Efficient delivery of angiostatin K1-5 into tumors following insertion of an NGR peptide into adenovirus capsid View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-12

AUTHORS

B Jullienne, F Vigant, E Muth, R Chaligné, C Bouquet, S Giraudier, M Perricaudet, K Benihoud

ABSTRACT

Adenovirus (Ad)-mediated delivery of anti-angiogenic molecules into tumors constitutes an appealing approach for growth inhibition. However, lack of expression on tumors of Ad receptors leads to weak tumor transduction. Therefore, to provide Ad with a new entry pathway into tumors, an NGR peptide was inserted into either fiber (AdFNGR) or hexon (AdHNGR) capsid proteins. This strategy provided Ad with a very efficient entry pathway in both endothelial cells and tumor cells, with the highest efficacy observed for AdHNGR. Using pharmacological, biochemical and genetic approaches, AdHNGR and AdFNGR were shown to bind not only to CD13 receptor, but also to alphavbeta3 integrins. Both vectors were efficient tools to deliver angiostatin K1-5 cDNA into endothelial cells, thus leading to a dramatic inhibition of their proliferation and increased cell death. Although AdHNGR and Adwt were found to display similar gene transduction efficacy in Lewis lung carcinoma (LLC), pseudotyping AdHNGR with an Ad3-fiber unmasked the ability of NGR-peptide to target these tumors. As a result, delivery of angiostatin K1-5 cDNA into highly aggressive tumors translated into a stronger inhibition of their growth. Altogether, our results suggest that NGR-bearing Ad are valuable tools to realize the potential of this anti-angiogenic approach to anti-tumor therapy. More... »

PAGES

1405

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/gt.2009.97

DOI

http://dx.doi.org/10.1038/gt.2009.97

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014664513

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19641530


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenoviridae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiostatins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD13 Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Capsid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Lewis Lung", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokine Receptor gp130", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endothelial Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Transfer Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Vectors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligopeptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transduction, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Paris-Sud", 
          "id": "https://www.grid.ac/institutes/grid.5842.b", 
          "name": [
            "CNRS UMR 8121, Vectorologie et Transfert de G\u00e8nes, Institut Gustave Roussy, Villejuif Cedex, France", 
            "Universit\u00e9 Paris\u2212Sud, Orsay Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jullienne", 
        "givenName": "B", 
        "id": "sg:person.01045012247.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045012247.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Paris-Sud", 
          "id": "https://www.grid.ac/institutes/grid.5842.b", 
          "name": [
            "CNRS UMR 8121, Vectorologie et Transfert de G\u00e8nes, Institut Gustave Roussy, Villejuif Cedex, France", 
            "Universit\u00e9 Paris\u2212Sud, Orsay Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vigant", 
        "givenName": "F", 
        "id": "sg:person.0624512035.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624512035.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Paris-Sud", 
          "id": "https://www.grid.ac/institutes/grid.5842.b", 
          "name": [
            "CNRS UMR 8121, Vectorologie et Transfert de G\u00e8nes, Institut Gustave Roussy, Villejuif Cedex, France", 
            "Universit\u00e9 Paris\u2212Sud, Orsay Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Muth", 
        "givenName": "E", 
        "id": "sg:person.01254154622.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254154622.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Paris-Sud", 
          "id": "https://www.grid.ac/institutes/grid.5842.b", 
          "name": [
            "NSERM U790, H\u00e9matopo\u00ef\u00e8se et cellules souches normales et pathologiques, Universit\u00e9 Paris-Sud, Institut Gustave Roussy, Villejuif Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chalign\u00e9", 
        "givenName": "R", 
        "id": "sg:person.0747225154.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747225154.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Onxeo (France)", 
          "id": "https://www.grid.ac/institutes/grid.432920.e", 
          "name": [
            "CNRS UMR 8121, Vectorologie et Transfert de G\u00e8nes, Institut Gustave Roussy, Villejuif Cedex, France", 
            "Bioalliance, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bouquet", 
        "givenName": "C", 
        "id": "sg:person.0651420766.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651420766.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Paris-Sud", 
          "id": "https://www.grid.ac/institutes/grid.5842.b", 
          "name": [
            "NSERM U790, H\u00e9matopo\u00ef\u00e8se et cellules souches normales et pathologiques, Universit\u00e9 Paris-Sud, Institut Gustave Roussy, Villejuif Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giraudier", 
        "givenName": "S", 
        "id": "sg:person.01340652360.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340652360.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Paris-Sud", 
          "id": "https://www.grid.ac/institutes/grid.5842.b", 
          "name": [
            "CNRS UMR 8121, Vectorologie et Transfert de G\u00e8nes, Institut Gustave Roussy, Villejuif Cedex, France", 
            "Universit\u00e9 Paris\u2212Sud, Orsay Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Perricaudet", 
        "givenName": "M", 
        "id": "sg:person.01356122110.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356122110.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Paris-Sud", 
          "id": "https://www.grid.ac/institutes/grid.5842.b", 
          "name": [
            "CNRS UMR 8121, Vectorologie et Transfert de G\u00e8nes, Institut Gustave Roussy, Villejuif Cedex, France", 
            "Universit\u00e9 Paris\u2212Sud, Orsay Cedex, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Benihoud", 
        "givenName": "K", 
        "id": "sg:person.0666311547.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666311547.47"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1006/mthe.2001.0446", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002517780"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005166945", 
          "https://doi.org/10.1038/sj.onc.1209044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005166945", 
          "https://doi.org/10.1038/sj.onc.1209044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005166945", 
          "https://doi.org/10.1038/sj.onc.1209044"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.124.3.373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007113982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1471-4914(02)02429-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007921223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1471-4914(02)02429-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007921223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009118919", 
          "https://doi.org/10.1038/sj.gt.3302474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009118919", 
          "https://doi.org/10.1038/sj.gt.3302474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.80.12.3734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009220557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1026525121027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010171258", 
          "https://doi.org/10.1023/a:1026525121027"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-04-150862", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012067464"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/viro.1999.0171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012568031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jgm.553", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013937388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014799294", 
          "https://doi.org/10.1038/nrc2152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexcr.2005.11.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019835379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1525-0016(03)00182-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020473752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1525-0016(03)00182-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020473752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/mt.2008.132", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021330704"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.74.1.354-362.2000", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023427156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025220143", 
          "https://doi.org/10.1038/sj.gt.3301453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025220143", 
          "https://doi.org/10.1038/sj.gt.3301453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jgm.348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026268733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-5521(03)00169-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028760437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1074-5521(03)00169-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028760437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-2427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030009125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.11.6367", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032303568"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2006.07.051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033042438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.78.9.4454-4462.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036606362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.addr.2005.01.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040266749"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.23.13415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040840601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042592997", 
          "https://doi.org/10.1038/sj.gt.3302249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042592997", 
          "https://doi.org/10.1038/sj.gt.3302249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm197108122850711", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042994614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd2115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043012915", 
          "https://doi.org/10.1038/nrd2115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(94)90200-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045528308"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/mthe.2002.0599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047202151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/10430340150503975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059202161"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/10430340252837215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059202391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005392-199904010-00449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060217086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005392-199904010-00449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060217086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005392-199904010-00449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060217086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1153615", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062457353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.272.5259.263", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062552729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.275.5304.1320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062555928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.279.5349.377", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062559324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074369790", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074454661", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074575244", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074708120", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074800449", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074870459", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074993568", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075314259", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082671836", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083163705", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083345376", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083366816", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083382569", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-12", 
    "datePublishedReg": "2009-12-01", 
    "description": "Adenovirus (Ad)-mediated delivery of anti-angiogenic molecules into tumors constitutes an appealing approach for growth inhibition. However, lack of expression on tumors of Ad receptors leads to weak tumor transduction. Therefore, to provide Ad with a new entry pathway into tumors, an NGR peptide was inserted into either fiber (AdFNGR) or hexon (AdHNGR) capsid proteins. This strategy provided Ad with a very efficient entry pathway in both endothelial cells and tumor cells, with the highest efficacy observed for AdHNGR. Using pharmacological, biochemical and genetic approaches, AdHNGR and AdFNGR were shown to bind not only to CD13 receptor, but also to alphavbeta3 integrins. Both vectors were efficient tools to deliver angiostatin K1-5 cDNA into endothelial cells, thus leading to a dramatic inhibition of their proliferation and increased cell death. Although AdHNGR and Adwt were found to display similar gene transduction efficacy in Lewis lung carcinoma (LLC), pseudotyping AdHNGR with an Ad3-fiber unmasked the ability of NGR-peptide to target these tumors. As a result, delivery of angiostatin K1-5 cDNA into highly aggressive tumors translated into a stronger inhibition of their growth. Altogether, our results suggest that NGR-bearing Ad are valuable tools to realize the potential of this anti-angiogenic approach to anti-tumor therapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/gt.2009.97", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1105638", 
        "issn": [
          "0969-7128", 
          "1476-5462"
        ], 
        "name": "Gene Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Efficient delivery of angiostatin K1-5 into tumors following insertion of an NGR peptide into adenovirus capsid", 
    "pagination": "1405", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "45dd4573f1242828b673b71acd9eec375a5444eb2ef62940dfe6de8322e243f3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19641530"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9421525"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/gt.2009.97"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1014664513"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/gt.2009.97", 
      "https://app.dimensions.ai/details/publication/pub.1014664513"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000345_0000000345/records_64106_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/gt200997"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/gt.2009.97'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/gt.2009.97'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/gt.2009.97'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/gt.2009.97'


 

This table displays all metadata directly associated to this object as RDF triples.

333 TRIPLES      21 PREDICATES      95 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/gt.2009.97 schema:about N01bb585ad73e4cafaf5cc972f50b505b
2 N0a8013d1598142c7993344d39b5be3ea
3 N10ce4cac27a1497588630cd6899dcba4
4 N153a5972df6041f99bf69e86e2f8b05d
5 N16e4151db8e14748a8f61d8fc0794f86
6 N304f426b40254583a13a61737b42225a
7 N6a31ddae94cd40baba0c0f2844679d67
8 N6c622696bea644bc8f399190163f2442
9 N84996a1e19884117bb2fc774f67ebba9
10 N8ba96dbd4d9b4d16b2c2326dc595bd72
11 N9182048d302c4ac5a644b6aeb17ca25e
12 Na53ff124d9f247cca4aabbaa0db45e68
13 Ndbcbc5067ea14cbcaa7638c58549c720
14 Ne60464c9ed5a470ca64767e703e75812
15 Ne9836e481a5344ef902626356c85325a
16 Neff5472e8bab43dc88195b7eb8617547
17 Nf934506f55fb47e1833b72290348b20e
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author Na514fb1e34c2432aa2911fd04663730d
21 schema:citation sg:pub.10.1023/a:1026525121027
22 sg:pub.10.1038/nrc2152
23 sg:pub.10.1038/nrd2115
24 sg:pub.10.1038/sj.gt.3301453
25 sg:pub.10.1038/sj.gt.3302249
26 sg:pub.10.1038/sj.gt.3302474
27 sg:pub.10.1038/sj.onc.1209044
28 https://app.dimensions.ai/details/publication/pub.1074369790
29 https://app.dimensions.ai/details/publication/pub.1074454661
30 https://app.dimensions.ai/details/publication/pub.1074575244
31 https://app.dimensions.ai/details/publication/pub.1074708120
32 https://app.dimensions.ai/details/publication/pub.1074800449
33 https://app.dimensions.ai/details/publication/pub.1074870459
34 https://app.dimensions.ai/details/publication/pub.1074993568
35 https://app.dimensions.ai/details/publication/pub.1075314259
36 https://app.dimensions.ai/details/publication/pub.1082671836
37 https://app.dimensions.ai/details/publication/pub.1083163705
38 https://app.dimensions.ai/details/publication/pub.1083345376
39 https://app.dimensions.ai/details/publication/pub.1083366816
40 https://app.dimensions.ai/details/publication/pub.1083382569
41 https://doi.org/10.1002/jgm.348
42 https://doi.org/10.1002/jgm.553
43 https://doi.org/10.1006/mthe.2001.0446
44 https://doi.org/10.1006/mthe.2002.0599
45 https://doi.org/10.1006/viro.1999.0171
46 https://doi.org/10.1016/0092-8674(94)90200-3
47 https://doi.org/10.1016/j.addr.2005.01.007
48 https://doi.org/10.1016/j.bbrc.2006.07.051
49 https://doi.org/10.1016/j.yexcr.2005.11.015
50 https://doi.org/10.1016/s1074-5521(03)00169-8
51 https://doi.org/10.1016/s1471-4914(02)02429-2
52 https://doi.org/10.1016/s1525-0016(03)00182-5
53 https://doi.org/10.1038/mt.2008.132
54 https://doi.org/10.1056/nejm197108122850711
55 https://doi.org/10.1073/pnas.80.12.3734
56 https://doi.org/10.1073/pnas.95.11.6367
57 https://doi.org/10.1073/pnas.96.23.13415
58 https://doi.org/10.1083/jcb.124.3.373
59 https://doi.org/10.1089/10430340150503975
60 https://doi.org/10.1089/10430340252837215
61 https://doi.org/10.1097/00005392-199904010-00449
62 https://doi.org/10.1126/science.1153615
63 https://doi.org/10.1126/science.272.5259.263
64 https://doi.org/10.1126/science.275.5304.1320
65 https://doi.org/10.1126/science.279.5349.377
66 https://doi.org/10.1128/jvi.74.1.354-362.2000
67 https://doi.org/10.1128/jvi.78.9.4454-4462.2004
68 https://doi.org/10.1158/0008-5472.can-04-2427
69 https://doi.org/10.1182/blood-2008-04-150862
70 schema:datePublished 2009-12
71 schema:datePublishedReg 2009-12-01
72 schema:description Adenovirus (Ad)-mediated delivery of anti-angiogenic molecules into tumors constitutes an appealing approach for growth inhibition. However, lack of expression on tumors of Ad receptors leads to weak tumor transduction. Therefore, to provide Ad with a new entry pathway into tumors, an NGR peptide was inserted into either fiber (AdFNGR) or hexon (AdHNGR) capsid proteins. This strategy provided Ad with a very efficient entry pathway in both endothelial cells and tumor cells, with the highest efficacy observed for AdHNGR. Using pharmacological, biochemical and genetic approaches, AdHNGR and AdFNGR were shown to bind not only to CD13 receptor, but also to alphavbeta3 integrins. Both vectors were efficient tools to deliver angiostatin K1-5 cDNA into endothelial cells, thus leading to a dramatic inhibition of their proliferation and increased cell death. Although AdHNGR and Adwt were found to display similar gene transduction efficacy in Lewis lung carcinoma (LLC), pseudotyping AdHNGR with an Ad3-fiber unmasked the ability of NGR-peptide to target these tumors. As a result, delivery of angiostatin K1-5 cDNA into highly aggressive tumors translated into a stronger inhibition of their growth. Altogether, our results suggest that NGR-bearing Ad are valuable tools to realize the potential of this anti-angiogenic approach to anti-tumor therapy.
73 schema:genre research_article
74 schema:inLanguage en
75 schema:isAccessibleForFree true
76 schema:isPartOf N0fe82874ca2241079ea69cf4fa69d74f
77 Ndeebd981adb54d5a8787cef1f440323a
78 sg:journal.1105638
79 schema:name Efficient delivery of angiostatin K1-5 into tumors following insertion of an NGR peptide into adenovirus capsid
80 schema:pagination 1405
81 schema:productId N51ff99916174409dad3344de75bef854
82 N8bd8cce90be74a169f4f673cc0a1d776
83 Nc4e3d520c652461d988e7559ef7042d4
84 Nd6240a06f2d841f299ba09fdb03f7be2
85 Nf81b4a67f07c429e8a4a6c65c833afae
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014664513
87 https://doi.org/10.1038/gt.2009.97
88 schema:sdDatePublished 2019-04-11T09:25
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher N14787d4ace9e4b07badb323847210b89
91 schema:url https://www.nature.com/articles/gt200997
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N01bb585ad73e4cafaf5cc972f50b505b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Adenoviridae
97 rdf:type schema:DefinedTerm
98 N0a8013d1598142c7993344d39b5be3ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name CD13 Antigens
100 rdf:type schema:DefinedTerm
101 N0fe82874ca2241079ea69cf4fa69d74f schema:volumeNumber 16
102 rdf:type schema:PublicationVolume
103 N10ce4cac27a1497588630cd6899dcba4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Mice
105 rdf:type schema:DefinedTerm
106 N14787d4ace9e4b07badb323847210b89 schema:name Springer Nature - SN SciGraph project
107 rdf:type schema:Organization
108 N153a5972df6041f99bf69e86e2f8b05d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Gene Transfer Techniques
110 rdf:type schema:DefinedTerm
111 N16e4151db8e14748a8f61d8fc0794f86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Neoplasms
113 rdf:type schema:DefinedTerm
114 N1b8e03a353a34a608f8153238d584f86 rdf:first sg:person.01340652360.75
115 rdf:rest Nab9b47e4bac9418d8c83ba37bc9cc38b
116 N304f426b40254583a13a61737b42225a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Angiostatins
118 rdf:type schema:DefinedTerm
119 N38924fc2ab1246c6892513c0c9bbc113 rdf:first sg:person.0651420766.22
120 rdf:rest N1b8e03a353a34a608f8153238d584f86
121 N51ff99916174409dad3344de75bef854 schema:name readcube_id
122 schema:value 45dd4573f1242828b673b71acd9eec375a5444eb2ef62940dfe6de8322e243f3
123 rdf:type schema:PropertyValue
124 N6a31ddae94cd40baba0c0f2844679d67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Genetic Vectors
126 rdf:type schema:DefinedTerm
127 N6c622696bea644bc8f399190163f2442 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Cell Line, Tumor
129 rdf:type schema:DefinedTerm
130 N7b9f2c3a42d4471f9fe3b210b7ba9fac rdf:first sg:person.0666311547.47
131 rdf:rest rdf:nil
132 N84996a1e19884117bb2fc774f67ebba9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Oligopeptides
134 rdf:type schema:DefinedTerm
135 N8543d33417a94356abe506cad58621b1 rdf:first sg:person.0624512035.51
136 rdf:rest Nd8215d1735314b8eb330a52702f5c51a
137 N8ba96dbd4d9b4d16b2c2326dc595bd72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Carcinoma, Lewis Lung
139 rdf:type schema:DefinedTerm
140 N8bd8cce90be74a169f4f673cc0a1d776 schema:name dimensions_id
141 schema:value pub.1014664513
142 rdf:type schema:PropertyValue
143 N9182048d302c4ac5a644b6aeb17ca25e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Animals
145 rdf:type schema:DefinedTerm
146 N944763505eab4dda9272cdc054561bf5 rdf:first sg:person.0747225154.01
147 rdf:rest N38924fc2ab1246c6892513c0c9bbc113
148 Na514fb1e34c2432aa2911fd04663730d rdf:first sg:person.01045012247.53
149 rdf:rest N8543d33417a94356abe506cad58621b1
150 Na53ff124d9f247cca4aabbaa0db45e68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Genetic Therapy
152 rdf:type schema:DefinedTerm
153 Nab9b47e4bac9418d8c83ba37bc9cc38b rdf:first sg:person.01356122110.74
154 rdf:rest N7b9f2c3a42d4471f9fe3b210b7ba9fac
155 Nc4e3d520c652461d988e7559ef7042d4 schema:name doi
156 schema:value 10.1038/gt.2009.97
157 rdf:type schema:PropertyValue
158 Nd6240a06f2d841f299ba09fdb03f7be2 schema:name pubmed_id
159 schema:value 19641530
160 rdf:type schema:PropertyValue
161 Nd8215d1735314b8eb330a52702f5c51a rdf:first sg:person.01254154622.57
162 rdf:rest N944763505eab4dda9272cdc054561bf5
163 Ndbcbc5067ea14cbcaa7638c58549c720 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Capsid
165 rdf:type schema:DefinedTerm
166 Ndeebd981adb54d5a8787cef1f440323a schema:issueNumber 12
167 rdf:type schema:PublicationIssue
168 Ne60464c9ed5a470ca64767e703e75812 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Humans
170 rdf:type schema:DefinedTerm
171 Ne9836e481a5344ef902626356c85325a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Endothelial Cells
173 rdf:type schema:DefinedTerm
174 Neff5472e8bab43dc88195b7eb8617547 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Transduction, Genetic
176 rdf:type schema:DefinedTerm
177 Nf81b4a67f07c429e8a4a6c65c833afae schema:name nlm_unique_id
178 schema:value 9421525
179 rdf:type schema:PropertyValue
180 Nf934506f55fb47e1833b72290348b20e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Cytokine Receptor gp130
182 rdf:type schema:DefinedTerm
183 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
184 schema:name Medical and Health Sciences
185 rdf:type schema:DefinedTerm
186 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
187 schema:name Oncology and Carcinogenesis
188 rdf:type schema:DefinedTerm
189 sg:journal.1105638 schema:issn 0969-7128
190 1476-5462
191 schema:name Gene Therapy
192 rdf:type schema:Periodical
193 sg:person.01045012247.53 schema:affiliation https://www.grid.ac/institutes/grid.5842.b
194 schema:familyName Jullienne
195 schema:givenName B
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01045012247.53
197 rdf:type schema:Person
198 sg:person.01254154622.57 schema:affiliation https://www.grid.ac/institutes/grid.5842.b
199 schema:familyName Muth
200 schema:givenName E
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254154622.57
202 rdf:type schema:Person
203 sg:person.01340652360.75 schema:affiliation https://www.grid.ac/institutes/grid.5842.b
204 schema:familyName Giraudier
205 schema:givenName S
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01340652360.75
207 rdf:type schema:Person
208 sg:person.01356122110.74 schema:affiliation https://www.grid.ac/institutes/grid.5842.b
209 schema:familyName Perricaudet
210 schema:givenName M
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356122110.74
212 rdf:type schema:Person
213 sg:person.0624512035.51 schema:affiliation https://www.grid.ac/institutes/grid.5842.b
214 schema:familyName Vigant
215 schema:givenName F
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624512035.51
217 rdf:type schema:Person
218 sg:person.0651420766.22 schema:affiliation https://www.grid.ac/institutes/grid.432920.e
219 schema:familyName Bouquet
220 schema:givenName C
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651420766.22
222 rdf:type schema:Person
223 sg:person.0666311547.47 schema:affiliation https://www.grid.ac/institutes/grid.5842.b
224 schema:familyName Benihoud
225 schema:givenName K
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0666311547.47
227 rdf:type schema:Person
228 sg:person.0747225154.01 schema:affiliation https://www.grid.ac/institutes/grid.5842.b
229 schema:familyName Chaligné
230 schema:givenName R
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747225154.01
232 rdf:type schema:Person
233 sg:pub.10.1023/a:1026525121027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010171258
234 https://doi.org/10.1023/a:1026525121027
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/nrc2152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014799294
237 https://doi.org/10.1038/nrc2152
238 rdf:type schema:CreativeWork
239 sg:pub.10.1038/nrd2115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043012915
240 https://doi.org/10.1038/nrd2115
241 rdf:type schema:CreativeWork
242 sg:pub.10.1038/sj.gt.3301453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025220143
243 https://doi.org/10.1038/sj.gt.3301453
244 rdf:type schema:CreativeWork
245 sg:pub.10.1038/sj.gt.3302249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042592997
246 https://doi.org/10.1038/sj.gt.3302249
247 rdf:type schema:CreativeWork
248 sg:pub.10.1038/sj.gt.3302474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009118919
249 https://doi.org/10.1038/sj.gt.3302474
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/sj.onc.1209044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005166945
252 https://doi.org/10.1038/sj.onc.1209044
253 rdf:type schema:CreativeWork
254 https://app.dimensions.ai/details/publication/pub.1074369790 schema:CreativeWork
255 https://app.dimensions.ai/details/publication/pub.1074454661 schema:CreativeWork
256 https://app.dimensions.ai/details/publication/pub.1074575244 schema:CreativeWork
257 https://app.dimensions.ai/details/publication/pub.1074708120 schema:CreativeWork
258 https://app.dimensions.ai/details/publication/pub.1074800449 schema:CreativeWork
259 https://app.dimensions.ai/details/publication/pub.1074870459 schema:CreativeWork
260 https://app.dimensions.ai/details/publication/pub.1074993568 schema:CreativeWork
261 https://app.dimensions.ai/details/publication/pub.1075314259 schema:CreativeWork
262 https://app.dimensions.ai/details/publication/pub.1082671836 schema:CreativeWork
263 https://app.dimensions.ai/details/publication/pub.1083163705 schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1083345376 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1083366816 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1083382569 schema:CreativeWork
267 https://doi.org/10.1002/jgm.348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026268733
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1002/jgm.553 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013937388
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1006/mthe.2001.0446 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002517780
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1006/mthe.2002.0599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047202151
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1006/viro.1999.0171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012568031
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/0092-8674(94)90200-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045528308
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.addr.2005.01.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040266749
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.bbrc.2006.07.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033042438
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.yexcr.2005.11.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019835379
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/s1074-5521(03)00169-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028760437
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s1471-4914(02)02429-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007921223
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/s1525-0016(03)00182-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020473752
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1038/mt.2008.132 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021330704
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1056/nejm197108122850711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042994614
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1073/pnas.80.12.3734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009220557
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1073/pnas.95.11.6367 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032303568
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1073/pnas.96.23.13415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040840601
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1083/jcb.124.3.373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007113982
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1089/10430340150503975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202161
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1089/10430340252837215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059202391
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1097/00005392-199904010-00449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060217086
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1126/science.1153615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062457353
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1126/science.272.5259.263 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552729
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1126/science.275.5304.1320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062555928
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1126/science.279.5349.377 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062559324
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1128/jvi.74.1.354-362.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023427156
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1128/jvi.78.9.4454-4462.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036606362
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1158/0008-5472.can-04-2427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030009125
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1182/blood-2008-04-150862 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012067464
324 rdf:type schema:CreativeWork
325 https://www.grid.ac/institutes/grid.432920.e schema:alternateName Onxeo (France)
326 schema:name Bioalliance, Paris, France
327 CNRS UMR 8121, Vectorologie et Transfert de Gènes, Institut Gustave Roussy, Villejuif Cedex, France
328 rdf:type schema:Organization
329 https://www.grid.ac/institutes/grid.5842.b schema:alternateName University of Paris-Sud
330 schema:name CNRS UMR 8121, Vectorologie et Transfert de Gènes, Institut Gustave Roussy, Villejuif Cedex, France
331 NSERM U790, Hématopoïèse et cellules souches normales et pathologiques, Université Paris-Sud, Institut Gustave Roussy, Villejuif Cedex, France
332 Université Paris−Sud, Orsay Cedex, France
333 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...