Drusen prevalence and pigmentary changes in Caucasians aged 18–54 years View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-10

AUTHORS

G Silvestri, M A Williams, C McAuley, K Oakes, E Sillery, D C Henderson, S Ferguson, V Silvestri, K A Muldrew

ABSTRACT

AIMS AND PURPOSE: The aim of this study was to describe the prevalence and characteristics of drusen and pigmentary changes in a middle-aged population. METHODS: Retinal images from 500 individuals aged 18-54 years were included. The source of participants was two UK optometry practices. Retinal images were graded using the Wisconsin Age-Related Maculopathy Grading System. However, owing to the relatively young age of the population studied, a new category of drusen of smaller size (<31.5 μm) was introduced. RESULTS: Drusen were identified within the central macular grid in 91.48% of all gradable eyes and in 444 subjects. Drusen sized <31.5 μm were present in 89.7% of eyes, drusen sized >31.5 μm and <63 μm were present in 45.9% of all eyes and drusen >63 μm and <125 μm were present in only 1.7% of eyes. No eye had drusen larger or equal to 125 μm. Very few eyes (1.2%) showed pigmentary changes within the grid. Drusen load increased with increasing age, P <0.001. CONCLUSIONS: The frequency of drusen in a younger Caucasian population aged 18-54 years is high, with 91.48% of all gradable eyes having drusen. The most frequent drusen subtype was hard distinct drusen <31.5 μm. No druse greater or equal in size to 125 μm was seen. Pigmentary changes are rare. More... »

PAGES

1357

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/eye.2012.165

DOI

http://dx.doi.org/10.1038/eye.2012.165

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048812008

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22899005


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