Clinical implications of proliferation activity in T1 or T2 male gastric cancer patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-11-06

AUTHORS

Young-Woo Kim, Bang Wool Eom, Myeong-Cherl Kook, Han-Seong Kim, Mi-Kyung Kim, Hai-Li Hwang, Vishal Chandra, Shiv Poojan, Yura Song, Jae-Soo Koh, Chang-Dae Bae, Jungsil Ro, Kyeong-Man Hong

ABSTRACT

Proliferation activity has already been established as a prognostic marker or as a marker for anticancer drug sensitivity. In gastric cancer, however, the prognostic significance of proliferation activity is still being debated. Several studies evaluating proliferation activity using Ki-67 have shown controversial results in terms of the relationship between proliferation activity and overall survival (OS) or drug sensitivity in gastric cancer patients. Because cytoskeleton-associated protein 2 (CKAP2) staining has recently been introduced as a marker of proliferation activity, we analyzed 437 gastric cancer tissues through CKAP2 immunohistochemistry, and we evaluated the chromatin CKAP2-positive cell count (CPCC) for proliferation activity. Although the CPCC did not show any significant correlation with OS in the male, female or total number of cases, it did show a significant correlation in the T1 or T2 male patient subgroup, according to log-rank tests (P=0.001) and univariate analysis (P=0.045). Additionally, multivariate analysis with the Cox proportional hazard regression model showed a significant correlation between the CPCC and OS (P=0.039) for the co-variables of age, gender, T stage, N stage, histology, tumor location, tumor size and adjuvant chemotherapy. In male gastric cancer cell lines, faster-growing cancer cells showed higher sensitivity to cisplatin than slow-growing cells. Thus our study indicates that CPCC-measured proliferation activity demonstrates a significantly worse prognosis in T1 or T2 male gastric cancer patients. The CPCC will help to more precisely classify gastric cancer patients and to select excellent candidates for adjuvant chemotherapy, which in turn will facilitate further clinical chemotherapeutic trials. More... »

PAGES

e193

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/emm.2015.79

DOI

http://dx.doi.org/10.1038/emm.2015.79

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042781070

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26542785


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30 schema:description Proliferation activity has already been established as a prognostic marker or as a marker for anticancer drug sensitivity. In gastric cancer, however, the prognostic significance of proliferation activity is still being debated. Several studies evaluating proliferation activity using Ki-67 have shown controversial results in terms of the relationship between proliferation activity and overall survival (OS) or drug sensitivity in gastric cancer patients. Because cytoskeleton-associated protein 2 (CKAP2) staining has recently been introduced as a marker of proliferation activity, we analyzed 437 gastric cancer tissues through CKAP2 immunohistochemistry, and we evaluated the chromatin CKAP2-positive cell count (CPCC) for proliferation activity. Although the CPCC did not show any significant correlation with OS in the male, female or total number of cases, it did show a significant correlation in the T1 or T2 male patient subgroup, according to log-rank tests (P=0.001) and univariate analysis (P=0.045). Additionally, multivariate analysis with the Cox proportional hazard regression model showed a significant correlation between the CPCC and OS (P=0.039) for the co-variables of age, gender, T stage, N stage, histology, tumor location, tumor size and adjuvant chemotherapy. In male gastric cancer cell lines, faster-growing cancer cells showed higher sensitivity to cisplatin than slow-growing cells. Thus our study indicates that CPCC-measured proliferation activity demonstrates a significantly worse prognosis in T1 or T2 male gastric cancer patients. The CPCC will help to more precisely classify gastric cancer patients and to select excellent candidates for adjuvant chemotherapy, which in turn will facilitate further clinical chemotherapeutic trials.
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37 schema:keywords CKAP2 immunohistochemistry
38 CKAP2-positive cell count
39 CPCC
40 CPCC-measured proliferation activity
41 Cox proportional hazards regression model
42 Ki-67
43 T1
44 T2 male patient subgroup
45 activity
46 adjuvant chemotherapy
47 age
48 analysis
49 anticancer drug sensitivity
50 cancer
51 cancer cell lines
52 cancer cells
53 cancer patients
54 cancer tissues
55 candidates
56 cases
57 cell count
58 cell lines
59 cells
60 chemotherapeutic trials
61 chemotherapy
62 clinical chemotherapeutic trials
63 clinical implications
64 controversial results
65 correlation
66 count
67 cytoskeleton
68 drug sensitivity
69 excellent candidate
70 further clinical chemotherapeutic trials
71 gastric cancer
72 gastric cancer cell lines
73 gastric cancer patients
74 gastric cancer tissues
75 gender
76 hazards regression models
77 high sensitivity
78 histology
79 immunohistochemistry
80 implications
81 lines
82 location
83 log-rank test
84 male gastric cancer cell lines
85 male gastric cancer patients
86 male patient subgroup
87 markers
88 model
89 multivariate analysis
90 number
91 overall survival
92 patient subgroups
93 patients
94 prognosis
95 prognostic marker
96 prognostic significance
97 proliferation activity
98 proportional hazards regression models
99 protein 2 staining
100 regression models
101 relationship
102 results
103 sensitivity
104 significance
105 significant correlation
106 size
107 stage
108 staining
109 study
110 subgroups
111 survival
112 terms
113 test
114 tissue
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116 trials
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119 turn
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