Revisiting the role of erythropoietin for treatment of ocular disorders View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-10

AUTHORS

S L Shirley Ding, S N Leow, R Munisvaradass, E H Koh, M L C Bastion, K Y Then, S Kumar, P L Mok

ABSTRACT

Erythropoietin (EPO) is a glycoprotein hormone conventionally thought to be responsible only in producing red blood cells in our body. However, with the discovery of the presence of EPO and EPO receptors in the retinal layers, the EPO seems to have physiological roles in the eye. In this review, we revisit the role of EPO in the eye. We look into the biological role of EPO in the development of the eye and the physiologic roles that it has. Apart from that, we seek to understand the mechanisms and pathways of EPO that contributes to the therapeutic and pathological conditions of the various ocular disorders such as diabetic retinopathy, retinopathy of prematurity, glaucoma, age-related macular degeneration, optic neuritis, and retinal detachment. With these understandings, we discuss the clinical applications of EPO for treatment of ocular disorders, modes of administration, EPO formulations, current clinical trials, and its future directions. More... »

PAGES

1293-1309

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/eye.2016.94

    DOI

    http://dx.doi.org/10.1038/eye.2016.94

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1024639720

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27285322


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    556 Department of Medical Microbiology and Parasitology, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.
    557 Genetics and Regenerative Medicine Research Centre, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.
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    559 https://www.grid.ac/institutes/grid.240541.6 schema:alternateName University Kebangsaan Malaysia Medical Centre
    560 schema:name Department of Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.
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    562 https://www.grid.ac/institutes/grid.413461.5 schema:alternateName Sultanah Aminah Hospital
    563 schema:name Department of Ophthalmology, Hospital Sultanah Aminah, Johor Bahru, Malaysia.
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