Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-06

AUTHORS

Xinjian Liu, Fang Li, Qian Huang, Zhengxiang Zhang, Ling Zhou, Yu Deng, Min Zhou, Donald E Fleenor, He Wang, Michael B Kastan, Chuan-Yuan Li

ABSTRACT

DNA double-strand breaks (DSBs) are traditionally associated with cancer through their abilities to cause chromosomal instabilities or gene mutations. Here we report a new class of self-inflicted DNA DSBs that can drive tumor growth irrespective of their effects on genomic stability. We discover a mechanism through which cancer cells cause DSBs in their own genome spontaneously independent of reactive oxygen species or replication stress. In this mechanism, low-level cytochrome c leakage from the mitochondria leads to sublethal activation of apoptotic caspases and nucleases, which causes DNA DSBs. In response to these spontaneous DNA DSBs, ATM, a key factor involved in DNA damage response, is constitutively activated. Activated ATM leads to activation of transcription factors NF-κB and STAT3, known drivers of tumor growth. Moreover, self-inflicted DNA DSB formation and ATM activation are important in sustaining the stemness of patient-derived glioma cells. In human tumor tissues, elevated levels of activated ATM correlate with poor patient survival. Self-inflicted DNA DSBs therefore are functionally important for maintaining the malignancy of cancer cells. More... »

PAGES

764

References to SciGraph publications

  • 2009-10. The DNA-damage response in human biology and disease in NATURE
  • 2000-05. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors in ONCOGENE
  • 2005-04. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis in NATURE
  • 2003-03. ATM and related protein kinases: safeguarding genome integrity in NATURE REVIEWS CANCER
  • 2003-01. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation in NATURE
  • 2013-04. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2013-11. Genome engineering using the CRISPR-Cas9 system in NATURE PROTOCOLS
  • 1976-07. A soft agar colony assay for Lewis lung tumour and B16 melanoma taken directly from the mouse in BRITISH JOURNAL OF CANCER
  • 2005-04. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions in NATURE
  • 2004-11. Identification of human brain tumour initiating cells in NATURE
  • 2004-10. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells in NATURE
  • 2006-11. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints in NATURE
  • 2014-11. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? in NATURE REVIEWS CANCER
  • 2008-11. 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility in NATURE
  • 1997-09. Clustering of missense mutations in the ataxia-telanglectasia gene in a sporadic T-cell leukaemia in NATURE GENETICS
  • 2006-12. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response in NATURE
  • 2003-09. Mechanism and regulation of human non-homologous DNA end-joining in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2014-11. Revisiting STAT3 signalling in cancer: new and unexpected biological functions in NATURE REVIEWS CANCER
  • 2001-07. Endonuclease G is an apoptotic DNase when released from mitochondria in NATURE
  • 1998-01. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD in NATURE
  • 2002-03. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis in ONCOGENE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/cr.2017.41

    DOI

    http://dx.doi.org/10.1038/cr.2017.41

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1084127943

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28337983


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Ataxia Telangiectasia Mutated Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Cycle Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytochromes c", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Breaks, Double-Stranded", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Damage", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Replication", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "NF-kappa B", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "STAT3 Transcription Factor", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Duke University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.189509.c", 
              "name": [
                "Department of Dermatology, Duke University Medical Center, Durham, NC 27710, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Liu", 
            "givenName": "Xinjian", 
            "id": "sg:person.015617541067.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015617541067.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Duke University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.189509.c", 
              "name": [
                "Department of Dermatology, Duke University Medical Center, Durham, NC 27710, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Fang", 
            "id": "sg:person.016577250537.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016577250537.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Cancer Center, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201620, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Huang", 
            "givenName": "Qian", 
            "id": "sg:person.0643542454.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643542454.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Cancer Center, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201620, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhang", 
            "givenName": "Zhengxiang", 
            "id": "sg:person.0743223421.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743223421.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shanghai Jiao Tong University", 
              "id": "https://www.grid.ac/institutes/grid.16821.3c", 
              "name": [
                "Department of Surgery, Shanghai General Branch Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200081, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhou", 
            "givenName": "Ling", 
            "id": "sg:person.01027702424.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027702424.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Duke University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.189509.c", 
              "name": [
                "Department of Dermatology, Duke University Medical Center, Durham, NC 27710, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Deng", 
            "givenName": "Yu", 
            "id": "sg:person.012514076573.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012514076573.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shanghai Cancer Institute", 
              "id": "https://www.grid.ac/institutes/grid.419087.3", 
              "name": [
                "Department of Dermatology, Duke University Medical Center, Durham, NC 27710, USA", 
                "State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai JiaotongUniversity, Shanghai 200032, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Zhou", 
            "givenName": "Min", 
            "id": "sg:person.0706257076.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706257076.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Duke University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.189509.c", 
              "name": [
                "Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fleenor", 
            "givenName": "Donald E", 
            "id": "sg:person.01254043450.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254043450.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "West China Second University Hospital of Sichuan University", 
              "id": "https://www.grid.ac/institutes/grid.461863.e", 
              "name": [
                "West China Second University Hospital, Sichuan University, Chengdu 610041, China"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wang", 
            "givenName": "He", 
            "id": "sg:person.01274624024.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274624024.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Duke University", 
              "id": "https://www.grid.ac/institutes/grid.26009.3d", 
              "name": [
                "Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA", 
                "Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kastan", 
            "givenName": "Michael B", 
            "id": "sg:person.01277715415.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277715415.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Duke University", 
              "id": "https://www.grid.ac/institutes/grid.26009.3d", 
              "name": [
                "Department of Dermatology, Duke University Medical Center, Durham, NC 27710, USA", 
                "Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA", 
                "Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Li", 
            "givenName": "Chuan-Yuan", 
            "id": "sg:person.014106404044.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014106404044.26"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1146/annurev.biochem.77.061306.125255", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000560477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ccr.2009.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000677027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002815475", 
              "https://doi.org/10.1038/nature01368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature01368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002815475", 
              "https://doi.org/10.1038/nature01368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1074-7613(00)80618-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003307741"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005294665", 
              "https://doi.org/10.1038/nature03485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005294665", 
              "https://doi.org/10.1038/nature03485"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature07433", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006006481", 
              "https://doi.org/10.1038/nature07433"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006935562", 
              "https://doi.org/10.1038/sj.onc.1205260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1205260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006935562", 
              "https://doi.org/10.1038/sj.onc.1205260"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35083620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009664464", 
              "https://doi.org/10.1038/35083620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35083620", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009664464", 
              "https://doi.org/10.1038/35083620"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010441359", 
              "https://doi.org/10.1038/nrm1202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm1202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010441359", 
              "https://doi.org/10.1038/nrm1202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1121513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010937052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3818", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014076105", 
              "https://doi.org/10.1038/nrc3818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1083430", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014114228"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2013.143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016534425", 
              "https://doi.org/10.1038/nprot.2013.143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/34112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019010983", 
              "https://doi.org/10.1038/34112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/34112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019010983", 
              "https://doi.org/10.1038/34112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1231143", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019873131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.15.8461", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024134474"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2015.01.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024976933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026415083", 
              "https://doi.org/10.1038/sj.onc.1203551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1203551", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026415083", 
              "https://doi.org/10.1038/sj.onc.1203551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026716666", 
              "https://doi.org/10.1038/nrc1011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026716666", 
              "https://doi.org/10.1038/nrc1011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026716666", 
              "https://doi.org/10.1038/nrc1011"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2010.09.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027198160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027226854", 
              "https://doi.org/10.1038/nature03128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027226854", 
              "https://doi.org/10.1038/nature03128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1059108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027799699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1091/mbc.e11-11-0926", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027817942"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.13.2.152", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028446157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm198705213162101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028846880"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc3803", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029306453", 
              "https://doi.org/10.1038/nrc3803"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1976.119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029560762", 
              "https://doi.org/10.1038/bjc.1976.119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.1976.119", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029560762", 
              "https://doi.org/10.1038/bjc.1976.119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2015.03.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032608805"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.12.13.2048", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033063759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/emboj/18.15.4261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033558568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.90.21.10193", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034195516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.95.13.7445", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034383084"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037091000", 
              "https://doi.org/10.1038/nature03482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03482", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037091000", 
              "https://doi.org/10.1038/nature03482"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-08-2121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037485913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(95)90360-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039756136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039813470", 
              "https://doi.org/10.1038/nature05268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039813470", 
              "https://doi.org/10.1038/nature05268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039813470", 
              "https://doi.org/10.1038/nature05268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.273.10.5858", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040536653"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2010.09.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040893605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041233330", 
              "https://doi.org/10.1038/nature05236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041233330", 
              "https://doi.org/10.1038/nature05236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature05236", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041233330", 
              "https://doi.org/10.1038/nature05236"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng0997-96", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043997544", 
              "https://doi.org/10.1038/ng0997-96"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046218320", 
              "https://doi.org/10.1038/nature02989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature02989", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046218320", 
              "https://doi.org/10.1038/nature02989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrm3546", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047891925", 
              "https://doi.org/10.1038/nrm3546"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gku529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049310551"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(95)90482-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050858444"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052581766", 
              "https://doi.org/10.1038/nature08467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08467", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052581766", 
              "https://doi.org/10.1038/nature08467"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/82.9.779", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059816436"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.281.5383.1677", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062562417"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.288.5467.870", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062569393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7792600", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062649253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7855601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062649925"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074547600", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074596284", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076575059", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082701482", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-06", 
        "datePublishedReg": "2017-06-01", 
        "description": "DNA double-strand breaks (DSBs) are traditionally associated with cancer through their abilities to cause chromosomal instabilities or gene mutations. Here we report a new class of self-inflicted DNA DSBs that can drive tumor growth irrespective of their effects on genomic stability. We discover a mechanism through which cancer cells cause DSBs in their own genome spontaneously independent of reactive oxygen species or replication stress. In this mechanism, low-level cytochrome c leakage from the mitochondria leads to sublethal activation of apoptotic caspases and nucleases, which causes DNA DSBs. In response to these spontaneous DNA DSBs, ATM, a key factor involved in DNA damage response, is constitutively activated. Activated ATM leads to activation of transcription factors NF-\u03baB and STAT3, known drivers of tumor growth. Moreover, self-inflicted DNA DSB formation and ATM activation are important in sustaining the stemness of patient-derived glioma cells. In human tumor tissues, elevated levels of activated ATM correlate with poor patient survival. Self-inflicted DNA DSBs therefore are functionally important for maintaining the malignancy of cancer cells.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/cr.2017.41", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.2481216", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2481294", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2438807", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3803808", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3536071", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1107753", 
            "issn": [
              "1001-0602", 
              "1748-7838"
            ], 
            "name": "Cell Research", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "27"
          }
        ], 
        "name": "Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells", 
        "pagination": "764", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "501b3f86f5536a012cf5a9e5f355c35ec088f0d27b2f58de867841decdda2716"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28337983"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9425763"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/cr.2017.41"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1084127943"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/cr.2017.41", 
          "https://app.dimensions.ai/details/publication/pub.1084127943"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T13:57", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000434.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/cr201741"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/cr.2017.41'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/cr.2017.41'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/cr.2017.41'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/cr.2017.41'


     

    This table displays all metadata directly associated to this object as RDF triples.

    384 TRIPLES      21 PREDICATES      92 URIs      30 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/cr.2017.41 schema:about N08feeb769ab24d85946c9d15a97fea88
    2 N2acd03ffe89d451b8a0badd291191ba3
    3 N47911a5e188147998b027b73a630fa63
    4 N7b237711960c4226b14dac796e87ef0b
    5 N928a555951ee4209922f5f5134c1f9fa
    6 N95f06f9972d349ab9ee58e1bd0a33488
    7 Nbc24430996af4b1891ff48544cb49ded
    8 Nc38e9f8d219c44d5bcde2ef6ca16ca0e
    9 Ne421c302183f468cba172ced8ea94ed1
    10 anzsrc-for:11
    11 anzsrc-for:1112
    12 schema:author N4785e332a64e4fec8cf7f5828138ee51
    13 schema:citation sg:pub.10.1038/34112
    14 sg:pub.10.1038/35083620
    15 sg:pub.10.1038/bjc.1976.119
    16 sg:pub.10.1038/nature01368
    17 sg:pub.10.1038/nature02989
    18 sg:pub.10.1038/nature03128
    19 sg:pub.10.1038/nature03482
    20 sg:pub.10.1038/nature03485
    21 sg:pub.10.1038/nature05236
    22 sg:pub.10.1038/nature05268
    23 sg:pub.10.1038/nature07433
    24 sg:pub.10.1038/nature08467
    25 sg:pub.10.1038/ng0997-96
    26 sg:pub.10.1038/nprot.2013.143
    27 sg:pub.10.1038/nrc1011
    28 sg:pub.10.1038/nrc3803
    29 sg:pub.10.1038/nrc3818
    30 sg:pub.10.1038/nrm1202
    31 sg:pub.10.1038/nrm3546
    32 sg:pub.10.1038/sj.onc.1203551
    33 sg:pub.10.1038/sj.onc.1205260
    34 https://app.dimensions.ai/details/publication/pub.1074547600
    35 https://app.dimensions.ai/details/publication/pub.1074596284
    36 https://app.dimensions.ai/details/publication/pub.1076575059
    37 https://app.dimensions.ai/details/publication/pub.1082701482
    38 https://doi.org/10.1016/0092-8674(95)90360-7
    39 https://doi.org/10.1016/0092-8674(95)90482-4
    40 https://doi.org/10.1016/j.ccr.2009.01.001
    41 https://doi.org/10.1016/j.molcel.2010.09.019
    42 https://doi.org/10.1016/j.molcel.2015.01.018
    43 https://doi.org/10.1016/j.molcel.2015.03.003
    44 https://doi.org/10.1016/j.stem.2010.09.003
    45 https://doi.org/10.1016/s1074-7613(00)80618-4
    46 https://doi.org/10.1056/nejm198705213162101
    47 https://doi.org/10.1073/pnas.90.21.10193
    48 https://doi.org/10.1073/pnas.95.13.7445
    49 https://doi.org/10.1073/pnas.95.15.8461
    50 https://doi.org/10.1074/jbc.273.10.5858
    51 https://doi.org/10.1091/mbc.e11-11-0926
    52 https://doi.org/10.1093/emboj/18.15.4261
    53 https://doi.org/10.1093/jnci/82.9.779
    54 https://doi.org/10.1093/nar/gku529
    55 https://doi.org/10.1101/gad.12.13.2048
    56 https://doi.org/10.1101/gad.13.2.152
    57 https://doi.org/10.1126/science.1059108
    58 https://doi.org/10.1126/science.1083430
    59 https://doi.org/10.1126/science.1121513
    60 https://doi.org/10.1126/science.1231143
    61 https://doi.org/10.1126/science.281.5383.1677
    62 https://doi.org/10.1126/science.288.5467.870
    63 https://doi.org/10.1126/science.7792600
    64 https://doi.org/10.1126/science.7855601
    65 https://doi.org/10.1146/annurev.biochem.77.061306.125255
    66 https://doi.org/10.1158/0008-5472.can-08-2121
    67 schema:datePublished 2017-06
    68 schema:datePublishedReg 2017-06-01
    69 schema:description DNA double-strand breaks (DSBs) are traditionally associated with cancer through their abilities to cause chromosomal instabilities or gene mutations. Here we report a new class of self-inflicted DNA DSBs that can drive tumor growth irrespective of their effects on genomic stability. We discover a mechanism through which cancer cells cause DSBs in their own genome spontaneously independent of reactive oxygen species or replication stress. In this mechanism, low-level cytochrome c leakage from the mitochondria leads to sublethal activation of apoptotic caspases and nucleases, which causes DNA DSBs. In response to these spontaneous DNA DSBs, ATM, a key factor involved in DNA damage response, is constitutively activated. Activated ATM leads to activation of transcription factors NF-κB and STAT3, known drivers of tumor growth. Moreover, self-inflicted DNA DSB formation and ATM activation are important in sustaining the stemness of patient-derived glioma cells. In human tumor tissues, elevated levels of activated ATM correlate with poor patient survival. Self-inflicted DNA DSBs therefore are functionally important for maintaining the malignancy of cancer cells.
    70 schema:genre research_article
    71 schema:inLanguage en
    72 schema:isAccessibleForFree true
    73 schema:isPartOf N91251b6a8743426987f04b794f86142f
    74 Nc931b059b07d4d4b8e43ef9b353289ac
    75 sg:journal.1107753
    76 schema:name Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells
    77 schema:pagination 764
    78 schema:productId N1be357b2da3143d2871f8382b36df216
    79 N3e2903ec77414801a4cb255f26497350
    80 N864545ea4a0a4e459bc10b65ec615531
    81 Nc0ee67c7048e48088a7f0ae6f88bb9f3
    82 Ne1cb7c1c9f794f078f885012d89f2f9c
    83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084127943
    84 https://doi.org/10.1038/cr.2017.41
    85 schema:sdDatePublished 2019-04-10T13:57
    86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    87 schema:sdPublisher Nb766b72c91ea41f8a12e849df978bc32
    88 schema:url https://www.nature.com/articles/cr201741
    89 sgo:license sg:explorer/license/
    90 sgo:sdDataset articles
    91 rdf:type schema:ScholarlyArticle
    92 N0198d00b12fc4cda8edb98582ce1f554 rdf:first sg:person.01277715415.41
    93 rdf:rest N349a653c04274adabdc21cc6651a7805
    94 N08feeb769ab24d85946c9d15a97fea88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name DNA Replication
    96 rdf:type schema:DefinedTerm
    97 N1be357b2da3143d2871f8382b36df216 schema:name doi
    98 schema:value 10.1038/cr.2017.41
    99 rdf:type schema:PropertyValue
    100 N229fc79d70d34909a1d891c187732adc rdf:first sg:person.01027702424.29
    101 rdf:rest N66f0f386c2a7418f954486528795e64e
    102 N2acd03ffe89d451b8a0badd291191ba3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name DNA Breaks, Double-Stranded
    104 rdf:type schema:DefinedTerm
    105 N349a653c04274adabdc21cc6651a7805 rdf:first sg:person.014106404044.26
    106 rdf:rest rdf:nil
    107 N3e2903ec77414801a4cb255f26497350 schema:name nlm_unique_id
    108 schema:value 9425763
    109 rdf:type schema:PropertyValue
    110 N4785e332a64e4fec8cf7f5828138ee51 rdf:first sg:person.015617541067.53
    111 rdf:rest Nbd76d0eb3a4647d6ab28596cf7045d33
    112 N47911a5e188147998b027b73a630fa63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Ataxia Telangiectasia Mutated Proteins
    114 rdf:type schema:DefinedTerm
    115 N66f0f386c2a7418f954486528795e64e rdf:first sg:person.012514076573.91
    116 rdf:rest Na6077a9a3d4e4cc58eb2c28631236f3c
    117 N67de42f72c964d0b9e8aa28a7842c4ed rdf:first sg:person.0743223421.86
    118 rdf:rest N229fc79d70d34909a1d891c187732adc
    119 N7ae6382e1bd84159bb3dadc35446b9dc rdf:first sg:person.0643542454.04
    120 rdf:rest N67de42f72c964d0b9e8aa28a7842c4ed
    121 N7b237711960c4226b14dac796e87ef0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Cell Cycle Proteins
    123 rdf:type schema:DefinedTerm
    124 N864545ea4a0a4e459bc10b65ec615531 schema:name pubmed_id
    125 schema:value 28337983
    126 rdf:type schema:PropertyValue
    127 N91251b6a8743426987f04b794f86142f schema:volumeNumber 27
    128 rdf:type schema:PublicationVolume
    129 N928a555951ee4209922f5f5134c1f9fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Humans
    131 rdf:type schema:DefinedTerm
    132 N93bc608cc1a741e0a0a5eef6b0f41fb7 schema:name Cancer Center, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201620, China
    133 rdf:type schema:Organization
    134 N95f06f9972d349ab9ee58e1bd0a33488 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name DNA Damage
    136 rdf:type schema:DefinedTerm
    137 Na6077a9a3d4e4cc58eb2c28631236f3c rdf:first sg:person.0706257076.45
    138 rdf:rest Na78c2071f6674f5f954be85efe7844cf
    139 Na78c2071f6674f5f954be85efe7844cf rdf:first sg:person.01254043450.42
    140 rdf:rest Nfc58e23457f941e5af8269501b37077d
    141 Nb766b72c91ea41f8a12e849df978bc32 schema:name Springer Nature - SN SciGraph project
    142 rdf:type schema:Organization
    143 Nbc24430996af4b1891ff48544cb49ded schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Cytochromes c
    145 rdf:type schema:DefinedTerm
    146 Nbd76d0eb3a4647d6ab28596cf7045d33 rdf:first sg:person.016577250537.32
    147 rdf:rest N7ae6382e1bd84159bb3dadc35446b9dc
    148 Nc0ee67c7048e48088a7f0ae6f88bb9f3 schema:name readcube_id
    149 schema:value 501b3f86f5536a012cf5a9e5f355c35ec088f0d27b2f58de867841decdda2716
    150 rdf:type schema:PropertyValue
    151 Nc38e9f8d219c44d5bcde2ef6ca16ca0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name NF-kappa B
    153 rdf:type schema:DefinedTerm
    154 Nc931b059b07d4d4b8e43ef9b353289ac schema:issueNumber 6
    155 rdf:type schema:PublicationIssue
    156 Ne1cb7c1c9f794f078f885012d89f2f9c schema:name dimensions_id
    157 schema:value pub.1084127943
    158 rdf:type schema:PropertyValue
    159 Ne421c302183f468cba172ced8ea94ed1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name STAT3 Transcription Factor
    161 rdf:type schema:DefinedTerm
    162 Nfb0db24a6a08451195ec3a8390873457 schema:name Cancer Center, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201620, China
    163 rdf:type schema:Organization
    164 Nfc58e23457f941e5af8269501b37077d rdf:first sg:person.01274624024.79
    165 rdf:rest N0198d00b12fc4cda8edb98582ce1f554
    166 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    167 schema:name Medical and Health Sciences
    168 rdf:type schema:DefinedTerm
    169 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    170 schema:name Oncology and Carcinogenesis
    171 rdf:type schema:DefinedTerm
    172 sg:grant.2438807 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2017.41
    173 rdf:type schema:MonetaryGrant
    174 sg:grant.2481216 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2017.41
    175 rdf:type schema:MonetaryGrant
    176 sg:grant.2481294 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2017.41
    177 rdf:type schema:MonetaryGrant
    178 sg:grant.3536071 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2017.41
    179 rdf:type schema:MonetaryGrant
    180 sg:grant.3803808 http://pending.schema.org/fundedItem sg:pub.10.1038/cr.2017.41
    181 rdf:type schema:MonetaryGrant
    182 sg:journal.1107753 schema:issn 1001-0602
    183 1748-7838
    184 schema:name Cell Research
    185 rdf:type schema:Periodical
    186 sg:person.01027702424.29 schema:affiliation https://www.grid.ac/institutes/grid.16821.3c
    187 schema:familyName Zhou
    188 schema:givenName Ling
    189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027702424.29
    190 rdf:type schema:Person
    191 sg:person.012514076573.91 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
    192 schema:familyName Deng
    193 schema:givenName Yu
    194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012514076573.91
    195 rdf:type schema:Person
    196 sg:person.01254043450.42 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
    197 schema:familyName Fleenor
    198 schema:givenName Donald E
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254043450.42
    200 rdf:type schema:Person
    201 sg:person.01274624024.79 schema:affiliation https://www.grid.ac/institutes/grid.461863.e
    202 schema:familyName Wang
    203 schema:givenName He
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274624024.79
    205 rdf:type schema:Person
    206 sg:person.01277715415.41 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
    207 schema:familyName Kastan
    208 schema:givenName Michael B
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277715415.41
    210 rdf:type schema:Person
    211 sg:person.014106404044.26 schema:affiliation https://www.grid.ac/institutes/grid.26009.3d
    212 schema:familyName Li
    213 schema:givenName Chuan-Yuan
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014106404044.26
    215 rdf:type schema:Person
    216 sg:person.015617541067.53 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
    217 schema:familyName Liu
    218 schema:givenName Xinjian
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015617541067.53
    220 rdf:type schema:Person
    221 sg:person.016577250537.32 schema:affiliation https://www.grid.ac/institutes/grid.189509.c
    222 schema:familyName Li
    223 schema:givenName Fang
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016577250537.32
    225 rdf:type schema:Person
    226 sg:person.0643542454.04 schema:affiliation N93bc608cc1a741e0a0a5eef6b0f41fb7
    227 schema:familyName Huang
    228 schema:givenName Qian
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643542454.04
    230 rdf:type schema:Person
    231 sg:person.0706257076.45 schema:affiliation https://www.grid.ac/institutes/grid.419087.3
    232 schema:familyName Zhou
    233 schema:givenName Min
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706257076.45
    235 rdf:type schema:Person
    236 sg:person.0743223421.86 schema:affiliation Nfb0db24a6a08451195ec3a8390873457
    237 schema:familyName Zhang
    238 schema:givenName Zhengxiang
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0743223421.86
    240 rdf:type schema:Person
    241 sg:pub.10.1038/34112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019010983
    242 https://doi.org/10.1038/34112
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1038/35083620 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009664464
    245 https://doi.org/10.1038/35083620
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1038/bjc.1976.119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029560762
    248 https://doi.org/10.1038/bjc.1976.119
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/nature01368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002815475
    251 https://doi.org/10.1038/nature01368
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1038/nature02989 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046218320
    254 https://doi.org/10.1038/nature02989
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1038/nature03128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027226854
    257 https://doi.org/10.1038/nature03128
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1038/nature03482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037091000
    260 https://doi.org/10.1038/nature03482
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1038/nature03485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005294665
    263 https://doi.org/10.1038/nature03485
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1038/nature05236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041233330
    266 https://doi.org/10.1038/nature05236
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1038/nature05268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039813470
    269 https://doi.org/10.1038/nature05268
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1038/nature07433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006006481
    272 https://doi.org/10.1038/nature07433
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1038/nature08467 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052581766
    275 https://doi.org/10.1038/nature08467
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1038/ng0997-96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043997544
    278 https://doi.org/10.1038/ng0997-96
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1038/nprot.2013.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016534425
    281 https://doi.org/10.1038/nprot.2013.143
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/nrc1011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026716666
    284 https://doi.org/10.1038/nrc1011
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/nrc3803 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029306453
    287 https://doi.org/10.1038/nrc3803
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/nrc3818 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014076105
    290 https://doi.org/10.1038/nrc3818
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/nrm1202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010441359
    293 https://doi.org/10.1038/nrm1202
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1038/nrm3546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047891925
    296 https://doi.org/10.1038/nrm3546
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1038/sj.onc.1203551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026415083
    299 https://doi.org/10.1038/sj.onc.1203551
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/sj.onc.1205260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006935562
    302 https://doi.org/10.1038/sj.onc.1205260
    303 rdf:type schema:CreativeWork
    304 https://app.dimensions.ai/details/publication/pub.1074547600 schema:CreativeWork
    305 https://app.dimensions.ai/details/publication/pub.1074596284 schema:CreativeWork
    306 https://app.dimensions.ai/details/publication/pub.1076575059 schema:CreativeWork
    307 https://app.dimensions.ai/details/publication/pub.1082701482 schema:CreativeWork
    308 https://doi.org/10.1016/0092-8674(95)90360-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039756136
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1016/0092-8674(95)90482-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050858444
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1016/j.ccr.2009.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000677027
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1016/j.molcel.2010.09.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027198160
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1016/j.molcel.2015.01.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024976933
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1016/j.molcel.2015.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032608805
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1016/j.stem.2010.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040893605
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.1016/s1074-7613(00)80618-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003307741
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.1056/nejm198705213162101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028846880
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.1073/pnas.90.21.10193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034195516
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.1073/pnas.95.13.7445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034383084
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.1073/pnas.95.15.8461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024134474
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.1074/jbc.273.10.5858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040536653
    333 rdf:type schema:CreativeWork
    334 https://doi.org/10.1091/mbc.e11-11-0926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027817942
    335 rdf:type schema:CreativeWork
    336 https://doi.org/10.1093/emboj/18.15.4261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033558568
    337 rdf:type schema:CreativeWork
    338 https://doi.org/10.1093/jnci/82.9.779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059816436
    339 rdf:type schema:CreativeWork
    340 https://doi.org/10.1093/nar/gku529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049310551
    341 rdf:type schema:CreativeWork
    342 https://doi.org/10.1101/gad.12.13.2048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033063759
    343 rdf:type schema:CreativeWork
    344 https://doi.org/10.1101/gad.13.2.152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028446157
    345 rdf:type schema:CreativeWork
    346 https://doi.org/10.1126/science.1059108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027799699
    347 rdf:type schema:CreativeWork
    348 https://doi.org/10.1126/science.1083430 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014114228
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1126/science.1121513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010937052
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1126/science.1231143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019873131
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1126/science.281.5383.1677 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062562417
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1126/science.288.5467.870 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062569393
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1126/science.7792600 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649253
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1126/science.7855601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062649925
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1146/annurev.biochem.77.061306.125255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000560477
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1158/0008-5472.can-08-2121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037485913
    365 rdf:type schema:CreativeWork
    366 https://www.grid.ac/institutes/grid.16821.3c schema:alternateName Shanghai Jiao Tong University
    367 schema:name Department of Surgery, Shanghai General Branch Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200081, China
    368 rdf:type schema:Organization
    369 https://www.grid.ac/institutes/grid.189509.c schema:alternateName Duke University Hospital
    370 schema:name Department of Dermatology, Duke University Medical Center, Durham, NC 27710, USA
    371 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    372 rdf:type schema:Organization
    373 https://www.grid.ac/institutes/grid.26009.3d schema:alternateName Duke University
    374 schema:name Department of Dermatology, Duke University Medical Center, Durham, NC 27710, USA
    375 Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    376 Duke Cancer Institute, Duke University Medical Center, Durham, NC 27710, USA
    377 rdf:type schema:Organization
    378 https://www.grid.ac/institutes/grid.419087.3 schema:alternateName Shanghai Cancer Institute
    379 schema:name Department of Dermatology, Duke University Medical Center, Durham, NC 27710, USA
    380 State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai JiaotongUniversity, Shanghai 200032, China
    381 rdf:type schema:Organization
    382 https://www.grid.ac/institutes/grid.461863.e schema:alternateName West China Second University Hospital of Sichuan University
    383 schema:name West China Second University Hospital, Sichuan University, Chengdu 610041, China
    384 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...