Genome-wide linkage analysis in a Dutch multigenerational family with attention deficit hyperactivity disorder View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-02

AUTHORS

Rinus Vegt, Aida M Bertoli-Avella, Joke H M Tulen, Bianca de Graaf, Annemieke J M H Verkerk, Jeroen Vervoort, Carla M Twigt, Anneke Maat-Kievit, Ruud van Tuijl, Marieke van der Lijn, Michiel W Hengeveld, Ben A Oostra

ABSTRACT

Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric disorder. Genetics has an important role in the aetiology of this disease. In this study, we describe the clinical findings in a Dutch family with eight patients suffering from ADHD, in whom five had at least one other psychiatric disorder. We performed a genome-wide (parametric and nonparametric) affected-only linkage analysis. Two genomic regions on chromosomes 7 and 14 showed an excess of allele sharing among the definitely affected members of the family with suggestive LOD scores (2.1 and 2.08). Nonparametric linkage analyses (NPL) yielded a maxNPL of 2.92 (P=0.001) for marker D7S502 and a maxNPL score of 2.56 (P=0.003) for marker D14S275. We confirmed that all patients share the same haplotype in each region of 7p15.1-q31.33 and 14q11.2-q22.3. Interestingly, both loci have been reported before in Dutch (affected sib pairs) and German (extended families) ADHD linkage studies. Hopefully, the genome-wide association studies in ADHD will help to highlight specific polymorphisms and genes within the broad areas detected by our, as well as other, linkage studies. More... »

PAGES

206

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ejhg.2009.148

    DOI

    http://dx.doi.org/10.1038/ejhg.2009.148

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1041686687

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19707245


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