Brugada syndrome risk loci seem protective against atrial fibrillation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12

AUTHORS

Laura Andreasen, Jonas B Nielsen, Stine Darkner, Ingrid E Christophersen, Javad Jabbari, Lena Refsgaard, Jens J Thiis, Ahmad Sajadieh, Arnljot Tveit, Stig Haunsø, Jesper H Svendsen, Nicole Schmitt, Morten S Olesen

ABSTRACT

Several studies have shown an overlap between genes involved in the pathophysiological mechanisms of atrial fibrillation (AF) and Brugada Syndrome (BrS). We investigated whether three single-nucleotide polymorphisms (SNPs) (rs11708996; G>C located intronic to SCN5A, rs10428132; T>G located in SCN10A, and rs9388451; T>C located downstream to HEY2) at loci associated with BrS in a recent genome-wide association study (GWAS) also were associated with AF. A total of 657 patients diagnosed with AF and a control group comprising 741 individuals free of AF were included. The three SNPs were genotyped using TaqMan assays. The frequencies of risk alleles in the AF population and the control population were compared in two-by-two models. One variant, rs10428132 at SCN10A, was associated with a statistically significant decreased risk of AF (odds ratio (OR)=0.77, P=0.001). A meta-analysis was performed by enriching the control population with allele frequencies from controls in the recently published BrS GWAS (2230 alleles). In this meta-analysis, both rs10428132 at SCN10A (OR=0.73, P=5.7 × 10(-6)) and rs11708996 at SCN5A (OR=0.80, P=0.02) showed a statistically significant decreased risk of AF. When assessing the additive effect of the three loci, we found that the risk of AF decreased in a dose-responsive manner with increasing numbers of risk alleles (OR=0.50, P=0.001 for individuals carrying ≥4 risk alleles vs ≤1 allele). In conclusion, the prevalence of three risk alleles previously associated with BrS was lower in AF patients than in patients free of AF, suggesting a protective role of these loci in developing AF. More... »

PAGES

1357

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ejhg.2014.46

DOI

http://dx.doi.org/10.1038/ejhg.2014.46

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033458764

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24667784


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Atrial Fibrillation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brugada Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Frequency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Loci", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genome-Wide Association Study", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotyping Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Logistic Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark", 
            "Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark", 
            "The Ion Channel Group, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andreasen", 
        "givenName": "Laura", 
        "id": "sg:person.01371204511.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371204511.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Danish National Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.452938.1", 
          "name": [
            "Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark", 
            "Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nielsen", 
        "givenName": "Jonas B", 
        "id": "sg:person.0765074230.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765074230.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Danish National Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.452938.1", 
          "name": [
            "Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark", 
            "Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Darkner", 
        "givenName": "Stine", 
        "id": "sg:person.01055304326.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055304326.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "B\u00e6rum sykehus", 
          "id": "https://www.grid.ac/institutes/grid.414168.e", 
          "name": [
            "Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark", 
            "Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark", 
            "Department of Medical Research, B\u00e6rum Hospital, Vestre Viken Hospital Trust, Rud, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Christophersen", 
        "givenName": "Ingrid E", 
        "id": "sg:person.0620266371.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620266371.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Danish National Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.452938.1", 
          "name": [
            "Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark", 
            "Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jabbari", 
        "givenName": "Javad", 
        "id": "sg:person.01275557271.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275557271.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Danish National Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.452938.1", 
          "name": [
            "Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark", 
            "Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Refsgaard", 
        "givenName": "Lena", 
        "id": "sg:person.0626131215.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626131215.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Departments of Cardiothoracic Surgery and Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thiis", 
        "givenName": "Jens J", 
        "id": "sg:person.01202531752.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202531752.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sajadieh", 
        "givenName": "Ahmad", 
        "id": "sg:person.01215641063.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215641063.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "B\u00e6rum sykehus", 
          "id": "https://www.grid.ac/institutes/grid.414168.e", 
          "name": [
            "Department of Medical Research, B\u00e6rum Hospital, Vestre Viken Hospital Trust, Rud, Norway"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tveit", 
        "givenName": "Arnljot", 
        "id": "sg:person.01327731106.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327731106.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark", 
            "Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark", 
            "Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hauns\u00f8", 
        "givenName": "Stig", 
        "id": "sg:person.0110264253.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0110264253.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark", 
            "Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark", 
            "Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Svendsen", 
        "givenName": "Jesper H", 
        "id": "sg:person.01201204624.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201204624.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark", 
            "The Ion Channel Group, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schmitt", 
        "givenName": "Nicole", 
        "id": "sg:person.01116776147.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116776147.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Danish National Research Foundation", 
          "id": "https://www.grid.ac/institutes/grid.452938.1", 
          "name": [
            "Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark", 
            "Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olesen", 
        "givenName": "Morten S", 
        "id": "sg:person.01161330671.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161330671.71"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1001/jama.285.18.2370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000462528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.25.20.8960-8970.2005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001131997"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2010.09.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001726958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003591401", 
          "https://doi.org/10.1038/ng.517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.517", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003591401", 
          "https://doi.org/10.1038/ng.517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.112.274035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004002814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.112.274035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004002814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.112.274035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004002814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9343(99)80348-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005453448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.112.265173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008256035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.112.265173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008256035"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.hrthm.2004.07.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008582015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.111.960633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008855228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.111.960633", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008855228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052800", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009931822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/cvr142", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011278296"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.107.757955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012000794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.hrthm.2011.12.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012144695"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cjca.2012.08.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013811654"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.hrthm.2010.06.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014099993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/europace/eur007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018977880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.108.829192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019845404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.108.829192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019845404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yjmcc.2009.07.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020225709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphys.2013.00179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020571608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/cvq348", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024210737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/hc1102.105288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024967613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.91495.2007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030241256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000141136.85194.f0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031165849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000141136.85194.f0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031165849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphys.2012.00210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032292783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehs442", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032376036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.105.601294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032869002"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.98.10.946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034767295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci62613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035693257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci62613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035693257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.113.000133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036824128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.113.000133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036824128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cjca.2010.11.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037757594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.110.959130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037828321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.110.959130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037828321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038528145", 
          "https://doi.org/10.1038/ng.2712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.112.000604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039076794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.112.000604", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039076794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.111.962597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039077129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgenetics.111.962597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039077129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.252648999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039147910"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000152479.54298.51", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041139092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.716", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042403145", 
          "https://doi.org/10.1038/ng.716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0702447104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042621716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/147323001103900535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044080273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/147323001103900535", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044080273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ejhg.2013.139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046189912", 
          "https://doi.org/10.1038/ejhg.2013.139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0057216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046198620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cjca.2011.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048195140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000261693.13269.bf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048984373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.0000261693.13269.bf", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048984373"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/europace/euq350", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049112529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.hrthm.2011.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050824327"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/europace/eus150", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051885032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1050-1738(03)00082-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053009061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1050-1738(03)00082-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053009061"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehi169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053371801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.96.7.2455", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063338515"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-12", 
    "datePublishedReg": "2014-12-01", 
    "description": "Several studies have shown an overlap between genes involved in the pathophysiological mechanisms of atrial fibrillation (AF) and Brugada Syndrome (BrS). We investigated whether three single-nucleotide polymorphisms (SNPs) (rs11708996; G>C located intronic to SCN5A, rs10428132; T>G located in SCN10A, and rs9388451; T>C located downstream to HEY2) at loci associated with BrS in a recent genome-wide association study (GWAS) also were associated with AF. A total of 657 patients diagnosed with AF and a control group comprising 741 individuals free of AF were included. The three SNPs were genotyped using TaqMan assays. The frequencies of risk alleles in the AF population and the control population were compared in two-by-two models. One variant, rs10428132 at SCN10A, was associated with a statistically significant decreased risk of AF (odds ratio (OR)=0.77, P=0.001). A meta-analysis was performed by enriching the control population with allele frequencies from controls in the recently published BrS GWAS (2230 alleles). In this meta-analysis, both rs10428132 at SCN10A (OR=0.73, P=5.7 \u00d7 10(-6)) and rs11708996 at SCN5A (OR=0.80, P=0.02) showed a statistically significant decreased risk of AF. When assessing the additive effect of the three loci, we found that the risk of AF decreased in a dose-responsive manner with increasing numbers of risk alleles (OR=0.50, P=0.001 for individuals carrying \u22654 risk alleles vs \u22641 allele). In conclusion, the prevalence of three risk alleles previously associated with BrS was lower in AF patients than in patients free of AF, suggesting a protective role of these loci in developing AF. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ejhg.2014.46", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1103410", 
        "issn": [
          "1018-4813", 
          "1476-5438"
        ], 
        "name": "European Journal of Human Genetics", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "22"
      }
    ], 
    "name": "Brugada syndrome risk loci seem protective against atrial fibrillation", 
    "pagination": "1357", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9f63f6757438f128b7ddcdeb8d5a7e5cc5ab6f08e5096d716b4917200d79478b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24667784"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9302235"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ejhg.2014.46"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033458764"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ejhg.2014.46", 
      "https://app.dimensions.ai/details/publication/pub.1033458764"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000589.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/ejhg201446"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ejhg.2014.46'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ejhg.2014.46'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ejhg.2014.46'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ejhg.2014.46'


 

This table displays all metadata directly associated to this object as RDF triples.

400 TRIPLES      21 PREDICATES      98 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ejhg.2014.46 schema:about N083f23b9bcae4053be54d5c5c13411d3
2 N131948aeb1c845398170c875ce7ad3c7
3 N22138b2fc54d4116bf3493ea50aa5d62
4 N27da5affca86448cba6bdd50df4e5948
5 N2f405c6e2f774530a8024b36b67617ea
6 N34ab8ab906f24e629c0846e4bc2c6e41
7 N42b3d00e87544428b7f1254f08f94d76
8 N458a9f94a3844594bba11a37c321c86d
9 N5ccfddcf63c74c6fac21a19dae61d877
10 N5ea88a3b60cd4209b0114139df57f835
11 N784eeeb071574db8a14e3893bb47e6a7
12 N8d626f0abad6490aa97d5e5505d87e4f
13 Na0be9927686a4dbcaf1c624bccfb76a8
14 Na54efa52f0644a6694cdd5f7c9be1a87
15 Naa5bd7be616c46e7ac3e5416439d00b4
16 Nae424d7cf8854dc98403e56d76956dab
17 Nbd31f616b5ef405abbac4341dae0ee74
18 Nc79f14591a60459ea16f8b78a5bef9e3
19 Ndaddb7924a7540eda9688adff0419fab
20 Nef6170b7c7104d70a25634427a66be08
21 anzsrc-for:06
22 anzsrc-for:0604
23 schema:author N140e05fe8682445384727a2a51a01720
24 schema:citation sg:pub.10.1038/ejhg.2013.139
25 sg:pub.10.1038/ng.2712
26 sg:pub.10.1038/ng.517
27 sg:pub.10.1038/ng.716
28 https://doi.org/10.1001/jama.285.18.2370
29 https://doi.org/10.1016/j.cjca.2010.11.015
30 https://doi.org/10.1016/j.cjca.2011.01.003
31 https://doi.org/10.1016/j.cjca.2012.08.002
32 https://doi.org/10.1016/j.hrthm.2004.07.001
33 https://doi.org/10.1016/j.hrthm.2010.06.016
34 https://doi.org/10.1016/j.hrthm.2011.12.005
35 https://doi.org/10.1016/j.hrthm.2011.12.006
36 https://doi.org/10.1016/j.jacc.2010.09.013
37 https://doi.org/10.1016/j.yjmcc.2009.07.020
38 https://doi.org/10.1016/s0002-9343(99)80348-9
39 https://doi.org/10.1016/s1050-1738(03)00082-3
40 https://doi.org/10.1056/nejmoa052800
41 https://doi.org/10.1073/pnas.0702447104
42 https://doi.org/10.1073/pnas.252648999
43 https://doi.org/10.1093/cvr/cvq348
44 https://doi.org/10.1093/cvr/cvr142
45 https://doi.org/10.1093/eurheartj/ehi169
46 https://doi.org/10.1093/eurheartj/ehs442
47 https://doi.org/10.1093/europace/euq350
48 https://doi.org/10.1093/europace/eur007
49 https://doi.org/10.1093/europace/eus150
50 https://doi.org/10.1128/mcb.25.20.8960-8970.2005
51 https://doi.org/10.1152/ajpheart.91495.2007
52 https://doi.org/10.1161/01.cir.0000152479.54298.51
53 https://doi.org/10.1161/01.cir.96.7.2455
54 https://doi.org/10.1161/01.cir.98.10.946
55 https://doi.org/10.1161/01.res.0000141136.85194.f0
56 https://doi.org/10.1161/01.res.0000261693.13269.bf
57 https://doi.org/10.1161/circgenetics.108.829192
58 https://doi.org/10.1161/circgenetics.110.959130
59 https://doi.org/10.1161/circgenetics.111.960633
60 https://doi.org/10.1161/circgenetics.111.962597
61 https://doi.org/10.1161/circgenetics.113.000133
62 https://doi.org/10.1161/circresaha.112.265173
63 https://doi.org/10.1161/circresaha.112.274035
64 https://doi.org/10.1161/circulationaha.105.601294
65 https://doi.org/10.1161/circulationaha.107.757955
66 https://doi.org/10.1161/circulationaha.112.000604
67 https://doi.org/10.1161/hc1102.105288
68 https://doi.org/10.1172/jci62613
69 https://doi.org/10.1177/147323001103900535
70 https://doi.org/10.1371/journal.pone.0057216
71 https://doi.org/10.3389/fphys.2012.00210
72 https://doi.org/10.3389/fphys.2013.00179
73 schema:datePublished 2014-12
74 schema:datePublishedReg 2014-12-01
75 schema:description Several studies have shown an overlap between genes involved in the pathophysiological mechanisms of atrial fibrillation (AF) and Brugada Syndrome (BrS). We investigated whether three single-nucleotide polymorphisms (SNPs) (rs11708996; G>C located intronic to SCN5A, rs10428132; T>G located in SCN10A, and rs9388451; T>C located downstream to HEY2) at loci associated with BrS in a recent genome-wide association study (GWAS) also were associated with AF. A total of 657 patients diagnosed with AF and a control group comprising 741 individuals free of AF were included. The three SNPs were genotyped using TaqMan assays. The frequencies of risk alleles in the AF population and the control population were compared in two-by-two models. One variant, rs10428132 at SCN10A, was associated with a statistically significant decreased risk of AF (odds ratio (OR)=0.77, P=0.001). A meta-analysis was performed by enriching the control population with allele frequencies from controls in the recently published BrS GWAS (2230 alleles). In this meta-analysis, both rs10428132 at SCN10A (OR=0.73, P=5.7 × 10(-6)) and rs11708996 at SCN5A (OR=0.80, P=0.02) showed a statistically significant decreased risk of AF. When assessing the additive effect of the three loci, we found that the risk of AF decreased in a dose-responsive manner with increasing numbers of risk alleles (OR=0.50, P=0.001 for individuals carrying ≥4 risk alleles vs ≤1 allele). In conclusion, the prevalence of three risk alleles previously associated with BrS was lower in AF patients than in patients free of AF, suggesting a protective role of these loci in developing AF.
76 schema:genre research_article
77 schema:inLanguage en
78 schema:isAccessibleForFree true
79 schema:isPartOf N9b650a604d0d4fc5a3965a848c8481ba
80 Ne969c83890d24cfab652ab206f4f80b0
81 sg:journal.1103410
82 schema:name Brugada syndrome risk loci seem protective against atrial fibrillation
83 schema:pagination 1357
84 schema:productId N05b9466e14a14ce88dd05f5c671d1ea9
85 N16c5f81ae0d446c38a1699294941d71a
86 N5a46ce3bdf1a4119bd0efa0ae1aea7d8
87 Naefed70b4bfe4d7887e28bd99b10f596
88 Ne60c5ecdd48d4a8db990672c21519782
89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033458764
90 https://doi.org/10.1038/ejhg.2014.46
91 schema:sdDatePublished 2019-04-10T13:30
92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
93 schema:sdPublisher Nbf0461ac13a644948b6636dc4e85fe55
94 schema:url https://www.nature.com/articles/ejhg201446
95 sgo:license sg:explorer/license/
96 sgo:sdDataset articles
97 rdf:type schema:ScholarlyArticle
98 N05b9466e14a14ce88dd05f5c671d1ea9 schema:name pubmed_id
99 schema:value 24667784
100 rdf:type schema:PropertyValue
101 N083f23b9bcae4053be54d5c5c13411d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Polymorphism, Single Nucleotide
103 rdf:type schema:DefinedTerm
104 N131948aeb1c845398170c875ce7ad3c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Genetic Predisposition to Disease
106 rdf:type schema:DefinedTerm
107 N140e05fe8682445384727a2a51a01720 rdf:first sg:person.01371204511.45
108 rdf:rest N25355fa7ba8b4ef7ba62409b5980f714
109 N16c5f81ae0d446c38a1699294941d71a schema:name doi
110 schema:value 10.1038/ejhg.2014.46
111 rdf:type schema:PropertyValue
112 N22138b2fc54d4116bf3493ea50aa5d62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Humans
114 rdf:type schema:DefinedTerm
115 N25355fa7ba8b4ef7ba62409b5980f714 rdf:first sg:person.0765074230.63
116 rdf:rest N7a18b6c5547b4f8fb051075ac43070b0
117 N27da5affca86448cba6bdd50df4e5948 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Adolescent
119 rdf:type schema:DefinedTerm
120 N2f405c6e2f774530a8024b36b67617ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Female
122 rdf:type schema:DefinedTerm
123 N34ab8ab906f24e629c0846e4bc2c6e41 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Brugada Syndrome
125 rdf:type schema:DefinedTerm
126 N3864a2f9f4eb48ad88f6312429f8717b rdf:first sg:person.01327731106.37
127 rdf:rest N78862e05b0294a2b8e6cadeab8001286
128 N42b3d00e87544428b7f1254f08f94d76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Gene Frequency
130 rdf:type schema:DefinedTerm
131 N44c51a7041b34e239a9f8de345ab619a rdf:first sg:person.0620266371.52
132 rdf:rest N63393ad484d94e7091bf980070d33f3e
133 N458a9f94a3844594bba11a37c321c86d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Adult
135 rdf:type schema:DefinedTerm
136 N5a46ce3bdf1a4119bd0efa0ae1aea7d8 schema:name nlm_unique_id
137 schema:value 9302235
138 rdf:type schema:PropertyValue
139 N5ccfddcf63c74c6fac21a19dae61d877 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Aged
141 rdf:type schema:DefinedTerm
142 N5ea88a3b60cd4209b0114139df57f835 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Case-Control Studies
144 rdf:type schema:DefinedTerm
145 N63393ad484d94e7091bf980070d33f3e rdf:first sg:person.01275557271.99
146 rdf:rest N8faaec21c76b49e7a64417e6b05105db
147 N722c935a9c344f90a3cbe7674255e6fc rdf:first sg:person.01161330671.71
148 rdf:rest rdf:nil
149 N784eeeb071574db8a14e3893bb47e6a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Risk Factors
151 rdf:type schema:DefinedTerm
152 N78862e05b0294a2b8e6cadeab8001286 rdf:first sg:person.0110264253.77
153 rdf:rest Neea7d3f845144a3f80b41cd731ec227d
154 N7a18b6c5547b4f8fb051075ac43070b0 rdf:first sg:person.01055304326.53
155 rdf:rest N44c51a7041b34e239a9f8de345ab619a
156 N7f35f7e7db9042feb099d3c08f5e39cc rdf:first sg:person.01202531752.54
157 rdf:rest Nd94afdf3db3a4653af21e02231fdf00f
158 N8d626f0abad6490aa97d5e5505d87e4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Male
160 rdf:type schema:DefinedTerm
161 N8faaec21c76b49e7a64417e6b05105db rdf:first sg:person.0626131215.34
162 rdf:rest N7f35f7e7db9042feb099d3c08f5e39cc
163 N9b650a604d0d4fc5a3965a848c8481ba schema:volumeNumber 22
164 rdf:type schema:PublicationVolume
165 Na0be9927686a4dbcaf1c624bccfb76a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Young Adult
167 rdf:type schema:DefinedTerm
168 Na54efa52f0644a6694cdd5f7c9be1a87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Middle Aged
170 rdf:type schema:DefinedTerm
171 Naa5bd7be616c46e7ac3e5416439d00b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Alleles
173 rdf:type schema:DefinedTerm
174 Nae424d7cf8854dc98403e56d76956dab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Genotyping Techniques
176 rdf:type schema:DefinedTerm
177 Naefed70b4bfe4d7887e28bd99b10f596 schema:name readcube_id
178 schema:value 9f63f6757438f128b7ddcdeb8d5a7e5cc5ab6f08e5096d716b4917200d79478b
179 rdf:type schema:PropertyValue
180 Nb9f2b9a973ae4db7992f188e357d3bb6 rdf:first sg:person.01116776147.44
181 rdf:rest N722c935a9c344f90a3cbe7674255e6fc
182 Nbd31f616b5ef405abbac4341dae0ee74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Logistic Models
184 rdf:type schema:DefinedTerm
185 Nbf0461ac13a644948b6636dc4e85fe55 schema:name Springer Nature - SN SciGraph project
186 rdf:type schema:Organization
187 Nc53e0d09110747abba4bc2308d5ab59a schema:name Department of Cardiology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
188 rdf:type schema:Organization
189 Nc79f14591a60459ea16f8b78a5bef9e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Genetic Loci
191 rdf:type schema:DefinedTerm
192 Nd94afdf3db3a4653af21e02231fdf00f rdf:first sg:person.01215641063.55
193 rdf:rest N3864a2f9f4eb48ad88f6312429f8717b
194 Ndaddb7924a7540eda9688adff0419fab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Atrial Fibrillation
196 rdf:type schema:DefinedTerm
197 Ne60c5ecdd48d4a8db990672c21519782 schema:name dimensions_id
198 schema:value pub.1033458764
199 rdf:type schema:PropertyValue
200 Ne969c83890d24cfab652ab206f4f80b0 schema:issueNumber 12
201 rdf:type schema:PublicationIssue
202 Ned2bc4e5498b408b98d56bcd95fc68d1 schema:name Departments of Cardiothoracic Surgery and Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
203 rdf:type schema:Organization
204 Neea7d3f845144a3f80b41cd731ec227d rdf:first sg:person.01201204624.00
205 rdf:rest Nb9f2b9a973ae4db7992f188e357d3bb6
206 Nef6170b7c7104d70a25634427a66be08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
207 schema:name Genome-Wide Association Study
208 rdf:type schema:DefinedTerm
209 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
210 schema:name Biological Sciences
211 rdf:type schema:DefinedTerm
212 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
213 schema:name Genetics
214 rdf:type schema:DefinedTerm
215 sg:journal.1103410 schema:issn 1018-4813
216 1476-5438
217 schema:name European Journal of Human Genetics
218 rdf:type schema:Periodical
219 sg:person.01055304326.53 schema:affiliation https://www.grid.ac/institutes/grid.452938.1
220 schema:familyName Darkner
221 schema:givenName Stine
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055304326.53
223 rdf:type schema:Person
224 sg:person.0110264253.77 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
225 schema:familyName Haunsø
226 schema:givenName Stig
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0110264253.77
228 rdf:type schema:Person
229 sg:person.01116776147.44 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
230 schema:familyName Schmitt
231 schema:givenName Nicole
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01116776147.44
233 rdf:type schema:Person
234 sg:person.01161330671.71 schema:affiliation https://www.grid.ac/institutes/grid.452938.1
235 schema:familyName Olesen
236 schema:givenName Morten S
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01161330671.71
238 rdf:type schema:Person
239 sg:person.01201204624.00 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
240 schema:familyName Svendsen
241 schema:givenName Jesper H
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201204624.00
243 rdf:type schema:Person
244 sg:person.01202531752.54 schema:affiliation Ned2bc4e5498b408b98d56bcd95fc68d1
245 schema:familyName Thiis
246 schema:givenName Jens J
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202531752.54
248 rdf:type schema:Person
249 sg:person.01215641063.55 schema:affiliation Nc53e0d09110747abba4bc2308d5ab59a
250 schema:familyName Sajadieh
251 schema:givenName Ahmad
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215641063.55
253 rdf:type schema:Person
254 sg:person.01275557271.99 schema:affiliation https://www.grid.ac/institutes/grid.452938.1
255 schema:familyName Jabbari
256 schema:givenName Javad
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275557271.99
258 rdf:type schema:Person
259 sg:person.01327731106.37 schema:affiliation https://www.grid.ac/institutes/grid.414168.e
260 schema:familyName Tveit
261 schema:givenName Arnljot
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01327731106.37
263 rdf:type schema:Person
264 sg:person.01371204511.45 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
265 schema:familyName Andreasen
266 schema:givenName Laura
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371204511.45
268 rdf:type schema:Person
269 sg:person.0620266371.52 schema:affiliation https://www.grid.ac/institutes/grid.414168.e
270 schema:familyName Christophersen
271 schema:givenName Ingrid E
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620266371.52
273 rdf:type schema:Person
274 sg:person.0626131215.34 schema:affiliation https://www.grid.ac/institutes/grid.452938.1
275 schema:familyName Refsgaard
276 schema:givenName Lena
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626131215.34
278 rdf:type schema:Person
279 sg:person.0765074230.63 schema:affiliation https://www.grid.ac/institutes/grid.452938.1
280 schema:familyName Nielsen
281 schema:givenName Jonas B
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765074230.63
283 rdf:type schema:Person
284 sg:pub.10.1038/ejhg.2013.139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046189912
285 https://doi.org/10.1038/ejhg.2013.139
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/ng.2712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038528145
288 https://doi.org/10.1038/ng.2712
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/ng.517 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003591401
291 https://doi.org/10.1038/ng.517
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/ng.716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042403145
294 https://doi.org/10.1038/ng.716
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1001/jama.285.18.2370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000462528
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1016/j.cjca.2010.11.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037757594
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.cjca.2011.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048195140
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.cjca.2012.08.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013811654
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.hrthm.2004.07.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008582015
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.hrthm.2010.06.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014099993
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.hrthm.2011.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050824327
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/j.hrthm.2011.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012144695
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/j.jacc.2010.09.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001726958
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.yjmcc.2009.07.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020225709
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/s0002-9343(99)80348-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005453448
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/s1050-1738(03)00082-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053009061
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1056/nejmoa052800 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009931822
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1073/pnas.0702447104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042621716
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1073/pnas.252648999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039147910
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1093/cvr/cvq348 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024210737
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1093/cvr/cvr142 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011278296
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1093/eurheartj/ehi169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053371801
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1093/eurheartj/ehs442 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032376036
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1093/europace/euq350 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049112529
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1093/europace/eur007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018977880
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1093/europace/eus150 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051885032
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1128/mcb.25.20.8960-8970.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001131997
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1152/ajpheart.91495.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030241256
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1161/01.cir.0000152479.54298.51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041139092
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1161/01.cir.96.7.2455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063338515
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1161/01.cir.98.10.946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034767295
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1161/01.res.0000141136.85194.f0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031165849
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1161/01.res.0000261693.13269.bf schema:sameAs https://app.dimensions.ai/details/publication/pub.1048984373
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1161/circgenetics.108.829192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019845404
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1161/circgenetics.110.959130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037828321
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1161/circgenetics.111.960633 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008855228
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1161/circgenetics.111.962597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039077129
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1161/circgenetics.113.000133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036824128
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1161/circresaha.112.265173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008256035
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1161/circresaha.112.274035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004002814
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1161/circulationaha.105.601294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032869002
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1161/circulationaha.107.757955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012000794
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1161/circulationaha.112.000604 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039076794
373 rdf:type schema:CreativeWork
374 https://doi.org/10.1161/hc1102.105288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024967613
375 rdf:type schema:CreativeWork
376 https://doi.org/10.1172/jci62613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035693257
377 rdf:type schema:CreativeWork
378 https://doi.org/10.1177/147323001103900535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044080273
379 rdf:type schema:CreativeWork
380 https://doi.org/10.1371/journal.pone.0057216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046198620
381 rdf:type schema:CreativeWork
382 https://doi.org/10.3389/fphys.2012.00210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032292783
383 rdf:type schema:CreativeWork
384 https://doi.org/10.3389/fphys.2013.00179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020571608
385 rdf:type schema:CreativeWork
386 https://www.grid.ac/institutes/grid.414168.e schema:alternateName Bærum sykehus
387 schema:name Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark
388 Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Rud, Norway
389 Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
390 rdf:type schema:Organization
391 https://www.grid.ac/institutes/grid.452938.1 schema:alternateName Danish National Research Foundation
392 schema:name Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark
393 Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
394 rdf:type schema:Organization
395 https://www.grid.ac/institutes/grid.5254.6 schema:alternateName University of Copenhagen
396 schema:name Danish National Research Foundation Centre for Cardiac Arrhythmia, Copenhagen, Denmark
397 Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
398 Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
399 The Ion Channel Group, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
400 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...