rdf:first sg:person.01143143051.67
169 rdf:rest Nc34a8752df8043148d3660174c3b43b1
170 Nd2ea106ce64e477d9996abe0b7e752d9 schema:volumeNumber 24
171 rdf:type schema:PublicationVolume
172 Nd5217abe66b743eb83a91db765b68eb9 rdf:first sg:person.01313017623.51
173 rdf:rest N30aa5674db1a47a584ac580e81afbab0
174 Ndb292720462d48a5924d79f82bb2785d schema:name nlm_unique_id
175 schema:value 9421525
176 rdf:type schema:PropertyValue
177 Necc5dd052cee41b39d04cd07f6cce737 schema:name Invectys, Pepinière Paris Biotech Santé Cochin, Paris, France
178 rdf:type schema:Organization
179 Nf46a08fc8eba4f49bc5e271ea85ecb00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Male
181 rdf:type schema:DefinedTerm
182 Nf5a2ecf22e51402b9064635a470ad9da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Melanoma, Experimental
184 rdf:type schema:DefinedTerm
185 Nfc792885ea824a4b8dd5d1f2244ec6ae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Electroporation
187 rdf:type schema:DefinedTerm
188 Nfdf3a06db0ad4e11a874d56a61a6044a schema:name Invectys, Pepinière Paris Biotech Santé Cochin, Paris, France
189 rdf:type schema:Organization
190 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
191 schema:name Medical and Health Sciences
192 rdf:type schema:DefinedTerm
193 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
194 schema:name Oncology and Carcinogenesis
195 rdf:type schema:DefinedTerm
196 sg:journal.1105638 schema:issn 0969-7128
197 1476-5462
198 schema:name Gene Therapy
199 rdf:type schema:Periodical
200 sg:person.01104127415.03 schema:affiliation Na25fd027f5af4deb9e0e9db1e97a7b3b
201 schema:familyName Pliquet
202 schema:givenName E
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104127415.03
204 rdf:type schema:Person
205 sg:person.01143143051.67 schema:affiliation Nbf7a8de8045848109014d44bbd309b09
206 schema:familyName Kostrzak
207 schema:givenName A
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143143051.67
209 rdf:type schema:Person
210 sg:person.01230512515.92 schema:affiliation N1fd5cb0d61d04a81bddc13d70da08dbc
211 schema:familyName Bestetti
212 schema:givenName T
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230512515.92
214 rdf:type schema:Person
215 sg:person.01274264236.49 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
216 schema:familyName Caval
217 schema:givenName V
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274264236.49
219 rdf:type schema:Person
220 sg:person.01276625715.15 schema:affiliation N818239ae53f34f7e9b27202512da7101
221 schema:familyName Huet
222 schema:givenName T
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01276625715.15
224 rdf:type schema:Person
225 sg:person.01313017623.51 schema:affiliation https://www.grid.ac/institutes/grid.10992.33
226 schema:familyName Fiette
227 schema:givenName L
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01313017623.51
229 rdf:type schema:Person
230 sg:person.016626324455.76 schema:affiliation Necc5dd052cee41b39d04cd07f6cce737
231 schema:familyName Escande
232 schema:givenName M
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016626324455.76
234 rdf:type schema:Person
235 sg:person.055642406.07 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
236 schema:familyName Wain-Hobson
237 schema:givenName S
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.055642406.07
239 rdf:type schema:Person
240 sg:person.0637624375.02 schema:affiliation https://www.grid.ac/institutes/grid.428999.7
241 schema:familyName Langlade-Demoyen
242 schema:givenName P
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637624375.02
244 rdf:type schema:Person
245 sg:person.0642534517.39 schema:affiliation Nfdf3a06db0ad4e11a874d56a61a6044a
246 schema:familyName Thalmensi
247 schema:givenName J
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642534517.39
249 rdf:type schema:Person
250 sg:person.0741551627.71 schema:affiliation N18ab27bce398456bb5e7e72228cae0c8
251 schema:familyName Julithe
252 schema:givenName M
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741551627.71
254 rdf:type schema:Person
255 sg:pub.10.1007/978-1-59745-194-9_27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053027731
256 https://doi.org/10.1007/978-1-59745-194-9_27
257 rdf:type schema:CreativeWork
258 sg:pub.10.1007/bf00300234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038878459
259 https://doi.org/10.1007/bf00300234
260 rdf:type schema:CreativeWork
261 sg:pub.10.1007/s00262-009-0760-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020234535
262 https://doi.org/10.1007/s00262-009-0760-1
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/gt.2011.198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028398808
265 https://doi.org/10.1038/gt.2011.198
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/gt.2014.88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020751506
268 https://doi.org/10.1038/gt.2014.88
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/nature03884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023030166
271 https://doi.org/10.1038/nature03884
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/nature12477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050004918
274 https://doi.org/10.1038/nature12477
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/ncomms6129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050779071
277 https://doi.org/10.1038/ncomms6129
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/ng.2955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002579839
280 https://doi.org/10.1038/ng.2955
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nrc3237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049465305
283 https://doi.org/10.1038/nrc3237
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nrc3380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003607076
286 https://doi.org/10.1038/nrc3380
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/nsmb.1744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002558962
289 https://doi.org/10.1038/nsmb.1744
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/sj.cgt.7700976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047735548
292 https://doi.org/10.1038/sj.cgt.7700976
293 rdf:type schema:CreativeWork
294 sg:pub.10.1038/sj.gt.3301519 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011403111
295 https://doi.org/10.1038/sj.gt.3301519
296 rdf:type schema:CreativeWork
297 sg:pub.10.1038/sj.gt.3301802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015386551
298 https://doi.org/10.1038/sj.gt.3301802
299 rdf:type schema:CreativeWork
300 sg:pub.10.1186/1475-925x-9-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053050291
301 https://doi.org/10.1186/1475-925x-9-13
302 rdf:type schema:CreativeWork
303 sg:pub.10.1186/1479-5876-13-s1-o11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014959746
304 https://doi.org/10.1186/1479-5876-13-s1-o11
305 rdf:type schema:CreativeWork
306 https://app.dimensions.ai/details/publication/pub.1074539432 schema:CreativeWork
307 https://app.dimensions.ai/details/publication/pub.1074801116 schema:CreativeWork
308 https://doi.org/10.1002/eji.200425463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043064577
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1002/ijc.24418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029624199
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1002/jgm.760 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026793686
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1006/mthe.2000.0257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035046192
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1006/mthe.2002.0601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013965248
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.ctrv.2010.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010648678
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.cub.2006.01.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001980938
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/j.immuni.2006.03.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026551704
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/j.ymthe.2003.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038170829
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1016/s0065-2660(05)54005-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022721745
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1016/s0304-4165(00)00101-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1036810124
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1073/pnas.0603313103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007050514
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1073/pnas.1009687108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014441277
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1073/pnas.87.21.8350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014312250
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1073/pnas.97.1.354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051258754
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1093/jnci/94.10.762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030517264
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1093/molbev/mst195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036590406
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1093/nar/gkq174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000987600
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1093/nar/gkv935 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008538512
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1097/00008390-200012000-00010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010262913
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1101/gad.914401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051908786
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1126/science.1153201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062457319
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1128/jvi.01089-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004445400
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1146/annurev-immunol-032712-100008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024858697
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1158/0008-5472.can-11-3782 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007073195
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1200/jco.2007.13.9048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037498461
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1200/jco.2007.15.6794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204378
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1371/journal.pone.0063461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035667992
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1371/journal.ppat.1002221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006068211
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1517/14712598.8.11.1645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067589988
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1586/14760584.2013.836903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050446274
369 rdf:type schema:CreativeWork
370 https://doi.org/10.4049/jimmunol.180.6.4000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077616269
371 rdf:type schema:CreativeWork
372 https://doi.org/10.4161/onci.28131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072306638
373 rdf:type schema:CreativeWork
374 https://www.grid.ac/institutes/grid.10992.33 schema:alternateName Paris Descartes University
375 schema:name Human Histopathology and Animal Models, Infection & Epidemiology Department, Institut Pasteur, Paris, France
376 Université Paris Descartes, Sorbonne Paris-Cité, Paris, France
377 rdf:type schema:Organization
378 https://www.grid.ac/institutes/grid.428999.7 schema:alternateName Institut Pasteur
379 schema:name Invectys, Pepinière Paris Biotech Santé Cochin, Paris, France
380 Molecular Retrovirology Unit, Institut Pasteur, Paris, France
381 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...