People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-02

AUTHORS

Bruce Winney, Abdelhamid Boumertit, Tammy Day, Dan Davison, Chikodi Echeta, Irina Evseeva, Katarzyna Hutnik, Stephen Leslie, Kristin Nicodemus, Ellen C Royrvik, Susan Tonks, Xiaofeng Yang, James Cheshire, Paul Longley, Pablo Mateos, Alexandra Groom, Caroline Relton, D Tim Bishop, Kathryn Black, Emma Northwood, Louise Parkinson, Timothy M Frayling, Anna Steele, Julian R Sampson, Turi King, Ron Dixon, Derek Middleton, Barbara Jennings, Rory Bowden, Peter Donnelly, Walter Bodmer

ABSTRACT

There is a great deal of interest in a fine-scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to have a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. In this study, we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK-control population that can be used as a resource by the research community, as well as providing a fine-scale genetic information on the British population. So far, some 4000 samples have been collected, the majority of which fit the criteria of coming from a rural area and having all four grandparents from approximately the same area. Analysis of the first 3865 samples that have been geocoded indicates that 75% have a mean distance between grandparental places of birth of 37.3 km, and that about 70% of grandparental places of birth can be classed as rural. Preliminary genotyping of 1057 samples demonstrates the value of these samples for investigating a fine-scale population structure within the UK, and shows how this can be enhanced by the use of surnames. More... »

PAGES

ejhg2011127

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ejhg.2011.127

DOI

http://dx.doi.org/10.1038/ejhg.2011.127

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042565865

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21829225


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