Histone H3 lysine 4 monomethylation modulates long-range chromatin interactions at enhancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-02

AUTHORS

Jian Yan, Shi-An A Chen, Andrea Local, Tristin Liu, Yunjiang Qiu, Kristel M Dorighi, Sebastian Preissl, Chloe M Rivera, Chaochen Wang, Zhen Ye, Kai Ge, Ming Hu, Joanna Wysocka, Bing Ren

ABSTRACT

Long-range chromatin interactions between enhancers and promoters are essential for transcription of many developmentally controlled genes in mammals and other metazoans. Currently, the exact mechanisms that connect distal enhancers to their specific target promoters remain to be fully elucidated. Here, we show that the enhancer-specific histone H3 lysine 4 monomethylation (H3K4me1) and the histone methyltransferases MLL3 and MLL4 (MLL3/4) play an active role in this process. We demonstrate that in differentiating mouse embryonic stem cells, MLL3/4-dependent deposition of H3K4me1 at enhancers correlates with increased levels of chromatin interactions, whereas loss of this histone modification leads to reduced levels of chromatin interactions and defects in gene activation during differentiation. H3K4me1 facilitates recruitment of the Cohesin complex, a known regulator of chromatin organization, to chromatin in vitro and in vivo, providing a potential mechanism for MLL3/4 to promote chromatin interactions between enhancers and promoters. Taken together, our results support a role for MLL3/4-dependent H3K4me1 in orchestrating long-range chromatin interactions at enhancers in mammalian cells. More... »

PAGES

204

References to SciGraph publications

  • 2013-10. Histone H3 lysine 4 methyltransferases and demethylases in self-renewal anddifferentiation of stem cells in CELL & BIOSCIENCE
  • 2012-07. Genomic approaches towards finding cis-regulatory modules in animals in NATURE REVIEWS GENETICS
  • 2013-06. Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data in NATURE REVIEWS GENETICS
  • 2009-07. Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus in NATURE
  • 2017-11. Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability in NATURE GENETICS
  • 2013-11. A high-resolution map of the three-dimensional chromatin interactome in human cells in NATURE
  • 2011-06. Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease in GENOME MEDICINE
  • 2011-04. Enhancer function: new insights into the regulation of tissue-specific gene expression in NATURE REVIEWS GENETICS
  • 2009-01. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources in NATURE PROTOCOLS
  • 2011-05-05. Mapping and analysis of chromatin state dynamics in nine human cell types in NATURE
  • 2009-05. Histone modifications at human enhancers reflect global cell-type-specific gene expression in NATURE
  • 2014-04. CTCF: an architectural protein bridging genome topology and function in NATURE REVIEWS GENETICS
  • 2015-02. Chromatin architecture reorganization during stem cell differentiation in NATURE
  • 2015-02. Integrative analysis of 111 reference human epigenomes in NATURE
  • 2012-04-11. Spatial partitioning of the regulatory landscape of the X-inactivation centre in NATURE
  • 2014-12. Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe in NATURE
  • 2008-02. Cohesin mediates transcriptional insulation by CCCTC-binding factor in NATURE
  • 1999-07. The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins in NATURE
  • 2007-03. Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome in NATURE GENETICS
  • 2015-04. The effects of chromatin organization on variation in mutation rates in the genome in NATURE REVIEWS GENETICS
  • 2012-09. An integrated encyclopedia of DNA elements in the human genome in NATURE
  • 2012-03-01. Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks in NATURE PROTOCOLS
  • 2012-04-11. Topological domains in mammalian genomes identified by analysis of chromatin interactions in NATURE
  • 2012-09. The long-range interaction landscape of gene promoters in NATURE
  • 2010-09. Mediator and cohesin connect gene expression and chromatin architecture in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cr.2018.1

    DOI

    http://dx.doi.org/10.1038/cr.2018.1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1100267795

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29313530


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