Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-02-08

AUTHORS

Sung Nam Park, Kyung Tae Noh, Young-Il Jeong, In Duk Jung, Hyun Kyu Kang, Gil Sun Cha, Su Jung Lee, Jong Keun Seo, Dae Hwan Kang, Tae-Ho Hwang, Eun Kyung Lee, Byungsuk Kwon, Yeong-Min Park

ABSTRACT

We evaluated the effectiveness of rhamnogalacturonan II (RG-II)-stimulated bone marrow-derived dendritic cells (BMDCs) vaccination on the induction of antitumor immunity in a mouse lymphoma model using EG7-lymphoma cells expressing ovalbumin (OVA). BMDCs treated with RG-II had an activated phenotype. RG-II induced interleukin (IL)-12, IL-1β, tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) production during dendritic cell (DC) maturation. BMDCs stimulated with RG-II facilitate the proliferation of CD8+ T cells. Using BMDCs from the mice deficient in Toll-like receptors (TLRs), we revealed that RG-II activity is dependent on TLR4. RG-II showed a preventive effect of immunization with OVA-pulsed BMDCs against EG7 lymphoma. These results suggested that RG-II expedites the DC-based immune response through the TLR4 signaling pathway. More... »

PAGES

e8-e8

Journal

TITLE

Experimental & Molecular Medicine

ISSUE

2

VOLUME

45

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/emm.2013.14

DOI

http://dx.doi.org/10.1038/emm.2013.14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018367161

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23392255


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43 schema:description We evaluated the effectiveness of rhamnogalacturonan II (RG-II)-stimulated bone marrow-derived dendritic cells (BMDCs) vaccination on the induction of antitumor immunity in a mouse lymphoma model using EG7-lymphoma cells expressing ovalbumin (OVA). BMDCs treated with RG-II had an activated phenotype. RG-II induced interleukin (IL)-12, IL-1β, tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) production during dendritic cell (DC) maturation. BMDCs stimulated with RG-II facilitate the proliferation of CD8+ T cells. Using BMDCs from the mice deficient in Toll-like receptors (TLRs), we revealed that RG-II activity is dependent on TLR4. RG-II showed a preventive effect of immunization with OVA-pulsed BMDCs against EG7 lymphoma. These results suggested that RG-II expedites the DC-based immune response through the TLR4 signaling pathway.
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52 DC
53 EG7 lymphomas
54 IL-1β
55 RG
56 RG-II
57 T cells
58 TLR4
59 Toll-like receptor 4 agonist
60 Toll-like receptors
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