Adipose stem cell-derived nanovesicles inhibit emphysema primarily via an FGF2-dependent pathway View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-01-13

AUTHORS

You-Sun Kim, Ji-Young Kim, RyeonJin Cho, Dong-Myung Shin, Sei Won Lee, Yeon-Mok Oh

ABSTRACT

Cell therapy using stem cells has produced therapeutic benefits in animal models of COPD. Secretory mediators are proposed as one mechanism for stem cell effects because very few stem cells engraft after injection into recipient animals. Recently, nanovesicles that overcome the disadvantages of natural exosomes have been generated artificially from cells. We generated artificial nanovesicles from adipose-derived stem cells (ASCs) using sequential penetration through polycarbonate membranes. ASC-derived artificial nanovesicles displayed a 100 nm-sized spherical shape similar to ASC-derived natural exosomes and expressed both exosomal and stem cell markers. The proliferation rate of lung epithelial cells was increased in cells treated with ASC-derived artificial nanovesicles compared with cells treated with ASC-derived natural exosomes. The lower dose of ASC-derived artificial nanovesicles had similar regenerative capacity compared with a higher dose of ASCs and ASC-derived natural exosomes. In addition, FGF2 levels in the lungs of mice treated with ASC-derived artificial nanovesicles were increased. The uptake of ASC-derived artificial nanovesicles was inhibited by heparin, which is a competitive inhibitor of heparan sulfate proteoglycan that is associated with FGF2 signaling. Taken together, the data indicate that lower doses of ASC-derived artificial nanovesicles may have beneficial effects similar to higher doses of ASCs or ASC-derived natural exosomes in an animal model with emphysema, suggesting that artificial nanovesicles may have economic advantages that warrant future clinical studies. More... »

PAGES

e284

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/emm.2016.127

DOI

http://dx.doi.org/10.1038/emm.2016.127

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013308402

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28082743


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