Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-06-17

AUTHORS

Jung Min Ha, Seung Hoon Baek, Young Hwan Kim, Seo Yeon Jin, Hye Sun Lee, Sun Ja Kim, Hwa Kyoung Shin, Dong Hyung Lee, Sang Heon Song, Chi Dae Kim, Sun Sik Bae

ABSTRACT

Angiogenesis has an essential role in many pathophysiologies. Here, we show that phospholipase C-β3 (PLC-β3) isoform regulates endothelial cell function and retinal angiogenesis. Silencing of PLC-β3 in human umbilical vein endothelial cells (HUVECs) significantly delayed proliferation, migration and capillary-like tube formation. In addition, mice lacking PLC-β3 showed impaired retinal angiogenesis with delayed endothelial proliferation, reduced endothelial cell activation, abnormal vessel formation and hemorrhage. Finally, tumor formation was significantly reduced in mice lacking PLC-β3 and showed irregular size and shape of blood vessels. These results suggest that regulation of endothelial function by PLC-β3 may contribute to angiogenesis. More... »

PAGES

e240-e240

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/emm.2016.39

DOI

http://dx.doi.org/10.1038/emm.2016.39

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004298913

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27311705


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