Ontology type: schema:ScholarlyArticle Open Access: True
2012-06
AUTHORSE Di Pasquale, M V G Latronico, G S Jotti, G Condorelli
ABSTRACTEngineered recombinant viral vectors are a powerful tool for vehiculating genetic information into mammalian cells. Because of their ability to infect both dividing and non-dividing cells with high efficiency, lentiviral vectors have gained particular interest for basic research and preclinical studies in the cardiovascular field. We review here the major applications for lentiviral-vector technology in the cardiovascular field: we will discuss their use in trailing gene expression during the induction of differentiation, in protocols for the isolation of cardiac cells and in the tracking of cardiac cells after transplantation in vivo; we will also describe lentivirally-mediated gene delivery uses, such as the induction of a phenotype of interest in a target cell or the treatment of cardiovascular diseases. In addition, a section of the review will be dedicated to reprogramming approaches, focusing attention on the generation of pluripotent stem cells and on transdifferentiation, two emerging strategies for the production of cardiac myocytes from human cells and for the investigation of human diseases. Finally, in order to give a perspective on their future clinical use we will critically discuss advantages and disadvantages of lentivirus-based strategies for the treatment of cardiovascular diseases. More... »
PAGES642
http://scigraph.springernature.com/pub.10.1038/gt.2012.19
DOIhttp://dx.doi.org/10.1038/gt.2012.19
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1023735931
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/22378345
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1004",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical Biotechnology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/10",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Technology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cardiovascular Diseases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Differentiation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Transdifferentiation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Transfer Techniques",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genetic Therapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genetic Vectors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Induced Pluripotent Stem Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lentivirus",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Myocytes, Cardiac",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "MultiMedica",
"id": "https://www.grid.ac/institutes/grid.420421.1",
"name": [
"IRCCS Multimedica, Milan, Italy",
"Institute of Genetic and Biomedic Research (IRGB) \u2013 UOS Milan, Milan, Italy"
],
"type": "Organization"
},
"familyName": "Di Pasquale",
"givenName": "E",
"id": "sg:person.0646354141.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646354141.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Humanitas Research Hospital",
"id": "https://www.grid.ac/institutes/grid.417728.f",
"name": [
"IRCCS Istituto Clinico Humanitas, Rozzano, Italy"
],
"type": "Organization"
},
"familyName": "Latronico",
"givenName": "M V G",
"id": "sg:person.0576137377.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576137377.72"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Parma",
"id": "https://www.grid.ac/institutes/grid.10383.39",
"name": [
"Department of Public Health, University of Parma, Parma, Italy"
],
"type": "Organization"
},
"familyName": "Jotti",
"givenName": "G S",
"id": "sg:person.01335727115.57",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335727115.57"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Research Council",
"id": "https://www.grid.ac/institutes/grid.5326.2",
"name": [
"Department of Medicine, National Research Council of Italy, Milan, Italy"
],
"type": "Organization"
},
"familyName": "Condorelli",
"givenName": "G",
"id": "sg:person.016367365420.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016367365420.10"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1182/blood-2008-10-186684",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000155215"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.stem.2009.05.023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000372960"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0958-1669(98)80029-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000592141"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2009.03.034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001908973"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbrc.2006.12.103",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002726015"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/mt.2009.31",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003313356"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.101.4.408",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003432554"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature10147",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005736924",
"https://doi.org/10.1038/nature10147"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpheart.00294.2009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005797782"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1182/blood-2002-07-2238",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007133420"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/bit.20668",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007530839"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/bit.20668",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007530839"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09855",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007693382",
"https://doi.org/10.1038/nature09855"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/cdd.2011.205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008180118",
"https://doi.org/10.1038/cdd.2011.205"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/jmcc.1999.1035",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008913759"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.gt.3303017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010306179",
"https://doi.org/10.1038/sj.gt.3303017"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2007.11.019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010904856"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci6026",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011180393"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/jgm.1122",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012766384"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nbt788",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013128911",
"https://doi.org/10.1038/nbt788"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nbt788",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013128911",
"https://doi.org/10.1038/nbt788"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2006.07.024",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014573758"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00395-010-0111-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015150239",
"https://doi.org/10.1007/s00395-010-0111-6"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circulationaha.108.778795",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015365070"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci118769",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016900524"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1196/annals.1345.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018153323"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1196/annals.1345.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018153323"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09591",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018338276",
"https://doi.org/10.1038/nature09591"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09591",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018338276",
"https://doi.org/10.1038/nature09591"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/hc0802.105564",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018390851"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.gt.3301936",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018676645",
"https://doi.org/10.1038/sj.gt.3301936"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.gt.3301936",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018676645",
"https://doi.org/10.1038/sj.gt.3301936"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/mt.2008.30",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018744906"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/mt.2008.61",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020325859"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2008.02.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020546692"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fj.02-0104fje",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021917884"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08797",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022463782",
"https://doi.org/10.1038/nature08797"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08797",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022463782",
"https://doi.org/10.1038/nature08797"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/mt.2009.26",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022744936"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2010.07.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022964788"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2217/17460751.2.2.193",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023828881"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jjcc.2010.08.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023949571"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.pharmthera.2004.10.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026288803"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fj.05-5711com",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026405620"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/hum.2011.058",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026885676"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.282.5391.1145",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028898955"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1963910",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029715113"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.gt.3302570",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030168974",
"https://doi.org/10.1038/sj.gt.3302570"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.gt.3302570",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030168974",
"https://doi.org/10.1038/sj.gt.3302570"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.gt.3302570",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030168974",
"https://doi.org/10.1038/sj.gt.3302570"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.gt.3301893",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030828884",
"https://doi.org/10.1038/sj.gt.3301893"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.gt.3301893",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030828884",
"https://doi.org/10.1038/sj.gt.3301893"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cellbi.2009.08.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031078862"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/mthe.2002.0542",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031226791"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.93.21.11382",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031334968"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fj.00-0002com",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033051698"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/mt.2009.319",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034629360"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0005046",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035188037"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/hrt.2007.116483",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038110504"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/bjp.2008.349",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038153094"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ana.21473",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038432362"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ana.21473",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038432362"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circresaha.109.208967",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039370069"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circresaha.109.208967",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039370069"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2010.10.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039955191"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-59259-879-3_8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040343879",
"https://doi.org/10.1007/978-1-59259-879-3_8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-59259-879-3_8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040343879",
"https://doi.org/10.1007/978-1-59259-879-3_8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11307-010-0392-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041859720",
"https://doi.org/10.1007/s11307-010-0392-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature06894",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043777271",
"https://doi.org/10.1038/nature06894"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa0908679",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045309056"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.100.23.2308",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045605443"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.143.7.2045",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046406168"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2008.07.041",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047970638"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1151526",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048905674"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.gt.3302384",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049314774",
"https://doi.org/10.1038/sj.gt.3302384"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.gt.3302384",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049314774",
"https://doi.org/10.1038/sj.gt.3302384"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/physiol.00037.2006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049986785"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/hco.0b013e32834598ad",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050487179"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/hco.0b013e32834598ad",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050487179"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/hco.0b013e32834598ad",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050487179"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circresaha.109.206045",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050903812"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circresaha.109.206045",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050903812"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circulationaha.107.758516",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051671691"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051785467",
"https://doi.org/10.1038/nature09005"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature09005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051785467",
"https://doi.org/10.1038/nature09005"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nprot.2008.116",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053163483",
"https://doi.org/10.1038/nprot.2008.116"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.272.5259.263",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062552729"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.326.5959.1468-b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062602633"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2119/molmed.2009.00163",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1068965237",
"https://doi.org/10.2119/molmed.2009.00163"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.2119/molmed.2009.00163",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1068965237",
"https://doi.org/10.2119/molmed.2009.00163"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074882774",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077733754",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083326800",
"type": "CreativeWork"
}
],
"datePublished": "2012-06",
"datePublishedReg": "2012-06-01",
"description": "Engineered recombinant viral vectors are a powerful tool for vehiculating genetic information into mammalian cells. Because of their ability to infect both dividing and non-dividing cells with high efficiency, lentiviral vectors have gained particular interest for basic research and preclinical studies in the cardiovascular field. We review here the major applications for lentiviral-vector technology in the cardiovascular field: we will discuss their use in trailing gene expression during the induction of differentiation, in protocols for the isolation of cardiac cells and in the tracking of cardiac cells after transplantation in vivo; we will also describe lentivirally-mediated gene delivery uses, such as the induction of a phenotype of interest in a target cell or the treatment of cardiovascular diseases. In addition, a section of the review will be dedicated to reprogramming approaches, focusing attention on the generation of pluripotent stem cells and on transdifferentiation, two emerging strategies for the production of cardiac myocytes from human cells and for the investigation of human diseases. Finally, in order to give a perspective on their future clinical use we will critically discuss advantages and disadvantages of lentivirus-based strategies for the treatment of cardiovascular diseases.",
"genre": "research_article",
"id": "sg:pub.10.1038/gt.2012.19",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1105638",
"issn": [
"0969-7128",
"1476-5462"
],
"name": "Gene Therapy",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "19"
}
],
"name": "Lentiviral vectors and cardiovascular diseases: a genetic tool for manipulating cardiomyocyte differentiation and function",
"pagination": "642",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"71153832eca6d979bdd55ff1db3c9805774d56ef8de321f490ae13b7e41cadf5"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"22378345"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9421525"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/gt.2012.19"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1023735931"
]
}
],
"sameAs": [
"https://doi.org/10.1038/gt.2012.19",
"https://app.dimensions.ai/details/publication/pub.1023735931"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T19:46",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000434.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/gt201219"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/gt.2012.19'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/gt.2012.19'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/gt.2012.19'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/gt.2012.19'
This table displays all metadata directly associated to this object as RDF triples.
380 TRIPLES
21 PREDICATES
114 URIs
31 LITERALS
19 BLANK NODES