Haplotypic analysis of tag SNPs of the interleukin-18 gene in relation to cardiovascular disease events: the MORGAM Project View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-12

AUTHORS

Marie-Lise Grisoni, Carole Proust, Mervi Alanne, Maylis DeSuremain, Veikko Salomaa, Kari Kuulasmaa, François Cambien, Viviane Nicaud, Birgitta Stegmayr, Jarmo Virtamo, Denis Shields, Frank Kee, Laurence Tiret, Alun Evans, David-Alexandre Tregouet

ABSTRACT

Interleukin-18 (IL-18) is a key inflammatory molecule suspected of being involved in the etiology of cardiovascular diseases (CVD). Five single nucleotide polymorphisms (SNPs) capturing the common genetic variation of the IL-18 gene (tag SNPs) were genotyped in five European prospective CVD cohorts including 1933 cases and 1938 non-cases as part of the MORGAM Project. Not a single SNP was found associated with CVD. However, a significant (P=0.002) gene-smoking interaction was observed. In smokers, the -105T allele was more frequent in cases than in non-cases (0.29 vs 0.25) and associated with an increased risk of disease (odds ratio (OR)=1.25 (1.07-1.45), P=0.005), whereas the inverse relationship tended to be observed in non-smokers (OR=0.90 (0.78-1.02), P=0.131). The gene-smoking interaction was broadly homogenous across the cohorts and was also observed through haplotype analyses. In conclusion, using the concerted effort of several European prospective CVD cohorts, we are able to show that one IL-18 tag SNP interacts with smoking to modulate the risk of developing CVD. More... »

PAGES

ejhg2008127

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ejhg.2008.127

DOI

http://dx.doi.org/10.1038/ejhg.2008.127

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052035486

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18628791


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