A population-specific diabetogenic haplotype HLA-A2,Cw1,B56,DR4,DQ8 is associated with high birthweight in Finnish diabetic families View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-02-14

AUTHORS

T M Järvinen, V Harjutsalo, L Kinnunen, M E Miettinen, E Tuomilehto-Wolf, J Tuomilehto

ABSTRACT

Children with type 1 diabetes (T1D) susceptibility HLA genotypes are shown to have an increased birthweight. We investigated to what extent T1D-predisposing HLA haplotypes were associated with increased birthweight. A total of 1255 Finnish children comprising those with T1D and their non-diabetic siblings were investigated. A total of 342 children and their non-diabetic parents were HLA genotyped. Birthweight data were obtained from the national Medical Birth Registry. The population-specific diabetogenic haplotype HLA-A2,Cw1,B56,DR4,DQ8 was associated with high birthweight (P=0.0280) in families with a diabetic offspring. Other T1D-predisposing HLA haplotypes showed nonsignificant tendency with high birthweight. More infants with a birthweight ⩾4000 g were born in families with a T1D offspring than in the general Finnish population (P=0.0139). The previously observed direct association between birthweight and T1D risk may be mediated through the modulating effects that T1D susceptibility HLA genes have on weight. High birthweight and subsequent weight gain may accelerate the ongoing pancreatic autoimmune process in genetically susceptible individuals. The high proportion of infants having a birthweight ⩾4000 g in families with a diabetic offspring raises a concern of potential adverse health outcomes that high birthweight can have. More... »

PAGES

207-213

References to SciGraph publications

  • 2007-04-04. Relationship between increased relative birthweight and infections during pregnancy in children with a high-risk diabetes HLA genotype in DIABETOLOGIA
  • 2006-05-12. The relation between size at birth and risk of type 1 diabetes is not influenced by adjustment for the insulin gene (-23HphI) polymorphism or HLA-DQ genotype in DIABETOLOGIA
  • 1999-12. Worldwide increase in incidence of Type I diabetes – the analysis of the data on published incidence trends in DIABETOLOGIA
  • 2003-09. Environmental Triggers and Determinants of Beta-Cell Autoimmunity and Type 1 Diabetes in REVIEWS IN ENDOCRINE AND METABOLIC DISORDERS
  • 1992-03. HLA haplotypes in Type 1 (insulin-dependent) diabetes mellitus: molecular analysis of the HLA-DQ locus in DIABETOLOGIA
  • 2005-07-01. Diabetes-associated HLA genotypes affect birthweight in the general population in DIABETOLOGIA
  • 2005-04-30. Birthweight and risk of type 1 diabetes in children and young adults: a population-based register study in DIABETOLOGIA
  • 1997-02. Nordic Medical Birth Registers in epidemiological research in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 1994-01. A high weight gain early in life is associated with an increased risk of Type 1 (insulin-dependent) diabetes mellitus in DIABETOLOGIA
  • 1994-09. A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population in DIABETOLOGIA
  • 2002-03-28. Secular trends in overweight and obesity among Finnish adolescents in 1977–1999 in INTERNATIONAL JOURNAL OF OBESITY
  • 2003-03-18. Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes—indication of an increased environmental pressure? in DIABETOLOGIA
  • 2007-02-20. Fetal growth is increased by maternal type 1 diabetes and HLA DR4-related gene interactions in DIABETOLOGIA
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/gene.2008.3

    DOI

    http://dx.doi.org/10.1038/gene.2008.3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019031667

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18273034


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