Adaptation of cAMP signaling system in SH-SY5Y neuroblastoma cells following expression of a constitutively active stimulatory G protein α, Q227L ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2001-03-01

AUTHORS

Ik-Soon Jang, Yong-Sung Juhnn

ABSTRACT

Heterotrimeric GTP-binding proteins (G protein) are known to participate in the transduction of signals from ligand activated receptors to effector molecules to elicit cellular responses. Sustained activation of cAMP-G protein signaling system by agonist results in desensitization of the pathway at receptor levels, however it is not clear whether such receptor responses induce other changes in post-receptor signaling path that are associated with maintenance of AMP levels, i.e. cAMP-forming adenylate cyclase (AC), cAMP-degrading cyclic nucleotide phosphodiesterase (PDE) and cAMP-dependent protein kinase (PKA). Experiments were performed to determine the expression of AC, PDE, and PKA isoforms in SH-SY5Y neuroblastoma cells, in which cAMP system was activated by expressing a constitutively activated mutant of stimulatory G protein (Q227L Gsα). Expression of ACI mRNA was increased, but levels of ACVIII and ACIX mRNA were decreased. All of the 4 expressed isoforms of PDE (PDE1C, PDE2, PDE 4A, and PDE4B) were increased in mRNA expression; the levels of PKA RIα, RIβ, and RIIβ were increased moderately, however, those of RIIα and Cα were increased remarkably. The activities of AC, PDE and PKA were also increased in the SH-SY5Y cells expressing Q227L Gsα. The similar changes in expression and activity of AC, PDE and PKA were observed in the SH-SY5Y cells treated with dbcAMP for 6 days. Consequently, it is concluded that the cAMP system adapts at the post-receptor level to a sustained activation of the system by differential expression of the isoforms of AC, PDE, and PKA in SH-SY5Y neuroblastoma. We also showed that an increase in cellular cAMP concentration might mediate the observed changes in the cAMP system. More... »

PAGES

37-45

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/emm.2001.8

DOI

http://dx.doi.org/10.1038/emm.2001.8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021549065

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11322485


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0304", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medicinal and Biomolecular Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "3',5'-Cyclic-AMP Phosphodiesterases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenylyl Cyclases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromogranins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP-Dependent Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "GTP-Binding Protein alpha Subunits, Gs", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterotrimeric GTP-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isoenzymes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Isoproterenol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nerve Tissue Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neuroblastoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry and Cancer Research Institute, Seoul National University College of Medicine, Korea", 
          "id": "http://www.grid.ac/institutes/grid.31501.36", 
          "name": [
            "Department of Biochemistry and Cancer Research Institute, Seoul National University College of Medicine, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jang", 
        "givenName": "Ik-Soon", 
        "id": "sg:person.01317070447.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317070447.13"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Juhnn", 
        "givenName": "Yong-Sung", 
        "id": "sg:person.01051451562.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051451562.78"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2001-03-01", 
    "datePublishedReg": "2001-03-01", 
    "description": "Heterotrimeric GTP-binding proteins (G protein) are known to participate in the transduction of signals from ligand activated receptors to effector molecules to elicit cellular responses. Sustained activation of cAMP-G protein signaling system by agonist results in desensitization of the pathway at receptor levels, however it is not clear whether such receptor responses induce other changes in post-receptor signaling path that are associated with maintenance of AMP levels, i.e. cAMP-forming adenylate cyclase (AC), cAMP-degrading cyclic nucleotide phosphodiesterase (PDE) and cAMP-dependent protein kinase (PKA). Experiments were performed to determine the expression of AC, PDE, and PKA isoforms in SH-SY5Y neuroblastoma cells, in which cAMP system was activated by expressing a constitutively activated mutant of stimulatory G protein (Q227L Gs\u03b1). Expression of ACI mRNA was increased, but levels of ACVIII and ACIX mRNA were decreased. All of the 4 expressed isoforms of PDE (PDE1C, PDE2, PDE 4A, and PDE4B) were increased in mRNA expression; the levels of PKA RI\u03b1, RI\u03b2, and RII\u03b2 were increased moderately, however, those of RII\u03b1 and C\u03b1 were increased remarkably. The activities of AC, PDE and PKA were also increased in the SH-SY5Y cells expressing Q227L Gs\u03b1. The similar changes in expression and activity of AC, PDE and PKA were observed in the SH-SY5Y cells treated with dbcAMP for 6 days. Consequently, it is concluded that the cAMP system adapts at the post-receptor level to a sustained activation of the system by differential expression of the isoforms of AC, PDE, and PKA in SH-SY5Y neuroblastoma. We also showed that an increase in cellular cAMP concentration might mediate the observed changes in the cAMP system.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/emm.2001.8", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1085098", 
        "issn": [
          "1226-3613", 
          "2092-6413"
        ], 
        "name": "Experimental & Molecular Medicine", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "33"
      }
    ], 
    "keywords": [
      "protein kinase", 
      "SH-SY5Y neuroblastoma cells", 
      "SH-SY5Y cells", 
      "cAMP-dependent protein kinase", 
      "activity of AC", 
      "sustained activation", 
      "transduction of signals", 
      "elicit cellular responses", 
      "PKA isoforms", 
      "neuroblastoma cells", 
      "adenylate cyclase", 
      "heterotrimeric GTP", 
      "isoforms of phosphodiesterase", 
      "cellular cAMP concentration", 
      "PKA RI\u03b1", 
      "G protein", 
      "SH-SY5Y neuroblastoma", 
      "stimulatory G protein", 
      "cellular responses", 
      "stimulatory G protein \u03b1", 
      "differential expression", 
      "protein \u03b1", 
      "effector molecules", 
      "cyclic nucleotide phosphodiesterase", 
      "protein", 
      "isoforms", 
      "post-receptor level", 
      "expression", 
      "nucleotide phosphodiesterase", 
      "phosphodiesterase", 
      "cAMP concentration", 
      "Gs\u03b1", 
      "mRNA", 
      "cells", 
      "cAMP", 
      "mRNA expression", 
      "cAMP system", 
      "RII\u03b1", 
      "RI\u03b1", 
      "RII\u03b2", 
      "activation", 
      "agonists results", 
      "mutants", 
      "RI\u03b2", 
      "receptor responses", 
      "transduction", 
      "kinase", 
      "GTP", 
      "pathway", 
      "observed changes", 
      "receptor levels", 
      "C\u03b1", 
      "activity", 
      "AMP levels", 
      "cyclase", 
      "similar changes", 
      "adaptation", 
      "receptors", 
      "levels", 
      "response", 
      "maintenance", 
      "molecules", 
      "changes", 
      "dbcAMP", 
      "ligands", 
      "desensitization", 
      "signals", 
      "neuroblastoma", 
      "system", 
      "experiments", 
      "concentration", 
      "increase", 
      "days", 
      "results", 
      "path"
    ], 
    "name": "Adaptation of cAMP signaling system in SH-SY5Y neuroblastoma cells following expression of a constitutively active stimulatory G protein \u03b1, Q227L Gs\u03b1", 
    "pagination": "37-45", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021549065"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/emm.2001.8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "11322485"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/emm.2001.8", 
      "https://app.dimensions.ai/details/publication/pub.1021549065"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-20T07:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_330.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/emm.2001.8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/emm.2001.8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/emm.2001.8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/emm.2001.8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/emm.2001.8'


 

This table displays all metadata directly associated to this object as RDF triples.

203 TRIPLES      21 PREDICATES      116 URIs      108 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/emm.2001.8 schema:about N0c3262d16860482abc6107aa6a679f33
2 N0f6966eac3dc43588297d108611ba274
3 N11e5a9054d944ee68aa4e2e8ebfb4928
4 N3e25a90113e64bb4978292aad8e4ac5c
5 N4384960782a442588b8597d132750097
6 N50f1fd2d37ff46b7983d8002aa027c58
7 N51d812e7a5b8479f9b0dba3f4ff1422f
8 N599a87fe4dc446aebcb36dafc73152d5
9 N5ce0c244bc224121976df625387674dd
10 N6ff2bdc35c614f5da89ec1c6f6fc456c
11 N88a2c5212a80404188c624cea935b5a3
12 N923c67b41103417b8088a3c3cf553276
13 N963428f967434ddb9403085cab335400
14 Naeb30c3c868c4eb5b10f3c760cc63298
15 Nd6025287842d4017989c67d5fd729584
16 anzsrc-for:03
17 anzsrc-for:0304
18 schema:author N4aaed393317e415487a17b128dcb6266
19 schema:datePublished 2001-03-01
20 schema:datePublishedReg 2001-03-01
21 schema:description Heterotrimeric GTP-binding proteins (G protein) are known to participate in the transduction of signals from ligand activated receptors to effector molecules to elicit cellular responses. Sustained activation of cAMP-G protein signaling system by agonist results in desensitization of the pathway at receptor levels, however it is not clear whether such receptor responses induce other changes in post-receptor signaling path that are associated with maintenance of AMP levels, i.e. cAMP-forming adenylate cyclase (AC), cAMP-degrading cyclic nucleotide phosphodiesterase (PDE) and cAMP-dependent protein kinase (PKA). Experiments were performed to determine the expression of AC, PDE, and PKA isoforms in SH-SY5Y neuroblastoma cells, in which cAMP system was activated by expressing a constitutively activated mutant of stimulatory G protein (Q227L Gsα). Expression of ACI mRNA was increased, but levels of ACVIII and ACIX mRNA were decreased. All of the 4 expressed isoforms of PDE (PDE1C, PDE2, PDE 4A, and PDE4B) were increased in mRNA expression; the levels of PKA RIα, RIβ, and RIIβ were increased moderately, however, those of RIIα and Cα were increased remarkably. The activities of AC, PDE and PKA were also increased in the SH-SY5Y cells expressing Q227L Gsα. The similar changes in expression and activity of AC, PDE and PKA were observed in the SH-SY5Y cells treated with dbcAMP for 6 days. Consequently, it is concluded that the cAMP system adapts at the post-receptor level to a sustained activation of the system by differential expression of the isoforms of AC, PDE, and PKA in SH-SY5Y neuroblastoma. We also showed that an increase in cellular cAMP concentration might mediate the observed changes in the cAMP system.
22 schema:genre article
23 schema:inLanguage en
24 schema:isAccessibleForFree true
25 schema:isPartOf N31ee574bd85246dea4b3ffb77ba141ee
26 Ncc68631a4d494d1aa290a6bd41163aea
27 sg:journal.1085098
28 schema:keywords AMP levels
29
30 G protein
31 GTP
32 Gsα
33 PKA RIα
34 PKA isoforms
35 RIIα
36 RIIβ
37 RIα
38 RIβ
39 SH-SY5Y cells
40 SH-SY5Y neuroblastoma
41 SH-SY5Y neuroblastoma cells
42 activation
43 activity
44 activity of AC
45 adaptation
46 adenylate cyclase
47 agonists results
48 cAMP
49 cAMP concentration
50 cAMP system
51 cAMP-dependent protein kinase
52 cells
53 cellular cAMP concentration
54 cellular responses
55 changes
56 concentration
57 cyclase
58 cyclic nucleotide phosphodiesterase
59 days
60 dbcAMP
61 desensitization
62 differential expression
63 effector molecules
64 elicit cellular responses
65 experiments
66 expression
67 heterotrimeric GTP
68 increase
69 isoforms
70 isoforms of phosphodiesterase
71 kinase
72 levels
73 ligands
74 mRNA
75 mRNA expression
76 maintenance
77 molecules
78 mutants
79 neuroblastoma
80 neuroblastoma cells
81 nucleotide phosphodiesterase
82 observed changes
83 path
84 pathway
85 phosphodiesterase
86 post-receptor level
87 protein
88 protein kinase
89 protein α
90 receptor levels
91 receptor responses
92 receptors
93 response
94 results
95 signals
96 similar changes
97 stimulatory G protein
98 stimulatory G protein α
99 sustained activation
100 system
101 transduction
102 transduction of signals
103 schema:name Adaptation of cAMP signaling system in SH-SY5Y neuroblastoma cells following expression of a constitutively active stimulatory G protein α, Q227L Gsα
104 schema:pagination 37-45
105 schema:productId N431cbdc16553471eaa52440bfba4ede4
106 N926f92ef765f4c229de6c247547adfdb
107 Nd871478ff0344a6abfcb57a1b743919b
108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021549065
109 https://doi.org/10.1038/emm.2001.8
110 schema:sdDatePublished 2022-05-20T07:21
111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
112 schema:sdPublisher N1769c1ef65e74b88903d9ff9209424a6
113 schema:url https://doi.org/10.1038/emm.2001.8
114 sgo:license sg:explorer/license/
115 sgo:sdDataset articles
116 rdf:type schema:ScholarlyArticle
117 N0c3262d16860482abc6107aa6a679f33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Isoproterenol
119 rdf:type schema:DefinedTerm
120 N0f6966eac3dc43588297d108611ba274 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Mutation
122 rdf:type schema:DefinedTerm
123 N11e5a9054d944ee68aa4e2e8ebfb4928 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Humans
125 rdf:type schema:DefinedTerm
126 N1769c1ef65e74b88903d9ff9209424a6 schema:name Springer Nature - SN SciGraph project
127 rdf:type schema:Organization
128 N31ee574bd85246dea4b3ffb77ba141ee schema:volumeNumber 33
129 rdf:type schema:PublicationVolume
130 N3e25a90113e64bb4978292aad8e4ac5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Cyclic AMP
132 rdf:type schema:DefinedTerm
133 N431cbdc16553471eaa52440bfba4ede4 schema:name doi
134 schema:value 10.1038/emm.2001.8
135 rdf:type schema:PropertyValue
136 N4384960782a442588b8597d132750097 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Nerve Tissue Proteins
138 rdf:type schema:DefinedTerm
139 N4aaed393317e415487a17b128dcb6266 rdf:first sg:person.01317070447.13
140 rdf:rest Nc6083e84375648adacaff6d90c08cf12
141 N50f1fd2d37ff46b7983d8002aa027c58 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Adenylyl Cyclases
143 rdf:type schema:DefinedTerm
144 N51d812e7a5b8479f9b0dba3f4ff1422f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Heterotrimeric GTP-Binding Proteins
146 rdf:type schema:DefinedTerm
147 N599a87fe4dc446aebcb36dafc73152d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Isoenzymes
149 rdf:type schema:DefinedTerm
150 N5ce0c244bc224121976df625387674dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Tumor Cells, Cultured
152 rdf:type schema:DefinedTerm
153 N6ff2bdc35c614f5da89ec1c6f6fc456c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name 3',5'-Cyclic-AMP Phosphodiesterases
155 rdf:type schema:DefinedTerm
156 N88a2c5212a80404188c624cea935b5a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Cyclic AMP-Dependent Protein Kinases
158 rdf:type schema:DefinedTerm
159 N923c67b41103417b8088a3c3cf553276 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Neuroblastoma
161 rdf:type schema:DefinedTerm
162 N926f92ef765f4c229de6c247547adfdb schema:name pubmed_id
163 schema:value 11322485
164 rdf:type schema:PropertyValue
165 N963428f967434ddb9403085cab335400 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name GTP-Binding Protein alpha Subunits, Gs
167 rdf:type schema:DefinedTerm
168 Naeb30c3c868c4eb5b10f3c760cc63298 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Signal Transduction
170 rdf:type schema:DefinedTerm
171 Nc6083e84375648adacaff6d90c08cf12 rdf:first sg:person.01051451562.78
172 rdf:rest rdf:nil
173 Ncc68631a4d494d1aa290a6bd41163aea schema:issueNumber 1
174 rdf:type schema:PublicationIssue
175 Nd6025287842d4017989c67d5fd729584 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Chromogranins
177 rdf:type schema:DefinedTerm
178 Nd871478ff0344a6abfcb57a1b743919b schema:name dimensions_id
179 schema:value pub.1021549065
180 rdf:type schema:PropertyValue
181 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
182 schema:name Chemical Sciences
183 rdf:type schema:DefinedTerm
184 anzsrc-for:0304 schema:inDefinedTermSet anzsrc-for:
185 schema:name Medicinal and Biomolecular Chemistry
186 rdf:type schema:DefinedTerm
187 sg:journal.1085098 schema:issn 1226-3613
188 2092-6413
189 schema:name Experimental & Molecular Medicine
190 schema:publisher Springer Nature
191 rdf:type schema:Periodical
192 sg:person.01051451562.78 schema:familyName Juhnn
193 schema:givenName Yong-Sung
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051451562.78
195 rdf:type schema:Person
196 sg:person.01317070447.13 schema:affiliation grid-institutes:grid.31501.36
197 schema:familyName Jang
198 schema:givenName Ik-Soon
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317070447.13
200 rdf:type schema:Person
201 grid-institutes:grid.31501.36 schema:alternateName Department of Biochemistry and Cancer Research Institute, Seoul National University College of Medicine, Korea
202 schema:name Department of Biochemistry and Cancer Research Institute, Seoul National University College of Medicine, Korea
203 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...