TIM polymorphisms—genetics and function View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

J Lee, B Phong, A M Egloff, L P Kane

ABSTRACT

The transmembrane immunoglobulin and mucin domain (TIM) family was identified more than a decade ago. Although the founding member of the family was first described in a rat model of ischemia-reperfusion injury, much of the recent interest in the TIM family members has focused on their potential roles in immunity. There are now a large number of genetic studies that have investigated the possible association of various TIM1 and TIM3 polymorphisms with different diseases. Here, we review this body of literature, and highlight some of the most interesting studies. More... »

PAGES

595

References to SciGraph publications

  • 2009-06. Hepatitis A outbreaks in China during 2006: application of molecular epidemiology in HEPATOLOGY INTERNATIONAL
  • 2005-01. The polymorphisms of Tim-1 promoter region are associated with rheumatoid arthritis in a Korean population in IMMUNOGENETICS
  • 2012-04. Underexpression of TIM-3 and Blunted Galectin-9-Induced Apoptosis of CD4+ T Cells in Rheumatoid Arthritis in INFLAMMATION
  • 2004-02. TIM-1, a novel allergy and asthma susceptibility gene in SEMINARS IN IMMUNOPATHOLOGY
  • 2003-03. Insertion/deletion coding polymorphisms in hHAVcr-1 are not associated with atopic asthma in the Japanese population in GENES & IMMUNITY
  • 2010-08. Identification of HAVCR1 gene haplotypes associated with mRNA expression levels and susceptibility to autoimmune diseases in HUMAN GENETICS
  • 2003-10. Immunology: Hepatitis A virus link to atopic disease in NATURE
  • 2005-05. TIM-4 is the ligand for TIM-1, and the TIM-1–TIM-4 interaction regulates T cell proliferation in NATURE IMMUNOLOGY
  • 2002-01. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease in NATURE
  • 2003-06. The TIM gene family: emerging roles in immunity and disease in NATURE REVIEWS IMMUNOLOGY
  • 2002-07. Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury in KIDNEY INTERNATIONAL
  • 2001-12. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family in NATURE IMMUNOLOGY
  • 2006-09. Immune regulation by the TIM gene family in IMMUNOLOGIC RESEARCH
  • 2005-08. Evidence for natural selection in the HAVCR1 gene: high degree of amino-acid variability in the mucin domain of human HAVCR1 protein in GENES & IMMUNITY
  • Journal

    TITLE

    Genes & Immunity

    ISSUE

    8

    VOLUME

    12

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/gene.2011.75

    DOI

    http://dx.doi.org/10.1038/gene.2011.75

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1038165502

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22048452


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