Acanthamoeba keratitis—Resistance to medical therapy View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1990-11

AUTHORS

Linda Ficker, David Seal, David Warhurst, Peter Wright

ABSTRACT

Successful medical therapy of Acanthamoeba keratitis has been reported with combination therapy; topical Brolene and neomycin. Resistance has not so far been identified as a problem, but was the basis for recurrent disease observed in a patient with bilateral infection. Eradication of amoebae was finally achieved following prolonged topical therapy and two corneal grafts in each eye. Topical anti-amoebic therapy with paromomycin, benzethonium chloride, clotrimazole and R11/29 (a phenanthridinium compound), was continued for three months post-operatively. No further recurrences occurred during 14 months' follow-up. Drug sensitivities were performed for three isolates of Acanthamoeba sp (group II) which demonstrated the development of resistance to Brolene and arsenic. In addition, the resistant isolates were temperature-sensitive mutants which would not grow at temperatures above 30 degrees C. This could explain 'culture-negative' results in some cases of clinical recurrence when incubation of laboratory samples had only been performed at 37 degrees C. More... »

PAGES

eye1990132

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/eye.1990.132

DOI

http://dx.doi.org/10.1038/eye.1990.132

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011238828

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2101116


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