Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-07-07

AUTHORS

No-Joon Song, Seo-Hyuk Chang, Dean Y Li, Claudio J Villanueva, Kye Won Park

ABSTRACT

Adipose tissue is a central metabolic organ that controls energy homeostasis of the whole body. White adipose tissue (WAT) stores excess energy in the form of triglycerides, whereas brown adipose tissue (BAT) dissipates energy in the form of heat through mitochondrial uncoupling protein 1 (Ucp1). A newly identified adipose tissue called 'beige fat' (BAT-like) is produced through a process called WAT browning. This tissue mainly resides in WAT depots and displays intermediate characteristics of both WAT and BAT. Since the recent discovery of BAT in the human body, along with the identification of molecular targets for BAT activation, stimulating energy expenditure has been considered as a great strategy to treat human obesity and metabolic diseases. Here we summarize recent findings regarding molecular targets and thermogenic small molecules that can stimulate BAT and increase energy expenditure, with an emphasis on possible therapeutic applications in humans. More... »

PAGES

e353

References to SciGraph publications

  • 2013-12. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex in NATURE
  • 2015-12. Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue in NATURE COMMUNICATIONS
  • 2002-01. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase in NATURE
  • 2014-12. Berberine activates thermogenesis in white and brown adipose tissue in NATURE COMMUNICATIONS
  • 2011-09. 2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death in JOURNAL OF MEDICAL TOXICOLOGY
  • 2014-12-08. White-to-brown metabolic conversion of human adipocytes by JAK inhibition in NATURE CELL BIOLOGY
  • 2010-12. Determinants of brown adipocyte development and thermogenesis in INTERNATIONAL JOURNAL OF OBESITY
  • 2015-12. Russian roulette with unlicensed fat-burner drug 2,4-dinitrophenol (DNP): evidence from a multidisciplinary study of the internet, bodybuilding supplements and DNP users in SUBSTANCE ABUSE TREATMENT, PREVENTION, AND POLICY
  • 2010-10. Sympathetic and sensory innervation of brown adipose tissue in INTERNATIONAL JOURNAL OF OBESITY
  • 2014-04. Phenolic extractives in the trunk of Toxicodendron vernicifluum: chemical characteristics, contents and radial distribution in JOURNAL OF WOOD SCIENCE
  • 2016-12. 7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders in TRANSLATIONAL NEURODEGENERATION
  • 2014-08. Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity in NATURE MEDICINE
  • 2006-12. Adipocyte differentiation from the inside out in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2002-11. Cachexia in cancer patients in NATURE REVIEWS CANCER
  • 2002-12. Potential antimutagenic activity of berberine, a constituent of Mahonia aquifolium in BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
  • 2008-01. Orlistat-Associated Adverse Effects and Drug Interactions in DRUG SAFETY
  • 2016-07. Prdm4 induction by the small molecule butein promotes white adipose tissue browning in NATURE CHEMICAL BIOLOGY
  • 2016-03-30. Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1 in NATURE
  • 2013-12. In vitro biological assessment of berberis vulgaris and its active constituent, berberine: antioxidants, anti-acetylcholinesterase, anti-diabetic and anticancer effects in BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
  • 2014-01. Foxc2 over-expression in bone marrow mesenchymal stem cells stimulates osteogenic differentiation and inhibits adipogenic differentiation in MOLECULAR AND CELLULAR BIOCHEMISTRY
  • 2000-04. Towards a molecular understanding of adaptive thermogenesis in NATURE
  • 2014-05. Therapeutic modulation of Notch signalling — are we there yet? in NATURE REVIEWS DRUG DISCOVERY
  • 2015-12. Regulation of systemic energy homeostasis by serotonin in adipose tissues in NATURE COMMUNICATIONS
  • 2014-12. Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors in NATURE
  • 2011-11-20. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis in NATURE
  • 2009-08. Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex in NATURE
  • 2013-12. Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch in NATURE CELL BIOLOGY
  • 2015-02. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis in NATURE MEDICINE
  • 2014-09. Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia in NATURE
  • 2010-10. The 12<sup>th</sup> annual international symposium in obesity: rediscovering brown adipose tissue in INTERNATIONAL JOURNAL OF OBESITY
  • 2008-02. The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics in NATURE REVIEWS DRUG DISCOVERY
  • 2014-02. Recent advance in brown adipose physiology and its therapeutic potential in EXPERIMENTAL & MOLECULAR MEDICINE
  • 2013-10. Brown and beige fat: development, function and therapeutic potential in NATURE MEDICINE
  • 2008-08. PRDM16 controls a brown fat/skeletal muscle switch in NATURE
  • 2012-01-11. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis in NATURE
  • 2012-03. TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in mice in CELL RESEARCH
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/emm.2017.70

    DOI

    http://dx.doi.org/10.1038/emm.2017.70

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1090363606

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28684864


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical Physiology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adipocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adipose Tissue, Brown", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Energy Metabolism", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitochondrial Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Targeted Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Obesity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Thermogenesis", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Sungkyunkwan University", 
              "id": "https://www.grid.ac/institutes/grid.264381.a", 
              "name": [
                "Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon, Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Song", 
            "givenName": "No-Joon", 
            "id": "sg:person.0662213606.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662213606.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sungkyunkwan University", 
              "id": "https://www.grid.ac/institutes/grid.264381.a", 
              "name": [
                "Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon, Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chang", 
            "givenName": "Seo-Hyuk", 
            "id": "sg:person.01051032005.22", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051032005.22"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Utah", 
              "id": "https://www.grid.ac/institutes/grid.223827.e", 
              "name": [
                "Department of Medicine, Program in Molecular Medicine, University of Utah, Salt Lake City, UT, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Dean Y", 
            "id": "sg:person.01351542222.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351542222.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Utah", 
              "id": "https://www.grid.ac/institutes/grid.223827.e", 
              "name": [
                "Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Villanueva", 
            "givenName": "Claudio J", 
            "id": "sg:person.01312502256.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312502256.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sungkyunkwan University", 
              "id": "https://www.grid.ac/institutes/grid.264381.a", 
              "name": [
                "Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon, Korea."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Park", 
            "givenName": "Kye Won", 
            "id": "sg:person.0617741506.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617741506.65"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/nm.3766", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000291534", 
              "https://doi.org/10.1038/nm.3766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)81410-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000400694"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40035-015-0048-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000701679", 
              "https://doi.org/10.1186/s40035-015-0048-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7554/elife.03245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000869370"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.12.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001120440"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10086-013-1385-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002024210", 
              "https://doi.org/10.1007/s10086-013-1385-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2016.05.071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002129652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc927", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003750518", 
              "https://doi.org/10.1038/nrc927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc927", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003750518", 
              "https://doi.org/10.1038/nrc927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0103093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004693953"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m606114200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005113496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m606114200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005113496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1472-6882-2-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005283454", 
              "https://doi.org/10.1186/1472-6882-2-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2013.12.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006240168"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature17399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006952769", 
              "https://doi.org/10.1038/nature17399"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ijo.2010.241", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007873599", 
              "https://doi.org/10.1038/ijo.2010.241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fendo.2011.00085", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009270663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/415339a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009350695", 
              "https://doi.org/10.1038/415339a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/415339a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009350695", 
              "https://doi.org/10.1038/415339a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13011-015-0034-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009689981", 
              "https://doi.org/10.1186/s13011-015-0034-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/chemse/bjr100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010591526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.053942", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010985570"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1601-183x.2012.00801.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011483544"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.00015.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011751148"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0277-5379(91)90050-n", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012141424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.16.7.3410", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012198968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ijo.2010.182", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012577746", 
              "https://doi.org/10.1038/ijo.2010.182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10777", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013222833", 
              "https://doi.org/10.1038/nature10777"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.1666108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014661531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015088511", 
              "https://doi.org/10.1038/nature10653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnins.2015.00022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015206788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2013.12.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016676346"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3615", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017892138", 
              "https://doi.org/10.1038/nm.3615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00002018-200831010-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017962750", 
              "https://doi.org/10.2165/00002018-200831010-00005"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.05.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018204198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/diabetes.49.5.759", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018322807"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m402197200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018548049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.177857.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018781889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.09-133546", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018794208"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0808718", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020175954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2466", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020236350", 
              "https://doi.org/10.1038/nrd2466"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1603840113", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020588336"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12652", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020662049", 
              "https://doi.org/10.1038/nature12652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021087942", 
              "https://doi.org/10.1038/nrm2066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2066", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021087942", 
              "https://doi.org/10.1038/nrm2066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2012.01.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021542617"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/molecules19056474", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021968678"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2013.01.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022279142"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb3075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022368597", 
              "https://doi.org/10.1038/ncb3075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/emmm.201404508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022837024"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.12-221580", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023135550"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13181-011-0162-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023438402", 
              "https://doi.org/10.1007/s13181-011-0162-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms7794", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023510052", 
              "https://doi.org/10.1038/ncomms7794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbabio.2006.02.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025008268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000430433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025119086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000430433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025119086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2014.12.009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025234558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cr.2011.205", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025479254", 
              "https://doi.org/10.1038/cr.2011.205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1073160", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026205873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nchembio.2081", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026362516", 
              "https://doi.org/10.1038/nchembio.2081"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m809115200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026646120"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tem.2015.02.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027021199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db14-1125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027287241"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci60433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027882187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2006.04.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027888639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1345/aph.1m483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027935896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1345/aph.1m483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027935896"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0063626", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027945068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/md9101806", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028110296"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.chembiol.2015.02.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030544462"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-nutr-071813-105330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030561285"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2007.06.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031609856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2007.09.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031732497"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.252809.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031818344"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13528", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031873459", 
              "https://doi.org/10.1038/nature13528"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms6493", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031960915", 
              "https://doi.org/10.1038/ncomms6493"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.73.9.3141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032432901"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2014.12.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032467236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/emm.2013.163", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032957567", 
              "https://doi.org/10.1038/emm.2013.163"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd4252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033422606", 
              "https://doi.org/10.1038/nrd4252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci44271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033976802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci44271", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033976802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11010-013-1851-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034358716", 
              "https://doi.org/10.1007/s11010-013-1851-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.09.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034506837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2015.09.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034506837"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1472-6882-13-218", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035312171", 
              "https://doi.org/10.1186/1472-6882-13-218"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db09-0530", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035673676"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0003-9861(03)00031-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035840945"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2015.08.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037588868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-physiol-021115-105339", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037664464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci21752", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038086202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/physrev.00043.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038418702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07182", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038449435", 
              "https://doi.org/10.1038/nature07182"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2004.09.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038611749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.04.049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038679279"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2005.05.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039177300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2005.05.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039177300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.08.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039425794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2012.08.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039425794"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(01)00474-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040027356"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2016.05.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041079317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncb2867", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041812871", 
              "https://doi.org/10.1038/ncb2867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/md11125130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041818338"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1432-1033.2003.03422.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042432687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.252734.114", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042850342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.diabet.2015.08.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043071189"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1194/jlr.m035576", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044230918"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m101049200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044253702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms8235", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044779234", 
              "https://doi.org/10.1038/ncomms8235"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db14-0302", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045090294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046090919", 
              "https://doi.org/10.1038/nature08262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046090919", 
              "https://doi.org/10.1038/nature08262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ijo.2010.175", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046198421", 
              "https://doi.org/10.1038/ijo.2010.175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000262653.84850.8b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046453800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/01.res.0000262653.84850.8b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046453800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.06-7489com", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047338004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jmcb/mjs001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047997238"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature13816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048238951", 
              "https://doi.org/10.1038/nature13816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fendo.2015.00136", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048248668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35007527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049556603", 
              "https://doi.org/10.1038/35007527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35007527", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049556603", 
              "https://doi.org/10.1038/35007527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db14-0496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050091345"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/002215540205000103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050110742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/002215540205000103", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050110742"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.febslet.2008.04.046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051335478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2337/db13-1885", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051533061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.3361", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051594830", 
              "https://doi.org/10.1038/nm.3361"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2013.12.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052166349"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2014.12.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052650175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cmet.2014.06.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053404625"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/pr901175w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1056295291"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/jmf.2014.3262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059283438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.280.5368.1371", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062561249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/scisignal.2000511", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062682158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1210/jc.2010-1816", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064292393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/18715273113129990089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1069221999"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/mmr_00000189", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071524985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4161/21623945.2014.985009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072288907"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7326/0003-4819-152-6-201003160-00004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1073711402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077611453", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077695467", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078956378", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpendo.1983.245.6.e555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081614479"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpcell.1984.246.3.c301", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1081615394"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081883548", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083197078", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-07-07", 
        "datePublishedReg": "2017-07-07", 
        "description": "Adipose tissue is a central metabolic organ that controls energy homeostasis of the whole body. White adipose tissue (WAT) stores excess energy in the form of triglycerides, whereas brown adipose tissue (BAT) dissipates energy in the form of heat through mitochondrial uncoupling protein 1 (Ucp1). A newly identified adipose tissue called 'beige fat' (BAT-like) is produced through a process called WAT browning. This tissue mainly resides in WAT depots and displays intermediate characteristics of both WAT and BAT. Since the recent discovery of BAT in the human body, along with the identification of molecular targets for BAT activation, stimulating energy expenditure has been considered as a great strategy to treat human obesity and metabolic diseases. Here we summarize recent findings regarding molecular targets and thermogenic small molecules that can stimulate BAT and increase energy expenditure, with an emphasis on possible therapeutic applications in humans.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/emm.2017.70", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.4242065", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1085098", 
            "issn": [
              "1226-3613", 
              "2092-6413"
            ], 
            "name": "Experimental & Molecular Medicine", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "7", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "49"
          }
        ], 
        "name": "Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules", 
        "pagination": "e353", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "06ff2f3f32558e1f533d1f1c14b76c38fdb50c114c29921f3334e0fe3b6e195f"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28684864"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9607880"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/emm.2017.70"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1090363606"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/emm.2017.70", 
          "https://app.dimensions.ai/details/publication/pub.1090363606"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T00:03", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8695_00000422.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/emm/journal/v49/n7/full/emm201770a.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/emm.2017.70'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/emm.2017.70'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/emm.2017.70'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/emm.2017.70'


     

    This table displays all metadata directly associated to this object as RDF triples.

    570 TRIPLES      21 PREDICATES      170 URIs      30 LITERALS      19 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/emm.2017.70 schema:about N0895fa4cc12f47368497036ff149e375
    2 N2a04562b3fa641a1a117ee50a6aeda86
    3 N2c103a3f48e843418d584a77558310e5
    4 N58ca601f6ab744589ca0269b494ea59f
    5 N6fe1862427744e029d612f80ffa0a7c6
    6 N7fea6a68acba40ac9562825fd147cd9d
    7 N90571f3217fe4238bbcb8afab38f9865
    8 Nbbe552497a484656bdd00f99b63ef833
    9 Nc105c2dff15d4b48a259d4d7c8a9a8ef
    10 Nd5e1f0145f6a425d8cfffb575e877f4b
    11 anzsrc-for:11
    12 anzsrc-for:1116
    13 schema:author N80af958737114a2a9c7ae84087532779
    14 schema:citation sg:pub.10.1007/s10086-013-1385-8
    15 sg:pub.10.1007/s11010-013-1851-z
    16 sg:pub.10.1007/s13181-011-0162-6
    17 sg:pub.10.1038/35007527
    18 sg:pub.10.1038/415339a
    19 sg:pub.10.1038/cr.2011.205
    20 sg:pub.10.1038/emm.2013.163
    21 sg:pub.10.1038/ijo.2010.175
    22 sg:pub.10.1038/ijo.2010.182
    23 sg:pub.10.1038/ijo.2010.241
    24 sg:pub.10.1038/nature07182
    25 sg:pub.10.1038/nature08262
    26 sg:pub.10.1038/nature10653
    27 sg:pub.10.1038/nature10777
    28 sg:pub.10.1038/nature12652
    29 sg:pub.10.1038/nature13528
    30 sg:pub.10.1038/nature13816
    31 sg:pub.10.1038/nature17399
    32 sg:pub.10.1038/ncb2867
    33 sg:pub.10.1038/ncb3075
    34 sg:pub.10.1038/nchembio.2081
    35 sg:pub.10.1038/ncomms6493
    36 sg:pub.10.1038/ncomms7794
    37 sg:pub.10.1038/ncomms8235
    38 sg:pub.10.1038/nm.3361
    39 sg:pub.10.1038/nm.3615
    40 sg:pub.10.1038/nm.3766
    41 sg:pub.10.1038/nrc927
    42 sg:pub.10.1038/nrd2466
    43 sg:pub.10.1038/nrd4252
    44 sg:pub.10.1038/nrm2066
    45 sg:pub.10.1186/1472-6882-13-218
    46 sg:pub.10.1186/1472-6882-2-2
    47 sg:pub.10.1186/s13011-015-0034-1
    48 sg:pub.10.1186/s40035-015-0048-7
    49 sg:pub.10.2165/00002018-200831010-00005
    50 https://app.dimensions.ai/details/publication/pub.1077611453
    51 https://app.dimensions.ai/details/publication/pub.1077695467
    52 https://app.dimensions.ai/details/publication/pub.1078956378
    53 https://app.dimensions.ai/details/publication/pub.1081883548
    54 https://app.dimensions.ai/details/publication/pub.1083197078
    55 https://doi.org/10.1016/0277-5379(91)90050-n
    56 https://doi.org/10.1016/j.bbabio.2006.02.005
    57 https://doi.org/10.1016/j.bbrc.2005.05.002
    58 https://doi.org/10.1016/j.cell.2004.09.013
    59 https://doi.org/10.1016/j.cell.2012.05.016
    60 https://doi.org/10.1016/j.cell.2012.08.034
    61 https://doi.org/10.1016/j.cell.2013.12.012
    62 https://doi.org/10.1016/j.cell.2013.12.021
    63 https://doi.org/10.1016/j.cell.2014.04.049
    64 https://doi.org/10.1016/j.cell.2014.12.011
    65 https://doi.org/10.1016/j.cell.2015.09.035
    66 https://doi.org/10.1016/j.cell.2016.05.071
    67 https://doi.org/10.1016/j.celrep.2016.05.019
    68 https://doi.org/10.1016/j.chembiol.2015.02.003
    69 https://doi.org/10.1016/j.cmet.2006.04.002
    70 https://doi.org/10.1016/j.cmet.2007.06.001
    71 https://doi.org/10.1016/j.cmet.2007.09.012
    72 https://doi.org/10.1016/j.cmet.2012.01.019
    73 https://doi.org/10.1016/j.cmet.2013.01.016
    74 https://doi.org/10.1016/j.cmet.2013.12.003
    75 https://doi.org/10.1016/j.cmet.2013.12.017
    76 https://doi.org/10.1016/j.cmet.2014.06.011
    77 https://doi.org/10.1016/j.cmet.2014.12.009
    78 https://doi.org/10.1016/j.cmet.2015.08.001
    79 https://doi.org/10.1016/j.diabet.2015.08.006
    80 https://doi.org/10.1016/j.febslet.2008.04.046
    81 https://doi.org/10.1016/j.molcel.2014.12.005
    82 https://doi.org/10.1016/j.tem.2015.02.006
    83 https://doi.org/10.1016/s0003-9861(03)00031-6
    84 https://doi.org/10.1016/s0092-8674(00)81410-5
    85 https://doi.org/10.1016/s0092-8674(01)00474-3
    86 https://doi.org/10.1021/pr901175w
    87 https://doi.org/10.1046/j.1432-1033.2003.03422.x
    88 https://doi.org/10.1056/nejmoa0808718
    89 https://doi.org/10.1073/pnas.1603840113
    90 https://doi.org/10.1073/pnas.73.9.3141
    91 https://doi.org/10.1074/jbc.m101049200
    92 https://doi.org/10.1074/jbc.m109.053942
    93 https://doi.org/10.1074/jbc.m402197200
    94 https://doi.org/10.1074/jbc.m606114200
    95 https://doi.org/10.1074/jbc.m809115200
    96 https://doi.org/10.1089/jmf.2014.3262
    97 https://doi.org/10.1093/chemse/bjr100
    98 https://doi.org/10.1093/jmcb/mjs001
    99 https://doi.org/10.1096/fj.06-7489com
    100 https://doi.org/10.1096/fj.09-133546
    101 https://doi.org/10.1096/fj.12-221580
    102 https://doi.org/10.1101/gad.1666108
    103 https://doi.org/10.1101/gad.177857.111
    104 https://doi.org/10.1101/gad.252734.114
    105 https://doi.org/10.1101/gad.252809.114
    106 https://doi.org/10.1111/j.1601-183x.2012.00801.x
    107 https://doi.org/10.1126/science.1073160
    108 https://doi.org/10.1126/science.280.5368.1371
    109 https://doi.org/10.1126/scisignal.2000511
    110 https://doi.org/10.1128/mcb.16.7.3410
    111 https://doi.org/10.1146/annurev-nutr-071813-105330
    112 https://doi.org/10.1146/annurev-physiol-021115-105339
    113 https://doi.org/10.1152/ajpcell.1984.246.3.c301
    114 https://doi.org/10.1152/ajpendo.1983.245.6.e555
    115 https://doi.org/10.1152/physrev.00015.2003
    116 https://doi.org/10.1152/physrev.00043.2006
    117 https://doi.org/10.1159/000430433
    118 https://doi.org/10.1161/01.res.0000262653.84850.8b
    119 https://doi.org/10.1172/jci21752
    120 https://doi.org/10.1172/jci44271
    121 https://doi.org/10.1172/jci60433
    122 https://doi.org/10.1177/002215540205000103
    123 https://doi.org/10.1194/jlr.m035576
    124 https://doi.org/10.1210/jc.2010-1816
    125 https://doi.org/10.1345/aph.1m483
    126 https://doi.org/10.1371/journal.pone.0063626
    127 https://doi.org/10.1371/journal.pone.0103093
    128 https://doi.org/10.15252/emmm.201404508
    129 https://doi.org/10.2174/18715273113129990089
    130 https://doi.org/10.2337/db09-0530
    131 https://doi.org/10.2337/db13-1885
    132 https://doi.org/10.2337/db14-0302
    133 https://doi.org/10.2337/db14-0496
    134 https://doi.org/10.2337/db14-1125
    135 https://doi.org/10.2337/diabetes.49.5.759
    136 https://doi.org/10.3389/fendo.2011.00085
    137 https://doi.org/10.3389/fendo.2015.00136
    138 https://doi.org/10.3389/fnins.2015.00022
    139 https://doi.org/10.3390/md11125130
    140 https://doi.org/10.3390/md9101806
    141 https://doi.org/10.3390/molecules19056474
    142 https://doi.org/10.3892/mmr_00000189
    143 https://doi.org/10.4161/21623945.2014.985009
    144 https://doi.org/10.7326/0003-4819-152-6-201003160-00004
    145 https://doi.org/10.7554/elife.03245
    146 schema:datePublished 2017-07-07
    147 schema:datePublishedReg 2017-07-07
    148 schema:description Adipose tissue is a central metabolic organ that controls energy homeostasis of the whole body. White adipose tissue (WAT) stores excess energy in the form of triglycerides, whereas brown adipose tissue (BAT) dissipates energy in the form of heat through mitochondrial uncoupling protein 1 (Ucp1). A newly identified adipose tissue called 'beige fat' (BAT-like) is produced through a process called WAT browning. This tissue mainly resides in WAT depots and displays intermediate characteristics of both WAT and BAT. Since the recent discovery of BAT in the human body, along with the identification of molecular targets for BAT activation, stimulating energy expenditure has been considered as a great strategy to treat human obesity and metabolic diseases. Here we summarize recent findings regarding molecular targets and thermogenic small molecules that can stimulate BAT and increase energy expenditure, with an emphasis on possible therapeutic applications in humans.
    149 schema:genre research_article
    150 schema:inLanguage en
    151 schema:isAccessibleForFree true
    152 schema:isPartOf N60ce9168aa00416cb6fc6dc654761afc
    153 N8b9c5495a5534dfdbd6456159d112057
    154 sg:journal.1085098
    155 schema:name Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules
    156 schema:pagination e353
    157 schema:productId N23b9ef7aee5b4656b1e69832f4745f4d
    158 N27d7b39d9348464887a5932b3f99fb92
    159 N332d5fe3840e4294894108cf5ef26085
    160 Nad1c8ae2e1bc4c8e81ac0ec64a19d77c
    161 Ne4cb1479b4ad4f049c89f36ee0cee86e
    162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090363606
    163 https://doi.org/10.1038/emm.2017.70
    164 schema:sdDatePublished 2019-04-11T00:03
    165 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    166 schema:sdPublisher N38a3b1eb956d43439d79274e197f73a7
    167 schema:url http://www.nature.com/emm/journal/v49/n7/full/emm201770a.html
    168 sgo:license sg:explorer/license/
    169 sgo:sdDataset articles
    170 rdf:type schema:ScholarlyArticle
    171 N0895fa4cc12f47368497036ff149e375 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Molecular Targeted Therapy
    173 rdf:type schema:DefinedTerm
    174 N23b9ef7aee5b4656b1e69832f4745f4d schema:name pubmed_id
    175 schema:value 28684864
    176 rdf:type schema:PropertyValue
    177 N27d7b39d9348464887a5932b3f99fb92 schema:name doi
    178 schema:value 10.1038/emm.2017.70
    179 rdf:type schema:PropertyValue
    180 N2a04562b3fa641a1a117ee50a6aeda86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Animals
    182 rdf:type schema:DefinedTerm
    183 N2c103a3f48e843418d584a77558310e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    184 schema:name Adipocytes
    185 rdf:type schema:DefinedTerm
    186 N332d5fe3840e4294894108cf5ef26085 schema:name dimensions_id
    187 schema:value pub.1090363606
    188 rdf:type schema:PropertyValue
    189 N38a3b1eb956d43439d79274e197f73a7 schema:name Springer Nature - SN SciGraph project
    190 rdf:type schema:Organization
    191 N58ca601f6ab744589ca0269b494ea59f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    192 schema:name Thermogenesis
    193 rdf:type schema:DefinedTerm
    194 N60ce9168aa00416cb6fc6dc654761afc schema:issueNumber 7
    195 rdf:type schema:PublicationIssue
    196 N619319fdc80743ebb6e3dea5400a1488 rdf:first sg:person.01351542222.08
    197 rdf:rest Neb204ec924d34472b42f27a25c44c003
    198 N6fe1862427744e029d612f80ffa0a7c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Energy Metabolism
    200 rdf:type schema:DefinedTerm
    201 N79a3dd6cdc184c66a9054c8542d15cd9 rdf:first sg:person.01051032005.22
    202 rdf:rest N619319fdc80743ebb6e3dea5400a1488
    203 N7fea6a68acba40ac9562825fd147cd9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    204 schema:name Mitochondrial Proteins
    205 rdf:type schema:DefinedTerm
    206 N80af958737114a2a9c7ae84087532779 rdf:first sg:person.0662213606.99
    207 rdf:rest N79a3dd6cdc184c66a9054c8542d15cd9
    208 N8b9c5495a5534dfdbd6456159d112057 schema:volumeNumber 49
    209 rdf:type schema:PublicationVolume
    210 N90571f3217fe4238bbcb8afab38f9865 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    211 schema:name Humans
    212 rdf:type schema:DefinedTerm
    213 Nad1c8ae2e1bc4c8e81ac0ec64a19d77c schema:name nlm_unique_id
    214 schema:value 9607880
    215 rdf:type schema:PropertyValue
    216 Nb34a4fdf6af445728c3634bd5ac167cc rdf:first sg:person.0617741506.65
    217 rdf:rest rdf:nil
    218 Nbbe552497a484656bdd00f99b63ef833 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    219 schema:name Mice
    220 rdf:type schema:DefinedTerm
    221 Nc105c2dff15d4b48a259d4d7c8a9a8ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    222 schema:name Adipose Tissue, Brown
    223 rdf:type schema:DefinedTerm
    224 Nd5e1f0145f6a425d8cfffb575e877f4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    225 schema:name Obesity
    226 rdf:type schema:DefinedTerm
    227 Ne4cb1479b4ad4f049c89f36ee0cee86e schema:name readcube_id
    228 schema:value 06ff2f3f32558e1f533d1f1c14b76c38fdb50c114c29921f3334e0fe3b6e195f
    229 rdf:type schema:PropertyValue
    230 Neb204ec924d34472b42f27a25c44c003 rdf:first sg:person.01312502256.51
    231 rdf:rest Nb34a4fdf6af445728c3634bd5ac167cc
    232 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    233 schema:name Medical and Health Sciences
    234 rdf:type schema:DefinedTerm
    235 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
    236 schema:name Medical Physiology
    237 rdf:type schema:DefinedTerm
    238 sg:grant.4242065 http://pending.schema.org/fundedItem sg:pub.10.1038/emm.2017.70
    239 rdf:type schema:MonetaryGrant
    240 sg:journal.1085098 schema:issn 1226-3613
    241 2092-6413
    242 schema:name Experimental & Molecular Medicine
    243 rdf:type schema:Periodical
    244 sg:person.01051032005.22 schema:affiliation https://www.grid.ac/institutes/grid.264381.a
    245 schema:familyName Chang
    246 schema:givenName Seo-Hyuk
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051032005.22
    248 rdf:type schema:Person
    249 sg:person.01312502256.51 schema:affiliation https://www.grid.ac/institutes/grid.223827.e
    250 schema:familyName Villanueva
    251 schema:givenName Claudio J
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312502256.51
    253 rdf:type schema:Person
    254 sg:person.01351542222.08 schema:affiliation https://www.grid.ac/institutes/grid.223827.e
    255 schema:familyName Li
    256 schema:givenName Dean Y
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351542222.08
    258 rdf:type schema:Person
    259 sg:person.0617741506.65 schema:affiliation https://www.grid.ac/institutes/grid.264381.a
    260 schema:familyName Park
    261 schema:givenName Kye Won
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617741506.65
    263 rdf:type schema:Person
    264 sg:person.0662213606.99 schema:affiliation https://www.grid.ac/institutes/grid.264381.a
    265 schema:familyName Song
    266 schema:givenName No-Joon
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0662213606.99
    268 rdf:type schema:Person
    269 sg:pub.10.1007/s10086-013-1385-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002024210
    270 https://doi.org/10.1007/s10086-013-1385-8
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1007/s11010-013-1851-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1034358716
    273 https://doi.org/10.1007/s11010-013-1851-z
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1007/s13181-011-0162-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023438402
    276 https://doi.org/10.1007/s13181-011-0162-6
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/35007527 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049556603
    279 https://doi.org/10.1038/35007527
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/415339a schema:sameAs https://app.dimensions.ai/details/publication/pub.1009350695
    282 https://doi.org/10.1038/415339a
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/cr.2011.205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025479254
    285 https://doi.org/10.1038/cr.2011.205
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/emm.2013.163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032957567
    288 https://doi.org/10.1038/emm.2013.163
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/ijo.2010.175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046198421
    291 https://doi.org/10.1038/ijo.2010.175
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/ijo.2010.182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012577746
    294 https://doi.org/10.1038/ijo.2010.182
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/ijo.2010.241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007873599
    297 https://doi.org/10.1038/ijo.2010.241
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/nature07182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038449435
    300 https://doi.org/10.1038/nature07182
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/nature08262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046090919
    303 https://doi.org/10.1038/nature08262
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/nature10653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015088511
    306 https://doi.org/10.1038/nature10653
    307 rdf:type schema:CreativeWork
    308 sg:pub.10.1038/nature10777 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013222833
    309 https://doi.org/10.1038/nature10777
    310 rdf:type schema:CreativeWork
    311 sg:pub.10.1038/nature12652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020662049
    312 https://doi.org/10.1038/nature12652
    313 rdf:type schema:CreativeWork
    314 sg:pub.10.1038/nature13528 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031873459
    315 https://doi.org/10.1038/nature13528
    316 rdf:type schema:CreativeWork
    317 sg:pub.10.1038/nature13816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048238951
    318 https://doi.org/10.1038/nature13816
    319 rdf:type schema:CreativeWork
    320 sg:pub.10.1038/nature17399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006952769
    321 https://doi.org/10.1038/nature17399
    322 rdf:type schema:CreativeWork
    323 sg:pub.10.1038/ncb2867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041812871
    324 https://doi.org/10.1038/ncb2867
    325 rdf:type schema:CreativeWork
    326 sg:pub.10.1038/ncb3075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022368597
    327 https://doi.org/10.1038/ncb3075
    328 rdf:type schema:CreativeWork
    329 sg:pub.10.1038/nchembio.2081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026362516
    330 https://doi.org/10.1038/nchembio.2081
    331 rdf:type schema:CreativeWork
    332 sg:pub.10.1038/ncomms6493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031960915
    333 https://doi.org/10.1038/ncomms6493
    334 rdf:type schema:CreativeWork
    335 sg:pub.10.1038/ncomms7794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023510052
    336 https://doi.org/10.1038/ncomms7794
    337 rdf:type schema:CreativeWork
    338 sg:pub.10.1038/ncomms8235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044779234
    339 https://doi.org/10.1038/ncomms8235
    340 rdf:type schema:CreativeWork
    341 sg:pub.10.1038/nm.3361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051594830
    342 https://doi.org/10.1038/nm.3361
    343 rdf:type schema:CreativeWork
    344 sg:pub.10.1038/nm.3615 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017892138
    345 https://doi.org/10.1038/nm.3615
    346 rdf:type schema:CreativeWork
    347 sg:pub.10.1038/nm.3766 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000291534
    348 https://doi.org/10.1038/nm.3766
    349 rdf:type schema:CreativeWork
    350 sg:pub.10.1038/nrc927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003750518
    351 https://doi.org/10.1038/nrc927
    352 rdf:type schema:CreativeWork
    353 sg:pub.10.1038/nrd2466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020236350
    354 https://doi.org/10.1038/nrd2466
    355 rdf:type schema:CreativeWork
    356 sg:pub.10.1038/nrd4252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033422606
    357 https://doi.org/10.1038/nrd4252
    358 rdf:type schema:CreativeWork
    359 sg:pub.10.1038/nrm2066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021087942
    360 https://doi.org/10.1038/nrm2066
    361 rdf:type schema:CreativeWork
    362 sg:pub.10.1186/1472-6882-13-218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035312171
    363 https://doi.org/10.1186/1472-6882-13-218
    364 rdf:type schema:CreativeWork
    365 sg:pub.10.1186/1472-6882-2-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005283454
    366 https://doi.org/10.1186/1472-6882-2-2
    367 rdf:type schema:CreativeWork
    368 sg:pub.10.1186/s13011-015-0034-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009689981
    369 https://doi.org/10.1186/s13011-015-0034-1
    370 rdf:type schema:CreativeWork
    371 sg:pub.10.1186/s40035-015-0048-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000701679
    372 https://doi.org/10.1186/s40035-015-0048-7
    373 rdf:type schema:CreativeWork
    374 sg:pub.10.2165/00002018-200831010-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017962750
    375 https://doi.org/10.2165/00002018-200831010-00005
    376 rdf:type schema:CreativeWork
    377 https://app.dimensions.ai/details/publication/pub.1077611453 schema:CreativeWork
    378 https://app.dimensions.ai/details/publication/pub.1077695467 schema:CreativeWork
    379 https://app.dimensions.ai/details/publication/pub.1078956378 schema:CreativeWork
    380 https://app.dimensions.ai/details/publication/pub.1081883548 schema:CreativeWork
    381 https://app.dimensions.ai/details/publication/pub.1083197078 schema:CreativeWork
    382 https://doi.org/10.1016/0277-5379(91)90050-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1012141424
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1016/j.bbabio.2006.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025008268
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1016/j.bbrc.2005.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039177300
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1016/j.cell.2004.09.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038611749
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1016/j.cell.2012.05.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018204198
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1016/j.cell.2012.08.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039425794
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1016/j.cell.2013.12.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001120440
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1016/j.cell.2013.12.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052166349
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1016/j.cell.2014.04.049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038679279
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1016/j.cell.2014.12.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052650175
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1016/j.cell.2015.09.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034506837
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1016/j.cell.2016.05.071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002129652
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1016/j.celrep.2016.05.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041079317
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1016/j.chembiol.2015.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030544462
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1016/j.cmet.2006.04.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027888639
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1016/j.cmet.2007.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031609856
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1016/j.cmet.2007.09.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031732497
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1016/j.cmet.2012.01.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021542617
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1016/j.cmet.2013.01.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022279142
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1016/j.cmet.2013.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006240168
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1016/j.cmet.2013.12.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016676346
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1016/j.cmet.2014.06.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053404625
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1016/j.cmet.2014.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025234558
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1016/j.cmet.2015.08.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037588868
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1016/j.diabet.2015.08.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043071189
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1016/j.febslet.2008.04.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051335478
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1016/j.molcel.2014.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032467236
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1016/j.tem.2015.02.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027021199
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1016/s0003-9861(03)00031-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035840945
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1016/s0092-8674(00)81410-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000400694
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1016/s0092-8674(01)00474-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040027356
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1021/pr901175w schema:sameAs https://app.dimensions.ai/details/publication/pub.1056295291
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1046/j.1432-1033.2003.03422.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042432687
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1056/nejmoa0808718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020175954
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1073/pnas.1603840113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020588336
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1073/pnas.73.9.3141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032432901
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1074/jbc.m101049200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044253702
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1074/jbc.m109.053942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010985570
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1074/jbc.m402197200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018548049
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1074/jbc.m606114200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005113496
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1074/jbc.m809115200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026646120
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1089/jmf.2014.3262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059283438
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1093/chemse/bjr100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010591526
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.1093/jmcb/mjs001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047997238
    469 rdf:type schema:CreativeWork
    470 https://doi.org/10.1096/fj.06-7489com schema:sameAs https://app.dimensions.ai/details/publication/pub.1047338004
    471 rdf:type schema:CreativeWork
    472 https://doi.org/10.1096/fj.09-133546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018794208
    473 rdf:type schema:CreativeWork
    474 https://doi.org/10.1096/fj.12-221580 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023135550
    475 rdf:type schema:CreativeWork
    476 https://doi.org/10.1101/gad.1666108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014661531
    477 rdf:type schema:CreativeWork
    478 https://doi.org/10.1101/gad.177857.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018781889
    479 rdf:type schema:CreativeWork
    480 https://doi.org/10.1101/gad.252734.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042850342
    481 rdf:type schema:CreativeWork
    482 https://doi.org/10.1101/gad.252809.114 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031818344
    483 rdf:type schema:CreativeWork
    484 https://doi.org/10.1111/j.1601-183x.2012.00801.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011483544
    485 rdf:type schema:CreativeWork
    486 https://doi.org/10.1126/science.1073160 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026205873
    487 rdf:type schema:CreativeWork
    488 https://doi.org/10.1126/science.280.5368.1371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062561249
    489 rdf:type schema:CreativeWork
    490 https://doi.org/10.1126/scisignal.2000511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062682158
    491 rdf:type schema:CreativeWork
    492 https://doi.org/10.1128/mcb.16.7.3410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012198968
    493 rdf:type schema:CreativeWork
    494 https://doi.org/10.1146/annurev-nutr-071813-105330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030561285
    495 rdf:type schema:CreativeWork
    496 https://doi.org/10.1146/annurev-physiol-021115-105339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037664464
    497 rdf:type schema:CreativeWork
    498 https://doi.org/10.1152/ajpcell.1984.246.3.c301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081615394
    499 rdf:type schema:CreativeWork
    500 https://doi.org/10.1152/ajpendo.1983.245.6.e555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081614479
    501 rdf:type schema:CreativeWork
    502 https://doi.org/10.1152/physrev.00015.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011751148
    503 rdf:type schema:CreativeWork
    504 https://doi.org/10.1152/physrev.00043.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038418702
    505 rdf:type schema:CreativeWork
    506 https://doi.org/10.1159/000430433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025119086
    507 rdf:type schema:CreativeWork
    508 https://doi.org/10.1161/01.res.0000262653.84850.8b schema:sameAs https://app.dimensions.ai/details/publication/pub.1046453800
    509 rdf:type schema:CreativeWork
    510 https://doi.org/10.1172/jci21752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038086202
    511 rdf:type schema:CreativeWork
    512 https://doi.org/10.1172/jci44271 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033976802
    513 rdf:type schema:CreativeWork
    514 https://doi.org/10.1172/jci60433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027882187
    515 rdf:type schema:CreativeWork
    516 https://doi.org/10.1177/002215540205000103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050110742
    517 rdf:type schema:CreativeWork
    518 https://doi.org/10.1194/jlr.m035576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044230918
    519 rdf:type schema:CreativeWork
    520 https://doi.org/10.1210/jc.2010-1816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064292393
    521 rdf:type schema:CreativeWork
    522 https://doi.org/10.1345/aph.1m483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027935896
    523 rdf:type schema:CreativeWork
    524 https://doi.org/10.1371/journal.pone.0063626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027945068
    525 rdf:type schema:CreativeWork
    526 https://doi.org/10.1371/journal.pone.0103093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004693953
    527 rdf:type schema:CreativeWork
    528 https://doi.org/10.15252/emmm.201404508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022837024
    529 rdf:type schema:CreativeWork
    530 https://doi.org/10.2174/18715273113129990089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069221999
    531 rdf:type schema:CreativeWork
    532 https://doi.org/10.2337/db09-0530 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035673676
    533 rdf:type schema:CreativeWork
    534 https://doi.org/10.2337/db13-1885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051533061
    535 rdf:type schema:CreativeWork
    536 https://doi.org/10.2337/db14-0302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045090294
    537 rdf:type schema:CreativeWork
    538 https://doi.org/10.2337/db14-0496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050091345
    539 rdf:type schema:CreativeWork
    540 https://doi.org/10.2337/db14-1125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027287241
    541 rdf:type schema:CreativeWork
    542 https://doi.org/10.2337/diabetes.49.5.759 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018322807
    543 rdf:type schema:CreativeWork
    544 https://doi.org/10.3389/fendo.2011.00085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009270663
    545 rdf:type schema:CreativeWork
    546 https://doi.org/10.3389/fendo.2015.00136 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048248668
    547 rdf:type schema:CreativeWork
    548 https://doi.org/10.3389/fnins.2015.00022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015206788
    549 rdf:type schema:CreativeWork
    550 https://doi.org/10.3390/md11125130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041818338
    551 rdf:type schema:CreativeWork
    552 https://doi.org/10.3390/md9101806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028110296
    553 rdf:type schema:CreativeWork
    554 https://doi.org/10.3390/molecules19056474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021968678
    555 rdf:type schema:CreativeWork
    556 https://doi.org/10.3892/mmr_00000189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071524985
    557 rdf:type schema:CreativeWork
    558 https://doi.org/10.4161/21623945.2014.985009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072288907
    559 rdf:type schema:CreativeWork
    560 https://doi.org/10.7326/0003-4819-152-6-201003160-00004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073711402
    561 rdf:type schema:CreativeWork
    562 https://doi.org/10.7554/elife.03245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000869370
    563 rdf:type schema:CreativeWork
    564 https://www.grid.ac/institutes/grid.223827.e schema:alternateName University of Utah
    565 schema:name Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT, USA.
    566 Department of Medicine, Program in Molecular Medicine, University of Utah, Salt Lake City, UT, USA.
    567 rdf:type schema:Organization
    568 https://www.grid.ac/institutes/grid.264381.a schema:alternateName Sungkyunkwan University
    569 schema:name Department of Food Science and Biotechnology, Sungkyunkwan University, Suwon, Korea.
    570 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...