KIR-associated protection from CMV replication requires pre-existing immunity: a prospective study in solid organ transplant recipients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-07-10

AUTHORS

A Gonzalez, K Schmitter, H H Hirsch, C Garzoni, C van Delden, K Boggian, N J Mueller, C Berger, J Villard, O Manuel, P Meylan, M Stern, C Hess

ABSTRACT

Previous studies have associated activating Killer cell Immunoglobulin-like Receptor (KIR) genes with protection from cytomegalovirus (CMV) replication after organ transplantation. Whether KIR-associated protection is operating in the context of primary infection, re-activation, or both, remains unknown. Here we correlated KIR genotype and CMV serostatus at the time of transplantation with rates of CMV viremia in 517 heart (n=57), kidney (n=223), liver (n=165) or lung (n=72) allograft recipients reported to the Swiss Transplant Cohort Study. Across the entire cohort we found B haplotypes—which in contrast to A haplotypes may contain multiple activating KIR genes—to be protective in the most immunosuppressed patients (receiving anti-thymocyte globulin induction and intensive maintenance immunosuppression) (hazard ratio after adjustment for covariates 0.46, 95% confidence interval 0.29–0.75, P=0.002). Notably, a significant protection was detected only in recipients who were CMV-seropositive at the time of transplantation (HR 0.45, 95% CI 0.26–0.77, P=0.004), but not in CMV seronegative recipients (HR 0.59, 95% CI 0.22–1.53, P=0.28). These data indicate a prominent role for KIR—and presumably natural killer (NK) cells—in the control of CMV replication in CMV seropositive organ transplant recipients treated with intense immunosuppression. More... »

PAGES

495-499

Journal

TITLE

Genes & Immunity

ISSUE

7

VOLUME

15

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/gene.2014.39

DOI

http://dx.doi.org/10.1038/gene.2014.39

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048007899

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25008861


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