Structure of the human activated spliceosome in three conformational states View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-03

AUTHORS

Xiaofeng Zhang, Chuangye Yan, Xiechao Zhan, Lijia Li, Jianlin Lei, Yigong Shi

ABSTRACT

During each cycle of pre-mRNA splicing, the pre-catalytic spliceosome (B complex) is converted into the activated spliceosome (Bact complex), which has a well-formed active site but cannot proceed to the branching reaction. Here, we present the cryo-EM structure of the human Bact complex in three distinct conformational states. The EM map allows atomic modeling of nearly all protein components of the U2 small nuclear ribonucleoprotein (snRNP), including three of the SF3a complex and seven of the SF3b complex. The structure of the human Bact complex contains 52 proteins, U2, U5, and U6 small nuclear RNA (snRNA), and a pre-mRNA. Three distinct conformations have been captured, representing the early, mature, and late states of the human Bact complex. These complexes differ in the orientation of the Switch loop of Prp8, the splicing factors RNF113A and NY-CO-10, and most components of the NineTeen complex (NTC) and the NTC-related complex. Analysis of these three complexes and comparison with the B and C complexes reveal an ordered flux of components in the B-to-Bact and the Bact-to-B* transitions, which ultimately prime the active site for the branching reaction. More... »

PAGES

307

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/cr.2018.14

DOI

http://dx.doi.org/10.1038/cr.2018.14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100557128

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29360106


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Xiaofeng", 
        "id": "sg:person.014222105337.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014222105337.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yan", 
        "givenName": "Chuangye", 
        "id": "sg:person.01274436253.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274436253.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhan", 
        "givenName": "Xiechao", 
        "id": "sg:person.014755704334.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014755704334.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Lijia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tsinghua University", 
          "id": "https://www.grid.ac/institutes/grid.12527.33", 
          "name": [
            "Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China", 
            "Technology Center for Protein Sciences, Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lei", 
        "givenName": "Jianlin", 
        "id": "sg:person.0777074713.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777074713.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Westlake Institute for Advanced Study", 
          "id": "https://www.grid.ac/institutes/grid.494629.4", 
          "name": [
            "Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China", 
            "Institute of Biology, Westlake Institute for Advanced Study, Westlake University, Shilongshan Road No. 18, Hangzhou, Zhejiang 310064, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Yigong", 
        "id": "sg:person.012705321277.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012705321277.28"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ultramic.2013.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000304364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2016.07.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001976293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.22.7.2011-2024.2002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002496883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.8.24.3008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002840025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2012.7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002946988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.5.2944", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005730458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aag0291", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006149664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/emboj.2011.502", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007848379"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1084155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007856330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcc.20084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008225564"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2009.02.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008488757"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.2889", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008879557", 
          "https://doi.org/10.1038/nsmb.2889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/11.5.1475", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008969197"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.18722", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009291458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.2727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009301311", 
          "https://doi.org/10.1038/nmeth.2727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth1139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010210484", 
          "https://doi.org/10.1038/nmeth1139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aac8159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010514152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/cdf480", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011593191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2016.08.036", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012436068"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1536107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012921784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.16.12.6810", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013936927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/349487a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014289873", 
          "https://doi.org/10.1038/349487a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aag2235", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016279183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aag1906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017301600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1261/rna.033316.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017802496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkg213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018030929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/22.9.1548", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018921551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2012.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019988217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444904019158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020281098"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0907444996012255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020405374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature19316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022227837", 
          "https://doi.org/10.1038/nature19316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature21079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023854792", 
          "https://doi.org/10.1038/nature21079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2009.09.040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023972722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.95.8.4188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025132576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.10.2.233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026897092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2005.01.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029507842"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature21078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029605771", 
          "https://doi.org/10.1038/nature21078"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s1399004714016241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030014777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1107/s0021889808006985", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032551326"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0508048103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036907914"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.5.12b.2521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036915128"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1249410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041981392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aac7629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043702597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1524307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045427697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1086602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046882060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1261/rna.2456210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047293176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-9822(07)00345-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048841316"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsb.2015.11.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049504602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2008.05.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049619425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049734146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2003.07.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049802224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2003.07.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049802224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkm216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052481822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1017/s1355838202025050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054923789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aak9979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062668764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.00580-16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062713440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1992.tb05610.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076604165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1996.tb00481.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082887802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.4187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084129281", 
          "https://doi.org/10.1038/nmeth.4187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.4187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084129281", 
          "https://doi.org/10.1038/nmeth.4187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmeth.4193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084129286", 
          "https://doi.org/10.1038/nmeth.4193"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1261/rna.059378.116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084257240"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2017.04.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085459678"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature22799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085537692", 
          "https://doi.org/10.1038/nature22799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature22799", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085537692", 
          "https://doi.org/10.1038/nature22799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2017.07.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090806312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2017.07.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090952875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2017.08.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091775974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm.2017.86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091929398", 
          "https://doi.org/10.1038/nrm.2017.86"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.3463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092089897", 
          "https://doi.org/10.1038/nsmb.3463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.3463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092089897", 
          "https://doi.org/10.1038/nsmb.3463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.3463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092089897", 
          "https://doi.org/10.1038/nsmb.3463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.3463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092089897", 
          "https://doi.org/10.1038/nsmb.3463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb.3463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092089897", 
          "https://doi.org/10.1038/nsmb.3463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2017.10.038", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092728140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aar3462", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092734656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aar3729", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092734657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aar6401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100195246"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-03", 
    "datePublishedReg": "2018-03-01", 
    "description": "During each cycle of pre-mRNA splicing, the pre-catalytic spliceosome (B complex) is converted into the activated spliceosome (Bact complex), which has a well-formed active site but cannot proceed to the branching reaction. Here, we present the cryo-EM structure of the human Bact complex in three distinct conformational states. The EM map allows atomic modeling of nearly all protein components of the U2 small nuclear ribonucleoprotein (snRNP), including three of the SF3a complex and seven of the SF3b complex. The structure of the human Bact complex contains 52 proteins, U2, U5, and U6 small nuclear RNA (snRNA), and a pre-mRNA. Three distinct conformations have been captured, representing the early, mature, and late states of the human Bact complex. These complexes differ in the orientation of the Switch loop of Prp8, the splicing factors RNF113A and NY-CO-10, and most components of the NineTeen complex (NTC) and the NTC-related complex. Analysis of these three complexes and comparison with the B and C complexes reveal an ordered flux of components in the B-to-Bact and the Bact-to-B* transitions, which ultimately prime the active site for the branching reaction.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/cr.2018.14", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1107753", 
        "issn": [
          "1001-0602", 
          "1748-7838"
        ], 
        "name": "Cell Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "name": "Structure of the human activated spliceosome in three conformational states", 
    "pagination": "307", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3c9a5e7770f97222e9e7e03ee79e3d02a6b2f880ccffd679c67ad01a38500d8b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29360106"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9425763"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/cr.2018.14"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100557128"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/cr.2018.14", 
      "https://app.dimensions.ai/details/publication/pub.1100557128"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000603.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/cr201814"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cr.2018.14'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cr.2018.14'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cr.2018.14'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cr.2018.14'


 

This table displays all metadata directly associated to this object as RDF triples.

333 TRIPLES      21 PREDICATES      100 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/cr.2018.14 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N3817fb7fda20483c84184e7890e0eda9
4 schema:citation sg:pub.10.1038/349487a0
5 sg:pub.10.1038/nature19316
6 sg:pub.10.1038/nature21078
7 sg:pub.10.1038/nature21079
8 sg:pub.10.1038/nature22799
9 sg:pub.10.1038/nmeth.2727
10 sg:pub.10.1038/nmeth.4187
11 sg:pub.10.1038/nmeth.4193
12 sg:pub.10.1038/nmeth1139
13 sg:pub.10.1038/nrm.2017.86
14 sg:pub.10.1038/nsmb.2889
15 sg:pub.10.1038/nsmb.3463
16 https://doi.org/10.1002/j.1460-2075.1992.tb05610.x
17 https://doi.org/10.1002/j.1460-2075.1996.tb00481.x
18 https://doi.org/10.1002/jcc.20084
19 https://doi.org/10.1016/j.cell.2009.02.009
20 https://doi.org/10.1016/j.cell.2017.04.033
21 https://doi.org/10.1016/j.cell.2017.07.011
22 https://doi.org/10.1016/j.cell.2017.08.029
23 https://doi.org/10.1016/j.cell.2017.10.038
24 https://doi.org/10.1016/j.jmb.2003.07.013
25 https://doi.org/10.1016/j.jmb.2017.07.010
26 https://doi.org/10.1016/j.jsb.2005.01.002
27 https://doi.org/10.1016/j.jsb.2012.09.006
28 https://doi.org/10.1016/j.jsb.2015.11.003
29 https://doi.org/10.1016/j.jsb.2016.07.006
30 https://doi.org/10.1016/j.molcel.2008.05.003
31 https://doi.org/10.1016/j.molcel.2009.09.040
32 https://doi.org/10.1016/j.molcel.2016.08.036
33 https://doi.org/10.1016/j.ultramic.2013.06.004
34 https://doi.org/10.1016/s0960-9822(07)00345-4
35 https://doi.org/10.1017/s1355838202025050
36 https://doi.org/10.1038/emboj.2011.502
37 https://doi.org/10.1038/emboj.2012.7
38 https://doi.org/10.1038/sj.emboj.7600482
39 https://doi.org/10.1073/pnas.0508048103
40 https://doi.org/10.1073/pnas.95.8.4188
41 https://doi.org/10.1093/emboj/cdf480
42 https://doi.org/10.1093/nar/11.5.1475
43 https://doi.org/10.1093/nar/22.9.1548
44 https://doi.org/10.1093/nar/gkg213
45 https://doi.org/10.1093/nar/gkm216
46 https://doi.org/10.1101/gad.10.2.233
47 https://doi.org/10.1101/gad.1524307
48 https://doi.org/10.1101/gad.1536107
49 https://doi.org/10.1101/gad.5.12b.2521
50 https://doi.org/10.1101/gad.8.24.3008
51 https://doi.org/10.1107/s0021889808006985
52 https://doi.org/10.1107/s0907444904019158
53 https://doi.org/10.1107/s0907444996012255
54 https://doi.org/10.1107/s1399004714016241
55 https://doi.org/10.1126/science.1084155
56 https://doi.org/10.1126/science.1086602
57 https://doi.org/10.1126/science.1249410
58 https://doi.org/10.1126/science.aac7629
59 https://doi.org/10.1126/science.aac8159
60 https://doi.org/10.1126/science.aag0291
61 https://doi.org/10.1126/science.aag1906
62 https://doi.org/10.1126/science.aag2235
63 https://doi.org/10.1126/science.aak9979
64 https://doi.org/10.1126/science.aar3462
65 https://doi.org/10.1126/science.aar3729
66 https://doi.org/10.1126/science.aar6401
67 https://doi.org/10.1128/mcb.00580-16
68 https://doi.org/10.1128/mcb.16.12.6810
69 https://doi.org/10.1128/mcb.17.5.2944
70 https://doi.org/10.1128/mcb.22.7.2011-2024.2002
71 https://doi.org/10.1261/rna.033316.112
72 https://doi.org/10.1261/rna.059378.116
73 https://doi.org/10.1261/rna.2456210
74 https://doi.org/10.7554/elife.18722
75 schema:datePublished 2018-03
76 schema:datePublishedReg 2018-03-01
77 schema:description During each cycle of pre-mRNA splicing, the pre-catalytic spliceosome (B complex) is converted into the activated spliceosome (B<sup>act</sup> complex), which has a well-formed active site but cannot proceed to the branching reaction. Here, we present the cryo-EM structure of the human B<sup>act</sup> complex in three distinct conformational states. The EM map allows atomic modeling of nearly all protein components of the U2 small nuclear ribonucleoprotein (snRNP), including three of the SF3a complex and seven of the SF3b complex. The structure of the human B<sup>act</sup> complex contains 52 proteins, U2, U5, and U6 small nuclear RNA (snRNA), and a pre-mRNA. Three distinct conformations have been captured, representing the early, mature, and late states of the human B<sup>act</sup> complex. These complexes differ in the orientation of the Switch loop of Prp8, the splicing factors RNF113A and NY-CO-10, and most components of the NineTeen complex (NTC) and the NTC-related complex. Analysis of these three complexes and comparison with the B and C complexes reveal an ordered flux of components in the B-to-B<sup>act</sup> and the B<sup>act</sup>-to-B<sup>*</sup> transitions, which ultimately prime the active site for the branching reaction.
78 schema:genre research_article
79 schema:inLanguage en
80 schema:isAccessibleForFree true
81 schema:isPartOf Na86aa7e7158544f9ab3578b7faf07f52
82 Nee9a89d5a7a34cc4aa4906a7d89a9de2
83 sg:journal.1107753
84 schema:name Structure of the human activated spliceosome in three conformational states
85 schema:pagination 307
86 schema:productId N5d4719aa6e944b9a817532c433e0ca28
87 Nc3565d0f55864d778d02c2525c959561
88 Nc76230f7d3a14f46943e68158e691034
89 Ncbb858523bda40499dc423f0cfb9b11c
90 Ndacddb80d43545f78eaacd269e2f9806
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100557128
92 https://doi.org/10.1038/cr.2018.14
93 schema:sdDatePublished 2019-04-10T21:00
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher Nea3e7216be09474284d8d87b175856df
96 schema:url https://www.nature.com/articles/cr201814
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N04177ee50a22426e9cf0049605417ce2 rdf:first sg:person.01274436253.23
101 rdf:rest Nae311b52a99d461885e1727795ad79cc
102 N24a811fbbe2a4627b05c6704bfc1a3f8 rdf:first sg:person.012705321277.28
103 rdf:rest rdf:nil
104 N3817fb7fda20483c84184e7890e0eda9 rdf:first sg:person.014222105337.04
105 rdf:rest N04177ee50a22426e9cf0049605417ce2
106 N5d4719aa6e944b9a817532c433e0ca28 schema:name dimensions_id
107 schema:value pub.1100557128
108 rdf:type schema:PropertyValue
109 Na4d709bf3ba74aa6bf98f7391b4993a7 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
110 schema:familyName Li
111 schema:givenName Lijia
112 rdf:type schema:Person
113 Na86aa7e7158544f9ab3578b7faf07f52 schema:volumeNumber 28
114 rdf:type schema:PublicationVolume
115 Nae311b52a99d461885e1727795ad79cc rdf:first sg:person.014755704334.85
116 rdf:rest Ncbdb9228617f4f8eb2c2f2aa932b88eb
117 Nb83cb604e1134259b6063a04bcc0e8e6 rdf:first sg:person.0777074713.06
118 rdf:rest N24a811fbbe2a4627b05c6704bfc1a3f8
119 Nc3565d0f55864d778d02c2525c959561 schema:name nlm_unique_id
120 schema:value 9425763
121 rdf:type schema:PropertyValue
122 Nc76230f7d3a14f46943e68158e691034 schema:name readcube_id
123 schema:value 3c9a5e7770f97222e9e7e03ee79e3d02a6b2f880ccffd679c67ad01a38500d8b
124 rdf:type schema:PropertyValue
125 Ncbb858523bda40499dc423f0cfb9b11c schema:name pubmed_id
126 schema:value 29360106
127 rdf:type schema:PropertyValue
128 Ncbdb9228617f4f8eb2c2f2aa932b88eb rdf:first Na4d709bf3ba74aa6bf98f7391b4993a7
129 rdf:rest Nb83cb604e1134259b6063a04bcc0e8e6
130 Ndacddb80d43545f78eaacd269e2f9806 schema:name doi
131 schema:value 10.1038/cr.2018.14
132 rdf:type schema:PropertyValue
133 Nea3e7216be09474284d8d87b175856df schema:name Springer Nature - SN SciGraph project
134 rdf:type schema:Organization
135 Nee9a89d5a7a34cc4aa4906a7d89a9de2 schema:issueNumber 3
136 rdf:type schema:PublicationIssue
137 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
138 schema:name Biological Sciences
139 rdf:type schema:DefinedTerm
140 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
141 schema:name Biochemistry and Cell Biology
142 rdf:type schema:DefinedTerm
143 sg:journal.1107753 schema:issn 1001-0602
144 1748-7838
145 schema:name Cell Research
146 rdf:type schema:Periodical
147 sg:person.012705321277.28 schema:affiliation https://www.grid.ac/institutes/grid.494629.4
148 schema:familyName Shi
149 schema:givenName Yigong
150 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012705321277.28
151 rdf:type schema:Person
152 sg:person.01274436253.23 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
153 schema:familyName Yan
154 schema:givenName Chuangye
155 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274436253.23
156 rdf:type schema:Person
157 sg:person.014222105337.04 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
158 schema:familyName Zhang
159 schema:givenName Xiaofeng
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014222105337.04
161 rdf:type schema:Person
162 sg:person.014755704334.85 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
163 schema:familyName Zhan
164 schema:givenName Xiechao
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014755704334.85
166 rdf:type schema:Person
167 sg:person.0777074713.06 schema:affiliation https://www.grid.ac/institutes/grid.12527.33
168 schema:familyName Lei
169 schema:givenName Jianlin
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777074713.06
171 rdf:type schema:Person
172 sg:pub.10.1038/349487a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014289873
173 https://doi.org/10.1038/349487a0
174 rdf:type schema:CreativeWork
175 sg:pub.10.1038/nature19316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022227837
176 https://doi.org/10.1038/nature19316
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/nature21078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029605771
179 https://doi.org/10.1038/nature21078
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/nature21079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023854792
182 https://doi.org/10.1038/nature21079
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/nature22799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085537692
185 https://doi.org/10.1038/nature22799
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/nmeth.2727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009301311
188 https://doi.org/10.1038/nmeth.2727
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/nmeth.4187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129281
191 https://doi.org/10.1038/nmeth.4187
192 rdf:type schema:CreativeWork
193 sg:pub.10.1038/nmeth.4193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084129286
194 https://doi.org/10.1038/nmeth.4193
195 rdf:type schema:CreativeWork
196 sg:pub.10.1038/nmeth1139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010210484
197 https://doi.org/10.1038/nmeth1139
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/nrm.2017.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091929398
200 https://doi.org/10.1038/nrm.2017.86
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/nsmb.2889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008879557
203 https://doi.org/10.1038/nsmb.2889
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/nsmb.3463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092089897
206 https://doi.org/10.1038/nsmb.3463
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1002/j.1460-2075.1992.tb05610.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1076604165
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1002/j.1460-2075.1996.tb00481.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082887802
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1002/jcc.20084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008225564
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.cell.2009.02.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008488757
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.cell.2017.04.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085459678
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/j.cell.2017.07.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090952875
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/j.cell.2017.08.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091775974
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.cell.2017.10.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092728140
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.jmb.2003.07.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049802224
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.jmb.2017.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090806312
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.jsb.2005.01.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029507842
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.jsb.2012.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019988217
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/j.jsb.2015.11.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049504602
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/j.jsb.2016.07.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001976293
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/j.molcel.2008.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049619425
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/j.molcel.2009.09.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023972722
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/j.molcel.2016.08.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012436068
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/j.ultramic.2013.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000304364
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/s0960-9822(07)00345-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048841316
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1017/s1355838202025050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054923789
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1038/emboj.2011.502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007848379
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1038/emboj.2012.7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002946988
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1038/sj.emboj.7600482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049734146
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1073/pnas.0508048103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036907914
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1073/pnas.95.8.4188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025132576
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1093/emboj/cdf480 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011593191
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1093/nar/11.5.1475 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008969197
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1093/nar/22.9.1548 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018921551
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1093/nar/gkg213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018030929
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1093/nar/gkm216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052481822
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1101/gad.10.2.233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026897092
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1101/gad.1524307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045427697
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1101/gad.1536107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012921784
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1101/gad.5.12b.2521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036915128
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1101/gad.8.24.3008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002840025
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1107/s0021889808006985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032551326
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1107/s0907444904019158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020281098
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1107/s0907444996012255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020405374
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1107/s1399004714016241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030014777
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1126/science.1084155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007856330
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1126/science.1086602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046882060
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1126/science.1249410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041981392
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1126/science.aac7629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043702597
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1126/science.aac8159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010514152
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1126/science.aag0291 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006149664
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1126/science.aag1906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017301600
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1126/science.aag2235 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016279183
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1126/science.aak9979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062668764
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1126/science.aar3462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092734656
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1126/science.aar3729 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092734657
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1126/science.aar6401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100195246
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1128/mcb.00580-16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062713440
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1128/mcb.16.12.6810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013936927
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1128/mcb.17.5.2944 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005730458
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1128/mcb.22.7.2011-2024.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002496883
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1261/rna.033316.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017802496
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1261/rna.059378.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084257240
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1261/rna.2456210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047293176
323 rdf:type schema:CreativeWork
324 https://doi.org/10.7554/elife.18722 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009291458
325 rdf:type schema:CreativeWork
326 https://www.grid.ac/institutes/grid.12527.33 schema:alternateName Tsinghua University
327 schema:name Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China
328 Technology Center for Protein Sciences, Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
329 rdf:type schema:Organization
330 https://www.grid.ac/institutes/grid.494629.4 schema:alternateName Westlake Institute for Advanced Study
331 schema:name Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China
332 Institute of Biology, Westlake Institute for Advanced Study, Westlake University, Shilongshan Road No. 18, Hangzhou, Zhejiang 310064, China
333 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...