Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-09

AUTHORS

Birgit Debrabant, Mette Soerensen, Friederike Flachsbart, Serena Dato, Jonas Mengel-From, Tinna Stevnsner, Vilhelm A Bohr, Torben A Kruse, Stefan Schreiber, Almut Nebel, Kaare Christensen, Qihua Tan, Lene Christiansen

ABSTRACT

DNA-damage response and repair are crucial to maintain genetic stability, and are consequently considered central to aging and longevity. Here, we investigate whether this pathway overall associates to longevity, and whether specific sub-processes are more strongly associated with longevity than others. Data were applied on 592 SNPs from 77 genes involved in nine sub-processes: DNA-damage response, base excision repair (BER), nucleotide excision repair, mismatch repair, non-homologous end-joining, homologous recombinational repair (HRR), RecQ helicase activities (RECQ), telomere functioning and mitochondrial DNA processes. The study population was 1089 long-lived and 736 middle-aged Danes. A self-contained set-based test of all SNPs displayed association with longevity (P-value=9.9 × 10(-5)), supporting that the overall pathway could affect longevity. Investigation of the nine sub-processes using the competitive gene-set analysis by Wang et al indicated that BER, HRR and RECQ associated stronger with longevity than the respective remaining genes of the pathway (P-values=0.004-0.048). For HRR and RECQ, only one gene contributed to the significance, whereas for BER several genes contributed. These associations did, however, generally not pass correction for multiple testing. Still, these findings indicate that, of the entire pathway, variation in BER might influence longevity the most. These modest sized P-values were not replicated in a German sample. This might, though, be due to differences in genotyping procedures and investigated SNPs, potentially inducing differences in the coverage of gene regions. Specifically, five genes were not covered at all in the German data. Therefore, investigations in additional study populations are needed before final conclusion can be drawn. More... »

PAGES

1131

References to SciGraph publications

  • 2006-04. Genetic influence on human lifespan and longevity in HUMAN GENETICS
  • 2006-04. Association between the MLH1 gene and longevity in HUMAN GENETICS
  • 2010-08. Progeria syndromes and ageing: what is the connection? in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1993-04. Instability and decay of the primary structure of DNA in NATURE
  • 2010-12. Analysing biological pathways in genome-wide association studies in NATURE REVIEWS GENETICS
  • 2013-02. Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways in GEROSCIENCE
  • 2009-10-08. Finding the missing heritability of complex diseases in NATURE
  • 2001-05. Genome maintenance mechanisms for preventing cancer in NATURE
  • 2006-10. Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging in NATURE MEDICINE
  • 2006-06. The quest for genetic determinants of human longevity: challenges and insights in NATURE REVIEWS GENETICS
  • 2007-09. Cellular senescence: when bad things happen to good cells in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 1996-03. The heritability of human longevity: A population-based study of 2872 Danish twin pairs born 1870–1900 in HUMAN GENETICS
  • 2011-08. The genetic component of human longevity: analysis of the survival advantage of parents and siblings of Italian nonagenarians in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2000-11. Why do we age? in NATURE
  • 1994-01. Genetic associations with human longevity at the APOE and ACE loci in NATURE GENETICS
  • 2002-01. p53 mutant mice that display early ageing-associated phenotypes in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ejhg.2013.299

    DOI

    http://dx.doi.org/10.1038/ejhg.2013.299

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1017558418

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24518833


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Case-Control Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Damage", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Repair", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Repair Enzymes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Longevity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "University of Southern Denmark", 
              "id": "https://www.grid.ac/institutes/grid.10825.3e", 
              "name": [
                "Epidemiology, Biostatistics and Biodemography, The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Debrabant", 
            "givenName": "Birgit", 
            "id": "sg:person.0714567154.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714567154.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Odense University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.7143.1", 
              "name": [
                "Epidemiology, Biostatistics and Biodemography, The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark", 
                "Department of Clinical Genetics, Odense University Hospital, Odense, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Soerensen", 
            "givenName": "Mette", 
            "id": "sg:person.01030645127.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030645127.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Flachsbart", 
            "givenName": "Friederike", 
            "id": "sg:person.01256440720.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256440720.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Calabria", 
              "id": "https://www.grid.ac/institutes/grid.7778.f", 
              "name": [
                "Department of Biology, Ecology and Earth Science, University of Calabria, Rende, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dato", 
            "givenName": "Serena", 
            "id": "sg:person.0771103470.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771103470.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Odense University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.7143.1", 
              "name": [
                "Epidemiology, Biostatistics and Biodemography, The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark", 
                "Department of Clinical Genetics, Odense University Hospital, Odense, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mengel-From", 
            "givenName": "Jonas", 
            "id": "sg:person.01337663350.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337663350.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Aarhus University", 
              "id": "https://www.grid.ac/institutes/grid.7048.b", 
              "name": [
                "Department of Molecular Biology and Genetics, The Danish Aging Research Center, Aarhus University, Aarhus, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stevnsner", 
            "givenName": "Tinna", 
            "id": "sg:person.0634070300.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634070300.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Institute on Aging", 
              "id": "https://www.grid.ac/institutes/grid.419475.a", 
              "name": [
                "Department of Molecular Biology and Genetics, The Danish Aging Research Center, Aarhus University, Aarhus, Denmark", 
                "Laboratory of Molecular Gerontology, National Institute on Aging, National Institute of Health, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bohr", 
            "givenName": "Vilhelm A", 
            "id": "sg:person.012703150357.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012703150357.62"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Odense University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.7143.1", 
              "name": [
                "Department of Clinical Genetics, Odense University Hospital, Odense, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kruse", 
            "givenName": "Torben A", 
            "id": "sg:person.01167033770.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167033770.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Schreiber", 
            "givenName": "Stefan", 
            "id": "sg:person.01223143620.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223143620.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kiel University", 
              "id": "https://www.grid.ac/institutes/grid.9764.c", 
              "name": [
                "Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nebel", 
            "givenName": "Almut", 
            "id": "sg:person.0647612100.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647612100.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Odense University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.7143.1", 
              "name": [
                "Epidemiology, Biostatistics and Biodemography, The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark", 
                "Department of Clinical Genetics, Odense University Hospital, Odense, Denmark", 
                "Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Christensen", 
            "givenName": "Kaare", 
            "id": "sg:person.010113074200.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010113074200.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Odense University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.7143.1", 
              "name": [
                "Epidemiology, Biostatistics and Biodemography, The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark", 
                "Department of Clinical Genetics, Odense University Hospital, Odense, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tan", 
            "givenName": "Qihua", 
            "id": "sg:person.01213635722.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213635722.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Odense University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.7143.1", 
              "name": [
                "Epidemiology, Biostatistics and Biodemography, The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark", 
                "Department of Clinical Genetics, Odense University Hospital, Odense, Denmark"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Christiansen", 
            "givenName": "Lene", 
            "id": "sg:person.01021360764.20", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021360764.20"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1111/j.1474-9726.2010.00626.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001278403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1474-9726.2010.00626.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001278403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1474-9726.2010.00626.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001278403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1474-9726.2010.00626.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001278403"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1474-9726.2007.00340.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002493165"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0921-8734(91)90032-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004619230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005147626", 
              "https://doi.org/10.1038/nature08494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08494", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005147626", 
              "https://doi.org/10.1038/nature08494"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.19.5.3848", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006162066"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000064976", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006858010"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ygeno.2011.04.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007291924"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1474-9726.2010.00627.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007293045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1474-9726.2010.00627.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007293045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1474-9726.2010.00627.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007293045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1474-9726.2010.00627.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007293045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.arr.2008.09.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007797149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-006-0144-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009142294", 
              "https://doi.org/10.1007/s00439-006-0144-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-006-0144-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009142294", 
              "https://doi.org/10.1007/s00439-006-0144-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0801030105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009480352"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exger.2012.02.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009916017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exger.2012.02.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009916017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.exger.2012.02.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009916017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11357-011-9340-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011862500", 
              "https://doi.org/10.1007/s11357-011-9340-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0921-8734(95)00008-t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016188835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0921-8734(95)00008-t", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016188835"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35041682", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018373406", 
              "https://doi.org/10.1038/35041682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35041682", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018373406", 
              "https://doi.org/10.1038/35041682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/519795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019061180"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019321742", 
              "https://doi.org/10.1038/nrg2884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2884", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019321742", 
              "https://doi.org/10.1038/nrg2884"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/362709a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019428971", 
              "https://doi.org/10.1038/362709a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0809594106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020083315"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1096-8628(20001211)95:4<374::aid-ajmg14>3.0.co;2-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024488187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0027-5107(99)00202-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024582447"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btm051", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025522417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2944", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025973418", 
              "https://doi.org/10.1038/nrm2944"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tins.2004.07.005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026784174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.0030024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027010149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.09.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027198160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35077232", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027480321", 
              "https://doi.org/10.1038/35077232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35077232", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027480321", 
              "https://doi.org/10.1038/35077232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.mad.2011.06.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029270705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm2233", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030616797", 
              "https://doi.org/10.1038/nrm2233"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1474-9726.2008.00366.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032241917"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwm380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032332848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwm380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032332848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/aje/kwm380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032332848"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1006-1133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034665185", 
              "https://doi.org/10.1038/nm1006-1133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1006-1133", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034665185", 
              "https://doi.org/10.1038/nm1006-1133"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/089826430101300102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036421149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/089826430101300102", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036421149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02185763", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038378677", 
              "https://doi.org/10.1007/bf02185763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02185763", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038378677", 
              "https://doi.org/10.1007/bf02185763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.dnarep.2010.09.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039151996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.00265-09", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041533426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041768780", 
              "https://doi.org/10.1038/nrg1871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041768780", 
              "https://doi.org/10.1038/nrg1871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041768780", 
              "https://doi.org/10.1038/nrg1871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1871", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041768780", 
              "https://doi.org/10.1038/nrg1871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.88.12.5360", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042476932"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0194-29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044395319", 
              "https://doi.org/10.1038/ng0194-29"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ejhg.2011.40", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044611966", 
              "https://doi.org/10.1038/ejhg.2011.40"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2008.09.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044772487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0702703104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045720663"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/415045a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046252152", 
              "https://doi.org/10.1038/415045a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/415045a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046252152", 
              "https://doi.org/10.1038/415045a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/bmj.320.7228.141", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048108800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pneurobio.2011.04.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050518359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tig.2012.08.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050790397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-006-0148-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051613176", 
              "https://doi.org/10.1007/s00439-006-0148-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-006-0148-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051613176", 
              "https://doi.org/10.1007/s00439-006-0148-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00439-006-0148-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051613176", 
              "https://doi.org/10.1007/s00439-006-0148-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-1177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052610028"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1086/522374", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058793537"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/jad-2010-100018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078149440"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082592040", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-09", 
        "datePublishedReg": "2014-09-01", 
        "description": "DNA-damage response and repair are crucial to maintain genetic stability, and are consequently considered central to aging and longevity. Here, we investigate whether this pathway overall associates to longevity, and whether specific sub-processes are more strongly associated with longevity than others. Data were applied on 592 SNPs from 77 genes involved in nine sub-processes: DNA-damage response, base excision repair (BER), nucleotide excision repair, mismatch repair, non-homologous end-joining, homologous recombinational repair (HRR), RecQ helicase activities (RECQ), telomere functioning and mitochondrial DNA processes. The study population was 1089 long-lived and 736 middle-aged Danes. A self-contained set-based test of all SNPs displayed association with longevity (P-value=9.9 \u00d7 10(-5)), supporting that the overall pathway could affect longevity. Investigation of the nine sub-processes using the competitive gene-set analysis by Wang et al indicated that BER, HRR and RECQ associated stronger with longevity than the respective remaining genes of the pathway (P-values=0.004-0.048). For HRR and RECQ, only one gene contributed to the significance, whereas for BER several genes contributed. These associations did, however, generally not pass correction for multiple testing. Still, these findings indicate that, of the entire pathway, variation in BER might influence longevity the most. These modest sized P-values were not replicated in a German sample. This might, though, be due to differences in genotyping procedures and investigated SNPs, potentially inducing differences in the coverage of gene regions. Specifically, five genes were not covered at all in the German data. Therefore, investigations in additional study populations are needed before final conclusion can be drawn. ", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ejhg.2013.299", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2434655", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2722844", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2722848", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3782097", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2722847", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1103410", 
            "issn": [
              "1018-4813", 
              "1476-5438"
            ], 
            "name": "European Journal of Human Genetics", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "9", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "22"
          }
        ], 
        "name": "Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis", 
        "pagination": "1131", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "53a7ff7c92789be454b654c5d42bb78d2a910fc7e0a7d68d3020db78acc21f41"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24518833"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9302235"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ejhg.2013.299"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1017558418"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ejhg.2013.299", 
          "https://app.dimensions.ai/details/publication/pub.1017558418"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:21", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78974_00000000.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/ejhg2013299"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ejhg.2013.299'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ejhg.2013.299'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ejhg.2013.299'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ejhg.2013.299'


     

    This table displays all metadata directly associated to this object as RDF triples.

    397 TRIPLES      21 PREDICATES      92 URIs      33 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ejhg.2013.299 schema:about N11a1d8bf65ee436d9aac522676969321
    2 N14cb71e1cc02469a8a48deb001efa9ec
    3 N2643ae10a33042959e254d85b92e411d
    4 N4e96144a5bf74011a02f2458404d8a2a
    5 N9dbee4e44cde4e8c82d1361e3cfbdbcc
    6 Nab7ab09f4f2040dba8d0359c95cff437
    7 Nb66bcee71a77405db1ab01c0744f0ba2
    8 Nc0cbc69d42104893b9be3cf55afe25bf
    9 Nce97a7ee971f4b16823b456c2a1918d0
    10 Nde8edcd8058341c79d2aa4f8b00e1f0d
    11 Ne75ecbdd070e48d3a24aba2426af60c9
    12 Nea369699505540bfbb38d5ddd27a6851
    13 anzsrc-for:06
    14 anzsrc-for:0604
    15 schema:author N3654257b2592474b894d188f1b55baf0
    16 schema:citation sg:pub.10.1007/bf02185763
    17 sg:pub.10.1007/s00439-006-0144-y
    18 sg:pub.10.1007/s00439-006-0148-7
    19 sg:pub.10.1007/s11357-011-9340-3
    20 sg:pub.10.1038/35041682
    21 sg:pub.10.1038/35077232
    22 sg:pub.10.1038/362709a0
    23 sg:pub.10.1038/415045a
    24 sg:pub.10.1038/ejhg.2011.40
    25 sg:pub.10.1038/nature08494
    26 sg:pub.10.1038/ng0194-29
    27 sg:pub.10.1038/nm1006-1133
    28 sg:pub.10.1038/nrg1871
    29 sg:pub.10.1038/nrg2884
    30 sg:pub.10.1038/nrm2233
    31 sg:pub.10.1038/nrm2944
    32 https://app.dimensions.ai/details/publication/pub.1082592040
    33 https://doi.org/10.1002/1096-8628(20001211)95:4<374::aid-ajmg14>3.0.co;2-4
    34 https://doi.org/10.1016/0921-8734(91)90032-7
    35 https://doi.org/10.1016/0921-8734(95)00008-t
    36 https://doi.org/10.1016/j.arr.2008.09.001
    37 https://doi.org/10.1016/j.dnarep.2010.09.018
    38 https://doi.org/10.1016/j.exger.2012.02.010
    39 https://doi.org/10.1016/j.mad.2011.06.008
    40 https://doi.org/10.1016/j.molcel.2010.09.019
    41 https://doi.org/10.1016/j.pneurobio.2011.04.013
    42 https://doi.org/10.1016/j.tibs.2008.09.003
    43 https://doi.org/10.1016/j.tig.2012.08.003
    44 https://doi.org/10.1016/j.tins.2004.07.005
    45 https://doi.org/10.1016/j.ygeno.2011.04.006
    46 https://doi.org/10.1016/s0027-5107(99)00202-x
    47 https://doi.org/10.1073/pnas.0702703104
    48 https://doi.org/10.1073/pnas.0801030105
    49 https://doi.org/10.1073/pnas.0809594106
    50 https://doi.org/10.1073/pnas.88.12.5360
    51 https://doi.org/10.1086/519795
    52 https://doi.org/10.1086/522374
    53 https://doi.org/10.1093/aje/kwm380
    54 https://doi.org/10.1093/bioinformatics/btm051
    55 https://doi.org/10.1111/j.1474-9726.2007.00340.x
    56 https://doi.org/10.1111/j.1474-9726.2008.00366.x
    57 https://doi.org/10.1111/j.1474-9726.2010.00626.x
    58 https://doi.org/10.1111/j.1474-9726.2010.00627.x
    59 https://doi.org/10.1128/mcb.00265-09
    60 https://doi.org/10.1128/mcb.19.5.3848
    61 https://doi.org/10.1136/bmj.320.7228.141
    62 https://doi.org/10.1158/0008-5472.can-06-1177
    63 https://doi.org/10.1159/000064976
    64 https://doi.org/10.1177/089826430101300102
    65 https://doi.org/10.1371/journal.pgen.0030024
    66 https://doi.org/10.3233/jad-2010-100018
    67 schema:datePublished 2014-09
    68 schema:datePublishedReg 2014-09-01
    69 schema:description DNA-damage response and repair are crucial to maintain genetic stability, and are consequently considered central to aging and longevity. Here, we investigate whether this pathway overall associates to longevity, and whether specific sub-processes are more strongly associated with longevity than others. Data were applied on 592 SNPs from 77 genes involved in nine sub-processes: DNA-damage response, base excision repair (BER), nucleotide excision repair, mismatch repair, non-homologous end-joining, homologous recombinational repair (HRR), RecQ helicase activities (RECQ), telomere functioning and mitochondrial DNA processes. The study population was 1089 long-lived and 736 middle-aged Danes. A self-contained set-based test of all SNPs displayed association with longevity (P-value=9.9 × 10(-5)), supporting that the overall pathway could affect longevity. Investigation of the nine sub-processes using the competitive gene-set analysis by Wang et al indicated that BER, HRR and RECQ associated stronger with longevity than the respective remaining genes of the pathway (P-values=0.004-0.048). For HRR and RECQ, only one gene contributed to the significance, whereas for BER several genes contributed. These associations did, however, generally not pass correction for multiple testing. Still, these findings indicate that, of the entire pathway, variation in BER might influence longevity the most. These modest sized P-values were not replicated in a German sample. This might, though, be due to differences in genotyping procedures and investigated SNPs, potentially inducing differences in the coverage of gene regions. Specifically, five genes were not covered at all in the German data. Therefore, investigations in additional study populations are needed before final conclusion can be drawn.
    70 schema:genre research_article
    71 schema:inLanguage en
    72 schema:isAccessibleForFree true
    73 schema:isPartOf N2176e195e55b49518572d17f4fd09af9
    74 N2f97c645ee37456bb83ea9ae075eac28
    75 sg:journal.1103410
    76 schema:name Human longevity and variation in DNA damage response and repair: study of the contribution of sub-processes using competitive gene-set analysis
    77 schema:pagination 1131
    78 schema:productId N0125a315d19f43d19015ba0bdddeece2
    79 N3b28a3f58e254d339f779da0fde8ece7
    80 Na6d3d35ffa1a4df59d511bde75cd8f20
    81 Naa6b7010c5fb4327a95519c67f216672
    82 Ndece342fdb1545c38800cbd1d303cd41
    83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017558418
    84 https://doi.org/10.1038/ejhg.2013.299
    85 schema:sdDatePublished 2019-04-11T13:21
    86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    87 schema:sdPublisher N3659c11953ac4736afbf156eac73738a
    88 schema:url https://www.nature.com/articles/ejhg2013299
    89 sgo:license sg:explorer/license/
    90 sgo:sdDataset articles
    91 rdf:type schema:ScholarlyArticle
    92 N0125a315d19f43d19015ba0bdddeece2 schema:name readcube_id
    93 schema:value 53a7ff7c92789be454b654c5d42bb78d2a910fc7e0a7d68d3020db78acc21f41
    94 rdf:type schema:PropertyValue
    95 N11a1d8bf65ee436d9aac522676969321 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Longevity
    97 rdf:type schema:DefinedTerm
    98 N14cb71e1cc02469a8a48deb001efa9ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Aged, 80 and over
    100 rdf:type schema:DefinedTerm
    101 N2176e195e55b49518572d17f4fd09af9 schema:volumeNumber 22
    102 rdf:type schema:PublicationVolume
    103 N2643ae10a33042959e254d85b92e411d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Polymorphism, Single Nucleotide
    105 rdf:type schema:DefinedTerm
    106 N2f97c645ee37456bb83ea9ae075eac28 schema:issueNumber 9
    107 rdf:type schema:PublicationIssue
    108 N328114e4abda4a1689486f557fb1bb3f rdf:first sg:person.01030645127.23
    109 rdf:rest Nf9ca7c37e41c4d0c8f7b490265d9b01b
    110 N3432d79291804ff9882d8ff321066ebc rdf:first sg:person.01223143620.01
    111 rdf:rest Nb7feb52f5af0459ca574b10c7e2dacc1
    112 N3654257b2592474b894d188f1b55baf0 rdf:first sg:person.0714567154.08
    113 rdf:rest N328114e4abda4a1689486f557fb1bb3f
    114 N3659c11953ac4736afbf156eac73738a schema:name Springer Nature - SN SciGraph project
    115 rdf:type schema:Organization
    116 N3b28a3f58e254d339f779da0fde8ece7 schema:name pubmed_id
    117 schema:value 24518833
    118 rdf:type schema:PropertyValue
    119 N4bb4b6ece0244787a38311b4d1730bb0 rdf:first sg:person.01167033770.39
    120 rdf:rest N3432d79291804ff9882d8ff321066ebc
    121 N4e96144a5bf74011a02f2458404d8a2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Aged
    123 rdf:type schema:DefinedTerm
    124 N726daf1e4ca246ef9ff62904d6fd4ed1 rdf:first sg:person.01213635722.41
    125 rdf:rest Nc4f590fde1f647e2a556c9832766e4fa
    126 N9dbee4e44cde4e8c82d1361e3cfbdbcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    127 schema:name DNA Repair Enzymes
    128 rdf:type schema:DefinedTerm
    129 Na6d3d35ffa1a4df59d511bde75cd8f20 schema:name dimensions_id
    130 schema:value pub.1017558418
    131 rdf:type schema:PropertyValue
    132 Naa6b7010c5fb4327a95519c67f216672 schema:name nlm_unique_id
    133 schema:value 9302235
    134 rdf:type schema:PropertyValue
    135 Nab7ab09f4f2040dba8d0359c95cff437 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Male
    137 rdf:type schema:DefinedTerm
    138 Nb66bcee71a77405db1ab01c0744f0ba2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name DNA Repair
    140 rdf:type schema:DefinedTerm
    141 Nb6ddb267bab848cf9081f13a917f8234 rdf:first sg:person.0771103470.29
    142 rdf:rest Ne5d61e1c1ea84ec686147132ae5d7d7d
    143 Nb7feb52f5af0459ca574b10c7e2dacc1 rdf:first sg:person.0647612100.21
    144 rdf:rest Nddd317575d554fe4828464d8c180721e
    145 Nc0cbc69d42104893b9be3cf55afe25bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name DNA Damage
    147 rdf:type schema:DefinedTerm
    148 Nc4f590fde1f647e2a556c9832766e4fa rdf:first sg:person.01021360764.20
    149 rdf:rest rdf:nil
    150 Nce176f27d49441e4a61bcd186b696ad6 rdf:first sg:person.012703150357.62
    151 rdf:rest N4bb4b6ece0244787a38311b4d1730bb0
    152 Nce97a7ee971f4b16823b456c2a1918d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Humans
    154 rdf:type schema:DefinedTerm
    155 Nddd317575d554fe4828464d8c180721e rdf:first sg:person.010113074200.18
    156 rdf:rest N726daf1e4ca246ef9ff62904d6fd4ed1
    157 Nde8edcd8058341c79d2aa4f8b00e1f0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Middle Aged
    159 rdf:type schema:DefinedTerm
    160 Ndece342fdb1545c38800cbd1d303cd41 schema:name doi
    161 schema:value 10.1038/ejhg.2013.299
    162 rdf:type schema:PropertyValue
    163 Ne5d61e1c1ea84ec686147132ae5d7d7d rdf:first sg:person.01337663350.19
    164 rdf:rest Nf5c8dddafbd24614a2e530ffbdd84da4
    165 Ne75ecbdd070e48d3a24aba2426af60c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Female
    167 rdf:type schema:DefinedTerm
    168 Nea369699505540bfbb38d5ddd27a6851 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Case-Control Studies
    170 rdf:type schema:DefinedTerm
    171 Nf5c8dddafbd24614a2e530ffbdd84da4 rdf:first sg:person.0634070300.63
    172 rdf:rest Nce176f27d49441e4a61bcd186b696ad6
    173 Nf9ca7c37e41c4d0c8f7b490265d9b01b rdf:first sg:person.01256440720.50
    174 rdf:rest Nb6ddb267bab848cf9081f13a917f8234
    175 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    176 schema:name Biological Sciences
    177 rdf:type schema:DefinedTerm
    178 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Genetics
    180 rdf:type schema:DefinedTerm
    181 sg:grant.2434655 http://pending.schema.org/fundedItem sg:pub.10.1038/ejhg.2013.299
    182 rdf:type schema:MonetaryGrant
    183 sg:grant.2722844 http://pending.schema.org/fundedItem sg:pub.10.1038/ejhg.2013.299
    184 rdf:type schema:MonetaryGrant
    185 sg:grant.2722847 http://pending.schema.org/fundedItem sg:pub.10.1038/ejhg.2013.299
    186 rdf:type schema:MonetaryGrant
    187 sg:grant.2722848 http://pending.schema.org/fundedItem sg:pub.10.1038/ejhg.2013.299
    188 rdf:type schema:MonetaryGrant
    189 sg:grant.3782097 http://pending.schema.org/fundedItem sg:pub.10.1038/ejhg.2013.299
    190 rdf:type schema:MonetaryGrant
    191 sg:journal.1103410 schema:issn 1018-4813
    192 1476-5438
    193 schema:name European Journal of Human Genetics
    194 rdf:type schema:Periodical
    195 sg:person.010113074200.18 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
    196 schema:familyName Christensen
    197 schema:givenName Kaare
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010113074200.18
    199 rdf:type schema:Person
    200 sg:person.01021360764.20 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
    201 schema:familyName Christiansen
    202 schema:givenName Lene
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021360764.20
    204 rdf:type schema:Person
    205 sg:person.01030645127.23 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
    206 schema:familyName Soerensen
    207 schema:givenName Mette
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01030645127.23
    209 rdf:type schema:Person
    210 sg:person.01167033770.39 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
    211 schema:familyName Kruse
    212 schema:givenName Torben A
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167033770.39
    214 rdf:type schema:Person
    215 sg:person.01213635722.41 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
    216 schema:familyName Tan
    217 schema:givenName Qihua
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213635722.41
    219 rdf:type schema:Person
    220 sg:person.01223143620.01 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    221 schema:familyName Schreiber
    222 schema:givenName Stefan
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223143620.01
    224 rdf:type schema:Person
    225 sg:person.01256440720.50 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    226 schema:familyName Flachsbart
    227 schema:givenName Friederike
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256440720.50
    229 rdf:type schema:Person
    230 sg:person.012703150357.62 schema:affiliation https://www.grid.ac/institutes/grid.419475.a
    231 schema:familyName Bohr
    232 schema:givenName Vilhelm A
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012703150357.62
    234 rdf:type schema:Person
    235 sg:person.01337663350.19 schema:affiliation https://www.grid.ac/institutes/grid.7143.1
    236 schema:familyName Mengel-From
    237 schema:givenName Jonas
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01337663350.19
    239 rdf:type schema:Person
    240 sg:person.0634070300.63 schema:affiliation https://www.grid.ac/institutes/grid.7048.b
    241 schema:familyName Stevnsner
    242 schema:givenName Tinna
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0634070300.63
    244 rdf:type schema:Person
    245 sg:person.0647612100.21 schema:affiliation https://www.grid.ac/institutes/grid.9764.c
    246 schema:familyName Nebel
    247 schema:givenName Almut
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647612100.21
    249 rdf:type schema:Person
    250 sg:person.0714567154.08 schema:affiliation https://www.grid.ac/institutes/grid.10825.3e
    251 schema:familyName Debrabant
    252 schema:givenName Birgit
    253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714567154.08
    254 rdf:type schema:Person
    255 sg:person.0771103470.29 schema:affiliation https://www.grid.ac/institutes/grid.7778.f
    256 schema:familyName Dato
    257 schema:givenName Serena
    258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0771103470.29
    259 rdf:type schema:Person
    260 sg:pub.10.1007/bf02185763 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038378677
    261 https://doi.org/10.1007/bf02185763
    262 rdf:type schema:CreativeWork
    263 sg:pub.10.1007/s00439-006-0144-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1009142294
    264 https://doi.org/10.1007/s00439-006-0144-y
    265 rdf:type schema:CreativeWork
    266 sg:pub.10.1007/s00439-006-0148-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051613176
    267 https://doi.org/10.1007/s00439-006-0148-7
    268 rdf:type schema:CreativeWork
    269 sg:pub.10.1007/s11357-011-9340-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011862500
    270 https://doi.org/10.1007/s11357-011-9340-3
    271 rdf:type schema:CreativeWork
    272 sg:pub.10.1038/35041682 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018373406
    273 https://doi.org/10.1038/35041682
    274 rdf:type schema:CreativeWork
    275 sg:pub.10.1038/35077232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027480321
    276 https://doi.org/10.1038/35077232
    277 rdf:type schema:CreativeWork
    278 sg:pub.10.1038/362709a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019428971
    279 https://doi.org/10.1038/362709a0
    280 rdf:type schema:CreativeWork
    281 sg:pub.10.1038/415045a schema:sameAs https://app.dimensions.ai/details/publication/pub.1046252152
    282 https://doi.org/10.1038/415045a
    283 rdf:type schema:CreativeWork
    284 sg:pub.10.1038/ejhg.2011.40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044611966
    285 https://doi.org/10.1038/ejhg.2011.40
    286 rdf:type schema:CreativeWork
    287 sg:pub.10.1038/nature08494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005147626
    288 https://doi.org/10.1038/nature08494
    289 rdf:type schema:CreativeWork
    290 sg:pub.10.1038/ng0194-29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044395319
    291 https://doi.org/10.1038/ng0194-29
    292 rdf:type schema:CreativeWork
    293 sg:pub.10.1038/nm1006-1133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034665185
    294 https://doi.org/10.1038/nm1006-1133
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/nrg1871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041768780
    297 https://doi.org/10.1038/nrg1871
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/nrg2884 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019321742
    300 https://doi.org/10.1038/nrg2884
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/nrm2233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030616797
    303 https://doi.org/10.1038/nrm2233
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/nrm2944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025973418
    306 https://doi.org/10.1038/nrm2944
    307 rdf:type schema:CreativeWork
    308 https://app.dimensions.ai/details/publication/pub.1082592040 schema:CreativeWork
    309 https://doi.org/10.1002/1096-8628(20001211)95:4<374::aid-ajmg14>3.0.co;2-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024488187
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1016/0921-8734(91)90032-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004619230
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1016/0921-8734(95)00008-t schema:sameAs https://app.dimensions.ai/details/publication/pub.1016188835
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1016/j.arr.2008.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007797149
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1016/j.dnarep.2010.09.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039151996
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/j.exger.2012.02.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009916017
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/j.mad.2011.06.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029270705
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/j.molcel.2010.09.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027198160
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/j.pneurobio.2011.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050518359
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/j.tibs.2008.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044772487
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/j.tig.2012.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050790397
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/j.tins.2004.07.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026784174
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/j.ygeno.2011.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007291924
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1016/s0027-5107(99)00202-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024582447
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1073/pnas.0702703104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045720663
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1073/pnas.0801030105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009480352
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1073/pnas.0809594106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020083315
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1073/pnas.88.12.5360 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042476932
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1086/519795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019061180
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1086/522374 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058793537
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1093/aje/kwm380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032332848
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1093/bioinformatics/btm051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025522417
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1111/j.1474-9726.2007.00340.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1002493165
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1111/j.1474-9726.2008.00366.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032241917
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1111/j.1474-9726.2010.00626.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1001278403
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1111/j.1474-9726.2010.00627.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007293045
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1128/mcb.00265-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041533426
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1128/mcb.19.5.3848 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006162066
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1136/bmj.320.7228.141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048108800
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1158/0008-5472.can-06-1177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052610028
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1159/000064976 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006858010
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1177/089826430101300102 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036421149
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1371/journal.pgen.0030024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027010149
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.3233/jad-2010-100018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078149440
    376 rdf:type schema:CreativeWork
    377 https://www.grid.ac/institutes/grid.10825.3e schema:alternateName University of Southern Denmark
    378 schema:name Epidemiology, Biostatistics and Biodemography, The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    379 rdf:type schema:Organization
    380 https://www.grid.ac/institutes/grid.419475.a schema:alternateName National Institute on Aging
    381 schema:name Department of Molecular Biology and Genetics, The Danish Aging Research Center, Aarhus University, Aarhus, Denmark
    382 Laboratory of Molecular Gerontology, National Institute on Aging, National Institute of Health, Baltimore, MD, USA
    383 rdf:type schema:Organization
    384 https://www.grid.ac/institutes/grid.7048.b schema:alternateName Aarhus University
    385 schema:name Department of Molecular Biology and Genetics, The Danish Aging Research Center, Aarhus University, Aarhus, Denmark
    386 rdf:type schema:Organization
    387 https://www.grid.ac/institutes/grid.7143.1 schema:alternateName Odense University Hospital
    388 schema:name Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
    389 Department of Clinical Genetics, Odense University Hospital, Odense, Denmark
    390 Epidemiology, Biostatistics and Biodemography, The Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    391 rdf:type schema:Organization
    392 https://www.grid.ac/institutes/grid.7778.f schema:alternateName University of Calabria
    393 schema:name Department of Biology, Ecology and Earth Science, University of Calabria, Rende, Italy
    394 rdf:type schema:Organization
    395 https://www.grid.ac/institutes/grid.9764.c schema:alternateName Kiel University
    396 schema:name Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
    397 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...