Oncolytic virus therapy for pancreatic cancer using the adenovirus library displaying random peptides on the fiber knob View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-05

AUTHORS

T Nishimoto, K Yoshida, Y Miura, A Kobayashi, H Hara, S Ohnami, K Kurisu, T Yoshida, K Aoki

ABSTRACT

A conditionally replicative adenovirus is a novel anticancer agent designed to replicate selectively in tumor cells. However, a leak of the virus into systemic circulation from the tumors often causes ectopic infection of various organs. Therefore, suppression of naive viral tropism and addition of tumor-targeting potential are necessary to secure patient safety and increase the therapeutic effect of an oncolytic adenovirus in the clinical setting. We have recently developed a direct selection method of targeted vector from a random peptide library displayed on an adenoviral fiber knob to overcome the limitation that many cell type-specific ligands for targeted adenovirus vectors are not known. Here we examined whether the addition of a tumor-targeting ligand to a replication-competent adenovirus ablated for naive tropism enhances its therapeutic index. First, a peptide-display adenovirus library was screened on a pancreatic cancer cell line (AsPC-1), and particular peptide sequences were selected. The replication-competent adenovirus displaying the selected ligand (AdDeltaCAR-SYE) showed higher oncolytic potency in several other pancreatic cancer cell lines as well as AsPC-1 compared with the untargeted adenovirus (AdDeltaCAR). An intratumoral injection of AdDeltaCAR-SYE significantly suppressed the growth of AsPC-1 subcutaneous tumors, and an analysis of adenovirus titer in the tumors revealed an effective replication of the virus in the tumors. Ectopic liver gene transduction following the intratumoral injection of AdDeltaCAR-SYE was not increased compared with the AdDeltaCAR. The results showed that a tumor-targeting strategy using an adenovirus library is promising for optimizing the safety and efficacy of oncolytic adenovirus therapy. More... »

PAGES

gt20091

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/gt.2009.1

DOI

http://dx.doi.org/10.1038/gt.2009.1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005455177

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19225547


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenoviridae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Death", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Vectors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Nude", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncolytic Virotherapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Library", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tissue Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transduction, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Viral Tropism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Virus Replication", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Xenograft Model Antitumor Assays", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hiroshima University", 
          "id": "https://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "Section for Studies on Host-Immune Response, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan", 
            "Department of Neurosurgery, Graduate School of Medicine, Hiroshima University, Minami-ku, Hiroshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishimoto", 
        "givenName": "T", 
        "id": "sg:person.01072157121.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072157121.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Section for Studies on Host-Immune Response, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "K", 
        "id": "sg:person.01367760473.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367760473.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Section for Studies on Host-Immune Response, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miura", 
        "givenName": "Y", 
        "id": "sg:person.014370345602.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014370345602.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Section for Studies on Host-Immune Response, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kobayashi", 
        "givenName": "A", 
        "id": "sg:person.01125663453.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125663453.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Section for Studies on Host-Immune Response, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hara", 
        "givenName": "H", 
        "id": "sg:person.01066175310.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066175310.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Genetics Division, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohnami", 
        "givenName": "S", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hiroshima University", 
          "id": "https://www.grid.ac/institutes/grid.257022.0", 
          "name": [
            "Department of Neurosurgery, Graduate School of Medicine, Hiroshima University, Minami-ku, Hiroshima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurisu", 
        "givenName": "K", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Genetics Division, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "T", 
        "id": "sg:person.014057530702.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014057530702.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Centre", 
          "id": "https://www.grid.ac/institutes/grid.272242.3", 
          "name": [
            "Section for Studies on Host-Immune Response, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Aoki", 
        "givenName": "K", 
        "id": "sg:person.01113535615.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113535615.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ymthe.2005.05.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001561607"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002588566", 
          "https://doi.org/10.1038/sj.bjc.6602713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002588566", 
          "https://doi.org/10.1038/sj.bjc.6602713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6602713", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002588566", 
          "https://doi.org/10.1038/sj.bjc.6602713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/8647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006786374", 
          "https://doi.org/10.1038/8647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/8647", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006786374", 
          "https://doi.org/10.1038/8647"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3303007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014366990", 
          "https://doi.org/10.1038/sj.gt.3303007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(86)91072-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017206168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302830", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017386364", 
          "https://doi.org/10.1038/sj.gt.3302830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302830", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017386364", 
          "https://doi.org/10.1038/sj.gt.3302830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/77283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020669485", 
          "https://doi.org/10.1038/77283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/77283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020669485", 
          "https://doi.org/10.1038/77283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.01.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024393270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025220143", 
          "https://doi.org/10.1038/sj.gt.3301453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3301453", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025220143", 
          "https://doi.org/10.1038/sj.gt.3301453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.75.23.11284-11291.2001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029385882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030158718", 
          "https://doi.org/10.1038/sj.cgt.7700733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cgt.7700733", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030158718", 
          "https://doi.org/10.1038/sj.cgt.7700733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(99)01309-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031870659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/14796694.2.1.137", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033275514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038778689", 
          "https://doi.org/10.1038/sj.gt.3302103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3302103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038778689", 
          "https://doi.org/10.1038/sj.gt.3302103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/mthe.2001.0489", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039255649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-006-0158-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040647291", 
          "https://doi.org/10.1007/s00262-006-0158-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00262-006-0158-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040647291", 
          "https://doi.org/10.1007/s00262-006-0158-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt856", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041089332", 
          "https://doi.org/10.1038/nbt856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt856", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041089332", 
          "https://doi.org/10.1038/nbt856"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00063030-200216020-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044281217", 
          "https://doi.org/10.2165/00063030-200216020-00001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00063030-200216020-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044281217", 
          "https://doi.org/10.2165/00063030-200216020-00001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045507199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/path.1896", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045507199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2005.01.080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047005128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1998.5271", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048824566"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2004.tb03204.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049325154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1349-7006.2004.tb03204.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049325154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3300914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049931617", 
          "https://doi.org/10.1038/sj.gt.3300914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gt.3300914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049931617", 
          "https://doi.org/10.1038/sj.gt.3300914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jgm.526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050468554"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074495012", 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03402119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074507569", 
          "https://doi.org/10.1007/bf03402119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074767480", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074870426", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075012380", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076839532", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082989496", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083026699", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-05", 
    "datePublishedReg": "2009-05-01", 
    "description": "A conditionally replicative adenovirus is a novel anticancer agent designed to replicate selectively in tumor cells. However, a leak of the virus into systemic circulation from the tumors often causes ectopic infection of various organs. Therefore, suppression of naive viral tropism and addition of tumor-targeting potential are necessary to secure patient safety and increase the therapeutic effect of an oncolytic adenovirus in the clinical setting. We have recently developed a direct selection method of targeted vector from a random peptide library displayed on an adenoviral fiber knob to overcome the limitation that many cell type-specific ligands for targeted adenovirus vectors are not known. Here we examined whether the addition of a tumor-targeting ligand to a replication-competent adenovirus ablated for naive tropism enhances its therapeutic index. First, a peptide-display adenovirus library was screened on a pancreatic cancer cell line (AsPC-1), and particular peptide sequences were selected. The replication-competent adenovirus displaying the selected ligand (AdDeltaCAR-SYE) showed higher oncolytic potency in several other pancreatic cancer cell lines as well as AsPC-1 compared with the untargeted adenovirus (AdDeltaCAR). An intratumoral injection of AdDeltaCAR-SYE significantly suppressed the growth of AsPC-1 subcutaneous tumors, and an analysis of adenovirus titer in the tumors revealed an effective replication of the virus in the tumors. Ectopic liver gene transduction following the intratumoral injection of AdDeltaCAR-SYE was not increased compared with the AdDeltaCAR. The results showed that a tumor-targeting strategy using an adenovirus library is promising for optimizing the safety and efficacy of oncolytic adenovirus therapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/gt.2009.1", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1105638", 
        "issn": [
          "0969-7128", 
          "1476-5462"
        ], 
        "name": "Gene Therapy", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "16"
      }
    ], 
    "name": "Oncolytic virus therapy for pancreatic cancer using the adenovirus library displaying random peptides on the fiber knob", 
    "pagination": "gt20091", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "19fdebd9f1fdc193782ec16e5a9b4f91b23a4041c130bfb0695b15b3e102c18f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "19225547"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9421525"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/gt.2009.1"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005455177"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/gt.2009.1", 
      "https://app.dimensions.ai/details/publication/pub.1005455177"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000421.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/gt20091"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/gt.2009.1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/gt.2009.1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/gt.2009.1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/gt.2009.1'


 

This table displays all metadata directly associated to this object as RDF triples.

302 TRIPLES      21 PREDICATES      79 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/gt.2009.1 schema:about N187b002345dc478cb6968a870575120d
2 N19161f6cbfae49abb194d47227ebc016
3 N26ea00e2e746467f860e1c9d25186ecf
4 N3c90bdba75f945eebf03ae82a7791bc5
5 N49bb9191327849f887e09fd32c3dcfc4
6 N5d79f10e112b44b2b873306058ac1e1d
7 N664d4abaad6f4ff0ab4761e083145e36
8 N71cce994c770459cbfcdfe2ce1ab559d
9 N96d750c450164186be8db6b7cfb7ec10
10 Nbcdac996d09f4ab1bb7198dcc92bfb10
11 Nbd335ea76760477bbbc99ff1843fc39b
12 Nbd7bc29d19264023957bab7372a7a52b
13 Nc6ef54346a114d28b58260a568a2a17f
14 Neda107d0711a4fc9a9513547d2f21fe4
15 Nf46e2828907341d8b3bb65961b67c51a
16 Nf6d75f3f1d5c4a198c1a41ce335bfef2
17 Nf71e0de8892a4a7aa5f94d61c1585900
18 Nf9930c2ff19a4089999a02e09428a15e
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author N0a0b6b9c42e64126bb1762143850f96c
22 schema:citation sg:pub.10.1007/bf03402119
23 sg:pub.10.1007/s00262-006-0158-2
24 sg:pub.10.1038/77283
25 sg:pub.10.1038/8647
26 sg:pub.10.1038/nbt856
27 sg:pub.10.1038/sj.bjc.6602713
28 sg:pub.10.1038/sj.cgt.7700733
29 sg:pub.10.1038/sj.gt.3300914
30 sg:pub.10.1038/sj.gt.3301453
31 sg:pub.10.1038/sj.gt.3302103
32 sg:pub.10.1038/sj.gt.3302830
33 sg:pub.10.1038/sj.gt.3303007
34 sg:pub.10.2165/00063030-200216020-00001
35 https://app.dimensions.ai/details/publication/pub.1074495012
36 https://app.dimensions.ai/details/publication/pub.1074767480
37 https://app.dimensions.ai/details/publication/pub.1074870426
38 https://app.dimensions.ai/details/publication/pub.1075012380
39 https://app.dimensions.ai/details/publication/pub.1076839532
40 https://app.dimensions.ai/details/publication/pub.1082989496
41 https://app.dimensions.ai/details/publication/pub.1083026699
42 https://doi.org/10.1002/jgm.526
43 https://doi.org/10.1002/path.1896
44 https://doi.org/10.1006/geno.1998.5271
45 https://doi.org/10.1006/mthe.2001.0489
46 https://doi.org/10.1016/0006-291x(86)91072-7
47 https://doi.org/10.1016/j.bbrc.2005.01.080
48 https://doi.org/10.1016/j.cell.2008.01.016
49 https://doi.org/10.1016/j.ymthe.2005.05.008
50 https://doi.org/10.1016/s0014-5793(99)01309-5
51 https://doi.org/10.1111/j.1349-7006.2004.tb03204.x
52 https://doi.org/10.1128/jvi.75.23.11284-11291.2001
53 https://doi.org/10.2217/14796694.2.1.137
54 schema:datePublished 2009-05
55 schema:datePublishedReg 2009-05-01
56 schema:description A conditionally replicative adenovirus is a novel anticancer agent designed to replicate selectively in tumor cells. However, a leak of the virus into systemic circulation from the tumors often causes ectopic infection of various organs. Therefore, suppression of naive viral tropism and addition of tumor-targeting potential are necessary to secure patient safety and increase the therapeutic effect of an oncolytic adenovirus in the clinical setting. We have recently developed a direct selection method of targeted vector from a random peptide library displayed on an adenoviral fiber knob to overcome the limitation that many cell type-specific ligands for targeted adenovirus vectors are not known. Here we examined whether the addition of a tumor-targeting ligand to a replication-competent adenovirus ablated for naive tropism enhances its therapeutic index. First, a peptide-display adenovirus library was screened on a pancreatic cancer cell line (AsPC-1), and particular peptide sequences were selected. The replication-competent adenovirus displaying the selected ligand (AdDeltaCAR-SYE) showed higher oncolytic potency in several other pancreatic cancer cell lines as well as AsPC-1 compared with the untargeted adenovirus (AdDeltaCAR). An intratumoral injection of AdDeltaCAR-SYE significantly suppressed the growth of AsPC-1 subcutaneous tumors, and an analysis of adenovirus titer in the tumors revealed an effective replication of the virus in the tumors. Ectopic liver gene transduction following the intratumoral injection of AdDeltaCAR-SYE was not increased compared with the AdDeltaCAR. The results showed that a tumor-targeting strategy using an adenovirus library is promising for optimizing the safety and efficacy of oncolytic adenovirus therapy.
57 schema:genre research_article
58 schema:inLanguage en
59 schema:isAccessibleForFree true
60 schema:isPartOf N139ed5d3d606406bb658d5526c12b787
61 N9d27e0d56868487f9c13d38af9fbece8
62 sg:journal.1105638
63 schema:name Oncolytic virus therapy for pancreatic cancer using the adenovirus library displaying random peptides on the fiber knob
64 schema:pagination gt20091
65 schema:productId N51b5f24322cd423992ea2939bc1ddc65
66 N83fa1064d9db41f49388655017954876
67 N90235168b2b8480eb243c2e2400b27e7
68 N9fa0d1b33658486eb2688619a884c2e2
69 Nc1b5ced4a1fc4a60a2fe6be1d7f4e565
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005455177
71 https://doi.org/10.1038/gt.2009.1
72 schema:sdDatePublished 2019-04-10T19:45
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N3099311fb0994f21b7b8132522d86ce1
75 schema:url http://www.nature.com/articles/gt20091
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N0a0b6b9c42e64126bb1762143850f96c rdf:first sg:person.01072157121.05
80 rdf:rest N20185c3810204ee4aca2e83007b58635
81 N0d19aaec807f45988af5501f2af63d42 rdf:first sg:person.014057530702.35
82 rdf:rest Nfcf811383b21426e9c502fe8530c8d21
83 N139ed5d3d606406bb658d5526c12b787 schema:issueNumber 5
84 rdf:type schema:PublicationIssue
85 N187b002345dc478cb6968a870575120d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Humans
87 rdf:type schema:DefinedTerm
88 N19161f6cbfae49abb194d47227ebc016 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Mice
90 rdf:type schema:DefinedTerm
91 N20185c3810204ee4aca2e83007b58635 rdf:first sg:person.01367760473.05
92 rdf:rest Nc85aa3fceb1a409998ebc36845d3e0a8
93 N26ea00e2e746467f860e1c9d25186ecf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Mice, Inbred BALB C
95 rdf:type schema:DefinedTerm
96 N3099311fb0994f21b7b8132522d86ce1 schema:name Springer Nature - SN SciGraph project
97 rdf:type schema:Organization
98 N3c90bdba75f945eebf03ae82a7791bc5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Xenograft Model Antitumor Assays
100 rdf:type schema:DefinedTerm
101 N49bb9191327849f887e09fd32c3dcfc4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Mice, Nude
103 rdf:type schema:DefinedTerm
104 N51b5f24322cd423992ea2939bc1ddc65 schema:name pubmed_id
105 schema:value 19225547
106 rdf:type schema:PropertyValue
107 N5bae5d9ba0c14c3ea97081ae760b80d5 rdf:first sg:person.01066175310.45
108 rdf:rest N76e0d505bcfb45cd902b5a140cbe4d64
109 N5d79f10e112b44b2b873306058ac1e1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Genetic Vectors
111 rdf:type schema:DefinedTerm
112 N5df4e3042f7641bab671c5707bc9d4b3 schema:affiliation https://www.grid.ac/institutes/grid.257022.0
113 schema:familyName Kurisu
114 schema:givenName K
115 rdf:type schema:Person
116 N664d4abaad6f4ff0ab4761e083145e36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Virus Replication
118 rdf:type schema:DefinedTerm
119 N71cce994c770459cbfcdfe2ce1ab559d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Adenoviridae
121 rdf:type schema:DefinedTerm
122 N76e0d505bcfb45cd902b5a140cbe4d64 rdf:first Ndb6eb1cedff44bc286620eba0ed2f02e
123 rdf:rest Neb559985f38c48cfb4e5f409b2ae35d1
124 N83fa1064d9db41f49388655017954876 schema:name readcube_id
125 schema:value 19fdebd9f1fdc193782ec16e5a9b4f91b23a4041c130bfb0695b15b3e102c18f
126 rdf:type schema:PropertyValue
127 N8f1789dfc38e45d9933131aa1f9cee49 rdf:first sg:person.01125663453.05
128 rdf:rest N5bae5d9ba0c14c3ea97081ae760b80d5
129 N90235168b2b8480eb243c2e2400b27e7 schema:name dimensions_id
130 schema:value pub.1005455177
131 rdf:type schema:PropertyValue
132 N96d750c450164186be8db6b7cfb7ec10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Peptide Library
134 rdf:type schema:DefinedTerm
135 N9d27e0d56868487f9c13d38af9fbece8 schema:volumeNumber 16
136 rdf:type schema:PublicationVolume
137 N9fa0d1b33658486eb2688619a884c2e2 schema:name nlm_unique_id
138 schema:value 9421525
139 rdf:type schema:PropertyValue
140 Nbcdac996d09f4ab1bb7198dcc92bfb10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Transduction, Genetic
142 rdf:type schema:DefinedTerm
143 Nbd335ea76760477bbbc99ff1843fc39b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Viral Tropism
145 rdf:type schema:DefinedTerm
146 Nbd7bc29d19264023957bab7372a7a52b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Tumor Cells, Cultured
148 rdf:type schema:DefinedTerm
149 Nc1b5ced4a1fc4a60a2fe6be1d7f4e565 schema:name doi
150 schema:value 10.1038/gt.2009.1
151 rdf:type schema:PropertyValue
152 Nc6ef54346a114d28b58260a568a2a17f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Female
154 rdf:type schema:DefinedTerm
155 Nc85aa3fceb1a409998ebc36845d3e0a8 rdf:first sg:person.014370345602.80
156 rdf:rest N8f1789dfc38e45d9933131aa1f9cee49
157 Ndb6eb1cedff44bc286620eba0ed2f02e schema:affiliation https://www.grid.ac/institutes/grid.272242.3
158 schema:familyName Ohnami
159 schema:givenName S
160 rdf:type schema:Person
161 Neb559985f38c48cfb4e5f409b2ae35d1 rdf:first N5df4e3042f7641bab671c5707bc9d4b3
162 rdf:rest N0d19aaec807f45988af5501f2af63d42
163 Neda107d0711a4fc9a9513547d2f21fe4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Cell Death
165 rdf:type schema:DefinedTerm
166 Nf46e2828907341d8b3bb65961b67c51a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Tissue Distribution
168 rdf:type schema:DefinedTerm
169 Nf6d75f3f1d5c4a198c1a41ce335bfef2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Oncolytic Virotherapy
171 rdf:type schema:DefinedTerm
172 Nf71e0de8892a4a7aa5f94d61c1585900 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Pancreatic Neoplasms
174 rdf:type schema:DefinedTerm
175 Nf9930c2ff19a4089999a02e09428a15e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Animals
177 rdf:type schema:DefinedTerm
178 Nfcf811383b21426e9c502fe8530c8d21 rdf:first sg:person.01113535615.46
179 rdf:rest rdf:nil
180 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
181 schema:name Medical and Health Sciences
182 rdf:type schema:DefinedTerm
183 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
184 schema:name Oncology and Carcinogenesis
185 rdf:type schema:DefinedTerm
186 sg:journal.1105638 schema:issn 0969-7128
187 1476-5462
188 schema:name Gene Therapy
189 rdf:type schema:Periodical
190 sg:person.01066175310.45 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
191 schema:familyName Hara
192 schema:givenName H
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066175310.45
194 rdf:type schema:Person
195 sg:person.01072157121.05 schema:affiliation https://www.grid.ac/institutes/grid.257022.0
196 schema:familyName Nishimoto
197 schema:givenName T
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072157121.05
199 rdf:type schema:Person
200 sg:person.01113535615.46 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
201 schema:familyName Aoki
202 schema:givenName K
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113535615.46
204 rdf:type schema:Person
205 sg:person.01125663453.05 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
206 schema:familyName Kobayashi
207 schema:givenName A
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01125663453.05
209 rdf:type schema:Person
210 sg:person.01367760473.05 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
211 schema:familyName Yoshida
212 schema:givenName K
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01367760473.05
214 rdf:type schema:Person
215 sg:person.014057530702.35 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
216 schema:familyName Yoshida
217 schema:givenName T
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014057530702.35
219 rdf:type schema:Person
220 sg:person.014370345602.80 schema:affiliation https://www.grid.ac/institutes/grid.272242.3
221 schema:familyName Miura
222 schema:givenName Y
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014370345602.80
224 rdf:type schema:Person
225 sg:pub.10.1007/bf03402119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074507569
226 https://doi.org/10.1007/bf03402119
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/s00262-006-0158-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040647291
229 https://doi.org/10.1007/s00262-006-0158-2
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/77283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020669485
232 https://doi.org/10.1038/77283
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/8647 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006786374
235 https://doi.org/10.1038/8647
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/nbt856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041089332
238 https://doi.org/10.1038/nbt856
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/sj.bjc.6602713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002588566
241 https://doi.org/10.1038/sj.bjc.6602713
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/sj.cgt.7700733 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030158718
244 https://doi.org/10.1038/sj.cgt.7700733
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/sj.gt.3300914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049931617
247 https://doi.org/10.1038/sj.gt.3300914
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/sj.gt.3301453 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025220143
250 https://doi.org/10.1038/sj.gt.3301453
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/sj.gt.3302103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038778689
253 https://doi.org/10.1038/sj.gt.3302103
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/sj.gt.3302830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017386364
256 https://doi.org/10.1038/sj.gt.3302830
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/sj.gt.3303007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014366990
259 https://doi.org/10.1038/sj.gt.3303007
260 rdf:type schema:CreativeWork
261 sg:pub.10.2165/00063030-200216020-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044281217
262 https://doi.org/10.2165/00063030-200216020-00001
263 rdf:type schema:CreativeWork
264 https://app.dimensions.ai/details/publication/pub.1074495012 schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1074767480 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1074870426 schema:CreativeWork
267 https://app.dimensions.ai/details/publication/pub.1075012380 schema:CreativeWork
268 https://app.dimensions.ai/details/publication/pub.1076839532 schema:CreativeWork
269 https://app.dimensions.ai/details/publication/pub.1082989496 schema:CreativeWork
270 https://app.dimensions.ai/details/publication/pub.1083026699 schema:CreativeWork
271 https://doi.org/10.1002/jgm.526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050468554
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1002/path.1896 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045507199
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1006/geno.1998.5271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048824566
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1006/mthe.2001.0489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039255649
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/0006-291x(86)91072-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017206168
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.bbrc.2005.01.080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047005128
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.cell.2008.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024393270
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.ymthe.2005.05.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001561607
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/s0014-5793(99)01309-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031870659
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1111/j.1349-7006.2004.tb03204.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049325154
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1128/jvi.75.23.11284-11291.2001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029385882
292 rdf:type schema:CreativeWork
293 https://doi.org/10.2217/14796694.2.1.137 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033275514
294 rdf:type schema:CreativeWork
295 https://www.grid.ac/institutes/grid.257022.0 schema:alternateName Hiroshima University
296 schema:name Department of Neurosurgery, Graduate School of Medicine, Hiroshima University, Minami-ku, Hiroshima, Japan
297 Section for Studies on Host-Immune Response, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan
298 rdf:type schema:Organization
299 https://www.grid.ac/institutes/grid.272242.3 schema:alternateName National Cancer Centre
300 schema:name Genetics Division, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan
301 Section for Studies on Host-Immune Response, National Cancer Center Research Institute, Chuo-ku, Tokyo, Japan
302 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...