Engineering ligand-responsive gene-control elements: lessons learned from natural riboswitches View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-10

AUTHORS

K H Link, R R Breaker

ABSTRACT

In the last two decades, remarkable advances have been made in the development of technologies used to engineer new aptamers and ribozymes. This has encouraged interest among researchers who seek to create new types of gene-control systems that can be made to respond specifically to small-molecule signals. Validation of the fact that RNA molecules can exhibit the characteristics needed to serve as precision genetic switches has come from the discovery of numerous classes of natural ligand-sensing RNAs called riboswitches. Although a great deal of progress has been made toward engineering useful designer riboswitches, considerable advances are needed before the performance characteristics of these RNAs match those of protein systems that have been co-opted to regulate gene expression. In this review, we will evaluate the potential for engineered RNAs to regulate gene expression and lay out possible paths to designer riboswitches based on currently available technologies. Furthermore, we will discuss some technical advances that would empower RNA engineers who seek to make routine the production of designer riboswitches that can function in eukaryotes. More... »

PAGES

gt200981

References to SciGraph publications

  • 2007-11. The distributions, mechanisms, and structures of metabolite-binding riboswitches in GENOME BIOLOGY
  • 2008-09. The impact of microRNAs on protein output in NATURE
  • 1999-11-01. Allosteric selection of ribozymes that respond to the second messengers cGMP and cAMP in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2004-09. Exogenous control of mammalian gene expression through modulation of RNA self-cleavage in NATURE
  • 2006-09. Overview of bacterial expression systems for heterologous protein production: from molecular and biochemical fundamentals to commercial systems in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2004-06. Gene regulation by riboswitches in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2007-01. Illuminating the silence: understanding the structure and function of small RNAs in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2001-04. Immobilized RNA switches for the analysis of complex chemical and biological mixtures in NATURE BIOTECHNOLOGY
  • 2004-03. Control of gene expression by a natural metabolite-responsive ribozyme in NATURE
  • 2004-09. B2 RNA binds directly to RNA polymerase II to repress transcript synthesis in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2004-09. The SINE-encoded mouse B2 RNA represses mRNA transcription in response to heat shock in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2005-05. Ribozyme catalysis: not different, just worse in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2002-12. Group I aptazymes as genetic regulatory switches in BMC BIOTECHNOLOGY
  • 2004-04. Gene therapy progress and prospects: transcription regulatory systems in GENE THERAPY
  • 2002-10-16. Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression in NATURE
  • 2005-04. A highly conserved 6S RNA structure is required for regulation of transcription in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-08. A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA in NATURE
  • 2004-12. Natural and engineered nucleic acids as tools to explore biology in NATURE
  • 2003-09. Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2004-07. MicroRNAs: small RNAs with a big role in gene regulation in NATURE REVIEWS GENETICS
  • 2004-01. Adenine riboswitches and gene activation by disruption of a transcription terminator in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008-09. Widespread changes in protein synthesis induced by microRNAs in NATURE
  • 2006-05. RNA synthetic biology in NATURE BIOTECHNOLOGY
  • 2007-05-24. Control of alternative RNA splicing and gene expression by eukaryotic riboswitches in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/gt.2009.81

    DOI

    http://dx.doi.org/10.1038/gt.2009.81

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053537940

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19587710


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