Optogenetic therapy for retinitis pigmentosa View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-10-13

AUTHORS

V Busskamp, S Picaud, J A Sahel, B Roska

ABSTRACT

Retinitis pigmentosa (RP) refers to a diverse group of progressive, hereditary diseases of the retina that lead to incurable blindness and affect two million people worldwide. Artificial photoreceptors constructed by gene delivery of light-activated channels or pumps (‘optogenetic tools’) to surviving cell types in the remaining retinal circuit has been shown to restore photosensitivity in animal models of RP at the level of the retina and cortex as well as behaviorally. The translational potential of this optogenetic approach has been evaluated using in vitro studies involving post-mortem human retinas. Here, we review recent developments in this expanding field and discuss the potential and limitations of optogenetic engineering for the treatment of RP. More... »

PAGES

169-175

References to SciGraph publications

  • 2004-10. Parallel processing in the mammalian retina in NATURE REVIEWS NEUROSCIENCE
  • 2001-09. The fundamental plan of the retina in NATURE NEUROSCIENCE
  • 1999-10. Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse in NATURE MEDICINE
  • 2007-04. Multimodal fast optical interrogation of neural circuitry in NATURE
  • 2007-08. Circuit-breakers: optical technologies for probing neural signals and systems in NATURE REVIEWS NEUROSCIENCE
  • 2008-12-07. Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa in NATURE NEUROSCIENCE
  • 2008-04-27. Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration in NATURE NEUROSCIENCE
  • 2011-03-13. Ultra light-sensitive and fast neuronal activation with the Ca2+-permeable channelrhodopsin CatCh in NATURE NEUROSCIENCE
  • 2008-11-04. Photoreceptor Cell Death Mechanisms in Inherited Retinal Degeneration in MOLECULAR NEUROBIOLOGY
  • 2001-03. Vertical interactions across ten parallel, stacked representations in the mammalian retina in NATURE
  • 2010-03-09. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait in NATURE REVIEWS GENETICS
  • 2008-12-08. Bi-stable neural state switches in NATURE NEUROSCIENCE
  • 2009-09-16. Gene therapy for red-green colour blindness in adult primates in NATURE
  • 2006-10-11. Retinitis pigmentosa in ORPHANET JOURNAL OF RARE DISEASES
  • 2005-08-14. Millisecond-timescale, genetically targeted optical control of neural activity in NATURE NEUROSCIENCE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/gt.2011.155

    DOI

    http://dx.doi.org/10.1038/gt.2011.155

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1036508493

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21993174


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blindness", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carrier Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chlamydomonas reinhardtii", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genetic Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Halobacteriaceae", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Halorhodopsins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retina", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Retinitis Pigmentosa", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "NCCR Frontiers in Genetics Program, University of Geneva, Geneva, Switzerland", 
              "id": "http://www.grid.ac/institutes/grid.8591.5", 
              "name": [
                "Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland", 
                "NCCR Frontiers in Genetics Program, University of Geneva, Geneva, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Busskamp", 
            "givenName": "V", 
            "id": "sg:person.0774232004.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774232004.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Fondation Ophtalmologique Adolphe de Rothschild, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.417888.a", 
              "name": [
                "Inserm, UMR_S968, Institut de la Vision, Paris, France", 
                "UPMC Univ Paris 06, UMR_S968, Institut de la Vision, Paris, France", 
                "CNRS, UMR_7210, Paris, France", 
                "Fondation Ophtalmologique Adolphe de Rothschild, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Picaud", 
            "givenName": "S", 
            "id": "sg:person.0642273724.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642273724.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre d\u2019Investigation Clinique 503, Inserm-Centre Hospitalier National d\u2019Ophtalmologie des, Quinze-Vingts, Paris, France", 
              "id": "http://www.grid.ac/institutes/grid.415610.7", 
              "name": [
                "Inserm, UMR_S968, Institut de la Vision, Paris, France", 
                "UPMC Univ Paris 06, UMR_S968, Institut de la Vision, Paris, France", 
                "CNRS, UMR_7210, Paris, France", 
                "Fondation Ophtalmologique Adolphe de Rothschild, Paris, France", 
                "Centre d\u2019Investigation Clinique 503, Inserm-Centre Hospitalier National d\u2019Ophtalmologie des, Quinze-Vingts, Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sahel", 
            "givenName": "J A", 
            "id": "sg:person.01104041722.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104041722.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland", 
              "id": "http://www.grid.ac/institutes/grid.482245.d", 
              "name": [
                "Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Roska", 
            "givenName": "B", 
            "id": "sg:person.0731757704.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731757704.90"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nature05744", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000034210", 
              "https://doi.org/10.1038/nature05744"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1750-1172-1-40", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052342763", 
              "https://doi.org/10.1186/1750-1172-1-40"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08401", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040124069", 
              "https://doi.org/10.1038/nature08401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn1497", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012560945", 
              "https://doi.org/10.1038/nrn1497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12035-008-8045-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025129651", 
              "https://doi.org/10.1007/s12035-008-8045-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2776", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047761855", 
              "https://doi.org/10.1038/nn.2776"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/13508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048713982", 
              "https://doi.org/10.1038/13508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn0901-877", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005436641", 
              "https://doi.org/10.1038/nn0901-877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2717", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026483567", 
              "https://doi.org/10.1038/nrg2717"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35069068", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004850591", 
              "https://doi.org/10.1038/35069068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2234", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039125224", 
              "https://doi.org/10.1038/nn.2234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2247", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028782300", 
              "https://doi.org/10.1038/nn.2247"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrn2192", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012184032", 
              "https://doi.org/10.1038/nrn2192"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2117", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042715089", 
              "https://doi.org/10.1038/nn.2117"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1525", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043162871", 
              "https://doi.org/10.1038/nn1525"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2011-10-13", 
        "datePublishedReg": "2011-10-13", 
        "description": "Retinitis pigmentosa (RP) refers to a diverse group of progressive, hereditary diseases of the retina that lead to incurable blindness and affect two million people worldwide. Artificial photoreceptors constructed by gene delivery of light-activated channels or pumps (\u2018optogenetic tools\u2019) to surviving cell types in the remaining retinal circuit has been shown to restore photosensitivity in animal models of RP at the level of the retina and cortex as well as behaviorally. The translational potential of this optogenetic approach has been evaluated using in vitro studies involving post-mortem human retinas. Here, we review recent developments in this expanding field and discuss the potential and limitations of optogenetic engineering for the treatment of RP.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/gt.2011.155", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1105638", 
            "issn": [
              "0969-7128", 
              "1476-5462"
            ], 
            "name": "Gene Therapy", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "19"
          }
        ], 
        "keywords": [
          "retinitis pigmentosa", 
          "treatment of RP", 
          "retinal circuits", 
          "animal models", 
          "incurable blindness", 
          "post-mortem human retinas", 
          "optogenetic therapy", 
          "translational potential", 
          "human retina", 
          "optogenetic approach", 
          "retina", 
          "hereditary disease", 
          "light-activated channels", 
          "pigmentosa", 
          "cell types", 
          "therapy", 
          "cortex", 
          "disease", 
          "optogenetic engineering", 
          "blindness", 
          "treatment", 
          "gene delivery", 
          "diverse group", 
          "photoreceptors", 
          "delivery", 
          "group", 
          "levels", 
          "photosensitivity", 
          "study", 
          "potential", 
          "people", 
          "artificial photoreceptors", 
          "development", 
          "pump", 
          "types", 
          "recent developments", 
          "limitations", 
          "model", 
          "channels", 
          "approach", 
          "circuit", 
          "field", 
          "engineering"
        ], 
        "name": "Optogenetic therapy for retinitis pigmentosa", 
        "pagination": "169-175", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1036508493"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/gt.2011.155"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "21993174"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/gt.2011.155", 
          "https://app.dimensions.ai/details/publication/pub.1036508493"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:25", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_542.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/gt.2011.155"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/gt.2011.155'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/gt.2011.155'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/gt.2011.155'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/gt.2011.155'


     

    This table displays all metadata directly associated to this object as RDF triples.

    247 TRIPLES      22 PREDICATES      95 URIs      72 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/gt.2011.155 schema:about N0210846dd4d441038ec0eca538bfa53a
    2 N0a265f20ade44a2d9d61fa84a1cb0f5e
    3 N1fd17be88c014000bbd4dc7e9774dcfb
    4 N66f2b60c56e64b8eb20c270101055477
    5 N68ff332b4c9a4f949d98509231bf0e7c
    6 N77798440a18a4d3c81c09a07ae56af59
    7 N9c55afbfc7c540d093ae8013266f13aa
    8 Nb26ae117de884f7f89c9170dcaa18639
    9 Nbc582693aa7946e1b0d5ba540243d21f
    10 Nd12b94762130482691412242134d3ad2
    11 Ne609c081d3d149d09be4bde161221b82
    12 anzsrc-for:11
    13 anzsrc-for:1109
    14 schema:author N9c084ce1f81e44d79622a05422d0ac2f
    15 schema:citation sg:pub.10.1007/s12035-008-8045-9
    16 sg:pub.10.1038/13508
    17 sg:pub.10.1038/35069068
    18 sg:pub.10.1038/nature05744
    19 sg:pub.10.1038/nature08401
    20 sg:pub.10.1038/nn.2117
    21 sg:pub.10.1038/nn.2234
    22 sg:pub.10.1038/nn.2247
    23 sg:pub.10.1038/nn.2776
    24 sg:pub.10.1038/nn0901-877
    25 sg:pub.10.1038/nn1525
    26 sg:pub.10.1038/nrg2717
    27 sg:pub.10.1038/nrn1497
    28 sg:pub.10.1038/nrn2192
    29 sg:pub.10.1186/1750-1172-1-40
    30 schema:datePublished 2011-10-13
    31 schema:datePublishedReg 2011-10-13
    32 schema:description Retinitis pigmentosa (RP) refers to a diverse group of progressive, hereditary diseases of the retina that lead to incurable blindness and affect two million people worldwide. Artificial photoreceptors constructed by gene delivery of light-activated channels or pumps (‘optogenetic tools’) to surviving cell types in the remaining retinal circuit has been shown to restore photosensitivity in animal models of RP at the level of the retina and cortex as well as behaviorally. The translational potential of this optogenetic approach has been evaluated using in vitro studies involving post-mortem human retinas. Here, we review recent developments in this expanding field and discuss the potential and limitations of optogenetic engineering for the treatment of RP.
    33 schema:genre article
    34 schema:inLanguage en
    35 schema:isAccessibleForFree true
    36 schema:isPartOf N9317cc2558864a4899d097affa8c5519
    37 Nbe670276a3c3496ba8b5656a8ddc35d0
    38 sg:journal.1105638
    39 schema:keywords animal models
    40 approach
    41 artificial photoreceptors
    42 blindness
    43 cell types
    44 channels
    45 circuit
    46 cortex
    47 delivery
    48 development
    49 disease
    50 diverse group
    51 engineering
    52 field
    53 gene delivery
    54 group
    55 hereditary disease
    56 human retina
    57 incurable blindness
    58 levels
    59 light-activated channels
    60 limitations
    61 model
    62 optogenetic approach
    63 optogenetic engineering
    64 optogenetic therapy
    65 people
    66 photoreceptors
    67 photosensitivity
    68 pigmentosa
    69 post-mortem human retinas
    70 potential
    71 pump
    72 recent developments
    73 retina
    74 retinal circuits
    75 retinitis pigmentosa
    76 study
    77 therapy
    78 translational potential
    79 treatment
    80 treatment of RP
    81 types
    82 schema:name Optogenetic therapy for retinitis pigmentosa
    83 schema:pagination 169-175
    84 schema:productId N12755befcdc94887bf5d0d0284425f96
    85 N7ff9d8eac0464e34a5623c5e8ed3a430
    86 N9bc27e04776c435c8ad50cf621f6460e
    87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036508493
    88 https://doi.org/10.1038/gt.2011.155
    89 schema:sdDatePublished 2022-01-01T18:25
    90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    91 schema:sdPublisher N6f8458d6fd724c39bc4b3c5f6d5ec736
    92 schema:url https://doi.org/10.1038/gt.2011.155
    93 sgo:license sg:explorer/license/
    94 sgo:sdDataset articles
    95 rdf:type schema:ScholarlyArticle
    96 N0210846dd4d441038ec0eca538bfa53a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    97 schema:name Genetic Therapy
    98 rdf:type schema:DefinedTerm
    99 N0a265f20ade44a2d9d61fa84a1cb0f5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Gene Expression
    101 rdf:type schema:DefinedTerm
    102 N12755befcdc94887bf5d0d0284425f96 schema:name dimensions_id
    103 schema:value pub.1036508493
    104 rdf:type schema:PropertyValue
    105 N1fd17be88c014000bbd4dc7e9774dcfb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Retinitis Pigmentosa
    107 rdf:type schema:DefinedTerm
    108 N3d1b6172f2d04305bb90db974d05fbbc rdf:first sg:person.01104041722.66
    109 rdf:rest Nc5ebae4f886740968bdde5fe0b24cd54
    110 N66f2b60c56e64b8eb20c270101055477 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Carrier Proteins
    112 rdf:type schema:DefinedTerm
    113 N68ff332b4c9a4f949d98509231bf0e7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Animals
    115 rdf:type schema:DefinedTerm
    116 N6f8458d6fd724c39bc4b3c5f6d5ec736 schema:name Springer Nature - SN SciGraph project
    117 rdf:type schema:Organization
    118 N77798440a18a4d3c81c09a07ae56af59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Halobacteriaceae
    120 rdf:type schema:DefinedTerm
    121 N7ff9d8eac0464e34a5623c5e8ed3a430 schema:name doi
    122 schema:value 10.1038/gt.2011.155
    123 rdf:type schema:PropertyValue
    124 N9317cc2558864a4899d097affa8c5519 schema:issueNumber 2
    125 rdf:type schema:PublicationIssue
    126 N9bc27e04776c435c8ad50cf621f6460e schema:name pubmed_id
    127 schema:value 21993174
    128 rdf:type schema:PropertyValue
    129 N9bd6e76a4b334e719b1de98884ebf197 rdf:first sg:person.0642273724.04
    130 rdf:rest N3d1b6172f2d04305bb90db974d05fbbc
    131 N9c084ce1f81e44d79622a05422d0ac2f rdf:first sg:person.0774232004.37
    132 rdf:rest N9bd6e76a4b334e719b1de98884ebf197
    133 N9c55afbfc7c540d093ae8013266f13aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Halorhodopsins
    135 rdf:type schema:DefinedTerm
    136 Nb26ae117de884f7f89c9170dcaa18639 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Humans
    138 rdf:type schema:DefinedTerm
    139 Nbc582693aa7946e1b0d5ba540243d21f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Chlamydomonas reinhardtii
    141 rdf:type schema:DefinedTerm
    142 Nbe670276a3c3496ba8b5656a8ddc35d0 schema:volumeNumber 19
    143 rdf:type schema:PublicationVolume
    144 Nc5ebae4f886740968bdde5fe0b24cd54 rdf:first sg:person.0731757704.90
    145 rdf:rest rdf:nil
    146 Nd12b94762130482691412242134d3ad2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Blindness
    148 rdf:type schema:DefinedTerm
    149 Ne609c081d3d149d09be4bde161221b82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name Retina
    151 rdf:type schema:DefinedTerm
    152 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    153 schema:name Medical and Health Sciences
    154 rdf:type schema:DefinedTerm
    155 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    156 schema:name Neurosciences
    157 rdf:type schema:DefinedTerm
    158 sg:journal.1105638 schema:issn 0969-7128
    159 1476-5462
    160 schema:name Gene Therapy
    161 schema:publisher Springer Nature
    162 rdf:type schema:Periodical
    163 sg:person.01104041722.66 schema:affiliation grid-institutes:grid.415610.7
    164 schema:familyName Sahel
    165 schema:givenName J A
    166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104041722.66
    167 rdf:type schema:Person
    168 sg:person.0642273724.04 schema:affiliation grid-institutes:grid.417888.a
    169 schema:familyName Picaud
    170 schema:givenName S
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0642273724.04
    172 rdf:type schema:Person
    173 sg:person.0731757704.90 schema:affiliation grid-institutes:grid.482245.d
    174 schema:familyName Roska
    175 schema:givenName B
    176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731757704.90
    177 rdf:type schema:Person
    178 sg:person.0774232004.37 schema:affiliation grid-institutes:grid.8591.5
    179 schema:familyName Busskamp
    180 schema:givenName V
    181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774232004.37
    182 rdf:type schema:Person
    183 sg:pub.10.1007/s12035-008-8045-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025129651
    184 https://doi.org/10.1007/s12035-008-8045-9
    185 rdf:type schema:CreativeWork
    186 sg:pub.10.1038/13508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048713982
    187 https://doi.org/10.1038/13508
    188 rdf:type schema:CreativeWork
    189 sg:pub.10.1038/35069068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004850591
    190 https://doi.org/10.1038/35069068
    191 rdf:type schema:CreativeWork
    192 sg:pub.10.1038/nature05744 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000034210
    193 https://doi.org/10.1038/nature05744
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1038/nature08401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040124069
    196 https://doi.org/10.1038/nature08401
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1038/nn.2117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042715089
    199 https://doi.org/10.1038/nn.2117
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/nn.2234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039125224
    202 https://doi.org/10.1038/nn.2234
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/nn.2247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028782300
    205 https://doi.org/10.1038/nn.2247
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/nn.2776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047761855
    208 https://doi.org/10.1038/nn.2776
    209 rdf:type schema:CreativeWork
    210 sg:pub.10.1038/nn0901-877 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005436641
    211 https://doi.org/10.1038/nn0901-877
    212 rdf:type schema:CreativeWork
    213 sg:pub.10.1038/nn1525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043162871
    214 https://doi.org/10.1038/nn1525
    215 rdf:type schema:CreativeWork
    216 sg:pub.10.1038/nrg2717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026483567
    217 https://doi.org/10.1038/nrg2717
    218 rdf:type schema:CreativeWork
    219 sg:pub.10.1038/nrn1497 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012560945
    220 https://doi.org/10.1038/nrn1497
    221 rdf:type schema:CreativeWork
    222 sg:pub.10.1038/nrn2192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012184032
    223 https://doi.org/10.1038/nrn2192
    224 rdf:type schema:CreativeWork
    225 sg:pub.10.1186/1750-1172-1-40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052342763
    226 https://doi.org/10.1186/1750-1172-1-40
    227 rdf:type schema:CreativeWork
    228 grid-institutes:grid.415610.7 schema:alternateName Centre d’Investigation Clinique 503, Inserm-Centre Hospitalier National d’Ophtalmologie des, Quinze-Vingts, Paris, France
    229 schema:name CNRS, UMR_7210, Paris, France
    230 Centre d’Investigation Clinique 503, Inserm-Centre Hospitalier National d’Ophtalmologie des, Quinze-Vingts, Paris, France
    231 Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
    232 Inserm, UMR_S968, Institut de la Vision, Paris, France
    233 UPMC Univ Paris 06, UMR_S968, Institut de la Vision, Paris, France
    234 rdf:type schema:Organization
    235 grid-institutes:grid.417888.a schema:alternateName Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
    236 schema:name CNRS, UMR_7210, Paris, France
    237 Fondation Ophtalmologique Adolphe de Rothschild, Paris, France
    238 Inserm, UMR_S968, Institut de la Vision, Paris, France
    239 UPMC Univ Paris 06, UMR_S968, Institut de la Vision, Paris, France
    240 rdf:type schema:Organization
    241 grid-institutes:grid.482245.d schema:alternateName Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    242 schema:name Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    243 rdf:type schema:Organization
    244 grid-institutes:grid.8591.5 schema:alternateName NCCR Frontiers in Genetics Program, University of Geneva, Geneva, Switzerland
    245 schema:name NCCR Frontiers in Genetics Program, University of Geneva, Geneva, Switzerland
    246 Neural Circuit Laboratories, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    247 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...