Effect of bortezomib on the efficacy of AAV9.SERCA2a treatment to preserve cardiac function in a rat pressure-overload model of heart ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-04

AUTHORS

Antoine H Chaanine, Mathieu Nonnenmacher, Erik Kohlbrenner, Dongzhu Jin, Jason C Kovacic, Fadi G Akar, Roger J Hajjar, Thomas Weber

ABSTRACT

Adeno-associated virus (AAV)-based vectors are promising vehicles for therapeutic gene delivery, including for the treatment for heart failure. It has been demonstrated for each of the AAV serotypes 1 through 8 that inhibition of the proteasome results in increased transduction efficiencies. For AAV9, however, the effect of proteasome inhibitors on in vivo transduction has until now not been evaluated. Here we demonstrate, in a well-established rodent heart failure model, that concurrent treatment with the proteasome inhibitor bortezomib does not enhance the efficacy of AAV9.SERCA2a to improve cardiac function as examined by echocardiography and pressure volume analysis. Western blot analysis of SERCA2a protein and reverse transcription-PCR of SERCA2a mRNA demonstrated that bortezomib had no effect on either endogenous rat SERCA2a levels nor on expression levels of human SERCA2a delivered by AAV9.SERCA2a. Similarly, the number of AAV9 genomes in heart samples was unaffected by bortezomib treatment. Interestingly, whereas transduction of HeLa cells and neonatal rat cardiomyocytes by AAV9 was stimulated by bortezomib, transduction of adult rat cardiomyocytes was inhibited. These results indicate an organ/cell-type-specific effect of proteasome inhibition on AAV9 transduction. A future detailed analysis of the underlying molecular mechanisms promises to facilitate the development of improved AAV vectors. More... »

PAGES

379

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/gt.2014.7

DOI

http://dx.doi.org/10.1038/gt.2014.7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020789195

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24572786


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Boronic Acids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bortezomib", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dependovirus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Vectors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Failure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocardium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Myocytes, Cardiac", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrazines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sarcoplasmic Reticulum Calcium-Transporting ATPases", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Icahn School of Medicine at Mount Sinai", 
          "id": "https://www.grid.ac/institutes/grid.59734.3c", 
          "name": [
            "Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chaanine", 
        "givenName": "Antoine H", 
        "id": "sg:person.0624016074.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624016074.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Icahn School of Medicine at Mount Sinai", 
          "id": "https://www.grid.ac/institutes/grid.59734.3c", 
          "name": [
            "Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nonnenmacher", 
        "givenName": "Mathieu", 
        "id": "sg:person.01241742614.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241742614.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Icahn School of Medicine at Mount Sinai", 
          "id": "https://www.grid.ac/institutes/grid.59734.3c", 
          "name": [
            "Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kohlbrenner", 
        "givenName": "Erik", 
        "id": "sg:person.0746415241.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746415241.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Icahn School of Medicine at Mount Sinai", 
          "id": "https://www.grid.ac/institutes/grid.59734.3c", 
          "name": [
            "Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jin", 
        "givenName": "Dongzhu", 
        "id": "sg:person.01030271051.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030271051.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Icahn School of Medicine at Mount Sinai", 
          "id": "https://www.grid.ac/institutes/grid.59734.3c", 
          "name": [
            "Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kovacic", 
        "givenName": "Jason C", 
        "id": "sg:person.0767760340.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767760340.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Icahn School of Medicine at Mount Sinai", 
          "id": "https://www.grid.ac/institutes/grid.59734.3c", 
          "name": [
            "Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akar", 
        "givenName": "Fadi G", 
        "id": "sg:person.0642517622.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642517622.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Icahn School of Medicine at Mount Sinai", 
          "id": "https://www.grid.ac/institutes/grid.59734.3c", 
          "name": [
            "Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hajjar", 
        "givenName": "Roger J", 
        "id": "sg:person.01147556575.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147556575.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Icahn School of Medicine at Mount Sinai", 
          "id": "https://www.grid.ac/institutes/grid.59734.3c", 
          "name": [
            "Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weber", 
        "givenName": "Thomas", 
        "id": "sg:person.01147340377.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147340377.69"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1161/01.cir.70.5.812", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000302187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2008.138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000519357", 
          "https://doi.org/10.1038/nprot.2008.138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuint.2009.05.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002043509"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hgtb.2011.229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006648253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/mt.2009.257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007316017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/gt.2008.120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008806280", 
          "https://doi.org/10.1038/gt.2008.120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.98.13.1329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009634038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.12.5719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009670761"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1549", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011727524", 
          "https://doi.org/10.1038/nm1549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiolgenomics.00035.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012287667"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2988", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013576129", 
          "https://doi.org/10.1038/nrg2988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/gt.2012.20", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014379444", 
          "https://doi.org/10.1038/gt.2012.20"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/gt.2011.105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014452527", 
          "https://doi.org/10.1038/gt.2011.105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1108046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015498213"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-59259-794-9_19", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019779873", 
          "https://doi.org/10.1007/978-1-59259-794-9_19"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hc3601.095574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020750124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.02309-08", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022372253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.75.9.4080-4090.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025476257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026777163", 
          "https://doi.org/10.1038/nature10407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cardfail.2009.01.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028172599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028630964", 
          "https://doi.org/10.1038/nprot.2006.207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2006.207", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028630964", 
          "https://doi.org/10.1038/nprot.2006.207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.mt.6300170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028785884"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.111.022889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031623859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/gt.2011.163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032089109", 
          "https://doi.org/10.1038/gt.2011.163"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2007.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032555797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hgtb.2012.049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036625136"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/japplphysiol.91322.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039374266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurjhf/hfq234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040802752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.76.5.2043-2053.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044089785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01826-13", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044488135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci8317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044786387"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2660(09)67002-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044852841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045575919", 
          "https://doi.org/10.1038/sj.gt.3302564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045575919", 
          "https://doi.org/10.1038/sj.gt.3302564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045575919", 
          "https://doi.org/10.1038/sj.gt.3302564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.virol.2011.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047503815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.182412299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048554587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)61992-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051322941"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/gt.2012.6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052765535", 
          "https://doi.org/10.1038/gt.2012.6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2007.12.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052828022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.75.4.1824-1833.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053694994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.1998.9.18-2745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059272231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/hum.2012.123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059273826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1566523054065057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069184364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/156652311796150354", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069184636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076636910", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077921626", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-04", 
    "datePublishedReg": "2014-04-01", 
    "description": "Adeno-associated virus (AAV)-based vectors are promising vehicles for therapeutic gene delivery, including for the treatment for heart failure. It has been demonstrated for each of the AAV serotypes 1 through 8 that inhibition of the proteasome results in increased transduction efficiencies. For AAV9, however, the effect of proteasome inhibitors on in vivo transduction has until now not been evaluated. Here we demonstrate, in a well-established rodent heart failure model, that concurrent treatment with the proteasome inhibitor bortezomib does not enhance the efficacy of AAV9.SERCA2a to improve cardiac function as examined by echocardiography and pressure volume analysis. Western blot analysis of SERCA2a protein and reverse transcription-PCR of SERCA2a mRNA demonstrated that bortezomib had no effect on either endogenous rat SERCA2a levels nor on expression levels of human SERCA2a delivered by AAV9.SERCA2a. Similarly, the number of AAV9 genomes in heart samples was unaffected by bortezomib treatment. Interestingly, whereas transduction of HeLa cells and neonatal rat cardiomyocytes by AAV9 was stimulated by bortezomib, transduction of adult rat cardiomyocytes was inhibited. These results indicate an organ/cell-type-specific effect of proteasome inhibition on AAV9 transduction. A future detailed analysis of the underlying molecular mechanisms promises to facilitate the development of improved AAV vectors. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/gt.2014.7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2440851", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2614174", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2541517", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2437983", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2684844", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2542176", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2345462", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2414444", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1105638", 
        "issn": [
          "0969-7128", 
          "1476-5462"
        ], 
        "name": "Gene Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Effect of bortezomib on the efficacy of AAV9.SERCA2a treatment to preserve cardiac function in a rat pressure-overload model of heart failure", 
    "pagination": "379", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "630e0f53f9a2518722e20128ea0b7641e7c6732bb16acdc530024e3755c6892c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24572786"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9421525"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/gt.2014.7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020789195"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/gt.2014.7", 
      "https://app.dimensions.ai/details/publication/pub.1020789195"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117112_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/gt20147"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/gt.2014.7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/gt.2014.7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/gt.2014.7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/gt.2014.7'


 

This table displays all metadata directly associated to this object as RDF triples.

335 TRIPLES      21 PREDICATES      88 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/gt.2014.7 schema:about N22b9e8bfabf9448e967de61621af9425
2 N62446286347c474e8391e8de72b6a57d
3 N68ea9a0d1384404385bfb30ff2a1421e
4 N7230e22ca298444bb7f22d57ee2c8438
5 N7bd94faa4e8e4068bff279739495e13c
6 N7bf96db6ce4549529d58d85904b06193
7 N8caaf1df409e4ec3971672cba9da17c2
8 N9b166f3a7a5e4c9ca55b50b5ab98845e
9 Na1d72701b2f2495db7fb84a44e3585f5
10 Nab232272324c4718a1abcfb62a826501
11 Nb0e87f04706b4b2bb1b3a9e0115e10ba
12 Ne29894269ee34512bbce9501fab8da8a
13 Ne32ce24006804e9fa35fa553ae915fbf
14 Ne61a2e35dd484ce68d9adb6f1ec7c0ab
15 anzsrc-for:11
16 anzsrc-for:1102
17 schema:author N483c4d07f8204d84898ec9285c622817
18 schema:citation sg:pub.10.1007/978-1-59259-794-9_19
19 sg:pub.10.1038/gt.2008.120
20 sg:pub.10.1038/gt.2011.105
21 sg:pub.10.1038/gt.2011.163
22 sg:pub.10.1038/gt.2012.20
23 sg:pub.10.1038/gt.2012.6
24 sg:pub.10.1038/nature10407
25 sg:pub.10.1038/nm1549
26 sg:pub.10.1038/nprot.2006.207
27 sg:pub.10.1038/nprot.2008.138
28 sg:pub.10.1038/nrg2988
29 sg:pub.10.1038/sj.gt.3302564
30 https://app.dimensions.ai/details/publication/pub.1076636910
31 https://app.dimensions.ai/details/publication/pub.1077921626
32 https://doi.org/10.1016/j.cardfail.2009.01.013
33 https://doi.org/10.1016/j.jacc.2007.12.014
34 https://doi.org/10.1016/j.neuint.2009.05.005
35 https://doi.org/10.1016/j.virol.2011.06.009
36 https://doi.org/10.1016/j.yjmcc.2007.01.003
37 https://doi.org/10.1016/s0065-2660(09)67002-4
38 https://doi.org/10.1016/s0140-6736(12)61992-8
39 https://doi.org/10.1038/mt.2009.257
40 https://doi.org/10.1038/sj.mt.6300170
41 https://doi.org/10.1056/nejmoa1108046
42 https://doi.org/10.1073/pnas.182412299
43 https://doi.org/10.1073/pnas.92.12.5719
44 https://doi.org/10.1089/hgtb.2011.229
45 https://doi.org/10.1089/hgtb.2012.049
46 https://doi.org/10.1089/hum.1998.9.18-2745
47 https://doi.org/10.1089/hum.2012.123
48 https://doi.org/10.1093/eurjhf/hfq234
49 https://doi.org/10.1128/jvi.01826-13
50 https://doi.org/10.1128/jvi.02309-08
51 https://doi.org/10.1128/jvi.75.4.1824-1833.2001
52 https://doi.org/10.1128/jvi.75.9.4080-4090.2001
53 https://doi.org/10.1128/jvi.76.5.2043-2053.2002
54 https://doi.org/10.1152/japplphysiol.91322.2008
55 https://doi.org/10.1152/physiolgenomics.00035.2001
56 https://doi.org/10.1161/01.cir.70.5.812
57 https://doi.org/10.1161/01.cir.98.13.1329
58 https://doi.org/10.1161/circulationaha.111.022889
59 https://doi.org/10.1161/hc3601.095574
60 https://doi.org/10.1172/jci8317
61 https://doi.org/10.2174/1566523054065057
62 https://doi.org/10.2174/156652311796150354
63 schema:datePublished 2014-04
64 schema:datePublishedReg 2014-04-01
65 schema:description Adeno-associated virus (AAV)-based vectors are promising vehicles for therapeutic gene delivery, including for the treatment for heart failure. It has been demonstrated for each of the AAV serotypes 1 through 8 that inhibition of the proteasome results in increased transduction efficiencies. For AAV9, however, the effect of proteasome inhibitors on in vivo transduction has until now not been evaluated. Here we demonstrate, in a well-established rodent heart failure model, that concurrent treatment with the proteasome inhibitor bortezomib does not enhance the efficacy of AAV9.SERCA2a to improve cardiac function as examined by echocardiography and pressure volume analysis. Western blot analysis of SERCA2a protein and reverse transcription-PCR of SERCA2a mRNA demonstrated that bortezomib had no effect on either endogenous rat SERCA2a levels nor on expression levels of human SERCA2a delivered by AAV9.SERCA2a. Similarly, the number of AAV9 genomes in heart samples was unaffected by bortezomib treatment. Interestingly, whereas transduction of HeLa cells and neonatal rat cardiomyocytes by AAV9 was stimulated by bortezomib, transduction of adult rat cardiomyocytes was inhibited. These results indicate an organ/cell-type-specific effect of proteasome inhibition on AAV9 transduction. A future detailed analysis of the underlying molecular mechanisms promises to facilitate the development of improved AAV vectors.
66 schema:genre research_article
67 schema:inLanguage en
68 schema:isAccessibleForFree true
69 schema:isPartOf Nd7630e6c38e94c0db5b94381b5e6f0c4
70 Ne99975d87704437dbbccf5a0c1167cbd
71 sg:journal.1105638
72 schema:name Effect of bortezomib on the efficacy of AAV9.SERCA2a treatment to preserve cardiac function in a rat pressure-overload model of heart failure
73 schema:pagination 379
74 schema:productId N5a82b9d5eef64a14aeac09c38ed79b22
75 N73231c9b4c5e446086fe6afcff9b08ce
76 N95fae89e5f71434cb3336f45a388c4c4
77 Nccf072c09f834b1fbf238cae59d8ca3a
78 Nfb04271bc22d4092a1be31bba6ad1b89
79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020789195
80 https://doi.org/10.1038/gt.2014.7
81 schema:sdDatePublished 2019-04-11T14:19
82 schema:sdLicense https://scigraph.springernature.com/explorer/license/
83 schema:sdPublisher N7484bc81c1f84ee3bbf75ac28ef551ae
84 schema:url https://www.nature.com/articles/gt20147
85 sgo:license sg:explorer/license/
86 sgo:sdDataset articles
87 rdf:type schema:ScholarlyArticle
88 N21528477fb7f40a6badbf073a2813ff0 rdf:first sg:person.0746415241.03
89 rdf:rest Nd139e69fc90d4648930ef3cb5b7fb7e3
90 N22b9e8bfabf9448e967de61621af9425 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Dependovirus
92 rdf:type schema:DefinedTerm
93 N483c4d07f8204d84898ec9285c622817 rdf:first sg:person.0624016074.19
94 rdf:rest N56ce3a8d4a194284ae61a369a2fd28a5
95 N56ce3a8d4a194284ae61a369a2fd28a5 rdf:first sg:person.01241742614.32
96 rdf:rest N21528477fb7f40a6badbf073a2813ff0
97 N5a82b9d5eef64a14aeac09c38ed79b22 schema:name nlm_unique_id
98 schema:value 9421525
99 rdf:type schema:PropertyValue
100 N62446286347c474e8391e8de72b6a57d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Heart Failure
102 rdf:type schema:DefinedTerm
103 N68ea9a0d1384404385bfb30ff2a1421e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Animals
105 rdf:type schema:DefinedTerm
106 N6d05e3d909de4e9093a5edad3e5bad8f rdf:first sg:person.0642517622.49
107 rdf:rest N8768b27afa5446e3849b3049122b020c
108 N7230e22ca298444bb7f22d57ee2c8438 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Disease Models, Animal
110 rdf:type schema:DefinedTerm
111 N73231c9b4c5e446086fe6afcff9b08ce schema:name pubmed_id
112 schema:value 24572786
113 rdf:type schema:PropertyValue
114 N7484bc81c1f84ee3bbf75ac28ef551ae schema:name Springer Nature - SN SciGraph project
115 rdf:type schema:Organization
116 N7bd94faa4e8e4068bff279739495e13c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Sarcoplasmic Reticulum Calcium-Transporting ATPases
118 rdf:type schema:DefinedTerm
119 N7bf96db6ce4549529d58d85904b06193 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Rats
121 rdf:type schema:DefinedTerm
122 N8768b27afa5446e3849b3049122b020c rdf:first sg:person.01147556575.27
123 rdf:rest Nc4d8cdaed3984598b53430c2a041bdef
124 N8caaf1df409e4ec3971672cba9da17c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Humans
126 rdf:type schema:DefinedTerm
127 N95fae89e5f71434cb3336f45a388c4c4 schema:name dimensions_id
128 schema:value pub.1020789195
129 rdf:type schema:PropertyValue
130 N9b166f3a7a5e4c9ca55b50b5ab98845e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Myocytes, Cardiac
132 rdf:type schema:DefinedTerm
133 Na1d72701b2f2495db7fb84a44e3585f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Bortezomib
135 rdf:type schema:DefinedTerm
136 Nab232272324c4718a1abcfb62a826501 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Genetic Therapy
138 rdf:type schema:DefinedTerm
139 Nb0e87f04706b4b2bb1b3a9e0115e10ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Pyrazines
141 rdf:type schema:DefinedTerm
142 Nc4d8cdaed3984598b53430c2a041bdef rdf:first sg:person.01147340377.69
143 rdf:rest rdf:nil
144 Nccf072c09f834b1fbf238cae59d8ca3a schema:name readcube_id
145 schema:value 630e0f53f9a2518722e20128ea0b7641e7c6732bb16acdc530024e3755c6892c
146 rdf:type schema:PropertyValue
147 Nd139e69fc90d4648930ef3cb5b7fb7e3 rdf:first sg:person.01030271051.00
148 rdf:rest Ne0a695f2d098433084a1d020eab17666
149 Nd7630e6c38e94c0db5b94381b5e6f0c4 schema:issueNumber 4
150 rdf:type schema:PublicationIssue
151 Ne0a695f2d098433084a1d020eab17666 rdf:first sg:person.0767760340.89
152 rdf:rest N6d05e3d909de4e9093a5edad3e5bad8f
153 Ne29894269ee34512bbce9501fab8da8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Genetic Vectors
155 rdf:type schema:DefinedTerm
156 Ne32ce24006804e9fa35fa553ae915fbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Myocardium
158 rdf:type schema:DefinedTerm
159 Ne61a2e35dd484ce68d9adb6f1ec7c0ab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Boronic Acids
161 rdf:type schema:DefinedTerm
162 Ne99975d87704437dbbccf5a0c1167cbd schema:volumeNumber 21
163 rdf:type schema:PublicationVolume
164 Nfb04271bc22d4092a1be31bba6ad1b89 schema:name doi
165 schema:value 10.1038/gt.2014.7
166 rdf:type schema:PropertyValue
167 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
168 schema:name Medical and Health Sciences
169 rdf:type schema:DefinedTerm
170 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
171 schema:name Cardiorespiratory Medicine and Haematology
172 rdf:type schema:DefinedTerm
173 sg:grant.2345462 http://pending.schema.org/fundedItem sg:pub.10.1038/gt.2014.7
174 rdf:type schema:MonetaryGrant
175 sg:grant.2414444 http://pending.schema.org/fundedItem sg:pub.10.1038/gt.2014.7
176 rdf:type schema:MonetaryGrant
177 sg:grant.2437983 http://pending.schema.org/fundedItem sg:pub.10.1038/gt.2014.7
178 rdf:type schema:MonetaryGrant
179 sg:grant.2440851 http://pending.schema.org/fundedItem sg:pub.10.1038/gt.2014.7
180 rdf:type schema:MonetaryGrant
181 sg:grant.2541517 http://pending.schema.org/fundedItem sg:pub.10.1038/gt.2014.7
182 rdf:type schema:MonetaryGrant
183 sg:grant.2542176 http://pending.schema.org/fundedItem sg:pub.10.1038/gt.2014.7
184 rdf:type schema:MonetaryGrant
185 sg:grant.2614174 http://pending.schema.org/fundedItem sg:pub.10.1038/gt.2014.7
186 rdf:type schema:MonetaryGrant
187 sg:grant.2684844 http://pending.schema.org/fundedItem sg:pub.10.1038/gt.2014.7
188 rdf:type schema:MonetaryGrant
189 sg:journal.1105638 schema:issn 0969-7128
190 1476-5462
191 schema:name Gene Therapy
192 rdf:type schema:Periodical
193 sg:person.01030271051.00 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
194 schema:familyName Jin
195 schema:givenName Dongzhu
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030271051.00
197 rdf:type schema:Person
198 sg:person.01147340377.69 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
199 schema:familyName Weber
200 schema:givenName Thomas
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147340377.69
202 rdf:type schema:Person
203 sg:person.01147556575.27 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
204 schema:familyName Hajjar
205 schema:givenName Roger J
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147556575.27
207 rdf:type schema:Person
208 sg:person.01241742614.32 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
209 schema:familyName Nonnenmacher
210 schema:givenName Mathieu
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241742614.32
212 rdf:type schema:Person
213 sg:person.0624016074.19 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
214 schema:familyName Chaanine
215 schema:givenName Antoine H
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624016074.19
217 rdf:type schema:Person
218 sg:person.0642517622.49 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
219 schema:familyName Akar
220 schema:givenName Fadi G
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642517622.49
222 rdf:type schema:Person
223 sg:person.0746415241.03 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
224 schema:familyName Kohlbrenner
225 schema:givenName Erik
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746415241.03
227 rdf:type schema:Person
228 sg:person.0767760340.89 schema:affiliation https://www.grid.ac/institutes/grid.59734.3c
229 schema:familyName Kovacic
230 schema:givenName Jason C
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767760340.89
232 rdf:type schema:Person
233 sg:pub.10.1007/978-1-59259-794-9_19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019779873
234 https://doi.org/10.1007/978-1-59259-794-9_19
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/gt.2008.120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008806280
237 https://doi.org/10.1038/gt.2008.120
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/gt.2011.105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014452527
240 https://doi.org/10.1038/gt.2011.105
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/gt.2011.163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032089109
243 https://doi.org/10.1038/gt.2011.163
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/gt.2012.20 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014379444
246 https://doi.org/10.1038/gt.2012.20
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/gt.2012.6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052765535
249 https://doi.org/10.1038/gt.2012.6
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/nature10407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026777163
252 https://doi.org/10.1038/nature10407
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/nm1549 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011727524
255 https://doi.org/10.1038/nm1549
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/nprot.2006.207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028630964
258 https://doi.org/10.1038/nprot.2006.207
259 rdf:type schema:CreativeWork
260 sg:pub.10.1038/nprot.2008.138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000519357
261 https://doi.org/10.1038/nprot.2008.138
262 rdf:type schema:CreativeWork
263 sg:pub.10.1038/nrg2988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013576129
264 https://doi.org/10.1038/nrg2988
265 rdf:type schema:CreativeWork
266 sg:pub.10.1038/sj.gt.3302564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045575919
267 https://doi.org/10.1038/sj.gt.3302564
268 rdf:type schema:CreativeWork
269 https://app.dimensions.ai/details/publication/pub.1076636910 schema:CreativeWork
270 https://app.dimensions.ai/details/publication/pub.1077921626 schema:CreativeWork
271 https://doi.org/10.1016/j.cardfail.2009.01.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028172599
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/j.jacc.2007.12.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052828022
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.neuint.2009.05.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002043509
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.virol.2011.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047503815
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.yjmcc.2007.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032555797
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/s0065-2660(09)67002-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044852841
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/s0140-6736(12)61992-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051322941
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1038/mt.2009.257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007316017
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1038/sj.mt.6300170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028785884
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1056/nejmoa1108046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015498213
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1073/pnas.182412299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048554587
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1073/pnas.92.12.5719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009670761
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1089/hgtb.2011.229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006648253
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1089/hgtb.2012.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036625136
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1089/hum.1998.9.18-2745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059272231
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1089/hum.2012.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059273826
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1093/eurjhf/hfq234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040802752
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1128/jvi.01826-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044488135
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1128/jvi.02309-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022372253
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1128/jvi.75.4.1824-1833.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053694994
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1128/jvi.75.9.4080-4090.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025476257
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1128/jvi.76.5.2043-2053.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044089785
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1152/japplphysiol.91322.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039374266
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1152/physiolgenomics.00035.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012287667
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1161/01.cir.70.5.812 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000302187
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1161/01.cir.98.13.1329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009634038
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1161/circulationaha.111.022889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031623859
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1161/hc3601.095574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020750124
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1172/jci8317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044786387
328 rdf:type schema:CreativeWork
329 https://doi.org/10.2174/1566523054065057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069184364
330 rdf:type schema:CreativeWork
331 https://doi.org/10.2174/156652311796150354 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069184636
332 rdf:type schema:CreativeWork
333 https://www.grid.ac/institutes/grid.59734.3c schema:alternateName Icahn School of Medicine at Mount Sinai
334 schema:name Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
335 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...